Advancing host-directed therapy for tuberculosis

Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response

Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

Keane, J., Gershon, S. K., Wise, R. P., Mirabile‐Levens, E., Kasznica, J. M., Schwieterman, W. D., Siegel, J. N., & Braun, M. M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011110 · Cited by 3,683

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252

Identification of a Primary Target of Thalidomide Teratogenicity

Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y., & Handa, H. (2010) · Science · doi:10.1126/science.1177319 · Cited by 2,136

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

Lu, G., Middleton, R. E., Sun, H., Naniong, M., Ott, C. J., Mitsiades, C. S., Wong, K.-K., Bradner, J. E., & Kaelin, W. G. (2014) · Science · doi:10.1126/science.1244917 · Cited by 1,583

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

Newport, M. J., Huxley, C. M., Huston, S., Hawrylowicz, C. M., Oostra, B. A., Williamson, R., & Levin, M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352602 · Cited by 1,198

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes.

Sampaio, E. P., Sarno, E. N., Gallily, R., Cohn, Z. A., & Kaplan, G. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.3.699 · Cited by 1,191

Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti–tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: A randomized, placebo‐controlled, 52‐week trial

Keystone, E. C., Kavanaugh, A. F., Sharp, J. T., Tannenbaum, H., Hua, Y., Teoh, L. S., Fischkoff, S. A., & Chartash, E. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20217 · Cited by 1,171

Regulatory T Cells Subvert Mycobacterial Containment in Patients Failing Extensively Drug-Resistant Tuberculosis Treatment

Davids, M., Pooran, A., Pietersen, E., Wainwright, H., Binder, A. B., Warren, R. M., & Dheda, K. U. J. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201707-1441oc · Cited by 35

Multidrug-resistant tuberculosis in children and adolescents: current strategies for prevention and treatment

Seddon, J. A., Johnson, S. M., Palmer, M., van der Zalm, M. M., López‐Varela, E., Hughes, J. A., & Schaaf, H. S. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2021.1828069 · Cited by 35

Antimicrobial Peptide against Mycobacterium Tuberculosis That Activates Autophagy Is an Effective Treatment for Tuberculosis

Coyotl, E. A. P., Barrios-Palacios, J., Muciño-Hernández, G., Moreno-Blas, D., Costas, M., Montes, T. M., Diener, C., Uribe‐Carvajal, S., Massieu, L., Castro‐Obregón, S., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111071 · Cited by 35

Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy

Singh, B., Moodley, C., Singh, D. K., Escobedo, R. A., Sharan, R., Arora, G., Ganatra, S., Shivanna, V., González, O., Hall-Ursone, S., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.163101 · Cited by 34

NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis

Pacl, H. T., Chinta, K. C., Reddy, V. P., Nadeem, S., Sevalkar, R. R., Nargan, K., Lumamba, K. D., Naidoo, T., Glasgow, J. N., Agarwal, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40545-x · Cited by 34

Personalized medicine for patients with MDR-TB: Table 1.

Olaru, I. D., Lange, C. G., & Heyckendorf, J. (2015) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv354 · Cited by 34

Metformin induced autophagy in diabetes mellitus – Tuberculosis co-infection patients: A case study

Novita, B. D., Ali, M., Pranoto, A. S., Soediono, E. I., & Mertaniasih, N. M. (2018) · Indian Journal of Tuberculosis · doi:10.1016/j.ijtb.2018.04.003 · Cited by 34

Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity

Yang, H., Wang, F., Guo, X., Liu, F., Liu, Z., Wu, X., Zhao, M., Ma, M., Liu, H., Qin, L., et al. (2021) · Cell Discovery · doi:10.1038/s41421-021-00301-1 · Cited by 33

Lysosome-Mediated Plasma Membrane Repair Is Dependent on the Small GTPase Arl8b and Determines Cell Death Type in Mycobacterium tuberculosis Infection

Michelet, X., Tuli, A., Gan, H., Geadas, C., Sharma, M., Remold, H. G., & Brenner, M. B. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700829 · Cited by 36

Recent Developments in Drug Delivery for Treatment of Tuberculosis by Targeting Macrophages

Gairola, A., Benjamin, A. B., Weatherston, J. D., Cirillo, J. D., & Wu, H. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202100193 · Cited by 34

Macrophage targeted polymeric curcumin nanoparticles limit intracellular survival of Mycobacterium tuberculosis through induction of autophagy and augment anti-TB activity of isoniazid in RAW 264.7 macrophages

Gupta, P. K., Jahagirdar, P. S., Tripathi, D., Devarajan, P. V., & Kulkarni, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1233630 · Cited by 32

Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection

del Rosario, R. C. H., Poschmann, J., Lim, C., Cheng, C. Y., Kumar, P., Riou, C., Ong, S. T., Gerges, S., Hajan, H. S., Kumar, D., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-021-01049-w · Cited by 32

Adjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis

Wallis, R. S., Sabi, I., Lalashowi, J., Bakuli, A., Mapamba, D. A., Olomi, W., Siyame, E., Ngaraguza, B., Chimbe, O., Charalambous, S., et al. (2024) · NEJM Evidence · doi:10.1056/evidoa2300332 · Cited by 32

Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα

Koh, H.-J., Kim, Y.-R., Kim, J., Yun, J.-S., Jang, K., & Yang, C. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006126 · Cited by 31

Albumin fusion with granulocyte-macrophage colony-stimulating factor acts as an immunotherapy against chronic tuberculosis

Chuang, Y.-M., He, L., Pinn, M. L., Tsai, Y.-C., Cheng, M. A., Farmer, E. A., Karakousis, P. C., & Hung, C. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0439-2 · Cited by 32

Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy

Cumming, B. M., Pacl, H. T., & Steyn, A. J. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.576596 · Cited by 31

Mortality in Severe Human Immunodeficiency Virus-Tuberculosis Associates With Innate Immune Activation and Dysfunction of Monocytes

Janssen, S., Schutz, C., Ward, A. M., Nemes, E., Wilkinson, K. A., Scriven, J. E., Huson, M. A., Aben, N., Maartens, G., Burton, R., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix254 · Cited by 32

Factors associated with pulmonary impairment in HIV-infected South African adults

Gupte, A., Wong, M., Msandiwa, R., Barnes, G. L., Golub, J. E., Chaisson, R. E., Hoffmann, C. J., & Martinson, N. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184530 · Cited by 32

The antimicrobial activity of innate host-directed therapies: A systematic review

Shapira, T., Christofferson, M., & Av-Gay, Y. (2024) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2024.107138 · Cited by 30

Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase

Chao, W., Yen, C., Hsieh, C.-Y., Huang, Y., Tseng, Y., Nigrovic, P. A., & Shieh, C.-C. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189453 · Cited by 30

Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect

Sharma, D., Bisht, D., & Khan, A. U. (2018) · Proteomes · doi:10.3390/proteomes6020026 · Cited by 30

Pasakbumin A controls the growth of Mycobacterium tuberculosis by enhancing the autophagy and production of antibacterial mediators in mouse macrophages

Lee, H.-J., Ko, H., Kim, S. H., & Jung, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0199799 · Cited by 29

Potential strategies for the management of drug-resistant tuberculosis

Sharma, D., Sharma, S., & Sharma, J. (2020) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2020.02.029 · Cited by 29

Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

Chatterjee, S., Yabaji, S. M., Rukhlenko, O. S., Bhattacharya, B., Waligurski, E., Vallavoju, N., Ray, S., Kholodenko, B. Ν., Brown, L. E., Beeler, A. B., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102845 · Cited by 29

Effect of 1,25-dihydroxyvitamin D3 on the expression of mannose receptor, DC-SIGN and autophagy genes in pulmonary tuberculosis

Afsal, K., & Selvaraj, P. (2016) · Tuberculosis · doi:10.1016/j.tube.2016.03.010 · Cited by 28

Rapid molecular diagnosis of live Mycobacterium tuberculosis on an integrated microfluidic system

Wang, C., Chang, J.-R., Hung, S., Dou, H.-Y., & Lee, G. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.131968 · Cited by 28

Ferroptosis hijacking by Mycobacterium tuberculosis

Gan, B. (2023) · Nature Communications · doi:10.1038/s41467-023-37149-w · Cited by 28

Immunotherapy Added to Antibiotic Treatment Reduces Relapse of Disease in a Mouse Model of Tuberculosis

Mourik, B. C., Leenen, P. J. M., de Knegt, G. J., Huizinga, R., van der Eerden, B. C. J., Wang, J., Krois, C. R., Napoli, J. L., Bakker‐Woudenberg, I. A. J. M., & de Steenwinkel, J. E. M. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0185oc · Cited by 27

Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery

O’Connor, G., Gleeson, L. E., Fagan-Murphy, A., Cryan, S., O’Sullivan, M. P., & Keane, J. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.024 · Cited by 27

Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions

Muylder, G. D., Vanhollebeke, B., Caljon, G., Wolfe, A. R., McKerrow, J. H., & Dujardin, J. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005234 · Cited by 26

Imatinib Triggers Phagolysosome Acidification and Antimicrobial Activity against Mycobacterium bovis Bacille Calmette–Guérin in Glucocorticoid-Treated Human Macrophages

Steiger, J., Stephan, A., Inkeles, M. S., Realegeno, S. E., Bruns, H., Kröll, P., Kroner, J. D. C., Sommer, A., Batinica, M., Pitzler, L., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502407 · Cited by 25

How mycobacteria take advantage of the weakness in human immune system in the modern world

Chao, W.-C., Yen, C., Wu, C., & Shieh, C.-C. K. (2019) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2019.10.008 · Cited by 25

Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection

Bhatt, K., Bhagavathula, M., Verma, S., Timmins, G. S., Deretic, V. P., Ellner, J. J., & Salgame, P. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.049018 · Cited by 26

Host-Directed Targeting of LincRNA-MIR99AHG Suppresses Intracellular Growth of Mycobacterium tuberculosis

Gcanga, L., Tamgue, O., Ozturk, M., Pillay, S., Jacobs, R., Chia, J. E., Mbandi, S. K., Davids, M., Dheda, K. U. J., Schmeier, S., et al. (2022) · Nucleic Acid Therapeutics · doi:10.1089/nat.2022.0009 · Cited by 25

Post translational modifications in tuberculosis: ubiquitination paradox

Shariq, M., Quadir, N., Sheikh, J. A., Singh, A. K., Bishai, W. R., Ehtesham, N. Z., & Hasnain, S. E. (2020) · Autophagy · doi:10.1080/15548627.2020.1850009 · Cited by 25

Potential Effect of Statins on Mycobacterium tuberculosis Infection

Guerra-de-Blas, P. D. C., Torres‐González, P., Bobadilla-del-Valle, M., Sada‐Ovalle, I., Ponce‐de‐León, A., & Sifuentes‐Osornio, J. (2018) · Journal of Immunology Research · doi:10.1155/2018/7617023 · Cited by 24

Insights into innovative therapeutics for drug-resistant tuberculosis: Host-directed therapy and autophagy inducing modified nanoparticles

Khoza, L. J., Kumar, P., Dube, A., Demana, P. H., & Choonara, Y. E. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121893 · Cited by 24

Potentials of Host-Directed Therapies in Tuberculosis Management

Dara, Y., Volcani, D., Shah, K., Shin, K., & Venketaraman, V. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081166 · Cited by 23

The evolving research agenda for paediatric tuberculosis infection

Seddon, J. A., Whittaker, E., Kampmann, B., Lewinsohn, D. A., Osman, M., Hesseling, A. C., Rustomjee, R., & Amanullah, F. (2019) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30787-4 · Cited by 23

Advancing the fight against tuberculosis: integrating innovation and public health in diagnosis, treatment, vaccine development, and implementation science

Elbehiry, A., Marzouk, E., Edrees, H. M., AlShaqi, R., Ellethy, A. T., Alzaben, F. A., Anagreyyah, S. A., Algarni, A., Almuhaydili, K., AlOtaibi, I. A. B., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1596579 · Cited by 23

Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages

Theobald, S. J., Gräb, J., Fritsch, M., Suárez, I., Eisfeld, H. S., Winter, S., Koch, M., Hölscher, C., Pasparakis, M., Kashkar, H., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00716-5 · Cited by 22

Lung and blood early biomarkers for host-directed tuberculosis therapies: Secondary outcome measures from a randomized controlled trial

Wallis, R. S., Ginindza, S., Beattie, T., Arjun, N., Likoti, M., Sebe, M. A., Edward, V., Rassool, M. S., Ahmed, K., Fielding, K., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0252097 · Cited by 22

Overexpression of a Mycobacterium ulcerans Ag85B-EsxH Fusion Protein in Recombinant BCG Improves Experimental Buruli Ulcer Vaccine Efficacy

Hart, B. E., & Lee, S. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005229 · Cited by 22

Cerebrospinal fluid matrix metalloproteinase 9 levels, blood-brain barrier permeability, and treatment outcome in tuberculous meningitis

Mailankody, S., Dangeti, G. V., Rajendiran, S., Joseph, N. M., Mandal, J., Dutta, T. K., & Kadhiravan, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181262 · Cited by 22

Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection

Denisenko, E., Guler, R., Mhlanga, M. M., Suzuki, H., Brombacher, F., & Schmeier, S. (2019) · BMC Genomics · doi:10.1186/s12864-019-5450-6 · Cited by 22

Opposite effects of statins on the risk of tuberculosis and herpes zoster in patients with diabetes: A population‐based cohort study

Pan, S., Yen, Y., Feng, J., Chuang, P., Su, V. Y., Kou, Y. R., Su, W., & Chan, Y. (2019) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14142 · Cited by 22

The effects of anti-inflammatory agents as host-directed adjunct treatment of tuberculosis in humans: a systematic review and meta-analysis

Hayford, F. E. A., Dolman, R., Blaauw, R., Nienaber, A., Smuts, C. M., Malan, L., & Ricci, C. (2020) · Respiratory Research · doi:10.1186/s12931-020-01488-9 · Cited by 21

The antifibrotic drug pirfenidone promotes pulmonary cavitation and drug resistance in a mouse model of chronic tuberculosis

Ahidjo, B. A., Maiga, M. C., Ihms, E. A., Maïga, M., Ordoñez, A. A., Cheung, L. S., Beck, S. E., Andrade, B. B., Jain, S. K., & Bishai, W. R. (2016) · JCI Insight · doi:10.1172/jci.insight.86017 · Cited by 21

Small Animal Model of Post-chemotherapy Tuberculosis Relapse in the Setting of HIV Co-infection

Huante, M. B., Saito, T. B., Nusbaum, R. J., Naqvi, K. F., Chauhan, S., Hunter, R. L., Actor, J. K., Rudra, J. S., Endsley, M. A., Lisinicchia, J. G., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00150 · Cited by 21

Immunomodulatory Nanoparticles Induce Autophagy in Macrophages and Reduce Mycobacterium tuberculosis Burden in the Lungs of Mice

Bekale, R. B., Maphasa, R. E., D’Souza, S., Hsu, N., Walters, A., Okugbeni, N., Kinnear, C. J., Jacobs, M., Sampson, S. L., Meyer, M., et al. (2025) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00713 · Cited by 20

Mycobacterium tuberculosis-Induced Upregulation of the COX-2/mPGES-1 Pathway in Human Macrophages Is Abrogated by Sulfasalazine

Wang, W., Ning, Y., Wang, Y., Deng, G., Pace, S., Barth, S., Menge, C., Zhang, K., Dai, Y., Cai, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.849583 · Cited by 20

Heparin-Binding Hemagglutinin of Mycobacterium tuberculosis Inhibits Autophagy via Toll-like Receptor 4 and Drives M2 Polarization in Macrophages

Zheng, Q. Y., Li, Z., Zhou, Y., Li, Y., Gong, M., Sun, H., Deng, X., & Ma, Y. (2024) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiae030 · Cited by 20

Soybean lectin induces autophagy through P2RX7 dependent activation of NF-κB-ROS pathway to kill intracellular mycobacteria

Mishra, A., Behura, A., Kumar, A., Ghosh, A., Naik, L., Mawatwal, S., Mohanty, S. S., Mishra, A., Saha, S., Bhutia, S. K., et al. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129806 · Cited by 21

c-Abl-TWIST1 Epigenetically Dysregulate Inflammatory Responses during Mycobacterial Infection by Co-Regulating Bone Morphogenesis Protein and miR27a

Mahadik, K., Prakhar, P., Rajmani, R. S., Singh, A., & Balaji, K. N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00085 · Cited by 20

CCR4-dependent reduction in the number and suppressor function of CD4+Foxp3+ cells augments IFN-γ-mediated pulmonary inflammation and aggravates tuberculosis pathogenesis

Bertolini, T. B., Piñeros, A. R., Prado, R. Q., Gembre, A. F., Ramalho, L. N. Z., Alves-Filho, J. C., & Bonato, V. L. D. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1240-3 · Cited by 20

Dual mTORC1/mTORC2 Inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis

Tasneen, R., Mortensen, D. S., Converse, P. J., Urbanowski, M. E., Upton, A. M., Fotouhi, N., Nuermberger, E. L., & Hawryluk, N. A. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00253-21 · Cited by 19

The pathway of autophagy in the epigenetic landscape of Mycobacterium -host interactions

Mishra, A., Rawat, V. P. S., Zhang, K., & Jagannath, C. (2025) · Autophagy · doi:10.1080/15548627.2025.2511074 · Cited by 18

Klebsiella pneumoniae: Host interactions, virulence mechanisms, and novel therapeutic strategies

Abhinand, K., Menon, A. M., Thomas, S. S., Anil, A. B., Mohanan, P. C. P., Arun, K. B., Edison, L. K., Babu, P., Kumar, G. B., Nair, B. G., et al. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107856 · Cited by 18

Increased susceptibility to pneumonia due to tumour necrosis factor inhibition and prospective immune system rescue via immunotherapy

Ha, R., Keynan, Y., & Rueda, Z. V. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.980868 · Cited by 18

Breaking the Cycle: Matrix Metalloproteinase Inhibitors as an Alternative Approach in Managing Tuberculosis Pathogenesis and Progression

Jhilta, A., Jadhav, K., Singh, R., Ray, E., Kumar, A., Singh, A., & Verma, R. K. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00385 · Cited by 18

Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1

Persaud, R., Li, S. C., Chao, J. D., Forestieri, R., Donohue, E., Balgi, A. D., Zheng, X., Chao, J. T., Yashiroda, Y., Yoshimura, M., et al. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.07.017 · Cited by 18

Usefulness of Chinese Herbal Medicines as Host-Directed Therapeutics against Mycobacterial Infections: A Review

Tomioka, H. (2017) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x17500860 · Cited by 18

Adalimumab for Corticosteroid and Infliximab-Resistant Immune Reconstitution Inflammatory Syndrome in the Setting of TB/HIV Coinfection

Lwin, N., Boyle, M., & Davis, J. S. (2018) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofy027 · Cited by 18

New Era of TB Drug Discovery and Its Impact on Disease Management

Zheng, X., & Av‐Gay, Y. (2016) · Current treatment options in infectious diseases/Current treatment options in infectious disease · doi:10.1007/s40506-016-0098-0 · Cited by 17

New management approaches to tuberculosis in people living with HIV

Mhango, D. V., Mzinza, D. T., Jambo, K., & Mwandumba, H. C. (2020) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000704 · Cited by 17

New Drugs and Regimens for Tuberculosis Disease Treatment in Children and Adolescents

Garcia‐Prats, A. J., Starke, J. R., Waning, B., Kaiser, B. L., & Seddon, J. A. (2022) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piac047 · Cited by 17

Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system

Gries, R., Chhen, J., van Gumpel, E., Theobald, S. J., Sonnenkalb, L., Utpatel, C., Metzen, F., Koch, M., Dallenga, T. K., Djaout, K., et al. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2023.12.007 · Cited by 19

The long and winding road to inhaled TB therapy: not only the bug’s fault

Giovagnoli, S., Schoubben, A., & Ricci, M. (2016) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2016.1272119 · Cited by 17

Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy

Yu, Z., Liang, Y. C., Berton, S., Liu, L., Zou, J., Chen, L., Xu, Z., Luo, C., Sun, J., & Yang, W. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00513 · Cited by 16

Metformin has immunomodulatory effects which support its potential use as adjunctive therapy in tuberculosis

Sutter, A., Landis, D. M., & NUGENT, K. M. (2023) · Indian Journal of Tuberculosis · doi:10.1016/j.ijtb.2023.05.011 · Cited by 16

Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB

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