Immunological hallmarks of stromal cells in the tumour microenvironment

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

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Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

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Oncology meets immunology: the cancer-immunity cycle.

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PD-1 blockade induces responses by inhibiting adaptive immune resistance

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Fibroblasts in cancer

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Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

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Tumor-Associated Macrophages: From Mechanisms to Therapy

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Microenvironmental regulation of metastasis

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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

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Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

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Molecular regulation of vessel maturation

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MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

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Stromal fibroblasts in cancer initiation and progression

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Extracellular Matrix Degradation and Remodeling in Development and Disease

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Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

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Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

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Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

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Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy

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Matrix metalloproteinases as modulators of inflammation and innate immunity

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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

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Smoldering and polarized inflammation in the initiation and promotion of malignant disease

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Friends or foes — bipolar effects of the tumour stroma in cancer

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CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

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Normalization of the Vasculature for Treatment of Cancer and Other Diseases

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Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

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The Pancreas Cancer Microenvironment

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Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.

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Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals

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History of myeloid-derived suppressor cells

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Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

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Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

Salmon, H., Franciszkiewicz, K., Damotte, D., Dieu-Nosjean, M.-C., Validire, P., Trautmann, A., Mami-Chouaib, F., & Donnadieu, E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci45817 · Cited by 1,138 · see citing works

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α

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Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

Jacobetz, M. A., Chan, D. S., Neesse, A., Bapiro, T. E., Cook, N., Frese, K. K., Feig, C., Nakagawa, T., Caldwell, M. E., Zecchini, H. I., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-302529 · Cited by 1,120 · see citing works

Indoleamine 2,3-dioxygenase and tumor-induced tolerance

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Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer

Lin, E. Y., Li, J.-F., Gnatovskiy, L., Deng, Y., Zhu, L., Grzesik, D. A., Qian, H., Xue, X.-N., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1278 · Cited by 1,074 · see citing works

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

Coussens, L. M., Zitvogel, L., & Palucka, A. K. (2013) · Science · doi:10.1126/science.1232227 · Cited by 1,070 · see citing works

Endothelial-pericyte interactions in angiogenesis

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Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

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Tumor Endothelium FasL Establishes a Selective Immune Barrier Promoting Tolerance in Tumors

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Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

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Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

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Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues

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Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients

Ko, J. S., Zea, A. H., Rini, B. I., Ireland, J. L., Elson, P. J., Cohen, P. A., Golshayan, A., Rayman, P. A., Wood, L. S., García, J. A., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1332 · Cited by 861 · see citing works

Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer

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Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

Caruana, I., Savoldo, B., Hoyos, V., Weber, G., Liu, H., Kim, E. S., Ittmann, M., Marchetti, D., & Dotti, G. (2015) · Nature Medicine · doi:10.1038/nm.3833 · Cited by 820 · see citing works

Identification of fibroblast heterogeneity in the tumor microenvironment

Sugimoto, H., Mundel, T. M., Kieran, M. W., & Kalluri, R. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.12.3354 · Cited by 700 · see citing works

Ectopic lymphoid-like structures in infection, cancer and autoimmunity

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Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

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Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity

Wang, L.-C. S., Lo, A., Scholler, J., Sun, J., Majumdar, R. S., Kapoor, V., Antzis, M., Cotner, C. E., Johnson, L. A., Durham, A. C., et al. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0027 · Cited by 653 · see citing works

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

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Bv8 regulates myeloid-cell-dependent tumour angiogenesis

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B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

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Targeting tumor‐associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

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A role for VEGF as a negative regulator of pericyte function and vessel maturation

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Co-evolution of tumor cells and their microenvironment

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Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

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Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor

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Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

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Vascular normalization in Rgs5-deficient tumours promotes immune destruction

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Autologous Chemotaxis as a Mechanism of Tumor Cell Homing to Lymphatics via Interstitial Flow and Autocrine CCR7 Signaling

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Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

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Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity

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Human Solid Tumors Contain High Endothelial Venules: Association with T- and B-Lymphocyte Infiltration and Favorable Prognosis in Breast Cancer

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Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors

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CD99 plays a major role in the migration of monocytes through endothelial junctions

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Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis

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Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

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Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

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Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance

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VEGF-A and the Induction of Pathological Angiogenesis

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Cancer Associated Fibroblasts Promote Tumor Growth and Metastasis by Modulating the Tumor Immune Microenvironment in a 4T1 Murine Breast Cancer Model

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Genes that Distinguish Physiological and Pathological Angiogenesis

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Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury

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Immune tolerance: What is unique about the liver

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Clinical Implications of Fibroblast Activation Protein in Patients with Colon Cancer

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Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro

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Stem Cell Pathways Contribute to Clinical Chemoresistance in Ovarian Cancer

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Focus on lymphangiogenesis in tumor metastasis

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Stromal Myofibroblasts Predict Disease Recurrence for Colorectal Cancer

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Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

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Lymph node fibroblastic reticular cells in health and disease

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VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

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Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

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B7-H1 Is Expressed by Human Endothelial Cells and Suppresses T Cell Cytokine Synthesis

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