Modulation of the immune system by UV radiation: More than just the effects of vitamin D?
Abstract
Humans obtain most of their vitamin D through the exposure of skin to sunlight. The immunoregulatory properties of vitamin D have been demonstrated in studies showing that vitamin D deficiency is associated with poor immune function and increased disease susceptibility. The benefits of moderate ultraviolet (UV) radiation exposure and the positive latitude gradients observed for some immune-mediated diseases may therefore reflect the activities of UV-induced vitamin D. Alternatively, other mediators that are induced by UV radiation may be more important for UV-mediated immunomodulation. Here, we compare and contrast the effects of UV radiation and vitamin D on immune function in immunopathological diseases, such as psoriasis, multiple sclerosis and asthma, and during infection.
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Activation of Toll-like receptor 1 and TLR2 by tuberculosis enhances 1α-hydroxylase expression, production of antimicrobial peptide cathelicidin, and induction of tolerogenic dendritic cells and T cells.
“Activation of Toll-like receptor 1 (TLR1) and TLR2 by tuberculosis enhances 1α-hydroxylase expression, the enzyme mediates the synthesis of 1,25(OH)2D3, production of antimicrobial peptide cathelicidin [87], and induction of tolerogenic DCs and T cells [60,84].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [60]
Cell differentiation reduces VDR expressions in macrophages and dendritic cells, preventing mature immune cells from responding to vitamin D and facilitating a normal adaptive immune response.
“Cell differentiation reduces VDR expressions in macrophages and DCs, preventing mature immune cells from responding to vitamin D and facilitating a normal adaptive immune response [60].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [60]
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- Authors
- Hart, P. H., Gorman, S., & Finlay-Jones, J. J.
- Affiliations
- The Kids Research Institute Australia (AU)
- Corresponding author
- Hart, Prue H.
- Venue
- Nature Reviews Immunology
- Published
- 2011-08-19
- Volume
- 11
- Issue
- 9
- Pages
- 584-596
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2036586400
- Cited by
- 465
- References
- 1
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 34 · 2023: 24 · 2022: 17 · 2021: 34 · 2020: 32 · 2019: 26 · 2018: 39 · 2017: 37 · 2016: 33 · 2015: 34 · 2014: 43 · 2013: 41 · 2012: 34
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Edith Cowan University Research Online (Edith Cowan University) (submittedVersion)
- Funders
- BrightSpark Foundation
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- ultraviolet radiation, vitamin D, immunomodulation, vitamin D deficiency, autoimmune disease, allergic asthma, psoriasis, multiple sclerosis, infection immunity, latitudinal gradient, sun exposure
- MeSH terms
- Animals, Asthma, Humans, Immune System, Multiple Sclerosis, Psoriasis, Skin, Sunlight, Ultraviolet Rays, Vitamin D, Mice
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