The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Immune-mediated cytokine storm and its role in severe dengue
Open accessAbstract
Dengue remains one of the most important mosquito-borne diseases worldwide. Infection with one of the serologically related dengue viruses (DENVs) can lead to a wide range of clinical manifestations and severity. Severe dengue is characterized by plasma leakage and abnormal bleeding that can lead to shock and death. There is currently no specific treatment for severe dengue due to gaps in understanding of the underlying mechanisms. The transient period of vascular leakage is usually followed by a rapid recovery and is suggestive of the effects of short-lived biological mediators. Both the innate and the adaptive immune systems are activated in severe dengue and contribute to the cytokine production. We discuss the immunological events elicited during a DENV infection and identify candidate cytokines that may play a key role in the severe manifestations of dengue and possible interventions.
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Cites
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Cited by
Cytokine storms: understanding COVID-19
Mangalmurti, N., & Hunter, C. A. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.017 · Cited by 698
Nouveau, L., Buatois, V., Cons, L., Chatel, L., Pontini, G., Pleche, N., & Ferlin, W. G. (2021) · European Journal of Immunology · doi:10.1002/eji.202149181 · Cited by 25
A mRNA-LNP vaccine against Dengue Virus elicits robust, serotype-specific immunity
Wollner, C. J., Richner, M., Hassert, M. A., Pinto, A. K., Brien, J. D., & Richner, J. M. (2021) · doi:10.1101/2021.01.05.425517 · Cited by 6
Metadata
- Authors
- Srikiatkhachorn, A., Mathew, A., & Rothman, A. L.
- Venue
- Seminars in Immunopathology
- Published
- 2017-04-11
- Volume
- 39
- Issue
- 5
- Pages
- 563-574
- ISSN
- 1863-2297 (ISSN-L)
- 1863-2300
- OpenAlex
- W2607074353
- Cited by
- 267
- References
- 84
- FWCI
- 16.50
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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