The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Once and only once: mechanisms of centriole duplication and their deregulation in disease
Open accessAbstract
Centrioles are conserved microtubule-based organelles that form the core of the centrosome and act as templates for the formation of cilia and flagella. Centrioles have important roles in most microtubule-related processes, including motility, cell division and cell signalling. To coordinate these diverse cellular processes, centriole number must be tightly controlled. In cycling cells, one new centriole is formed next to each pre-existing centriole in every cell cycle. Advances in imaging, proteomics, structural biology and genome editing have revealed new insights into centriole biogenesis, how centriole numbers are controlled and how alterations in these processes contribute to diseases such as cancer and neurodevelopmental disorders. Moreover, recent work has uncovered the existence of surveillance pathways that limit the proliferation of cells with numerical centriole aberrations. Owing to this progress, we now have a better understanding of the molecular mechanisms governing centriole biogenesis, opening up new possibilities for targeting these pathways in the context of human disease.
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Cites
Cerebral organoids model human brain development and microcephaly
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Self-citationDNA breaks and chromosome pulverization from errors in mitosis
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Cited by
The tubulin code and its role in controlling microtubule properties and functions
Janke, C., & Magiera, M. M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0214-3 · Cited by 956
Ledur, P. F., Karmirian, K., Pedrosa, C. D. S. G., Souza, L. R. Q., Assis-de-Lemos, G., Martins, T. M., Ferreira, J. D. C. C. G., de Azevedo Reis, G. F., Silva, E. S., Silva, D., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-57914-x · Cited by 145
SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL
Kodani, A., Moyer, T., Chen, A., Holland, A., Walsh, C. A., & Reiter, J. F. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201803041 · Cited by 25
Self-citationStructural insights into SSNA1 self-assembly and its microtubule binding for centriole maintenance
Agostini, L., Pfister, J. A., Basnet, N., Ding, J., Zhang, R., Biertümpfel, C., O’Connell, K. F., & Mizuno, N. (2025) · Nature Communications · doi:10.1038/s41467-025-62696-9 · Cited by 10
Metadata
- Authors
- Nigg, E. A., & Holland, A. J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2018-01-24
- Volume
- 19
- Issue
- 5
- Pages
- 297-312
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2789611794
- Cited by
- 496
- References
- 6
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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