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Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms
Open accessAbstract
Dengue is a mosquito-borne viral disease of expanding geographical range and incidence. The existence of four viral serotypes and the association of prior dengue virus infection with an increased risk for more severe disease have presented significant obstacles to vaccine development. An increased understanding of the adaptive immune response to natural dengue virus infection and candidate dengue vaccines has helped to define the specific antibody and T cell responses that are associated with either protective or pathological immunity during dengue infection. Further characterization of immunological correlates of disease outcome and the validation of these findings in vaccine trials will be invaluable for developing effective dengue vaccines.
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Cited by
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Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2
Nguyen, A., David, J. K., Maden, S. K., Wood, M. A., Weeder, B. R., Nellore, A., & Thompson, R. F. (2020) · Journal of Virology · doi:10.1128/jvi.00510-20 · Cited by 561
A materials-science perspective on tackling COVID-19
Tang, Z., Kong, N., Zhang, X., Liu, Y., Hu, P., Mou, S., Liljeström, P., Shi, J., Tan, W., Kim, J. S., et al. (2020) · Nature Reviews Materials · doi:10.1038/s41578-020-00247-y · Cited by 303
Immune-mediated cytokine storm and its role in severe dengue
Srikiatkhachorn, A., Mathew, A., & Rothman, A. L. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0625-1 · Cited by 267
Self-citationCross-serotype interactions and disease outcome prediction of dengue infections in Vietnam
Aguas, R., Dorigatti, I., Coudeville, L., Luxemburger, C., & Ferguson, N. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-45816-6 · Cited by 207
Metadata
- Authors
- Rothman, A. L.
- Venue
- Nature Reviews Immunology
- Published
- 2011-07-15
- Volume
- 11
- Issue
- 8
- Pages
- 532-543
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2081020320
- Cited by
- 770
- References
- 0
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Rothman, A. L. (2011). Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms. Nature Reviews Immunology. https://doi.org/10.1038/nri3014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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