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Signal integration and crosstalk during thymocyte migration and emigration

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Love, Paul E., Bhandoola, Avinash·2011·Nature Reviews Immunology
DOI 10.1038/nri2989PMC PMC3710714
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Abstract

The thymus produces self-tolerant functionally competent T cells. This process involves the import of multipotent haematopoietic progenitors that are then signalled to adopt the T cell fate. Expression of T cell-specific genes, including those encoding the T cell receptor (TCR), is followed by positive and negative selection and the eventual export of mature T cells. Significant progress has been made in elucidating the signals that direct progenitor cell trafficking to, within and out of the thymus. These advances are the subject of this Review, with a particular focus on the role of reciprocal cooperative and regulatory interactions between TCR- and chemokine receptor-mediated signalling.

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  • Following an unknown triggering signal, after a variable delay, cells in each cohort migrate centrifugally toward the outer thymic cortex, and cell surface marker expression patterns imply that lineage commitment occurs midway in this migration.

    “Following an unknown triggering signal, after a variable delay (125), the cells in each cohort then begin to migrate centrifugally toward the outer thymic cortex, and cell surface marker expression patterns imply that it is somewhere midway in the course of this migration that the individual cells undergo lineage commitment [reviewed by (60, 130)].”

    From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [130]

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Authors
Love, P. E., & Bhandoola, A.
Affiliations
  • National Institutes of Health (US)
  • University of Pennsylvania (US)
Corresponding author
Love, Paul E.
ORCID
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2011-06-24
Volume
11
Issue
7
Pages
469-477
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
DOI
10.1038/nri2989
PMC
PMC3710714
OpenAlex
W2124610030
Cited by
213
References
3
Citations by year
2026: 8 · 2025: 9 · 2024: 16 · 2023: 8 · 2022: 6 · 2021: 13 · 2020: 14 · 2019: 19 · 2018: 11 · 2017: 14 · 2016: 21 · 2015: 16 · 2014: 16 · 2013: 17 · 2012: 23
FWCI
1.66
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Leukemia and Lymphoma Society
  • National Institutes of Health (Z99HD999999, Z99 HL999999, Z99 MH999999, Z99 OD999999, Z99 DA999999)
  • National Heart, Lung, and Blood Institute (R01HL110741, RC1HL099758, R21HL086900)
  • National Institute of Allergy and Infectious Diseases (AI059621, R01AI059621)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZIAHD001803)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
thymocyte migration, thymocyte emigration, thymus, T cell homing, positive selection, negative selection, T cell receptor signaling, signal integration, crosstalk, T cell progenitors, self-tolerance
MeSH terms
Animals, Cell Movement, Humans, Receptors, Antigen, T-Cell, Stem Cells, T-Lymphocytes, Thymus Gland, Signal Transduction, Models, Immunological, Receptors, Chemokine

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