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The double life of a B-1 cell: self-reactivity selects for protective effector functions
Abstract
During their development, B and T cells with self-reactive antigen receptors are generally deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 cells in mice are positively selected for self-reactivity and form a pool of long-lived, self-renewing B cells that produce most of the circulating natural IgM antibodies. This Review provides an overview of the developmental processes that shape the B-1 cell pool in mice, outlines the functions of B-1 cells in both the steady state and during host defence, and discusses possible functional B-1 cell homologues that exist in humans.
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“B1 B cells are a subset of innate-like immune cells that play a pivotal role in early immune defense.”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [44]
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Metadata
- Authors
- Baumgarth, N.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Baumgarth, Nicole
- ORCID
- Baumgarth, Nicole
- Venue
- Nature Reviews Immunology
- Published
- 2010-12-10
- Volume
- 11
- Issue
- 1
- Pages
- 34-46
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2023502808
- Cited by
- 969
- References
- 152
- Citations by year
- 2026: 40 · 2025: 37 · 2024: 61 · 2023: 46 · 2022: 54 · 2021: 57 · 2020: 64 · 2019: 72 · 2018: 74 · 2017: 66 · 2016: 83 · 2015: 82 · 2014: 77 · 2013: 76 · 2012: 53
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI073911, AI051354, R01AI051354, AI073911)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- B-1 cells, innate-like B cells, natural antibodies, natural IgM, autoreactivity, positive selection, B cell development, mucosal immunity, tissue homeostasis, autoimmunity
- MeSH terms
- Animals, B-Lymphocytes, Humans, Immunoglobulin A, Immunoglobulin M, Lymphocyte Activation, B-Lymphocyte Subsets, Self Tolerance, Mice
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