Kinetics of Steady-state Differentiation and Mapping of Intrathymic-signaling Environments by Stem Cell Transplantation in Nonirradiated Mice
Open accessAbstract
Upon thymus entry, thymic-homing progenitors undergo distinct phases of differentiation as they migrate through the cortex to the capsule, suggesting that the signals that induce these differentiation steps may be stratified in corresponding cortical regions. To better define these regions, we transplanted purified stem cells into nonirradiated congenic recipients and followed their differentiation with respect to both tissue location and time. The earliest progenitors (DN1) remained confined to a very narrow region of the cortex for about the first 10 d of intrathymic residence; this region virtually overlaps the sites of thymic entry, suggesting that DN1 cells move very little during this lengthy period of proliferation and lineage commitment. Movement out of this region into the deeper cortex is asynchronous, and corresponds to the appearance of DN2 cells. Differentiation to the DN3 stage correlates with movement across the midpoint of the cortex, indicating that stromal signals that induce functions such as TCR gene rearrangement reside mainly in the outer half of the cortex. The minimum time to reach the capsule, and thus transit to the DP stage, is ∼13 d, with the average time a few days longer. These findings reveal for the first time the kinetics of steady-state progenitor differentiation in the thymus, as well as defining the boundaries of cortical regions that support different phases of the differentiation process. We also show that the first lineage-positive progeny of transplanted stem cells to appear in the thymus are dendritic cells in the medulla, suggesting that each new wave of new T cell production is preceded by a wave of regulatory cells that home to the medulla and ensure efficient tolerance and selection.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PU.1 activity probably extends for over 10 days for thymocytes in young adult mice, where it is crucial for successful T-cell generation.
“It probably extends for over 10 days for the thymocytes in young adult mice (153), where it is crucial for successful T-cell generation (2, 147).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [153]
The Results and Discussion (page unavailable) report that thymic progenitors take about 15 days to reach the double-positive stage, supporting a developmental interval longer than 10 days. The paper does not establish that PU.1 remains active throughout that interval. The statement about PU.1 being crucial for T-cell generation is attached to other citations, not this one. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253 · see citing works
Ardavı́n, C., Wu, L., Li, C., & Shortman, K. (1993) · Nature · doi:10.1038/362761a0 · Cited by 657 · see citing works
Lind, E. F., Prockop, S. E., Porritt, H. E., & Petrie, H. T. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.2.127 · Cited by 402 · see citing works
Self-citationDendritic cell potentials of early lymphoid and myeloid progenitors
Manz, M. G., Traver, D. J., Miyamoto, T., Weissman, I. L., & Akashi, K. (2001) · Blood · doi:10.1182/blood.v97.11.3333 · Cited by 394 · see citing works
The generation and fate of thymocytes.
Shortman, K., Egerton, M., Spangrude, G. J., & Scollay, R. G. (1990) · PubMed · Cited by 295 · see citing works
The Importation of Hematogenous Precursors by the Thymus Is a Gated Phenomenon in Normal Adult Mice
Foss, D. L., Donskoy, E., & Goldschneider, I. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.3.365 · Cited by 221 · see citing works
Ikawa, T., Kawamoto, H., Fujimoto, S., & Katsura, Y. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.11.1617 · Cited by 161 · see citing works
Spangrude, G. J., & Scollay, R. G. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.11.3661 · Cited by 146 · see citing works
Bone marrow cells give rise to distinct cell clones within the thymus
Ezine, S., Weissman, I. L., & Rouse, R. V. (1984) · Nature · doi:10.1038/309629a0 · Cited by 143 · see citing works
Brahim, F., & Osmond, D. G. (1970) · The Anatomical Record · doi:10.1002/ar.1091680202 · Cited by 121 · see citing works
Kyewski, B. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.2.520 · Cited by 113 · see citing works
Thymic stem cells in mouse bone marrow
Antica, M., Wu, L., Shortman, K., & Scollay, R. G. (1994) · Blood · doi:10.1182/blood.v84.1.111.111 · Cited by 104 · see citing works
Role of thymic organ structure and stromal composition in steady‐state postnatal T‐cell production
Petrie, H. T. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18902.x · Cited by 102 · see citing works
Self-citationProckop, S. E., Palencia, S., Ryan, C. M., Gordon, K. M., Gray, D. H. D., & Petrie, H. T. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4354 · Cited by 99 · see citing works
Self-citationDonskoy, E., & Goldschneider, I. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.7.3514 · Cited by 96 · see citing works
Dunon, D., Courtois, D., Vainio, O., Six, A., Chen, C.-L. H., Cooper, M. D., Dangy, J., & Imhof, B. A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.7.977 · Cited by 95 · see citing works
Clonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal Thymus
Michie, A. M., Carlyle, J. R., Schmitt, T. M., Ljutic, B., Cho, S. K., Fong, Q., & Zúñiga‐Pflücker, J. C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1730 · Cited by 88 · see citing works
An in vivo assay for thymus-homing bone marrow cells
Lepault, F., & Weissman, I. L. (1981) · Nature · doi:10.1038/293151a0 · Cited by 77 · see citing works
Characterization of thymus-seeding precursor cells from mouse bone marrow
Mori, S., Shortman, K., & Wu, L. (2001) · Blood · doi:10.1182/blood.v98.3.696 · Cited by 55 · see citing works
Molecular Biology of B-Cell and T-Cell Development
Monroe, J. G. (1998) · Humana Press eBooks · doi:10.1007/978-1-4757-2778-4 · Cited by 49 · see citing works
Migration of Cells to the Thymus Demonstrated by Parabiosis.
Brumby, M., & Metcalf, D. (1967) · Experimental Biology and Medicine · doi:10.3181/00379727-124-31675 · Cited by 45 · see citing works
Pénit, C. (1988) · Journal of Histochemistry & Cytochemistry · doi:10.1177/36.5.2895787 · Cited by 44 · see citing works
Gordon, K. M., Duckett, L., Daul, B., & Petrie, H. T. (2003) · Journal of Immunological Methods · doi:10.1016/s0022-1759(03)00009-7 · Cited by 35 · see citing works
Self-citationRepetitive bone marrow transplantation in nonmyeloablated recipients.
Blomberg, M., Rao, S. S., Reilly, J., Tiarks, C. Y., Peters, S. O., Kittler, E. L. W., & Quesenberry, P. J. (1998) · PubMed · Cited by 35 · see citing works
TCR-Independent Development of Pluripotent T-Cell Precursors
Wu, L., Livák, F., & Petrie, H. T. (1998) · Humana Press eBooks · doi:10.1007/978-1-4757-2778-4_16 · Cited by 9 · see citing works
Self-citationMulder, A., Visser, J. W. M., Zoetelief, J., & van Bekkum, D. W. (1988) · PubMed · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A CENTRAL ROLE FOR CENTRAL TOLERANCE
Kyewski, B., & Klein, L. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115601 · Cited by 743 · see citing works
Zoned Out: Functional Mapping of Stromal Signaling Microenvironments in the Thymus
Petrie, H. T., & Zúñiga-Pflücker, J. C. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115715 · Cited by 454 · see citing works
Self-citationPorritt, H. E., Rumfelt, L. L., Tabrizifard, S., Schmitt, T. M., Zúñiga-Pflücker, J. C., & Petrie, H. T. (2004) · Immunity · doi:10.1016/j.immuni.2004.05.004 · Cited by 432 · see citing works
Self-citationClonal deletion of thymocytes by circulating dendritic cells homing to the thymus
Bonasio, R., Scimone, M. L., Schaerli, P., Grabie, N., Lichtman, A. H., & von Andrian, U. H. (2006) · Nature Immunology · doi:10.1038/ni1385 · Cited by 424 · see citing works
A model 450 million years in the making: zebrafish and vertebrate immunity
Renshaw, S. A., & Trede, N. S. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.007138 · Cited by 350 · see citing works
Developmental gene networks: a triathlon on the course to T cell identity
Yui, M. A., & Rothenberg, E. V. (2014) · Nature Reviews Immunology · doi:10.1038/nri3702 · Cited by 342 · see citing works
Schmitt, T. M., Ciofani, M., Petrie, H. T., & Zúñiga‐Pflücker, J. C. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040394 · Cited by 328 · see citing works
Self-citationT-cell development made simple
Zúñiga‐Pflücker, J. C. (2004) · Nature reviews. Immunology · doi:10.1038/nri1257 · Cited by 325 · see citing works
Mechanisms of T Cell Development and Transformation
Koch, U., & Radtke, F. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154008 · Cited by 282 · see citing works
The Importance of Dendritic Cells in Maintaining Immune Tolerance
Audiger, C., Rahman, M. J., Yun, T. J., Tarbell, K. V., & Lesage, S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601629 · Cited by 276 · see citing works
Bhandoola, A., von Boehmer, H., Petrie, H. T., & Zúñiga‐Pflücker, J. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.009 · Cited by 272 · see citing works
Self-citationPlotkin, J., Prockop, S. E., Lepique, A. P., & Petrie, H. T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4521 · Cited by 238 · see citing works
Self-citationMechanisms of Tolerance Induction by Dendritic Cells In Vivo
Hasegawa, H., & Matsumoto, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00350 · Cited by 229 · see citing works
Maillard, I. P., Adler, S. H., & Pear, W. S. (2003) · Immunity · doi:10.1016/s1074-7613(03)00325-x · Cited by 219 · see citing works
Thymic T Cell Development and Progenitor Localization Depend on CCR7
Davalos‐Misslitz, A. C. M., Pabst, O., Hintzen, G., Ohl, L., Kremmer, E., Petrie, H. T., & Förster, R. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040383 · Cited by 218 · see citing works
Self-citationLi, J., Park, J., Foss, D. L., & Goldschneider, I. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082232 · Cited by 216 · see citing works
Rossi, S. W., Jeker, L. T., Ueno, T., Kuse, S., Keller, M. P., Zuklys, S., Gudkov, A. V., Takahama, Y., Krenger, W., Blazar, B. R., et al. (2007) · Blood · doi:10.1182/blood-2006-10-049767 · Cited by 215 · see citing works
Signal integration and crosstalk during thymocyte migration and emigration
Love, P. E., & Bhandoola, A. (2011) · Nature Reviews Immunology · doi:10.1038/nri2989 · Cited by 213 · see citing works
Circulating hematopoietic progenitors with T lineage potential
Schwarz, B. A., & Bhandoola, A. (2004) · Nature Immunology · doi:10.1038/ni1101 · Cited by 206 · see citing works
Regulation of Thymus Size by Competition for Stromal Niches among Early T Cell Progenitors
Prockop, S. E., & Petrie, H. T. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1604 · Cited by 190 · see citing works
Self-citationSelective Thymus Settling Regulated by Cytokine and Chemokine Receptors
Schwarz, B. A., Sambandam, A., Maillard, I. P., Harman, B. C., Love, P. E., & Bhandoola, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2008 · Cited by 185 · see citing works
Vezys, V., Masopust, D., Kemball, C. C., Barber, D. L., O’Mara, L. A., Larsen, C. P., Pearson, T. C., Ahmed, R., & Lukacher, A. E. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060995 · Cited by 185 · see citing works
From stem cell to T cell: one route or many?
Bhandoola, A., & Sambandam, A. (2006) · Nature reviews. Immunology · doi:10.1038/nri1778 · Cited by 145 · see citing works
Savino, W., Mendes‐da‐Cruz, D. A., Smaniotto, S., Silva, E., & Villa‐Verde, D. M. S. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.1003455 · Cited by 144 · see citing works
T cell ageing: effects of age on development, survival & function.
Salam, N., Rane, S., Das, R., Faulkner, M. F., Gund, R., Kandpal, U., Lewis, V., Mattoo, H., Prabhu, S. B., Ranganathan, V., et al. (2013) · Europe PMC (PubMed Central) · Cited by 138 · see citing works
Zoller, A. L., & Kersh, G. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7371 · Cited by 140 · see citing works
Bhattacharya, D., Rossi, D. J., Bryder, D., & Weissman, I. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051714 · Cited by 124 · see citing works
Benz, C., Heinzel, K., & Bleul, C. C. (2004) · European Journal of Immunology · doi:10.1002/eji.200425248 · Cited by 119 · see citing works
Ehrlich, L. I. R., Oh, D. Y., Weissman, I. L., & Lewis, R. S. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.020 · Cited by 108 · see citing works
Zhou, W., Yui, M. A., Williams, B. A., Yun, J., Wold, B. J., Cai, L., & Rothenberg, E. V. (2019) · Cell Systems · doi:10.1016/j.cels.2019.09.008 · Cited by 100 · see citing works
Identification of a bone marrow precursor of the earliest thymocytes in adult mouse
Lai, A. Y., & Kondo, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609608104 · Cited by 104 · see citing works
Visan, I., Tan, J. B. L., Yuan, J. S., Harper, J. A., Koch, U., & Guidos, C. J. (2006) · Nature Immunology · doi:10.1038/ni1345 · Cited by 103 · see citing works
A spatial human thymus cell atlas mapped to a continuous tissue axis
Yayon, N., Kedlian, V. R., Boehme, L., Suo, C., Wachter, B. T., Beuschel, R. T., Amsalem, O., Polański, K., Koplev, S., Tuck, E. J., et al. (2024) · Nature · doi:10.1038/s41586-024-07944-6 · Cited by 115 · see citing works
Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development
Rothenberg, E. V., Hosokawa, H., & Ungerbäck, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00228 · Cited by 99 · see citing works
“It probably extends for over 10 days for the thymocytes in young adult mice (153), where it is crucial for successful T-cell generation (2, 147).”
BackgroundThymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance Induction
Lopes, N., Sergé, A., Ferrier, P., & Irla, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00365 · Cited by 99 · see citing works
Theories and Quantification of Thymic Selection
Yates, A. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00013 · Cited by 99 · see citing works
Tumor growth impedes natural-killer-cell maturation in the bone marrow
Richards, J. O., Chang, X., Blaser, B. W., Caligiuri, M. A., Zheng, P., & Liu, Y. (2006) · Blood · doi:10.1182/blood-2005-11-4535 · Cited by 99 · see citing works
Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis
Munitić, I., Williams, J. A., Yang, Y., Dong, B., Lucas, P. J., Kassar, N. E., Gress, R. E., & Ashwell, J. D. (2004) · Blood · doi:10.1182/blood-2004-06-2484 · Cited by 94 · see citing works
Trafficking from the bone marrow to the thymus: a prerequisite for thymopoiesis
Schwarz, B. A., & Bhandoola, A. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00350.x · Cited by 92 · see citing works
Comprehensive Assessment and Mathematical Modeling of T Cell Population Dynamics and Homeostasis
Thomas‐Vaslin, V., Altes, H. K., de Boer, R. J., & Klatzmann, D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2240 · Cited by 86 · see citing works
Griffith, A. V., Fallahi, M., Nakase, H., Gosink, M. M., Young, B. M., & Petrie, H. T. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.024 · Cited by 84 · see citing works
Self-citationGoldberg, G. L., King, C. G., Nejat, R. A., Suh, D. Y., Smith, O. M., Bretz, J. C., Samstein, R. M., Dudakov, J. A., Chidgey, A. P., Chen‐Kiang, S., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801458 · Cited by 82 · see citing works
Multilayered specification of the T-cell lineage fate.
Rothenberg, E. V., Zhang, J., & Li, L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00964.x · Cited by 81 · see citing works
CCL25 increases thymopoiesis after androgen withdrawal
Williams, K. M., Lucas, P. J., Bare, C. V., Wang, J., Chu, Y., Tayler, E. B., Kapoor, V., & Gress, R. E. (2008) · Blood · doi:10.1182/blood-2008-04-153627 · Cited by 81 · see citing works
Cytokines, Transcription Factors, and the Initiation of T-Cell DevelopmentPreprint
Hosokawa, H., & Rothenberg, E. V. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028621 · Cited by 79 · see citing works
T Cell Development by the Numbers
Krueger, A., Ziętara, N., & Łyszkiewicz, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.10.007 · Cited by 71 · see citing works
Thymus-homing precursors and the thymic microenvironment
Boehm, T. L. J., & Bleul, C. C. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.08.004 · Cited by 72 · see citing works
Instructive Cues of Thymic T Cell Selection
Irla, M. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-022432 · Cited by 68 · see citing works
Chemokine-Mediated Choreography of Thymocyte Development and Selection
Lancaster, J. N., Li, Y., & Ehrlich, L. I. R. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.10.007 · Cited by 65 · see citing works
Bourgeois, C., Hao, Z., Rajewsky, K., Potocnik, A. J., & Stockinger, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803732105 · Cited by 64 · see citing works
Rothenberg, E. V., Ungerbäck, J., & Champhekar, A. (2016) · Advances in Immunology · doi:10.1016/bs.ai.2015.09.002 · Cited by 61 · see citing works
Goldberg, G. L., Dudakov, J. A., Reiseger, J. J., Seach, N., Ueno, T., Vlahos, K., Hammett, M. V., Young, L. F., Heng, T. S. P., Boyd, R. L., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0802445 · Cited by 60 · see citing works
Progression of regulatory gene expression states in fetal and adult pro-T-cell development
David‐Fung, E., Yui, M. A., Morales, M., Wang, H., Taghon, T., Diamond, R. A., & Rothenberg, E. V. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00355.x · Cited by 60 · see citing works
Finding their niche: chemokines directing cell migration in the thymus
Bunting, M. D., Comerford, I., & McColl, S. R. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.142 · Cited by 59 · see citing works
Regulation of intrathymic T‐cell development by Lunatic Fringe– Notch1 interactions
Visan, I., Yuan, J. S., Tan, J. B. L., Cretegny, K., & Guidos, C. J. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00360.x · Cited by 58 · see citing works
Tabrizifard, S., Olaru, A., Plotkin, J., Fallahi‐Sichani, M., Livák, F., & Petrie, H. T. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.1094 · Cited by 58 · see citing works
Self-citationZhou, W., Gao, F., Romero-Wolf, M., Jo, S., & Rothenberg, E. V. (2022) · Science Immunology · doi:10.1126/sciimmunol.abm1920 · Cited by 56 · see citing works
A Survival Guide to Early T Cell Development
Ciofani, M., & Zúñiga‐Pflücker, J. C. (2006) · Immunologic Research · doi:10.1385/ir:34:2:117 · Cited by 51 · see citing works
Goldschneider, I. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00354.x · Cited by 51 · see citing works
In vivo correction of ZAP-70 immunodeficiency by intrathymic gene transfer.
Adjali, O., Marodon, G., Steinberg, M., Mongellaz, C., Thomas-Vaslin, V., Jacquet, C., Taylor, N., & Klatzmann, D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23966 · Cited by 46 · see citing works
Modeling the Dynamics of T-Cell Development in the Thymus
Robert, P. A., Kunze‐Schumacher, H., Greiff, V., & Krueger, A. (2021) · Entropy · doi:10.3390/e23040437 · Cited by 43 · see citing works
Neuropilin 1 and CD25 co-regulation during early murine thymic differentiation
Corbel, C., Lemarchandel, V., Thomas‐Vaslin, V., Pelus, A.-S., Agboton, C., & Roméo, P. (2007) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2007.01.009 · Cited by 44 · see citing works
Zhang, S., & Bhandoola, A. (2013) · Current topics in microbiology and immunology · doi:10.1007/82_2013_324 · Cited by 42 · see citing works
Multicongenic fate mapping quantification of dynamics of thymus colonization
Ziętara, N., Łyszkiewicz, M., Puchałka, J., Witzlau, K., Reinhardt, A., Förster, R., Pabst, O., Prinz, I., & Krueger, A. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142143 · Cited by 40 · see citing works
Aging and T cell development: Interplay between progenitors and their environment
Zediak, V. P., & Bhandoola, A. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.004 · Cited by 38 · see citing works
Lymphotoxin β Receptor Controls T Cell Progenitor Entry to the Thymus
Lucas, B., James, K. D., Cosway, E. J., Parnell, S. M., Tumanov, A. V., Ware, C. F., Jenkinson, W. E., & Anderson, G. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601189 · Cited by 38 · see citing works
Molecular and cellular basis of T cell lineage commitment
Vicente, R., Swainson, L. A., Marty-Grès, S., de Barros, S. C., Kinet, S., Zimmermann, V. S., & Taylor, N. N. (2010) · Seminars in Immunology · doi:10.1016/j.smim.2010.04.016 · Cited by 37 · see citing works
Manesso, E., Chickarmane, V., Kueh, H. Y., Rothenberg, E. V., & Peterson, C. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.0774 · Cited by 37 · see citing works
T‐cell development: an extrathymic perspective
Blais, M., Louis, I., & Perreault, C. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00341.x · Cited by 38 · see citing works
Seach, N., Mattesich, M., Abberton, K. M., Matsuda, K., Tilkorn, D. J., Rophael, J. A., Boyd, R. L., & Morrison, W. A. (2009) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2009.0135 · Cited by 36 · see citing works
Single-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human
Rothenberg, E. V. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2020.12.005 · Cited by 35 · see citing works
Davalos‐Misslitz, A. C. M., Bernhardt, G., & Förster, R. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00351.x · Cited by 36 · see citing works
The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus
Hu, Z., Lancaster, J. N., & Ehrlich, L. I. R. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00398 · Cited by 35 · see citing works
Peripheral 4-1BB Signaling Negatively Regulates NK Cell Development through IFN-γ
Choi, B. K., Kim, Y. H., Kim, C. H., Kim, M. S., Kim, K. H., Oh, H. S., Lee, M. J., Lee, D. K., Vinay, D. S., & Kwon, B. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000850 · Cited by 34 · see citing works
Lineage choices in the developing thymus: choosing the T and NKT pathways
Pear, W. S., Tu, L., & Stein, P. L. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.01.011 · Cited by 34 · see citing works
Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis
Shi, J., Fallahi, M., Luo, J.-L., & Petrie, H. T. (2011) · Blood · doi:10.1182/blood-2011-04-346726 · Cited by 33 · see citing works
Self-citationEffects of purine nucleoside phosphorylase deficiency on thymocyte development
Papinazath, T., Min, W., Sujiththa, S., Cohen, A., Ackerley, C. A., Roifman, C. M., & Grunebaum, E. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.07.039 · Cited by 31 · see citing works
Asano, A., Tsubomatsu, K., Jung, C., Sasaki, N., & Agui, T. (2007) · Mammalian Genome · doi:10.1007/s00335-007-9062-0 · Cited by 30 · see citing works
Lucas, B., White, A. J., Parnell, S. M., Henley, P., Jenkinson, W. E., & Anderson, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-05182-7 · Cited by 29 · see citing works
Tunable, division-independent control of gene activation timing by a polycomb switch
Pease, N. A., Nguyen, P. H., Woodworth, M. A., Ng, K. K. H., Irwin, B., Vaughan, J. C., & Kueh, H. Y. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108888 · Cited by 28 · see citing works
Transcriptional network dynamics in early T cell development
Shin, B., Chang, S. J., MacNabb, B. W., & Rothenberg, E. V. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20230893 · Cited by 28 · see citing works
CCR7‐mediated migration in the thymus controls γδ T‐cell development
Reinhardt, A., Ravens, S., Fleige, H., Haas, J. D., Oberdörfer, L., Łyszkiewicz, M., Förster, R., & Prinz, I. (2014) · European Journal of Immunology · doi:10.1002/eji.201344330 · Cited by 27 · see citing works
Heterogeneity in the CD4 T Cell Compartment and the Variability of Neonatal Immune Responsiveness
Adkins, B. (2007) · Current Immunology Reviews · doi:10.2174/157339507781483496 · Cited by 27 · see citing works
Effects of RANKL on the thymic medulla
Ohigashi, I., Nitta, T., Lkhagvasuren, E., Yasuda, H., & Takahama, Y. (2011) · European Journal of Immunology · doi:10.1002/eji.201141480 · Cited by 27 · see citing works
Mechanisms of Thymus Medulla Development and Function
Anderson, G., Baik, S., Cowan, J. E., Holland, A. M., McCarthy, N. I., Nakamura, K., Parnell, S. M., White, A. J., Lane, P. J. L., Jenkinson, E. J., et al. (2013) · Current topics in microbiology and immunology · doi:10.1007/82_2013_320 · Cited by 27 · see citing works
Eph/Ephrin-Mediated Interactions in the Thymus
Múñoz, J. J., Cejalvo, T., Alonso‐Colmenar, L. M., Alfaro, D., García‐Ceca, J., & Zapata, A. G. (2011) · NeuroImmunoModulation · doi:10.1159/000329490 · Cited by 25 · see citing works
Immature T-cell clustering and efficient differentiation require the polarity protein Scribble
Pike, K. A., Kulkarni, S., & Pawson, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018224108 · Cited by 25 · see citing works
The Role of Dendritic Cells in Selection of Classical and Nonclassical CD8+ T Cells In Vivo
Cannarile, M. A., Décanis, N., van Meerwijk, J. P. M., & Brocker, T. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.8.4799 · Cited by 25 · see citing works
Adjali, O., Vicente, R., Ferrand, C., Jacquet, C., Mongellaz, C., Tiberghien, P., Chebli, K., Zimmermann, V., & Taylor, N. (2005) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0504268102 · Cited by 25 · see citing works
Umland, O., Mwangi, W. N., Anderson, B. M., Walker, J. C., & Petrie, H. T. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4147 · Cited by 22 · see citing works
Self-citationKenins, L., Gill, J. W., Holländer, G. A., & Wodnar‐Filipowicz, A. (2009) · European Journal of Immunology · doi:10.1002/eji.200839213 · Cited by 20 · see citing works
Visan, I., Yuan, J. S., Liu, Y. M., Stanley, P., & Guidos, C. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002008 · Cited by 20 · see citing works
Moreau, A., Vicente, R., Dubreil, L., Adjali, O., Podevin, G., Jacquet, C., Deschamps, J. Y., Klatzmann, D., Chérel, Y., Taylor, N. N., et al. (2008) · Molecular Therapy · doi:10.1038/mt.2008.272 · Cited by 20 · see citing works
Ramos, C. V., Ballesteros-Arias, L., da Silva, J. G., Paiva, R. A., Nogueira, M. F., Carneiro, J., Gjini, E., & Martins, V. C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107910 · Cited by 19 · see citing works
A spatial human thymus cell atlas mapped to a continuous tissue axisPreprint
Yayon, N., Kedlian, V. R., Boehme, L., Suo, C., Wachter, B. T., Beuschel, R. T., Amsalem, O., Polański, K., Koplev, S., Tuck, E. J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.25.562925 · Cited by 19 · see citing works
Identification of a novel lymphoid population in the murine epidermis
Almeida, F. F., Tenno, M., Brzostek, J., Li, J. L. Y., Allies, G., Hoeffel, G., See, P., Ng, L. G., Fehling, H. J., Gascoigne, N. R. J., et al. (2015) · Scientific Reports · doi:10.1038/srep12554 · Cited by 19 · see citing works
IL-7 Receptor Drives Early T Lineage Progenitor Expansion
Paiva, R. A., Ramos, C. V., Leiria, G., & Martins, V. C. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2101046 · Cited by 17 · see citing works
Schnell, F. J., Zoller, A. L., Patel, S. R., Williams, I. R., & Kersh, G. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.8.4740 · Cited by 17 · see citing works
RET/GFRα Signals Are Dispensable for Thymic T Cell Development In Vivo
Almeida, A. R. M., Arroz‐Madeira, S., Fonseca‐Pereira, D., Ribeiro, H., Lasrado, R., Pachnis, V., & Veiga‐Fernandes, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052949 · Cited by 16 · see citing works
Bone Marrow-Derived IL-13Rα1–Positive Thymic Progenitors Are Restricted to the Myeloid Lineage
Haymaker, C., Guloglu, F. B., Cascio, J. A., Hardaway, J. C., Dhakal, M., Wan, X., Hoeman, C. M., Zaghouani, S., Rowland, L. M., Tartar, D. M., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103316 · Cited by 16 · see citing works
- Authors
- Porritt, H. E., Gordon, K., & Petrie, H. T.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Gordon, Kristie
- ORCID
- Petrie, Howard T.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2003-09-15
- Volume
- 198
- Issue
- 6
- Pages
- 957-962
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2194209
- OpenAlex
- W2099130754
- Cited by
- 167
- References
- 26
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 7
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Memorial Sloan-Kettering Cancer Center
- Oklahoma Medical Research Foundation
- National Cancer Institute (CA08748, P30CA008748)
- National Institute of Allergy and Infectious Diseases (R21AI033940, R56AI033940, R01AI033940, AI 33940, R29AI033940)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- thymocyte differentiation, thymus, thymic cortex, thymic medulla, T-cell receptor gene rearrangement, dendritic cells, regulatory T cells, thymic selection, congenic mice
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Dendritic Cells, Hematopoietic Stem Cells, Mice, Inbred C57BL, T-Lymphocytes, Thymus Gland, Signal Transduction, Transplantation Chimera, Stem Cell Transplantation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
