The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Transcription–replication conflicts: how they occur and how they are resolved
Open accessAbstract
The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, between the transcription and replication machineries. These conflicts constitute a major intrinsic source of genome instability, which is a hallmark of cancer cells. How the replication machinery progresses along a DNA molecule occupied by an RNA polymerase is an old question. Here we review recent data on the biological relevance of transcription–replication conflicts, and the factors and mechanisms that are involved in either preventing or resolving them, mainly in eukaryotes. On the basis of these data, we provide our current view of how transcription can generate obstacles to replication, including torsional stress and non-B DNA structures, and of the different cellular processes that have evolved to solve them.
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Cites
Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
Rodriguez, R., Miller, K. M., Forment, J. V., Bradshaw, C. R., Nikan, M., Britton, S., Oelschlaegel, T., Xhemalce, B., Balasubramanian, S., & Jackson, S. P. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.780 · Cited by 741
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Direct restart of a replication fork stalled by a head-on RNA polymerase
Pomerantz, R. T., & O’Donnell, M. (2010) · Science · doi:10.1126/science.1179595 · Cited by 150
Ccr4-Not and TFIIS Function Cooperatively To Rescue Arrested RNA Polymerase II
Dutta, A., Babbarwal, V., Fu, J., Brunke-Reese, D., Libert, D. M., Willis, J., & Reese, J. C. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00044-15 · Cited by 61
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Scully, R., Panday, A., Elango, R., & Willis, N. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0152-0 · Cited by 1,457
De Magis, A., Manzo, S. G., Russo, M., Marinello, J., Morigi, R., Sordet, O., & Capranico, G. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1810409116 · Cited by 332
Zatreanu, D., Han, Z., Mitter, R., Tumini, E., Williams, H., Gregersen, L., Dirac-Svejstrup, A. B., Roma, S., Stewart, A., Aguilera, A., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.037 · Cited by 124
Self-citationContributions of DNA Damage to Alzheimer’s Disease
Lin, X., Kapoor, A., Gu, Y., Chow, M. J., Peng, J., Zhao, K., & Tang, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051666 · Cited by 117
Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor
Hasanova, Z., Klapstova, V., Porrua, O., Stefl, R., & Sebesta, M. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad092 · Cited by 60
Metadata
- Authors
- García-Muse, T., & Aguilera, A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2016-07-20
- Volume
- 17
- Issue
- 9
- Pages
- 553-563
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2500686989
- Cited by
- 410
- References
- 5
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- green
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