Advancing host-directed therapy for tuberculosis

Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response

Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

Keane, J., Gershon, S. K., Wise, R. P., Mirabile‐Levens, E., Kasznica, J. M., Schwieterman, W. D., Siegel, J. N., & Braun, M. M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011110 · Cited by 3,683

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252

Identification of a Primary Target of Thalidomide Teratogenicity

Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y., & Handa, H. (2010) · Science · doi:10.1126/science.1177319 · Cited by 2,136

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

Lu, G., Middleton, R. E., Sun, H., Naniong, M., Ott, C. J., Mitsiades, C. S., Wong, K.-K., Bradner, J. E., & Kaelin, W. G. (2014) · Science · doi:10.1126/science.1244917 · Cited by 1,583

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

Newport, M. J., Huxley, C. M., Huston, S., Hawrylowicz, C. M., Oostra, B. A., Williamson, R., & Levin, M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352602 · Cited by 1,198

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes.

Sampaio, E. P., Sarno, E. N., Gallily, R., Cohn, Z. A., & Kaplan, G. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.3.699 · Cited by 1,191

Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti–tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: A randomized, placebo‐controlled, 52‐week trial

Keystone, E. C., Kavanaugh, A. F., Sharp, J. T., Tannenbaum, H., Hua, Y., Teoh, L. S., Fischkoff, S. A., & Chartash, E. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20217 · Cited by 1,171

Respiratory health status is associated with treatment outcomes in pulmonary tuberculosis

Gupte, A., Selvaraju, S., Paradkar, M., Danasekaran, K., Shivakumar, S. V. B. Y., Thiruvengadam, K., Dolla, C. K., Shivaramakrishnan, G., Pradhan, N., Kohli, R. M., et al. (2019) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.18.0551 · Cited by 11

Real-world experience of adverse reactions-necessitated rifampicin-sparing treatment for drug-susceptible pulmonary tuberculosis

Kim, H., Lee, Y. J., Song, M. J., Kwon, B. S., Kim, Y. W., Lim, S. Y., Lee, Y. J., Park, J. S., Cho, Y., Lee, C., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-38394-1 · Cited by 12

Activities of Daily Living, Hypoxemia, and Lymphocytes Score for Predicting Mortality Risk in Patients With Pulmonary TB

Osawa, T., Watanabe, M., Morimoto, K., Yoshiyama, T., Matsuda, S., Fujiwara, K., Furuuchi, K., Shimoda, M., Ito, M., Kodama, T., et al. (2023) · CHEST Journal · doi:10.1016/j.chest.2023.09.008 · Cited by 10

More Tailored Approaches to Tuberculosis Treatment and Prevention

Bark, C. M., Boom, W. H., & Furin, J. J. (2023) · Annual Review of Medicine · doi:10.1146/annurev-med-100622-024848 · Cited by 10

Temporal modulation of host aerobic glycolysis determines the outcome of Mycobacterium marinum infection

Kan, Y., Lu, M., Xie, L., Liu, L., Dong, W., Feng, J., Yan, Y., Zhao, C., Peng, G., Wang, D., et al. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.11.051 · Cited by 10

Troglitazone Reduction of Intracellular Mycobacterium tuberculosis Survival Via Macrophage Autophagy Through LKB1-AMPKα Signaling

Bi, J., Guo, Q., Gong, Y., Chen, X., Wu, H., Song, L., Xu, Y., Ou, M., Wang, Z., Chen, J., et al. (2024) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiae523 · Cited by 9

Green synthesis and characterization of water soluble nanocarnosine: A prospective drug delivery system

Nagarajan, U., Naha, A., Anbarasu, A., Ramaiah, S., Kanth, S. V., & Natarajan, S. (2023) · Applied Materials Today · doi:10.1016/j.apmt.2023.101812 · Cited by 9

A potential target gene for the host-directed therapy of mycobacterial infection in murine macrophages

Bao, Z., Chen, R., Zhang, P., Lü, S., Chen, X., Yao, Y., Jin, X., Sun, Y., & Zhou, J. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2675 · Cited by 9

Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis

Cheng, C. Y., Böhme, J., & Singhal, A. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr0617-226r · Cited by 9

Pharmacologic Exhaustion of Suppressor Cells with Tasquinimod Enhances Bacterial Clearance during Tuberculosis

Gupta, S., Krug, S., Pokkali, S., Leanderson, T., Isaacs, J. T., Srikrishna, G., & Bishai, W. R. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201805-0820le · Cited by 9

Host-Directed Therapies Based on Protease Inhibitors to Control Mycobacterium tuberculosis and HIV Coinfection

Mandal, M., Pires, D., Azevedo‐Pereira, J. M., & Anes, E. (2025) · Microorganisms · doi:10.3390/microorganisms13051040 · Cited by 8

Relationship between metformin use and mortality in tuberculosis patients with diabetes: a nationwide cohort study

Chung, E., Jeong, D., Mok, J., Jeon, D., Kang, H., Kim, H., Kim, H.-S., Choi, H., & Kang, Y. A. (2024) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2023.303 · Cited by 8

Protocol for a case–control study of vitamin D status, adult multidrug-resistant tuberculosis disease and tuberculosis infection in Mumbai, India

Mistry, N. F., Hemler, E. C., Dholakia, Y. N., Bromage, S., Shukla, A., Dev, P., Govekar, L., Tipre, P., Shah, D., Keshavjee, S. A., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-039935 · Cited by 8

Endothelial lineage-specific interaction of Mycobacterium tuberculosis with the blood and lymphatic systems

Kim, P. M., Lee, J.-J., Choi, D., Eoh, H., & Hong, Y. (2018) · Tuberculosis · doi:10.1016/j.tube.2018.04.009 · Cited by 8

Metformin promotes smear conversion in tuberculosis‐diabetes comorbidity and construction of prediction models

Wang, Y., Zhou, Y., Chen, L., Cheng, Y., Lai, H., Lyu, M., Zeng, J., Zhang, Y., Feng, P., & Ying, B. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24755 · Cited by 7

Metformin: A review of its potential as enhancer for anti tuberculosis efficacy in diabetes mellitus-tuberculosis coinfection patients

Novita, B. D. (2019) · Indian Journal of Tuberculosis · doi:10.1016/j.ijtb.2019.02.013 · Cited by 7

Enhanced early immune response of leptospiral outer membrane protein LipL32 stimulated by narrow band mid-infrared exposure

Hong, C.-H., Tang, M.-R., Hsu, S., Yang, C.-H., Tseng, C., Ko, Y.-C., Guo, C.-S., Yang, C.-W., & Lee, S. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.111560 · Cited by 7

Comprehensive review of osteoarticular tuberculosis: from epidemiology to emerging therapies

Kumari, N., Sharma, I., Kumar, D., Goel, K., Singh, V., & Katoch, S. (2025) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20252594 · Cited by 6

Autophagy and Mycobacterium Tuberculosis: the role of autophagy in antimicrobial immunity and therapy

Lei, H., Lan, J., Chen, Y., Liu, J., Yao, Y., Nx, Z., Ding, X., & Jiang, Y. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1748677 · Cited by 6

Enhancement of CD4+ T Cell Function as a Strategy for Improving Antibiotic Therapy Efficacy in Tuberculosis: Does It Work?

Costa, D. L., Amaral, E. P., Namasivayam, S., Mittereder, L. R., Andrade, B. B., & Sher, A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.672527 · Cited by 6

Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis

Fard, S. N., Farroni, C., Petrone, L., Altera, A. M. G., Salmi, A., Vanini, V., Cuzzi, G., Alonzi, T., Nicastri, E., Gualano, G., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1411827 · Cited by 6

Nicotinamide and Demographic and Disease transitions: Moderation is Best

Williams, A. C., & Hill, L. J. (2019) · International Journal of Tryptophan Research · doi:10.1177/1178646919855940 · Cited by 6

Effect of anti-tuberculosis treatment on the systemic levels of tissue inhibitors of metalloproteinases in tuberculosis – Diabetes co-morbidity

Kumar, N. P., Moideen, K., Viswanathan, V., Sivakumar, S., Hissar, S. S., Kornfeld, H., & Babu, S. (2021) · Journal of Clinical Tuberculosis and Other Mycobacterial Diseases · doi:10.1016/j.jctube.2021.100237 · Cited by 6

Host-Directed Therapies for Tuberculosis

Venketaraman, V. (2020) · MDPI eBooks · doi:10.3390/books978-3-03943-502-9 · Cited by 6

JFD, a Novel Natural Inhibitor of Keap1 Alkylation, Suppresses Intracellular Mycobacterium Tuberculosis Growth through Keap1/Nrf2/SOD2-Mediated ROS Accumulation

Wan, H., Cai, Y., Xiao, L., Ling, Y., Ge, L., Mo, S., Xie, Q., Peng, S., Zhou, B., Zeng, X., et al. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/6726654 · Cited by 6

Antituberculosis agents: Beyond medicinal chemistry rules

Pieroni, M. (2019) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2019.06.001 · Cited by 6

A Long-Acting Thermoresponsive Injectable Formulation of Tin Protoporphyrin Sustains Antitubercular Efficacy in a Murine Infection Model

Adeleke, O. A., Fisher, L., Moore, I. N., Nardone, G. A., & Sher, A. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00185 · Cited by 6

Establishment and Initial Testing of a Medium-Sized, Surgically Feasible Animal Model for Brucellar Spondylodiscitis: A Preliminary Study

Cai, X., Xu, T., Xun, C., Abulizi, Y., Liu, Q., Sheng, W., Han, Z., Gao, L., & Maimaiti, M. (2019) · BioMed Research International · doi:10.1155/2019/7368627 · Cited by 5

Infection of pulmonary epithelial cells by clinical strains of M. tuberculosis induces alternate splicing events

Mvubu, N. E., Pillay, B., & Pillay, M. (2020) · Gene · doi:10.1016/j.gene.2020.144755 · Cited by 5

Immunoadjunctive Therapy against Bacterial Infections Using Herbal Medicines Based on Th17 Cell-mediated Protective Immunity

Tomioka, H., Tatano, Y., Shimizu, T., & Sano, C. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210608143449 · Cited by 5

Synergistic role of Mycobacterium indicus pranii and human beta Defensin-2 as adjunctive therapy against Mycobacterium tuberculosis

Faisal, S., Vats, D., Panda, S., Sharma, V., Luthra, K., Mohan, A., Kulkarni, S., Gupta, P. K., & Singh, A. (2024) · Tuberculosis · doi:10.1016/j.tube.2024.102571 · Cited by 4

Human lung organoids model for assessing host response to Mycobacterium tuberculosis infection

Li, C., Zhong, P., Yun, Z., Fang, L., Xiang, M., Su, Q., Wang, J., Chen, H., Chen, Z., Yue, L., et al. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1725344 · Cited by 4

Update in Mycobacterium tuberculosis Lung Disease 2014

Elkington, P. T., & Zumla, A. I. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201505-1009up · Cited by 4

Immunological roulette: Luck or something more? Considering the connections between host and environment in TB

Pearl, J. E., Das, M., & Cooper, A. M. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.145 · Cited by 4

Suppress for Success: A JAK Inhibitor for Adjunct Therapy of Tuberculosis

Dorhoi, A. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.08.010 · Cited by 4

Manipulation of autophagy for host-directed tuberculosis therapy

Gina, P., Davids, M., & Dheda, K. U. J. (2019) · African Journal of Thoracic and Critical Care Medicine · doi:10.7196/sarj.2019.v25i2.014 · Cited by 4

Nanomedicines in Tuberculosis: Diagnosis, Therapy and Nanodrug Delivery

Dakkah, A. N., Bataineh, Y. A., Al-Jaidi, B. A., Bayan, M. F., & Nimer, N. A. (2020) · Engineering materials · doi:10.1007/978-3-030-36260-7_13 · Cited by 3

Roles of autophagy in killing of mycobacterial pathogens by host macrophages – Effects of some medicinal plants

Tatano, Y., Shimizu, T., Sano, C., & Tomioka, H. (2024) · European Journal of Microbiology and Immunology · doi:10.1556/1886.2023.00062 · Cited by 3

PDCD4 as a marker of mTOR pathway activation and therapeutic target in mycobacterial infections

Paroha, R., Wang, J., & Lee, S. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00062-24 · Cited by 3

Metformin: A Leading HDT Candidate for TB

Singhal, A., & Kornfeld, H. (2020) · Springer eBooks · doi:10.1007/978-3-030-56905-1_7 · Cited by 3

Anti- Mycobacterium avium complex activity of clarithromycin, rifampin, rifabutin, and ethambutol in combination with adenosine 5′-triphosphate

Tatano, Y., Yamabe, S., Sano, C., & Tomioka, H. (2017) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2017.04.012 · Cited by 3

Enlisting the Host to Fight TB

Kornfeld, H., & Singhal, A. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.01.011 · Cited by 3

Towards host-directed therapy: The role of matrix metalloproteinases in the immunopathogenesis of tuberculosis

Loader, M.-C. I., Chong, D. L. W., Skolimowska, K. H., & Friedland, J. S. (2026) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2026.108525 · Cited by 2

When the host is not healthy: Rethinking tuberculosis drug targets in comorbid conditions

Meskini, M., & Aspatwar, A. (2026) · Tuberculosis · doi:10.1016/j.tube.2026.102781 · Cited by 2

The role and mechanisms of multiple immunoregulatory cells in pulmonary tuberculosis

Liu, H., Li, P., He, S., Yang, H., Yuan, T., He, X., & Tan, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1841581 · Cited by 2

A leap forward in assessing host-directed therapies for tuberculosis

Ignatius, E. H., & Dooley, K. E. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30528-2 · Cited by 2

Metformin for Tuberculosis Infection

Novita, B. D., Muliono, A. C., & Erwin, F. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99794 · Cited by 2

Tuberculosis/HIV Co-Infection: features of the immune response and management challenges

Hrek, I., Konstantynovska, O., & Kushnir, V. (2025) · Karazin Journal of Immunology · doi:10.26565/3083-5615-2025-15-07 · Cited by 2

Autophagy-related genes affect drug resistance of mycobacteria by regulating autophagy.

Chen, G., Wu, B., Wu, M.-Z., Liu, F., Qin, C., & Luo, W. (2019) · Europe PMC (PubMed Central) · Cited by 2

New Approaches to the Treatment of Tuberculosis

Paton, N. I. (2018) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v47n3p90 · Cited by 2

Macrophage-Targeted Chemotherapy for Tuberculosis

Shrivastava, P., Gautam, L., Vyas, S., & Vyas, S. P. (2022) · Springer eBooks · doi:10.1007/978-3-030-84164-5_17 · Cited by 2

Tuberculosis

Rustomjee, R. (2021) · doi:10.1093/med/9780198816805.003.0072 · Cited by 1

Reimagining Tuberculosis Treatment: The Promise of Immunotherapy and Drug Repurposing

Shinde, S., Rathod, S., & Chitlange, S. S. (2025) · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · doi:10.2174/0118756921381395250614152438 · Cited by 1

Sirtuin2 blockade inhibits replication of human immunodeficiency virus-1 and Mycobacterium tuberculosis in macrophages and humanized mice

Singh, V. K., Mishra, A., Truong, K., Bohórquez, J. A., Sharma, S., Khan, A., Bracher, F., Zhang, K. L., Endsley, J. J., Endsley, M. A., et al. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2026.03.019 · Cited by 1

Emerging Therapies

Lamichhane, G., & Grosset, J. H. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-26273-4_7 · Cited by 1

Combination drug delivery approaches for tuberculosis

Santos, F., & Duarte, A. R. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85873-1.00006-x · Cited by 1

Interleukin-37: A new Molecular Target for Host-Directed Therapy of Tuberculosis

Liu, H., & Ge, B. (2017) · Future Microbiology · doi:10.2217/fmb-2017-0030 · Cited by 1

PU.1 Shapes Host Epigenetic Responses to Mycobacterium tuberculosis and Represents a Target for Host Directed TherapyPreprint

Poschmann, J., Liu, J., Bomfim, C. C. B., Mollé, A., Sun, W., Foreman, T. W., Cruesy, C., Pierre, G., Kaushal, D., Libero, G. D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.09.675072 · Cited by 1

Concluding Remarks

Fourie, P. B., & Hafner, R. (2016) · Wiley eBooks · doi:10.1002/9781118943182.ch20

Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infectionPreprint

Denisenko, E., Guler, R., Mhlanga, M. M., Suzuki, H., Brombacher, F., & Schmeier, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/303552

Novel Antimycobacterial Drugs and Host-Directed Therapies for Tuberculosis

Teskey, G., Cato, C., Hernandez, J., Kaur, P., Koury, J., Lucero, M., Tran, A., & Venketaraman, V. (2018) · Springer eBooks · doi:10.1007/978-3-319-97367-8_5

Tuberculose et mycobactérioses pulmonaires: ce qu’il faut retenir des nouveautés 2019

Blanc, F. –. (2019) · Revue des Maladies Respiratoires Actualités · doi:10.1016/s1877-1203(19)30039-4

Channeling macrophage polarization via selective translation inhibition by rocaglates increases macrophage resistance to Mycobacterium tuberculosisPreprint

Chatterjee, S., Yabaji, S. M., Bhattacharya, B., Waligurski, E., Vallavoju, N., Ray, S., Brown, L. E., Beeler, A. B., Ivanov, A. R., Kobzik, L., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/691808

Introduction: An Overview of Host-Directed Therapies for Tuberculosis

Frank, D. J., & Mahon, R. N. (2020) · Springer eBooks · doi:10.1007/978-3-030-56905-1_1

Clinical Trials of TB-HDT Candidates

Wallis, R. S. (2020) · Springer eBooks · doi:10.1007/978-3-030-56905-1_20

Metformin Role in Diabetic Patients with Tuberculosis: a Review

Wibisono, E. A. (2021) · Journal Of Tropical Pharmacy And Chemistry · doi:10.25026/jtpc.v5i3.275

Antitubercular Agents

Aldrich, C. C., Wallis, R. S., Remmel, R. P., Hegde, P. V., & Stallings, C. L. (2021) · Wiley eBooks · doi:10.1002/0471266949.bmc298

The Role of Host Genetics (and Genomics) in Tuberculosis

Naranbhai, V. (2017) · ASM Press eBooks · doi:10.1128/9781555819569.ch19

Impact of Biologic and JAK Inhibitor Therapies on TB: How Do Biologic Therapies Affect the Presentation and Treatment Course of Pulmonary TB?

Matsumoto, T. (2022) · Respiratory disease series · doi:10.1007/978-981-19-3995-2_3

MECANISMOS IMUNOLÓGICOS NA COINFECÇÃO POR HIV E TUBERCULOSE

Cardoso, V. K. L., MARTINS, A. J., SILVA, E. D. S. D., NAJAR, L. J. D. S., & MUSTAFÁ, S. N. I. (2024) · Anais do II Congresso Brasileiro de Doenças Infectocontagiosas On-line · doi:10.51161/infectocon2024/38590

Immunotherapies Against Infectious Diseases, 2nd edition

(2024) · Frontiers research topics · doi:10.3389/978-2-8325-5662-7

ESTRATÉGIAS ADJUVANTES NO TRATAMENTO DA TUBERCULOSE: REDUÇÃO DO ESTRESSE OXIDATIVO E NEUROTOXICIDADE INDUZIDA POR FÁRMACOS

Gomes, R. N. D. S., Lopes, J. D. F. D. C. V., dos Santos, I. P., da Rocha, M. H., Fontes, T. A., Dias, T. D. O., & dos Anjos, J. S. P. (2025) · Journal of Media Critiques · doi:10.17349/jmcv11n27-066

How to train the body’s own cells to combat antibiotic resistance

Alam, Z. A. (2019) · doi:10.64628/aai.d4eh9cs5h

Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8 + T cell–macrophage interactions

McCaffrey, E., Delmastro, A. C., Singh, B., Devi, A., Munson, C. W., Priyanka, Golden, N., Khader, S. A., Angelo, M., Kaushal, D., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2528104123

The hypothesis – A dual-front attack on TB: Vitamin D–fluoroquinolone conjugates as next generation therapeutic strategy against drug-resistant Mycobacterium tuberculosis

Wavhale, S. R., Shaikh, A. R., & Wavhale, R. (2025) · Medical Hypotheses · doi:10.1016/j.mehy.2025.111761

A plasma proteomic signature of the actin-coagulation axis accurately predicts progression to active tuberculosis

Lu, P., Gao, W., Ding, X., Pan, J., Ding, H., Liu, Q., Zhu, L., & Huo, X. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1746190

Isolated glycoprotein STK11 from the nutshell of Cocos nucifera L. modulated macrophage polarization to prevent the Mycobacterium tuberculosis bacilli growth in J774A.1 macrophage

Samanta, A., Datta, N., Pramanik, M., Srinivasan, S., & Mahapatra, S. K. (2026) · Microbial Pathogenesis · doi:10.1016/j.micpath.2026.108456

Innovative platforms for drug discovery against mycobacteria: The success and challenges

Nitschke, J., Soldati, T., & Hanna, N. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36518-8.00021-7

Modulation de l'autophagie des macrophages : rôle des lipides de l'enveloppe

Bah, A. (2017) · theses.fr (ABES) · doi:10.70675/0170380fz0af5z4c02za7aezd5ac5153ffd8

Is Short Therapy an Appropriate Regimen for Children and Young Adolescents with Drug-Susceptible Tuberculosis?

Esposito, S., Fainardi, V., Campana, B. R., Arnesano, G. G., & Principi, N. (2026) · Pharmaceuticals · doi:10.3390/ph19050721

Combating Mycobacterial Infections: An Overview of Therapeutic Strategies

Shaji, A., Bhaskar, A., Dwivedi, V. P., & Singh, A. (2026) · Springer eBooks · doi:10.1007/978-981-92-0256-0_1

Integrated analysis of miRNA and transcription factor gene expression profiles associated with anti-tuberculosis treatment responses

Park, H., Lee, E. K., Park, S., Park, S., Kang, Y.-J., Lee, J., Whang, J., Kang, Y. A., Kim, S., Lee, H., et al. (2026) · BMC Infectious Diseases · doi:10.1186/s12879-026-13676-x

Pathways to Sustainable Biomanufacturing: Scalable Production of Biopharmaceutical Raw Materials and Biologics for Health Security

Reedy, J. M., Mariita, R. M., Munga, H. G., & Häfner, B. (2026) · Global South & Sustainable Development · doi:10.53941/gssd.2026.100019

Comparison of immune evasion mechanisms of multidrug-resistant Mycobacterium tuberculosis versus nontuberculous mycobacteria

Nahar, N., Jannat, R., Nuha, S. M., & Fakruddin, M. (2026) · Microbes & Immunity · doi:10.36922/mi026210052

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