Regulation of B-cell signal transduction by adaptor proteins
Abstract
An important role has emerged for adaptor molecules in linking cell-surface receptors, such as the B-cell antigen receptor, with effector enzymes. Adaptor proteins direct the appropriate subcellular localization of effectors and regulate their activity by inducing conformational changes, both of which, in turn, contribute to the spatio-temporal precision of B-cell signal-transduction events. In addition, adaptor molecules participate in establishing negative- or positive-feedback regulatory loops in signalling networks, thereby fine-tuning the B-cell response.
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Anti-IgM antibodies stimulate B cells through the B cell receptor (BCR) thereby activating downstream signaling cascades like PI3K, AKT and MAPK pathways.
“Anti-IgM antibodies stimulate B cells through the B cell receptor (BCR) thereby activating further downstream signaling cascades like the phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) pathways [51–53].”
From The oncoprotein TBX3 is controlling severity in experimental arthritis (2019) · cites this paper as [52]
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Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors
Wang, D., Feng, J., Wen, R., Marine, J.-C., Sangster, M. Y., Parganas, E., Hoffmeyer, A., Jackson, C. W., Cleveland, J. L., Murray, P. J., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00005-4 · Cited by 475 · see citing works
Cutting Edge: Essential Role of Phospholipase C-γ2 in B Cell Development and Function
Hashimoto, A., Takeda, K., Inaba, M., Sekimata, M., Kaisho, T., Ikehara, S., Homma, Y., Akira, S., & Kurosaki, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.1738 · Cited by 155 · see citing works
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Cell-type specific gene expression profiles of leukocytes in human peripheral blood
Palmer, C., Diehn, M., Alizadeh, A. A., & Brown, P. O. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-115 · Cited by 331 · see citing works
Weber, M., Treanor, B., Depoil, D., Shinohara, H., Harwood, N. E., Hikida, M., Kurosaki, T., & Batista, F. D. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072619 · Cited by 170 · see citing works
Self-citationIsozyme-specific stimulation of phospholipase C-γ2 by Rac GTPases
Piechulek, T., Rehlen, T., Walliser, C., Vatter, P., Moepps, B., & Gierschik, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509396200 · Cited by 80 · see citing works
Walliser, C., Retlich, M., Harris, R., Everett, K. L., Josephs, M. B., Vatter, P., Esposito, D., Driscoll, P. C., Katan, M., Gierschik, P., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803316200 · Cited by 56 · see citing works
Integrin β1 regulates marginal zone B cell differentiation and PI3K signaling
Andreani, V., Ramamoorthy, S., Fässler, R., & Grosschedl, R. (2023) · Journal of Experimental Medicine · doi:10.1084/jem.20220342 · Cited by 18 · see citing works
The oncoprotein TBX3 is controlling severity in experimental arthritis
Sardar, S., Kerr, A., Vaartjes, D., Moltved, E. R., Karosiene, E., Gupta, R., & Andersson, Å. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1797-3 · Cited by 13 · see citing works
- Authors
- Kurosaki, T.
- Affiliations
- Kansai Medical University (JP)
- Corresponding author
- Kurosaki, Tomohiro
- ORCID
- Kurosaki, Tomohiro
- Venue
- Nature Reviews Immunology
- Published
- 2002-05-01
- Volume
- 2
- Issue
- 5
- Pages
- 354-363
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2049070107
- Cited by
- 209
- References
- 2
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 9 · 2014: 5 · 2013: 9 · 2012: 7
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Toray Science Foundation
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- adaptor proteins, B cell receptor, receptor-effector coupling, subcellular localization, conformational change, spatiotemporal control, feedback regulatory loop, B cell response
- MeSH terms
- Animals, B-Lymphocytes, Carrier Proteins, Membrane Proteins, Phosphatidylinositols, Phosphoproteins, Protein-Tyrosine Kinases, Receptors, Antigen, B-Cell, Signal Transduction, Models, Immunological, Membrane Microdomains, Intercellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing
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