The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Lymph node fibroblastic reticular cells in health and disease
Open accessAbstract
Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs) — immunologically specialized myofibroblasts found in lymphoid tissue — has promoted these cells from benign bystanders to major players in the immune response. In this Review, we focus on recent advances regarding the immunobiology of lymph node-derived FRCs, presenting an updated view of crucial checkpoints during their development and their dynamic control of lymph node expansion and contraction during infection. We highlight the robust effects of FRCs on systemic B cell and T cell responses, and we present an emerging view of FRCs as drivers of pathology following acute and chronic viral infections. Lastly, we review emerging therapeutic advances that harness the immunoregulatory properties of FRCs.
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Cites
Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications
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Stromal Cell Networks Regulate Lymphocyte Entry, Migration, and Territoriality in Lymph Nodes
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Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
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Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation
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Self-citationConduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles
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Lymphatic endothelial cells of the lymph node
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Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney
Sato, Y., Mii, A., Hamazaki, Y., Fujita, H., Nakata, H., Masuda, K., Nishiyama, S., Shibuya, S., Haga, H., Ogawa, O., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.87680 · Cited by 148
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Metadata
- Authors
- Fletcher, A. L., Acton, S. E., & Knoblich, K.
- Venue
- Nature Reviews Immunology
- Published
- 2015-05-22
- Volume
- 15
- Issue
- 6
- Pages
- 350-361
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1592500890
- Cited by
- 340
- References
- 82
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- green
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