The anaphase promoting complex/cyclosome: a machine designed to destroy
Abstract
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.
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Negative interactions associated with the 19S proteasome highlighted diverse functions that are particularly important when proteasome activity is compromised, including interactions with genes encoding the APC.
“negative interactions associated with the 19S proteasome highlighted diverse functions that are particularly important when proteasome activity is compromised (Fig. 8B), including interactions with genes encoding the APC”
From A global genetic interaction network maps a wiring diagram of cellular function (2016) · cites this paper as [34]
The APC is a large, multisubunit E3 ligase that induces exit from mitosis by targeting cyclin B and securin for proteasomal degradation.
“The APC is a large, multisubunit E3 ligase that induces exit from mitosis by targeting cyclin B and securin for proteasomal degradation 123 .”
From Targeted protein degradation: expanding the toolbox (2019) · cites this paper as [123]
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References 171 · Cited by 1,315
- Authors
- Peters, J.-M.
- Affiliations
- Research Institute of Molecular Pathology (AT)
- Corresponding author
- Peters, Jan-Michael
- ORCID
- Peters, Jan-Michael
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2006-08-09
- Volume
- 7
- Issue
- 9
- Pages
- 644-656
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1969236463
- Cited by
- 1,315
- References
- 171
- Citations by year
- 2026: 33 · 2025: 36 · 2024: 32 · 2023: 42 · 2022: 34 · 2021: 40 · 2020: 53 · 2019: 53 · 2018: 38 · 2017: 51 · 2016: 54 · 2015: 68 · 2014: 82 · 2013: 101 · 2012: 96
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- anaphase-promoting complex, ubiquitin ligase, ubiquitination, cell cycle regulation, substrate recognition, E3 ubiquitin ligase, protein degradation
- MeSH terms
- Animals, Humans, Multienzyme Complexes, Protein Processing, Post-Translational, Substrate Specificity, Catalytic Domain, Ubiquitin, Ubiquitin-Protein Ligase Complexes, Anaphase-Promoting Complex-Cyclosome
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