Cited by 979T-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies ResearchImmune Response and Inflammation

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The double life of a B-1 cell: self-reactivity selects for protective effector functions

Baumgarth, Nicole·2011·Nature Reviews Immunology

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Abstract

During their development, B and T cells with self-reactive antigen receptors are generally deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 cells in mice are positively selected for self-reactivity and form a pool of long-lived, self-renewing B cells that produce most of the circulating natural IgM antibodies. This Review provides an overview of the developmental processes that shape the B-1 cell pool in mice, outlines the functions of B-1 cells in both the steady state and during host defence, and discusses possible functional B-1 cell homologues that exist in humans.

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Authors: Baumgarth, N.
Affiliations: University of California, Davis (US)
Corresponding author: Baumgarth, Nicole
ORCID: Baumgarth, Nicole
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2010-12-10
Volume: 11
Issue: 1
Pages: 34-46
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2901
OpenAlex: W2023502808
Cited by: 969
References: 152
Citations by year: 2026: 40 · 2025: 37 · 2024: 61 · 2023: 46 · 2022: 54 · 2021: 57 · 2020: 64 · 2019: 72 · 2018: 74 · 2017: 66 · 2016: 83 · 2015: 82 · 2014: 77 · 2013: 76 · 2012: 53
FWCI: 3.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI073911, AI051354, R01AI051354, AI073911)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: B-1 cells, innate-like B cells, natural antibodies, natural IgM, autoreactivity, positive selection, B cell development, mucosal immunity, tissue homeostasis, autoimmunity
MeSH terms: Animals, B-Lymphocytes, Humans, Immunoglobulin A, Immunoglobulin M, Lymphocyte Activation, B-Lymphocyte Subsets, Self Tolerance, Mice

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The double life of a B-1 cell: self-reactivity selects for protective effector functions

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