Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

Pathogen Recognition and Innate Immunity

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

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Approaching the asymptote? Evolution and revolution in immunology.Preprint

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Recognition of microorganisms and activation of the immune response

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Innate immune recognition of viral infection

Kawai, T., & Akira, S. (2006) · Nature Immunology · doi:10.1038/ni1303 · Cited by 1,899 · see citing works

Immune Signaling by RIG-I-like Receptors

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Immunity to fungal infections

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Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

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The immune response of Drosophila

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Signalling through C-type lectin receptors: shaping immune responses

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The SYK tyrosine kinase: A crucial player in diverse biological functions

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Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

Rathinam, V. A. K., Jiang, Z., Waggoner, S. N., Sharma, S., Cole, L. E., Waggoner, L., Vanaja, S. K., Monks, B. G., Ganesan, S., Latz, E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1864 · Cited by 1,331 · see citing works

Intracellular Toll-like Receptors

Blasius, A. L., & Beutler, B. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.012 · Cited by 1,329 · see citing works

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

von Bernuth, H., Pïcard, C., Jin, Z., Sranujit, R. P., Xiao, H. Q., Ku, C., Chrabieh, M., Ben‐Mustapha, I., Ghandil, P., Çamcıoğlu, Y., et al. (2008) · Science · doi:10.1126/science.1158298 · Cited by 1,287 · see citing works

Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases

Gilliet, M., Cao, W., & Liu, Y.-J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2358 · Cited by 1,190 · see citing works

TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

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Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection1

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Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

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TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

Yarovinsky, F., Zhang, D., Andersen, J. F., Bannenberg, G. L., Serhan, C. N., Hayden, M. S., Hieny, S. E., Sutterwala, F. S., Flavell, R. A., Ghosh, S., et al. (2005) · Science · doi:10.1126/science.1109893 · Cited by 1,049 · see citing works

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

Tabeta, K., Georgel, P., Janssen, E. M., Du, X., Hoebe, K. H. N., Crozat, K., Mudd, S., Shamel, L., Sovath, S., Goode, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400525101 · Cited by 956 · see citing works

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Groß, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V. L. J., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 922 · see citing works

Toll-like receptor 3 promotes cross-priming to virus-infected cells

Schulz, O., Diebold, S. S., Chen, M., Näslund, T. I., Nolte, M. A., Alexopoulou, L., Azuma, Y., Flavell, R. A., Liljeström, P., & Sousa, C. R. E. (2005) · Nature · doi:10.1038/nature03326 · Cited by 919 · see citing works

Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

Honda, K., Ohba, Y., Yanai, H., Negishi, H., Mizutani, T., Takaoka, A., Taya, C., & Taniguchi, T. (2005) · Nature · doi:10.1038/nature03547 · Cited by 908 · see citing works

Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells

Lee, H. K., Lund, J. M., Ramanathan, B., Mizushima, N., & Iwasaki, A. (2007) · Science · doi:10.1126/science.1136880 · Cited by 865 · see citing works

Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

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TLRs and innate immunity

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Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

Pïcard, C., Puel, A., Bonnet, M., Ku, C., Bustamante, J. C., Yang, K., Soudais, C., Boisson‐Dupuis, S., Feinberg, J. M., Fieschi, C., et al. (2003) · Science · doi:10.1126/science.1081902 · Cited by 828 · see citing works

A Homozygous <i>CARD9</i> Mutation in a Family with Susceptibility to Fungal Infections

Glocker, E.-O., Hennigs, A., Nabavi, M., Schäffer, A. A., Woellner, C., Salzer, U., Pfeifer, D., Veelken, H., Warnatz, K., Tahami, F., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810719 · Cited by 800 · see citing works

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

Ishikawa, E., Ishikawa, T., Morita, Y. S., Toyonaga, K., Yamada, H., Takeuchi, O., Kinoshita, T., Akira, S., Yoshikai, Y., & Yamasaki, S. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091750 · Cited by 794 · see citing works

Toll-like receptor 2 controls expansion and function of regulatory T cells

Sutmuller, R. P. M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25439 · Cited by 750 · see citing works

Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency

Casrouge, A., Zhang, S.-Y., Eidenschenk, C., Jouanguy, E., Puel, A., Yang, K., Alcais, A., Picard, C., Mahfoufi, N., Nicolas, N., et al. (2006) · Science · doi:10.1126/science.1128346 · Cited by 749 · see citing works

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

Uematsu, S., Fujimoto, K., Jang, M. H., Yang, B., Jung, Y.-J., Nishiyama, M., Sato, S., Tsujimura, T., Yamamoto, M., Yokota, Y., et al. (2008) · Nature Immunology · doi:10.1038/ni.1622 · Cited by 746 · see citing works

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

Tabeta, K., Hoebe, K. H. N., Janssen, E. M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., et al. (2006) · Nature Immunology · doi:10.1038/ni1297 · Cited by 736 · see citing works

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

Fernandes-Alnemri, T., Yu, J.-W., Juliana, C., Solorzano, L., Kang, S., Wu, J., Datta, P., McCormick, M., Huang, L., McDermott, E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1859 · Cited by 732 · see citing works

A cell biological view of Toll-like receptor function: regulation through compartmentalization

Barton, G. M., & Kagan, J. C. (2009) · Nature reviews. Immunology · doi:10.1038/nri2587 · Cited by 713 · see citing works

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

Kim, Y., Brinkmann, M. M., Paquet, M.-È., & Ploegh, H. L. (2008) · Nature · doi:10.1038/nature06726 · Cited by 699 · see citing works

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

Yanai, H., Ban, T., Wang, Z., Choi, M. K., Kawamura, T., Negishi, H., Nakasato, M., Lu, Y., Hangai, S., Koshiba, R., et al. (2009) · Nature · doi:10.1038/nature08512 · Cited by 683 · see citing works

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

Longhi, M. P., Trumpfheller, C., Idoyaga, J., Caskey, M. F., de Matos, I. G., Kluger, C., Salazar, A. Μ., Colonna, M., & Steinman, R. M. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090247 · Cited by 663 · see citing works

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

Coban, C., Ishii, K. J., Kawai, T., Hemmi, H., Sato, S., Uematsu, S., Yamamoto, M., Takeuchi, O., Itagaki, S., Kumar, N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041836 · Cited by 640 · see citing works

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

Ishii, K. J., Kawagoe, T., Koyama, S., Matsui, K., Kumar, H., Kawai, T., Uematsu, S., Takeuchi, O., Takeshita, F., Coban, C., et al. (2008) · Nature · doi:10.1038/nature06537 · Cited by 628 · see citing works

Plasmacytoid Dendritic Cells: Recent Progress and Open Questions

Reizis, B., Bunin, A., Ghosh, H. S., Lewis, K. L. T., & Sisirak, V. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101345 · Cited by 624 · see citing works

Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells

Netea, M. G., Sutmuller, R. P. M., Hermann, C., van der Graaf, C. A. A., van der Meer, J. W. M., van Krieken, J. H., Härtung, T., Adema, G. J., & Kullberg, B. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3712 · Cited by 611 · see citing works

Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling

Gavin, A. L., Hoebe, K. H. N., Duong, B. H., Ota, T., Martin, C. E., Beutler, B., & Nemazee, D. A. (2006) · Science · doi:10.1126/science.1135299 · Cited by 581 · see citing works

Nucleic acid recognition by the innate immune system

Barbalat, R., Ewald, S. E., Mouchess, M. L., & Barton, G. M. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101340 · Cited by 577 · see citing works

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

Hise, A. G., Tomalka, J. A., Ganesan, S., Patel, K., Hall, B. A., Brown, G. D., & Fitzgerald, K. A. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.002 · Cited by 568 · see citing works

Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α + DC correlates with unresponsiveness to imidazoquinolines

Edwards, A. D., Diebold, S. S., Slack, E. M. C., Tomizawa, H., Hemmi, H., Kaisho, T., Akira, S., & Sousa, C. R. E. (2003) · European Journal of Immunology · doi:10.1002/eji.200323797 · Cited by 550 · see citing works

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

Rehermann, B. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39133 · Cited by 530 · see citing works

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

Poeck, H., Bscheider, M., Groß, O., Finger, K., Roth, S., Rebsamen, M., Hannesschläger, N., Schlee, M., Rothenfußer, S., Barchet, W., et al. (2009) · Nature Immunology · doi:10.1038/ni.1824 · Cited by 518 · see citing works

The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo

Bellocchio, S., Montagnoli, C., Bozza, S., Gaziano, R., Rossi, G., Mambula, S. S., Vecchi, A., Mantovani, A., Levitz, S. M., & Romani, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3059 · Cited by 515 · see citing works

Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia

Goffic, R. L., Balloy, V., Lagranderie, M., Alexopoulou, L., Escriou, N., Flavell, R. A., Chignard, M., & Si‐Tahar, M. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020053 · Cited by 512 · see citing works

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

Schoenen, H., Bodendorfer, B., Hitchens, K., Manzanero, S., Werninghaus, K., Nimmerjahn, F., Agger, E. M., Stenger, S., Andersen, P. L., Ruland, J., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904013 · Cited by 493 · see citing works

Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

Mayer-Barber, K. D., Barber, D. L., Shenderov, K., White, S., Wilson, M. S., Cheever, A. W., Kugler, D. G., Hieny, S. E., Caspar, P., Núñez, G., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904189 · Cited by 472 · see citing works

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

Barbalat, R., Lau, L., Locksley, R. M., & Barton, G. M. (2009) · Nature Immunology · doi:10.1038/ni.1792 · Cited by 453 · see citing works

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells

Uematsu, S., Jang, M. H., Chevrier, N., Guo, Z., Kumagai, Y., Yamamoto, M., Kato, H., Sougawa, N., Matsui, H., Kuwata, H., et al. (2006) · Nature Immunology · doi:10.1038/ni1362 · Cited by 450 · see citing works

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

Brinkmann, M. M., Spooner, E., Hoebe, K. H. N., Beutler, B., Ploegh, H. L., & Kim, Y. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612056 · Cited by 444 · see citing works

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

Dostert, C., Guarda, G., Romero, J. F., Menu, P., Groß, O., Tardivel, A., Suvà, M.-L., Stehle, J., Köpf, M., Stamenkovic, I., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006510 · Cited by 397 · see citing works

Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses

Kumagai, Y., Takeuchi, O., Kato, H., Kumar, H., Matsui, K., Morii, E., Aozasa, K., Kawai, T., & Akira, S. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.013 · Cited by 390 · see citing works

Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense

Osorio, F., & Sousa, C. R. E. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.001 · Cited by 377 · see citing works

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

Casanova, J., Abel, L., & Quintana‐Murci, L. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101335 · Cited by 369 · see citing works

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

Shio, M. T., Eisenbarth, S. C., Savaria, M., Vinet, A. F., Bellemare, M.-J., Harder, K. W., Sutterwala, F. S., Bohle, D. S., Descoteaux, A., Flavell, R. A., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000559 · Cited by 361 · see citing works

Regulation of the Antimicrobial Response by NLR Proteins

Elinav, E., Strowig, T., Henao‐Mejia, J., & Flavell, R. A. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.007 · Cited by 360 · see citing works

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

Daffis, S., Samuel, M. A., Suthar, M. S., Gale, M., & Diamond, M. (2008) · Journal of Virology · doi:10.1128/jvi.00935-08 · Cited by 359 · see citing works

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

Sasai, M., Linehan, M. M., & Iwasaki, A. (2010) · Science · doi:10.1126/science.1187029 · Cited by 357 · see citing works

Does Toll-like receptor 3 play a biological role in virus infections?

Edelmann, K. H., Richardson-Burns, S. M., Alexopoulou, L., Tyler, K. L., Flavell, R. A., & Oldstone, M. B. A. (2004) · Virology · doi:10.1016/j.virol.2004.01.033 · Cited by 354 · see citing works

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

Mancuso, G., Gambuzza, M. E., Midiri, A., Biondo, C., Papasergi, S., Akira, S., Teti, G., & Beninati, C. (2009) · Nature Immunology · doi:10.1038/ni.1733 · Cited by 351 · see citing works

MyD88 Mediates Neutrophil Recruitment Initiated by IL-1R but Not TLR2 Activation in Immunity against Staphylococcus aureus

Miller, L. S., O’Connell, R. M., Gutiérrez, M. Á., Pietras, E. M., Shahangian, A., Gross, C. E., Thirumala, A., Cheung, A. L., Cheng, G., & Modlin, R. L. (2006) · Immunity · doi:10.1016/j.immuni.2005.11.011 · Cited by 348 · see citing works

Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis

de Diego, R. P., Sancho‐Shimizu, V., Lorenzo, L., Puel, A., Plancoulaine, S., Pïcard, C., Casadio, M., Cardon, A., Durandy, A., Bustamante, J. C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.014 · Cited by 348 · see citing works

IL-1 Receptor-Mediated Signal Is an Essential Component of MyD88-Dependent Innate Response to Mycobacterium tuberculosis Infection

Fremond, C., Togbe, D., Doz, E., Rose, S., Vasseur, V., Maillet, I., Jacobs, M., Ryffel, B., & Quesniaux, V. F. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1178 · Cited by 339 · see citing works

Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria

Feuillet, V., Medjane, S., Mondor, I., Demaria, O., Pagni, P. P., Galán, J. E., Flavell, R. A., & Alexopoulou, L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605200103 · Cited by 337 · see citing works

Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism

Gazzinelli, R. T., & Denkers, E. (2006) · Nature reviews. Immunology · doi:10.1038/nri1978 · Cited by 322 · see citing works

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRγ–Syk–Card9–dependent innate immune activation

Werninghaus, K., Babiak, A., Groß, O., Hölscher, C., Dietrich, H., Agger, E. M., Mages, J., Mócsai, A., Schoenen, H., Finger, K., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081445 · Cited by 317 · see citing works

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

Ewald, S. E., Engel, A., Lee, J., Wang, M., Bogyo, M. S., & Barton, G. M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100682 · Cited by 314 · see citing works

Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination

Koyama, S., Ishii, K. J., Kumar, H., Tanimoto, T., Coban, C., Uematsu, S., Kawai, T., & Akira, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4711 · Cited by 309 · see citing works

The DNA Sugar Backbone 2′ Deoxyribose Determines Toll-like Receptor 9 Activation

Haas, T. L., Metzger, J., Schmitz, F., Heit, A., Müller, T. R., Latz, E., & Wagner, H. (2008) · Immunity · doi:10.1016/j.immuni.2008.01.013 · Cited by 298 · see citing works

Cutting Edge: <i>Candida albicans</i> Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

Joly, S., Ma, N., Sadler, J. J., Soll, D. R., Cassel, S. L., & Sutterwala, F. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901323 · Cited by 296 · see citing works

TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system

Miao, E. A., Andersen‐Nissen, E., Warren, S. E., & Aderem, A. A. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0078-z · Cited by 296 · see citing works

Cutting Edge: TLR9 and TLR2 Signaling Together Account for MyD88-Dependent Control of Parasitemia in Trypanosoma cruzi Infection

Báfica, A. L. B., Santiago, H. C., Goldszmid, R. S., Ropert, C., Gazzinelli, R. T., & Sher, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3515 · Cited by 295 · see citing works

Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses

Barber, G. N. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.12.015 · Cited by 282 · see citing works

Plasmacytoid dendritic cells sense hepatitis C virus–infected cells, produce interferon, and inhibit infection

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TLR Signaling Is Required for Salmonella typhimurium Virulence

Arpaia, N., Godec, J., Lau, L., Sivick, K. E., McLaughlin, L. M., Jones, M. B., Dracheva, T., Peterson, S. N., Monack, D. M., & Barton, G. M. (2011) · Cell · doi:10.1016/j.cell.2011.01.031 · Cited by 260 · see citing works

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

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Toll-Like Receptors Are Temporally Involved in Host Defense

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Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan ParasiteLeishmania major

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