Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer

Damiani, Elisabetta; Ullrich, Stephen E.

doi:10.1016/j.plipres.2016.03.004

Cited by 78Sphingolipid Metabolism and SignalingSkin Protection and AgingInflammatory mediators and NSAID effects

Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer

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Damiani, Elisabetta, Ullrich, Stephen E.·2016·Progress in Lipid Research

DOI 10.1016/j.plipres.2016.03.004PMC PMC4975990

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Abstract

Lipid mediators of inflammation play important roles in several diseases including skin cancer, the most prevalent type of cancer found in the industrialized world. Ultraviolet (UV) radiation is a complete carcinogen and is the primary cause of skin cancer. UV radiation is also a potent immunosuppressive agent, and UV-induced immunosuppression is a well-known risk factor for skin cancer induction. An essential mediator in this process is the glyercophosphocholine 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine commonly referred to as platelet-activating factor (PAF). PAF is produced by keratinocytes in response to diverse stimuli and exerts its biological effects by binding to a single specific G-protein-coupled receptor (PAF-R) expressed on a variety of cells. This review will attempt to describe how this lipid mediator is involved in transmitting the immunosuppressive signal from the skin to the immune system, starting from its production by keratinocytes, to its role in activating mast cell migration in vivo, and to the mechanisms involved that ultimately lead to immune suppression. Recent findings related to its role in regulating DNA repair and activating epigenetic mechanisms, further pinpoint the importance of this bioactive lipid, which may serve as a critical molecular mediator that links the environment (UVB radiation) to the immune system and the epigenome.

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CPDs remaining in the genome function as one of the main causes of UV-induced immune suppression.
“CPDs remaining in the genome also function as one of the main causes of UV-induced immune suppression25,26.”
From Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways (2018) · cites this paper as [25]
Rapid repair of dipyrimidine photoproducts is expected to greatly minimize UV-induced immune suppression because the duration of unrepaired CPDs in genomic DNA is a primary signal for initiating this suppression.
“This rapid repair of dipyrimidine photoproducts is also expected to greatly minimize UV-induced immune suppression since one of the primary signals for initiating this suppression is the duration of unrepaired CPDs in genomic DNAs25,37–39.”
From Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways (2018) · cites this paper as [25]

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651 · see citing works
The skin: an indispensable barrier
Proksch, E., Brandner, J. M., & Jensen, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00786.x · Cited by 2,054 · see citing works
A role for sunlight in skin-cancer – UV-induced p53 mutations in squamous-cell carcinoma
Brash, D. E., Rudolph, J. A., Simon, J. A., Lin, A., McKenna, G. J., Baden, H. P., Halperin, A. J., & Pontén, J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10124 · Cited by 1,959 · see citing works
The Immune Response in Tuberculosis
O’Garra, A., Redford, P. S., McNab, F. W., Bloom, C. I., Wilkinson, R. J., & Berry, M. P. R. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095939 · Cited by 1,351 · see citing works
Radiation-induced cell cycle arrest compromised by p21 deficiency
Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T., & Hannon, G. J. (1995) · Nature · doi:10.1038/377552a0 · Cited by 1,242 · cited 1× · see citing works
“It also serves as a regulator of cell cycle progression [174], and plays a pivotal role in regulating cell quiescence, senescence and differentiation [175–177].”
LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETS
Benveniste, J., Henson, P. M., & Cochrane, C. G. (1972) · The Journal of Experimental Medicine · doi:10.1084/jem.136.6.1356 · Cited by 1,225 · see citing works
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205 · cited 1× · see citing works
“Skin homeostasis and wound repair are also mediated by residentmacrophages since depleting these cells leads to a rapid reduction in skinwound repair [101].”
Review: Ultraviolet radiation and skin cancer
Narayanan, D. L., Saladi, R. N., & FOX, J. L. (2010) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2010.04474.x · Cited by 1,186 · see citing works
Changes in biologically active ultraviolet radiation reaching the Earth's surface
Madronich, S., McKenzie, R. L., Björn, L. O., & Caldwell, M. M. (1998) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(98)00182-1 · Cited by 1,086 · see citing works
The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.
Gartel, A. L., & Tyner, A. L. (2002) · PubMed · Cited by 924 · see citing works
Platelet-activating factor.
Prescott, S. M., Zimmerman, G. A., & McIntyre, T. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38167-5 · Cited by 891 · see citing works
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity
Jiang, X., Clark, R. A., Liu, L., Wagers, A. J., Fuhlbrigge, R. C., & Kupper, T. S. (2012) · Nature · doi:10.1038/nature10851 · Cited by 883 · see citing works
The mammalian ultraviolet response is triggered by activation of src tyrosine kinases
Devary, Y., Gottlieb, R. A., Smeal, T., & Karin, M. (1992) · Cell · doi:10.1016/s0092-8674(05)80058-3 · Cited by 852 · see citing works
Properties and Regulation of Cytosolic Phospholipase A2
Leslie, C. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16709 · Cited by 809 · see citing works
New developments in mast cell biology
Kalesnikoff, J., & Galli, S. J. (2008) · Nature Immunology · doi:10.1038/ni.f.216 · Cited by 750 · see citing works
Platelet-Activating Factor and Related Lipid Mediators
Prescott, S. M., Zimmerman, G. A., Stafforini, D. M., & McIntyre, T. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.419 · Cited by 747 · see citing works
Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis
Simpson, S., Blizzard, L., Otahal, P., Van der Mei, I., & Taylor, B. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2011.240432 · Cited by 718 · see citing works
Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation
Mouret, S., Baudouin, C., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604213103 · Cited by 684 · see citing works
A Role for Skin γδ T Cells in Wound Repair
Jameson, J., Ugarte, K., Chen, N., Yachi, P. P., Fuchs, E. V., Boismenu, R., & Havran, W. L. (2002) · Science · doi:10.1126/science.1069639 · Cited by 639 · see citing works
A review on CXCR4/CXCL12 axis in oncology: No place to hide
Domańska, U., Kruizinga, R. C., Nagengast, W. B., Timmer‐Bosscha, H., Huls, G. A., de Vries, E. G. E., & Walenkamp, A. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.05.005 · Cited by 631 · see citing works
Cytokines and chemokines orchestrate atopic skin inflammation
Homey, B., Steinhoff, M. S., Ruzicka, T., & Leung, D. Y. M. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.03.047 · Cited by 579 · see citing works
Nonmelanoma Cancers of the Skin
Preston, D. S., & Stern, R. S. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212033272307 · Cited by 546 · see citing works
Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology.
Fabo, E. C. D., & Noonan, F. P. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.158.1.84 · Cited by 522 · see citing works
Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice.
Kripke, M. L., Cox, P. A., Alas, L., & Yarosh, D. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7516 · Cited by 507 · see citing works
Guidelines for topical photodynamic therapy: update
Morton, C. A., McKenna, K. E., & Rhodes, L. E. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08882.x · Cited by 469 · see citing works
Modulation of the immune system by UV radiation: More than just the effects of vitamin D?
Hart, P. H., Gorman, S., & Finlay-Jones, J. J. (2011) · Nature Reviews Immunology · doi:10.1038/nri3045 · Cited by 465 · see citing works
Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells
Sénéschal, J., Clark, R. A., Gehad, A. E., Baecher‐Allan, C., & Kupper, T. S. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.018 · Cited by 454 · see citing works
Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10.
Rivas, J. M., & Ullrich, S. E. (1992) · Journal of Immunology · doi:10.4049/jimmunol.149.12.3865 · Cited by 436 · see citing works
Self-citation
Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells
Hishikawa, D., Hashidate, T., Shimizu, T., & Shindou, H. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046094 · Cited by 436 · see citing works
Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response
Cazzalini, O., Scovassi, A. I., Savio, M., Stivala, L. A., & Prosperi, E. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2010.01.009 · Cited by 430 · see citing works
Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion.
Lewis, M. S., Whatley, R. E., Cain, P., McIntyre, T. M., Prescott, S. M., & Zimmerman, G. A. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113825 · Cited by 415 · see citing works
Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection
Wondrak, G. T., Jacobson, M. K., & Jacobson, E. L. (2006) · Photochemical & Photobiological Sciences · doi:10.1039/b504573h · Cited by 411 · see citing works
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
Loser, K., Mehling, A., Loeser, S., Apelt, J., Kuhn, A., Grabbe, S., Schwarz, T., Penninger, J. M., & Beissert, S. (2006) · Nature Medicine · doi:10.1038/nm1518 · Cited by 402 · see citing works
Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
Ishii, S., & Shimizu, T. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(99)00016-8 · Cited by 384 · see citing works
A cytokine cascade including prostaglandin E2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression.
Shreedhar, V., Giese, T., Sung, V. W., & Ullrich, S. E. (1998) · Journal of Immunology · doi:10.4049/jimmunol.160.8.3783 · Cited by 369 · see citing works
Self-citation
Update of Immune Events in the Murine Contact Hypersensitivity Model: Toward the Understanding of Allergic Contact Dermatitis
Honda, T., Egawa, G., Grabbe, S., & Kabashima, K. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.284 · Cited by 365 · see citing works
Identification of committed NK cell progenitors in adult murine bone marrow
Rosmaraki, E. E., Douagi, I., Roth, C., Colucci, F., Cumano, A., & Santo, J. P. D. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200106)31:6 · Cited by 361 · see citing works
Chemical and biochemical aspects of platelet activating factor: A novel class of acetylated ether‐linked choline‐phospholipids
Snyder, F. F. C. (1985) · Medicinal Research Reviews · doi:10.1002/med.2610050105 · Cited by 356 · see citing works
Ultraviolet radiation and skin cancer: molecular mechanisms
Hussein, M. R. (2005) · Journal of Cutaneous Pathology · doi:10.1111/j.0303-6987.2005.00281.x · Cited by 352 · see citing works
Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation
Kvam, E. (1997) · Carcinogenesis · doi:10.1093/carcin/18.12.2379 · Cited by 344 · see citing works
The Skin Immune System (SIS): Distribution and Immunophenotype of Lymphocyte Subpopulations in Normal Human Skin
Bos, J. D., Zonneveld, I. M., Das, P. K., Krieg, S. R., van der Loos, C. M., & Kapsenberg, M. L. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470172 · Cited by 341 · see citing works
Sun exposure and non-melanocytic skin cancer
Kricker, A., Armstrong, B. K., & English, D. R. (1994) · Cancer Causes & Control · doi:10.1007/bf01804988 · Cited by 340 · see citing works
Mechanisms underlying UV-induced immune suppression.
Ullrich, S. (2005) · Mutation research · doi:10.1016/j.mrfmmm.2004.06.059 · Cited by 332 · see citing works
Self-citation
Immune suppression and skin cancer development: regulation by NKT cells
Moodycliffe, A. M., Nghiem, D. X., Clydesdale, G. J., & Ullrich, S. E. (2000) · Nature Immunology · doi:10.1038/82782 · Cited by 318 · see citing works
Self-citation
Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.
Tada, T., Takemori, T., Okumura, K., Nonaka, M., & Tokuhisa, T. (1978) · The Journal of Experimental Medicine · doi:10.1084/jem.147.2.446 · Cited by 318 · see citing works
Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells.
Heery, J. M., Kozak, M., Stafforini, D. M., Jones, D. A., Zimmerman, G. A., McIntyre, T. M., & Prescott, S. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118288 · Cited by 306 · see citing works
Persistence of skin-resident memory T cells within an epidermal niche
Zaid, A., Mackay, L. K., Rahimpour, A., Braun, A., Veldhoen, M., Carbone, F. R., Manton, J. H., Heath, W. R., & Mueller, S. N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322292111 · Cited by 306 · see citing works
Inflammatory lipid mediators in adipocyte function and obesity
Iyer, A., Fairlie, D. P., Prins, J. B., Hammock, B. D., & Brown, L. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.264 · Cited by 284 · see citing works
Cutaneous immunosurveillance by self-renewing dermal γδ T cells
Sumaria, N., Roediger, B., Ng, L. G., Qin, J., Pinto, R., Cavanagh, L. L., Shklovskaya, E., Groth, B. F. D. S., Triccas, J. A., & Weninger, W. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101824 · Cited by 277 · see citing works
Platelet-activating Factor, a Molecular Sensor for Cellular Damage, Activates Systemic Immune Suppression
Walterscheid, J. P., Ullrich, S., & Nghiem, D. (2002) · Journal of Experimental Medicine · doi:10.1084/jem.20011450 · Cited by 247 · see citing works
Self-citation
Cloning and Characterization of Mouse Lung-type Acyl-CoA:Lysophosphatidylcholine Acyltransferase 1 (LPCAT1)
Nakanishi, H., Shindou, H., Hishikawa, D., 原山, 武., Ogasawara, R., Suwabe, A., Taguchi, R., & Shimizu, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600225200 · Cited by 244 · see citing works
Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in mice
Hart, P. H., Grimbaldeston, M. A., Swift, G. J., Jaksic, A., Noonan, F. P., & Finlay-Jones, J. J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.12.2045 · Cited by 241 · see citing works
Platelet-Activating Factor, a Pleiotrophic Mediator of Physiological and Pathological Processes
Stafforini, D. M., McIntyre, T. M., Zimmerman, G. A., & Prescott, S. M. (2003) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/714037693 · Cited by 234 · see citing works
Bioactive lipid mediators in skin inflammation and immunity
Kendall, A. C., & Nicolaou, A. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.10.003 · Cited by 229 · see citing works
p53 and the pathogenesis of skin cancer
Benjamin, C. L., & Ananthaswamy, H. N. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.12.006 · Cited by 215 · see citing works
Platelet-activating factor and its analogs: metabolic pathways and related intracellular processes
Snyder, F. F. C. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)00192-2 · Cited by 198 · see citing works
25 years of UV‐induced Immunosuppression Mediated by T Cells—From Disregarded T Suppressor Cells to Highly Respected Regulatory T Cells †
Schwarz, T. (2007) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00223.x · Cited by 197 · see citing works
Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells
Chen, X., Hyatt, B. A., Mucenski, M. L., Mason, R. J., & Shannon, J. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604946103 · Cited by 193 · see citing works
Paracrine Effects of Adipose-Derived Stem Cells on Keratinocytes and Dermal Fibroblasts
Lee, S. H., Jin, S. Y., Song, J. S., et al. (2012) · Annals of Dermatology · doi:10.5021/ad.2012.24.2.136 · Cited by 190 · see citing works
Mechanisms of induction of skin cancer by UV radiation
Ananthaswamy, H. N. (1997) · Frontiers in bioscience · doi:10.2741/a211 · Cited by 189 · see citing works
Functions of the aryl hydrocarbon receptor in the skin
Esser, C., Bargen, I., Weighardt, H., Haarmann-Stemmann, T., & Krutmann, J. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0394-4 · Cited by 187 · see citing works
Platelet-activating factor: the biosynthetic and catabolic enzymes
Snyder, F. F. C. (1995) · Biochemical Journal · doi:10.1042/bj3050689 · Cited by 186 · see citing works
Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression
Morita, Y., Sakaguchi, T., Ikegami, K., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.02.030 · Cited by 181 · see citing works
Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells
de Agüero, M. G., Vocanson, M., Hacini‐Rachinel, F., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59725 · Cited by 180 · see citing works
Ecologic analysis of some immune-related disorders, including type 1 diabetes, in Australia: latitude, regional ultraviolet radiation, and disease prevalence.
Staples, J., Ponsonby, A., Lim, L. L.-Y., & McMichael, A. J. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.5941 · Cited by 170 · see citing works
UVB Light Induces Nuclear Factor κB (NFκB) Activity Independently from Chromosomal DNA Damage in Cell-Free Cytosolic Extracts
Simon, M. M., Aragane, Y., Schwarz, A., Luger, T. A., & Schwarz, T. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12372194 · Cited by 167 · see citing works
Langerhans cells are precommitted to immune tolerance induction
Shklovskaya, E., O’Sullivan, B., Ng, L. G., Roediger, B., Thomas, R., Weninger, W., & Groth, B. F. D. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110076108 · Cited by 166 · see citing works
The emerging roles of PAF acetylhydrolase
McIntyre, T. M., Prescott, S. M., & Stafforini, D. M. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800024-jlr200 · Cited by 164 · see citing works
Cis -urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT 2A receptor
Walterscheid, J. P., Nghiem, D. X., Kazimi, N., Nutt, L. K., McConkey, D. J., Norval, M., & Ullrich, S. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603119103 · Cited by 163 · see citing works
Self-citation
Cellular aspects of photocarcinogenesis
Nishigori, C. (2006) · Photochemical & Photobiological Sciences · doi:10.1039/b507471a · Cited by 161 · see citing works
Regulation of growth arrest in senescence: Telomere damage is not the end of the story
Herbig, U., & Sedivy, J. M. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.002 · Cited by 159 · see citing works
Mast Cell Migration from the Skin to the Draining Lymph Nodes upon Ultraviolet Irradiation Represents a Key Step in the Induction of Immune Suppression
Byrne, S. N., Limón-Flores, A. Y., & Ullrich, S. E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4648 · Cited by 157 · see citing works
Self-citation
Activation of human mast cells through the platelet-activating factor receptor
Kajiwara, N., Sasaki, T., Bradding, P. H., Cruse, G., Sagara, H., Ohmori, K., Saito, H., Ra, C., & Okayama, Y. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.01.056 · Cited by 154 · see citing works
Langerhans Cells Are Required for UVR-Induced Immunosuppression
Schwarz, A., Noordegraaf, M., Maeda, A., Torii, K., Clausen, B. E., & Schwarz, T. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.429 · Cited by 152 · see citing works
Generation of membrane diversity by lysophospholipid acyltransferases
Shindou, H., Hishikawa, D., 原山, 武., Eto, M., & Shimizu, T. (2013) · The Journal of Biochemistry · doi:10.1093/jb/mvt048 · Cited by 144 · see citing works
The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses
Yost, C. C., Weyrich, A. S., & Zimmerman, G. A. (2010) · Biochimie · doi:10.1016/j.biochi.2010.02.011 · Cited by 141 · see citing works
Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis
Gill, P., Jindal, N. L., Jagdis, A., & Vadas, P. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.04.019 · Cited by 140 · see citing works
PAF Produced by Human Breast Cancer Cells Promotes Migration and Proliferation of Tumor Cells and Neo-Angiogenesis
Bussolati, B., Biancone, L., Cassoni, P., Russo, S., Rola‐Pleszczynski, M., Montrucchio, G., & Camussi, G. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64808-0 · Cited by 140 · see citing works
Platelet-activating factor receptor
Ishii, S., Nagase, T., & Shimizu, T. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00058-8 · Cited by 139 · see citing works
Physiological, pathological and potential therapeutic roles of adipokines
Falcão‐Pires, I., Castro‐Chaves, P., Miranda‐Silva, D., Lourenço, A. P., & Leite-Moreira, A. F. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.04.007 · Cited by 128 · see citing works
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer
Mansilla, F., da Costa, K.-A., Wang, S., et al. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0409-0 · Cited by 127 · see citing works
Activation of the Epidermal Platelet-Activating Factor Receptor Results in Cytokine and Cyclooxygenase-2 Biosynthesis
Pei, Y., Barber, L. A., Murphy, R. C., Johnson, C. A., Kelley, S. W., Dy, L. C., Fertel, R. H., Nguyen, T. M., Williams, D. A., & Travers, J. B. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.4.1954 · Cited by 127 · see citing works
Platelet-activating factor and leukotriene biosynthesis is inhibited in polymorphonuclear leukocytes depleted of arachidonic acid.
Ramesha, C. S., & Pickett, W. C. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57436-1 · Cited by 126 · see citing works
Structure and Function of Skin
Monteiro-Riviere, N. A. (2010) · CRC Press eBooks · doi:10.3109/9781420079180-3 · Cited by 126 · see citing works
The Immune-Modulating Cytokine and Endogenous Alarmin Interleukin-33 Is Upregulated in Skin Exposed to Inflammatory UVB Radiation
Byrne, S. N., Beaugie, C., O’Sullivan, C., Leighton, S., & Halliday, G. M. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.010 · Cited by 124 · see citing works
Immune functions of the skin
Bangert, C., Brunner, P. M., & Stingl, G. (2011) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2011.01.006 · Cited by 124 · see citing works
p21 (WAF1/CIP1) Expression Is Induced in Newly Nondividing Cells in Diverse Epithelia and during Differentiation of the Caco-2 Intestinal Cell Line
Gartel, A. L., Serfas, M. S., Gartel, M., et al. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0264 · Cited by 120 · see citing works
Prostaglandin E 2 –prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression
Soontrapa, K., Honda, T., Sakata, D., Yao, C., Hirata, T., Hori, S., Matsuoka, T., Kita, Y., Shimizu, T., Kabashima, K., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018625108 · Cited by 119 · see citing works
Platelet-activating Factor Mediates MMP-2 Expression and Activation via Phosphorylation of cAMP-response Element-binding Protein and Contributes to Melanoma Metastasis
Melnikova, V. O., Mourad-Zeidan, A. A., Lev, D. C., & Bar‐Eli, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508683200 · Cited by 113 · see citing works
Ultraviolet A Radiation Suppresses an Established Immune Response: Implications for Sunscreen Design
Nghiem, D. X., Kazimi, N., Clydesdale, G. J., Ananthaswamy, H. N., Kripke, M. L., & Ullrich, S. E. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01503.x · Cited by 113 · see citing works
Self-citation
A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis
Elledge, S. J., Winston, J. T., & Harper, J. W. (1996) · Trends in Cell Biology · doi:10.1016/0962-8924(96)10030-1 · Cited by 113 · see citing works
Antihypertensive functions of the kidney: Arthur C. Corcoran memorial lecture.
Muirhead, E. E. (1980) · Hypertension · doi:10.1161/01.hyp.2.4.444 · Cited by 109 · see citing works
COX-2 and Prostaglandin EP3/EP4 Signaling Regulate the Tumor Stromal Proangiogenic Microenvironment via CXCL12-CXCR4 Chemokine Systems
Katoh, H., Hosono, K., Ito, Y., Suzuki, T., Ogawa, Y., Kubo, H., Kamata, H., Mishima, T., Tamaki, H., Sakagami, H., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090607 · Cited by 108 · see citing works
Dermal Dendritic Cells, and Not Langerhans Cells, Play an Essential Role in Inducing an Immune Response
Fukunaga, A., Khaskhely, N. M., Sreevidya, C. S., Byrne, S. N., & Ullrich, S. E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3057 · Cited by 107 · see citing works
Self-citation
Ultraviolet B Radiation Generates Platelet-activating Factor-like Phospholipids underlying Cutaneous Damage
Marathe, G. K., Johnson, C. N., Billings, S. D., Southall, M. D., Pei, Y., Spandau, D. F., Murphy, R. C., Zimmerman, G. A., McIntyre, T. M., & Travers, J. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503811200 · Cited by 107 · see citing works
The Immunologic Revolution: Photoimmunology
Ullrich, S. E., & Byrne, S. N. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.405 · Cited by 103 · see citing works
Self-citation
Ultraviolet A Radiation: Its Role in Immunosuppression and Carcinogenesis
Halliday, G. M., Byrne, S. N., & Damian, D. L. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.08.002 · Cited by 103 · see citing works
Mast Cell-Derived IL-10 Suppresses Germinal Center Formation by Affecting T Follicular Helper Cell Function
Chacón‐Salinas, R., Limón-Flores, A. Y., Chávez-Blanco, A. D., Gonzalez‐Estrada, A., & Ullrich, S. E. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001657 · Cited by 102 · see citing works
Self-citation
Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas
Wang, Y., DiGiovanna, J. J., Stern, J. B., Hornyak, T. J., Raffeld, M. A., Khan, S. G., Oh, K., Hollander, M. C., Dennis, P. A., & Kraemer, K. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812401106 · Cited by 101 · see citing works
Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice.
Beissert, S., Hosoi, J., Kühn, R., Rajewsky, K., Müller, W., & Granstein, R. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12582809 · Cited by 100 · see citing works
Platelet-Activating Factor Is Crucial in Psoralen and Ultraviolet A-Induced Immune Suppression, Inflammation, and Apoptosis
Wolf, P., Nghiem, D. X., Walterscheid, J. P., Byrne, S. N., Matsumura, Y., Matsumura, Y., Bucana, C., Ananthaswamy, H. N., & Ullrich, S. E. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060079 · Cited by 99 · see citing works
Self-citation
The immunosuppressive side of PDT
Mróz, P., & Hamblin, M. R. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c0pp00345j · Cited by 97 · see citing works
Inflammation and melanoma growth and metastasis: The role of platelet-activating factor (PAF) and its receptor
Melnikova, V. O., & Bar‐Eli, M. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9092-9 · Cited by 97 · see citing works
The erythemal response of human skin to ultraviolet radiation
Farr, P. M., & Diffey, B. L. (1985) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1985.tb02045.x · Cited by 95 · see citing works
Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair
Sreevidya, C. S., Fukunaga, A., Khaskhely, N. M., Masaki, T., Ono, R., Nishigori, C., & Ullrich, S. E. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.329 · Cited by 92 · see citing works
Self-citation
At what age do sunburn episodes play a crucial role for the development of malignant melanoma
Westerdahl, J., Olsson, H. L., & Ingvar, C. (1994) · European Journal of Cancer · doi:10.1016/0959-8049(94)00337-5 · Cited by 88 · see citing works
Platelet activating factor in allergies
Pałgan, K., & Bartuzi, Z. (2015) · International Journal of Immunopathology and Pharmacology · doi:10.1177/0394632015600598 · Cited by 88 · see citing works
To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase
Marathe, G. K., Pandit, C., Lakshmikanth, C. L., Chaithra, V. H., Jacob, S. P., & D'Souza, C. J. M. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r045492 · Cited by 87 · see citing works
Sunlight-Induced Immunosuppression in Humans Is Initially Because of UVB, Then UVA, Followed by Interactive Effects
Poon, T. S. C., Barnetson, R. S., & Halliday, G. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23894.x · Cited by 86 · see citing works
CD8 T Cells Producing IL-17 and IFN-γ Initiate the Innate Immune Response Required for Responses to Antigen Skin Challenge
Kish, D. D., Li, X., & Fairchild, R. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802830 · Cited by 81 · see citing works
Broad-Spectrum Sunscreens Provide Better Protection from the Suppression of the Elicitation Phase of Delayed-Type Hypersensitivity Response in Humans
Moyal, D. D., & Fourtanier, A. M. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01545.x · Cited by 81 · see citing works
Langerhans Cells Serve as Immunoregulatory Cells by Activating NKT Cells
Fukunaga, A., Khaskhely, N. M., Ma, Y., Sreevidya, C. S., Taguchi, K., Nishigori, C., & Ullrich, S. E. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000246 · Cited by 81 · see citing works
Self-citation
Langerhans cells: critical regulators of skin immunity?
Clausen, B. E., & Kel, J. M. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.40 · Cited by 80 · see citing works
The expression level of lysophosphatidylcholine acyltransferase 1 (LPCAT1) correlates to the progression of prostate cancer
Zhou, X., Lawrence, T. J., He, Z., Pound, C. R., Mao, J., & Bigler, S. A. (2011) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2011.11.001 · Cited by 79 · see citing works
Cyclobutane pyrimidine dimer formation is a molecular trigger for solar-simulated ultraviolet radiation-induced suppression of memory immunity in humans
Kuchel, J. M., Barnetson, R. S., & Halliday, G. M. (2005) · Photochemical & Photobiological Sciences · doi:10.1039/b504068j · Cited by 79 · see citing works
Expression of the Platelet-activating Factor Receptor Results in Enhanced Ultraviolet B Radiation-induced Apoptosis in a Human Epidermal Cell Line
Barber, L. A., Spandau, D. F., Rathman, S. C., Murphy, R. C., Johnson, C. A., Kelley, S. W., Hurwitz, S. A., & Travers, J. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.30.18891 · Cited by 78 · see citing works
Ultraviolet A Irradiation of C57BL/6 Mice Suppresses Systemic Contact Hypersensitivity or Enhances Secondary Immunity Depending on Dose
Byrne, S. N., Spinks, N., & Halliday, G. M. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.00261.x · Cited by 75 · see citing works
UVB Radiation-Mediated Inhibition of Contact Hypersensitivity Reactions Is Dependent on the Platelet-Activating Factor System
Zhang, Q., Yao, Y., Konger, R. L., Sinn, A. L., Cai, S., Pollok, K. E., & Travers, J. B. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701251 · Cited by 73 · see citing works
Loss of p21CDKN1Aimpairs entry to quiescence and activates a DNA damage response in normal fibroblasts induced to quiescence
Perucca, P., Cazzalini, O., Madine, M. A., Savio, M., Laskey, R. A., Vannini, V., Prosperi, E., & Stivala, L. A. (2009) · Cell Cycle · doi:10.4161/cc.8.1.7507 · Cited by 71 · see citing works
Not Just a CDK Inhibitor: Regulation of Transcription by p21WAF1/CIP1/SDI1
Perkins, N. D. (2002) · Cell Cycle · doi:10.4161/cc.1.1.98 · Cited by 71 · see citing works
Modulation of immunity to Borrelia burgdorferi by ultraviolet irradiation: Differential effect on Th1 and Th2 immune responses
Brown, E. L., Rivas, J. M., Ullrich, S. E., Young, C. R., Norris, S. J., & Kripke, M. L. (1995) · European Journal of Immunology · doi:10.1002/eji.1830251105 · Cited by 71 · see citing works
Self-citation
Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma
Lee, G. R. (2004) · International Immunology · doi:10.1093/intimm/dxh117 · Cited by 68 · see citing works
The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists
Sahu, R. P., Turner, M. J., DaSilva‐Arnold, S. C., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs152 · Cited by 65 · see citing works
Dermal fibroblasts promote the migration of dendritic cells.
Saalbach, A., Klein, C., Schirmer, C., Briest, W., Anderegg, U., & Simon, J. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.253 · Cited by 63 · see citing works
Demonstration that platelet‐activating factor is capable of activating mast cells and inducing a chemotactic response
Nilsson, G. P., Metcalfe, D. D., & Taub, D. D. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00972.x · Cited by 60 · see citing works
Pharmacologically Antagonizing the CXCR4-CXCL12 Chemokine Pathway with AMD3100 Inhibits Sunlight-Induced Skin Cancer
Sarchio, S. N. E., Scolyer, R. A., Beaugie, C., McDonald, D. M., Marsh‐Wakefield, F., Halliday, G. M., & Byrne, S. N. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.424 · Cited by 59 · see citing works
Inhibition of Photocarcinogenesis by Platelet-Activating Factor or Serotonin Receptor Antagonists
Sreevidya, C. S., Khaskhely, N. M., Fukunaga, A., Khaskina, P., & Ullrich, S. E. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6132 · Cited by 59 · see citing works
Self-citation
Phosphorylation of Lysophosphatidylcholine Acyltransferase 2 at Ser34 Enhances Platelet-activating Factor Production in Endotoxin-stimulated Macrophages
Morimoto, R., Shindou, H., Oda, Y., & Shimizu, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.147025 · Cited by 58 · see citing works
Ultraviolet B Radiation Generated Platelet-Activating Factor Receptor Agonist Formation Involves EGF-R-Mediated Reactive Oxygen Species
Yao, Y., Wolverton, J. E., Zhang, Q., Marathe, G. K., Al‐Hassani, M., Konger, R. L., & Travers, J. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802689 · Cited by 57 · see citing works
Platelet-Activating Factor Biosynthesis Induced by Various Stimuli in Human HaCaT Keratinocytes
Travers, J. B., Harrison, K. A., Johnson, C. A., et al. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12298295 · Cited by 57 · see citing works
Acute keratinocyte damage stimulates platelet-activating factor production
Alappatt, C., Johnson, C. A., Clay, K. L., & Travers, J. B. (2000) · Archives of Dermatological Research · doi:10.1007/s004030050483 · Cited by 57 · see citing works
Association between melanoma and dermal mast cell prevalence in sun-unexposed skin
Grimbaldeston, M. A., Pearce, A. L., Robertson, B. O., Coventry, B. J., Marshman, G., Finlay‐Jones, J. J., & Hart, P. H. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.05966.x · Cited by 57 · see citing works
Suppression of an Established Immune Response by UVA— A Critical Role for Mast Cells
Ullrich, S. E., Nghiem, D. X., & Khaskina, P. (2007) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00184.x · Cited by 57 · see citing works
Self-citation
The Mandatory Role of IL-10–Producing and OX40 Ligand-Expressing Mature Langerhans Cells in Local UVB-Induced Immunosuppression
Yoshiki, R., Kabashima, K., Sakabe, J., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903254 · Cited by 54 · see citing works
Lysophosphatidylcholine Acyltransferase1 Overexpression Promotes Oral Squamous Cell Carcinoma Progression via Enhanced Biosynthesis of Platelet-Activating Factor
Shida-Sakazume, T., Endo‐Sakamoto, Y., Unozawa, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120143 · Cited by 53 · see citing works
Signaling via Platelet-Activating Factor Receptors Accounts for the Impairment of Neutrophil Migration in Polymicrobial Sepsis
Moreno, S. E., Alves-Filho, J. C., Rios-Santos, F., Silva, J. S., Ferreira, S. H., Cunha, F. Q., & Teixeira, M. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.1264 · Cited by 52 · see citing works
Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor
Zhang, Q. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25429 · Cited by 51 · see citing works
Biosynthesis of platelet activating factor and 1-O-acyl analogues by endothelial cells
Clay, K. L., Johnson, C. A., & Worthen, G. S. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(91)90024-r · Cited by 49 · see citing works
Platelet Activating Factor/Platelet Activating Factor Receptor Pathway as a Potential Therapeutic Target in Autoimmune Diseases
Edwards, L. J., & Constantinescu, C. S. (2009) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152809788681010 · Cited by 49 · see citing works
Effectiveness of information campaigns
Breitbart, E. W., Greinert, R., & Volkmer, B. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.02.023 · Cited by 49 · see citing works
Wavelength dependency for UVA-induced suppression of recall immunity in humans
Matthews, Y. J., Halliday, G. M., Phan, T. A., & Damian, D. L. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.07.005 · Cited by 49 · see citing works
Photoageing: the darker side of the sun
Tsoureli‐Nikita, E., Watson, R. E. B., & Griffiths, C. E. M. (2005) · Photochemical & Photobiological Sciences · doi:10.1039/b507492d · Cited by 49 · see citing works
An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation
Chacón‐Salinas, R., Chen, L., Chávez-Blanco, A. D., Limón-Flores, A. Y., Ma, Y., & Ullrich, S. E. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0811409 · Cited by 49 · see citing works
Self-citation
The Role of Platelet-Activating Factor in Endothelial Cells
Prescott, S. M., McIntyre, T. M., & Zimmerman, G. A. (1990) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1647261 · Cited by 48 · see citing works
Circulating Platelet-Activating Factor Is Primarily Cleared by Transport, Not Intravascular Hydrolysis by Lipoprotein-Associated Phospholipase A 2 / PAF Acetylhydrolase
Liu, J., Chen, R., Marathe, G. K., Febbraio, M., Zou, W., & McIntyre, T. M. (2010) · Circulation Research · doi:10.1161/circresaha.110.228742 · Cited by 47 · see citing works
Skin-Infiltrating Monocytes/Macrophages Migrate to Draining Lymph Nodes and Produce IL-10 After Contact Sensitizer Exposure to UV-Irradiated Skin
Toichi, E., Lu, K. Q., Swick, A. R., McCormick, T. S., & Cooper, K. D. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.137 · Cited by 46 · see citing works
Dermal mast cells affect the development of sunlight‐induced skin tumours
Sarchio, S. N. E., Kok, L., O’Sullivan, C., Halliday, G. M., & Byrne, S. N. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01438.x · Cited by 45 · see citing works
Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects
Konger, R. L., Marathe, G. K., Yao, Y., Zhang, Q., & Travers, J. B. (2008) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2008.04.002 · Cited by 45 · see citing works
Individual Photosensitivity of Human Skin and UVA-Induced Pyrimidine Dimers in DNA
Mouret, S., Leccia, M. ‐., Bourrain, J. ‐., Douki, T., & Béani, J. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.47 · Cited by 43 · see citing works
Local Ultraviolet B Irradiation Impairs Contact Hypersensitivity Induction by Triggering Release of Tumor Necrosis Factor-α from Mast Cells. Involvement of Mast Cells and Langerhans Cells in Susceptibility to Ultraviolet B
Alard, P., Niizeki, H., Hanninen, L. A., & Streilein, J. W. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00772.x · Cited by 43 · see citing works
Ultraviolet B Radiation of Human Skin Generates Platelet‐activating Factor Receptor Agonists
Travers, J. B., Berry, D., Yao, Y., Yi, Q., Konger, R. L., & Travers, J. B. (2010) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2010.00743.x · Cited by 41 · see citing works
Platelet-Activating Factor Receptors Mediate Excitatory Postsynaptic Hippocampal Injury in Experimental Autoimmune Encephalomyelitis
Bellizzi, M. J., Geathers, J. S., Allan, K. C., & Gelbard, H. A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1171-15.2016 · Cited by 41 · see citing works
Early time course of recruitment of immune surveillance in human skin after chemical provocation
Friedmann, P. S., Strickland, I., Memon, A. A., et al. (1993) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1993.tb05908.x · Cited by 40 · see citing works
Toll‐like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B 4 and platelet‐activating factor
Lefebvre, J. S., Marleau, S., Milot, V., Lévesque, T., Picard, S., Flamand, N., & Borgeat, P. (2009) · The FASEB Journal · doi:10.1096/fj.09-135624 · Cited by 39 · see citing works
The Osmolyte Taurine Protects against Ultraviolet B Radiation-Induced Immunosuppression
Rockel, N., Esser, C., Grether‐Beck, S., Warskulat, U., Flögel, U., Schwarz, A., Schwarz, T., Yarosh, D. B., Häussinger, D., & Krutmann, J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3604 · Cited by 38 · see citing works
The Alternative Complement Pathway Seems to be a UVA Sensor that Leads to Systemic Immunosuppression
Stapelberg, M., Williams, R. B. H., Byrne, S. N., & Halliday, G. M. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.128 · Cited by 37 · see citing works
Rapid Production of Platelet-activating Factor Is Induced by Protein Kinase Cα-mediated Phosphorylation of Lysophosphatidylcholine Acyltransferase 2 Protein
Morimoto, R., Shindou, H., Tarui, M., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.558874 · Cited by 35 · see citing works
The Role of Platelet-Activating Factor in Mesangial Pathophysiology
Reznichenko, A., & Korstanje, R. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.11.025 · Cited by 35 · see citing works
Augmentation of UVB Radiation-Mediated Early Gene Expression by the Epidermal Platelet-Activating Factor Receptor
Travers, J. B., Edenberg, H. J., Zhang, Q., Al‐Hassani, M., Yi, Q., Baskaran, S., & Konger, R. L. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701083 · Cited by 34 · see citing works
Topical Photodynamic Therapy Induces Systemic Immunosuppression via Generation of Platelet-Activating Factor Receptor Ligands
Ferracini, M., Sahu, R. P., Harrison, K. A., Waeiss, R. A., Murphy, R. C., Jancar, S., Konger, R. L., & Travers, J. B. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.313 · Cited by 32 · see citing works
Platelet Activating Factor in Heart Failure: Potential Role in Disease Progression and Novel Target for Therapy
Detopoulou, P., Nomikos, T., Fragopoulou, E., Chrysohoou, C. A., & Antonopoulou, S. (2013) · Current Heart Failure Reports · doi:10.1007/s11897-013-0131-2 · Cited by 29 · see citing works
Platelet activating factor induces transient blood‐brain barrier opening to facilitate edaravone penetration into the brain
Fang, W., Zhang, R., Sha, L., Lv, P., Shang, E., Han, D., Wei, J., Geng, X., Yang, Q., & Li, Y. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12507 · Cited by 27 · see citing works
Release of platelet activating factor (PAF) and eicosanoids in UVC-irradiated corneal stromal cells
盛耀华, & Birkle, D. L. (1995) · Current Eye Research · doi:10.3109/02713689508999931 · Cited by 25 · see citing works
Amniotic fluid platelet-activating factor (PAF) is elevated in patients with tocolytic failure and preterm delivery
Silver, R. K., Caplan, M. S., & Kelly, A. M. (1992) · Prostaglandins · doi:10.1016/0090-6980(92)90085-8 · Cited by 23 · see citing works
Isolation and identification of platelet-activating factor in UV-irradiated guinea pig skin
Calignano, A., Cirino, G., Meli, R., & Persico, P. (1988) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(88)90049-6 · Cited by 22 · see citing works
Antiobese function of platelet‐activating factor: increased adiposity in platelet‐activating factor receptor‐deficient mice with age
Sugatani, J., Sadamitsu, S., Yamaguchi, M., Yamazaki, Y., Higa, R., Hattori, Y., Uchida, T., Ikari, A., Sugiyama, W., Watanabe, T., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-233262 · Cited by 22 · see citing works
Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells
Puebla‐Osorio, N., Damiani, E., Bover, L. C., & Ullrich, S. E. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.115 · Cited by 21 · see citing works
Self-citation
Shedding light on proteins, nucleic acids, cells, humans and fish
Setlow, R. B. (2002) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(02)00004-2 · Cited by 21 · see citing works
Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells
Damiani, E., Puebla‐Osorio, N., Gorbea, E., & Ullrich, S. E. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.336 · Cited by 21 · see citing works
Self-citation
Involvement of Platelet-Activating Factor in Ultraviolet B-Induced Hyperalgesia
Zhang, Q., Sitzman, L. A., Al-Hassani, M., Cai, S., Pollok, K. E., Travers, J. B., & Hingtgen, C. M. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.181 · Cited by 20 · see citing works
Systemic Chemotherapy Is Modulated by Platelet‐Activating Factor‐Receptor Agonists
Sahu, R. P., Ferracini, M., & Travers, J. B. (2015) · Mediators of Inflammation · doi:10.1155/2015/820543 · Cited by 19 · see citing works
The Role of Platelet‐activating Factor in the Mammalian Female Reproductive Tract
Tiemann, U. (2008) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2007.00959.x · Cited by 19 · see citing works
Autocrine stimulation of B lymphocytes by a platelet-activating factor receptor agonist, 1-palmitoyl-2-acetyl-sn-glycero-3-phosphocholine.
Tordai, A., Franklin, R. A., Johnson, C., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.2.566 · Cited by 18 · see citing works
Langerhans Cell Migration: Not Necessarily Always at the Center of the Skin Sensitization Universe
Kimber, I., Cumberbatch, M., & Dearman, R. J. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.54 · Cited by 18 · see citing works
Potential mechanism for recruitment and migration of CD133 positive cells to areas of vascular inflammation
Rastogi, P., White, M. C., Rickard, A., et al. (2008) · Thrombosis Research · doi:10.1016/j.thromres.2008.03.020 · Cited by 17 · see citing works
The effect of ultraviolet radiation-induced suppressor cells on T-cell activity.
Ullrich, S. E. (1987) · PubMed · Cited by 16 · see citing works
Self-citation
Platelet‐activating Factor Does Not Mediate UVB‐induced Local Immune Suppression
Sahu, R. P., Yao, Y., Konger, R. L., et al. (2011) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.01071.x · Cited by 16 · see citing works
Brief review: molecular mechanisms of neutrophil binding to endothelium involving platelet-activating factor and cytokines.
Zimmerman, G. A., McIntyre, T. M., Prescott, S. M., et al. (1990) · PubMed · Cited by 13 · see citing works
Modulation of Platelet Activating Factor-Induced Glycogenolysis in the Perfused Rat Liver after Administration of Endotoxin In Vivo
Kimura, K., Moriyama, M., Nishisako, M., et al. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021901 · Cited by 6 · see citing works
Cutaneous malignancy of the head and neck: A multidisciplinary approach
Haerle, S. K., & Irish, J. C. (2012) · Head & Neck · doi:10.1002/hed.22938 · Cited by 6 · see citing works
Early T cell development can be traced in rat fetal liver
Alonso-C., L. M., Múñoz, J. J., & Zapata, A. G. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200012)30:12 · Cited by 6 · see citing works

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[82]Streilein JW Skin-associated lymphoid tissue: the next generation Bos D Skin Immune System Boca Raton, Fl CRC Press 1989 25 48

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Photoimmunology: how ultraviolet radiation affects the immune system
Bernard, J. J., Gallo, R. L., & Krutmann, J. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0185-9 · Cited by 329 · see citing works
Roles of UVA radiation and DNA damage responses in melanoma pathogenesis
Khan, A. Q., Travers, J. B., & Kemp, M. G. (2018) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22176 · Cited by 152 · see citing works
Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage
Brand, R. M., Wipf, P., Durham, A., Epperly, M. W., Greenberger, J. S., & Falo, L. D. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00920 · Cited by 124 · see citing works
Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways
Sha, Y., Vartanian, V., Owen, N., Mengden Koon, S. J., Calkins, M. J., Thompson, C. S., Mirafzali, Z., Mir, S., Goldsmith, L. E., He, H., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-17940-8 · Cited by 12 · see citing works

Authors: Damiani, E., & Ullrich, S. E.
Affiliations: Marche Polytechnic University (IT)
The University of Texas MD Anderson Cancer Center (US)
ORCID: Damiani, Elisabetta
Venue: Progress in Lipid Research
Publisher: Elsevier BV
Published: 2016-07
Volume: 63
Pages: 14-27
ISSN: 0163-7827 (ISSN-L)
DOI: 10.1016/j.plipres.2016.03.004
PMC: PMC4975990
OpenAlex: W2314107066
Cited by: 78
References: 181
Citations by year: 2026: 5 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 12 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 10 · 2016: 2
FWCI: 0.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Lipid Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion, public-domain)
Funders: National Cancer Institute (R01CA131207)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords: platelet-activating factor, ultraviolet radiation, UV-B radiation, skin cancer, UV-induced immunosuppression, keratinocytes, PAF receptor, mast cell migration, DNA repair, epigenetic regulation, glycerophosphocholine
MeSH terms: Animals, Blood Platelets, DNA Repair, Humans, Immunosuppression Therapy, Inflammation, Mast Cells, Platelet Activating Factor, Skin, Skin Neoplasms, Ultraviolet Rays, Receptors, G-Protein-Coupled

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Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer

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