Cited by 1,228DNA Repair MechanismsCancer-related Molecular PathwaysFungal and yeast genetics research

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Regulation of DNA repair throughout the cell cycle

Branzei, Dana, Foiani, Marco·2008·Nature Reviews Molecular Cell Biology

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Abstract

The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.

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Authors: Branzei, D., & Foiani, M.
Affiliations: IFOM (IT)
University of Milan (IT)
ORCID: Branzei, Dana
Foiani, Marco
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-02-20
Volume: 9
Issue: 4
Pages: 297-308
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2351
OpenAlex: W2093814864
Cited by: 1,228
References: 159
Citations by year: 2026: 18 · 2025: 51 · 2024: 54 · 2023: 48 · 2022: 50 · 2021: 72 · 2020: 71 · 2019: 91 · 2018: 119 · 2017: 107 · 2016: 57 · 2015: 66 · 2014: 61 · 2013: 77 · 2012: 67
FWCI: 5.64
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
Funders: Associazione Italiana per la Ricerca sul Cancro
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: DNA repair, cell cycle, DNA damage checkpoint, cell cycle arrest, cell cycle progression, genome stability, genotoxic stress, apoptosis, DNA lesions, cancer cells
MeSH terms: Animals, Cell Cycle, DNA Damage, DNA Repair, Humans, Protein Kinases, Small Ubiquitin-Related Modifier Proteins, Ubiquitination

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Regulation of DNA repair throughout the cell cycle

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