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Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases

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Cortical neurons gradually attain a post-mitotic state

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Quantitative and Site-Specific Chemoproteomic Profiling of Protein O-GlcNAcylation in the Cell Cycle

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Homologous Recombination in Eukaryotes

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Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2

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Transcriptomic analysis provides insights on hexavalent chromium induced DNA double strand breaks and their possible repair in midgut cells of Drosophila melanogaster larvae

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Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

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Using proteomic and transcriptomic data to assess activation of intracellular molecular pathways

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SUMO Boosts the DNA Damage Response Barrier against Cancer

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Genome-wide mapping of genomic DNA damage: methods and implications

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Regulatory Role of Ubiquitin in Eukaryotic DNA Translesion Synthesis

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Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity

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Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer

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SNP and indel frequencies at transcription start sites and at canonical and alternative translation initiation sites in the human genome

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Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells

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Non-SMC condensin I complex subunit H mediates mature chromosome condensation and DNA damage in pancreatic cancer cells

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Germicidal glowsticks: Side-emitting optical fibers inhibit Pseudomonas aeruginosa and Escherichia coli on surfaces

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Targeting protein–protein interactions in the DNA damage response pathways for cancer chemotherapy

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Tailoring in fungi for next generation cellulase production with special reference to CRISPR/CAS system

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CRISPR applications in cancer diagnosis and treatment

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The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression

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no polesencodes a predicted E3 ubiquitin ligase required for early embryonic development ofDrosophila

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Profiling Global Kinome Signatures of the Radioresistant MCF-7/C6 Breast Cancer Cells Using MRM-based Targeted Proteomics

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Navigating therapeutic strategies: HPV classification in head and neck cancer

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Emerging technology has a brilliant future: the CRISPR-Cas system for senescence, inflammation, and cartilage repair in osteoarthritis

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In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313

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Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage

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Genome maintenance functions of the INO80 chromatin remodeller

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Why Is the Immunoglobulin Heavy Chain Gene Mutation Status a Prognostic Indicator in Chronic Lymphocytic Leukemia?

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Ex Vivo Hepatocyte Reprograming Promotes Homology‐Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation

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Chk1 Inhibition Restores Inotuzumab Ozogamicin Citotoxicity in CD22-Positive Cells Expressing Mutant p53

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NMR Structure of the Human Rad18 Zinc Finger in Complex with Ubiquitin Defines a Class of UBZ Domains in Proteins Linked to the DNA Damage Response

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The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons

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Synergistic Effects of Arsenic Trioxide and Radiation in Osteosarcoma Cells through the Induction of Both Autophagy and Apoptosis

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Arabidopsis T-DNA insertional lines for CDC25 are hypersensitive to hydroxyurea but not to zeocin or salt stress

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Cell cycle-dependent resolution of DNA double-strand breaks

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Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer

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DNA damage signaling in the cellular responses to mustard vesicants

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Transcriptional responses to DNA damage

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Effects of chronic social stress on oligodendrocyte proliferation-maturation and myelin status in prefrontal cortex and amygdala in adult mice

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Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library

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A Novel Benzocoumarin-Stilbene Hybrid as a DNA ligase I inhibitor with in vitro and in vivo anti-tumor activity in breast cancer models

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Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells

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PHF6 promotes non‐homologous end joining and G2 checkpoint recovery

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Benzimidazole: A Multifacted Nucelus for Anticancer Agents

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USP24 promotes drug resistance during cancer therapy

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Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy

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Double-strand break toxicity is chromatin context independent

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The Implication of Topoisomerase II Inhibitors in Synthetic Lethality for Cancer Therapy

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Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance

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Comet sensitivity in assessing DNA damage and repair in different cell cycle stages

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A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer Cells

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Evaluation of ATM Kinase Inhibitor KU-55933 as Potential Anti-Toxoplasma gondii Agent

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Modeling Cellular Response in Large-Scale Radiogenomic Databases to Advance Precision Radiotherapy

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LncRNA UCA1 Antagonizes Arsenic‐Induced Cell Cycle Arrest through Destabilizing EZH2 and Facilitating NFATc2 Expression

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Cellular, Metabolic, and Developmental Dimensions of Whole-Body Regeneration in HydraPreprint

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Uracil DNA Glycosylase 2 negatively regulates HIV-1 LTR transcription

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Genetic variants of DNA repair-related genes predict efficacy of TAS-102 in patients with refractory metastatic colorectal cancer

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Radiation resistance of normal human astrocytes: the role of non-homologous end joining DNA repair activity

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Caspase-3 knockout attenuates radiation-induced tumor repopulation via impairing the ATM/p53/Cox-2/PGE2 pathway in non-small cell lung cancer

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A Guide for Using Transmission Electron Microscopy for Studying the Radiosensitizing Effects of Gold Nanoparticles In Vitro

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Precision Editing as a Therapeutic Approach for β-Hemoglobinopathies

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A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa

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Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication

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The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1

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S-phase Specific Downregulation of Human O6-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21cip1 Proteins in Glioma Cells

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Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo

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Atmospheric-pressure plasma jet induces DNA double-strand breaks that require a Rad51-mediated homologous recombination for repair in Saccharomyces cerevisiae

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GENETIC VARIATION AND DNA REPLICATION TIMING, OR WHY IS THERE LATE REPLICATING DNA?

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Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs

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Investigating the Anticancer Potential of Salvicine as a Modulator of Topoisomerase II and ROS Signaling Cascade

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Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury

Valentijn, F. A., Knoppert, S. N., Márquez‐Expósito, L., Rodrigues-Díez, R. R., Pissas, G., Tang, J., Tejedor-Santamaria, L., Broekhuizen, R., Samarakoon, R., Eleftheriadis, T., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.06.030 · Cited by 29

Nuclear Phosphoinositides as Key Determinants of Nuclear Functions

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Cell Cycle Adaptations and Maintenance of Genomic Integrity in Embryonic Stem Cells and Induced Pluripotent Stem Cells

Momčilović, O., Navara, C. S., & Schatten, G. P. (2011) · Results and problems in cell differentiation · doi:10.1007/978-3-642-19065-0_18 · Cited by 30

SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

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Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells

Tosato, V., Grüning, N., Breitenbach, M., Arnak, R., Ralser, M., & Bruschi, C. V. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2012.00212 · Cited by 31

Yeti, aDrosophila melanogasteressential gene, encodes a protein required for chromatin organization

Messina, G., Damia, E., Fanti, L., Atterrato, M. T., Celauro, E., Mariotti, F. R., Accardo, M. C., Walther, M., Vernı̀, F., Picchioni, D., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.150243 · Cited by 29

Cancer TARGETases: DSB repair as a pharmacological target

Samadder, P., Aithal, R., Beláň, O., & Krejčí, L. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.02.007 · Cited by 31

The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype

Marsden, C. G., Jensen, R. B., Zagelbaum, J., Rothenberg, E., Morrical, S. W., Wallace, S. S., & Sweasy, J. B. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006208 · Cited by 33

Bufalin enhances radiosensitivity of glioblastoma by suppressing mitochondrial function and DNA damage repair

Zhang, X., Huang, Q., Wang, X., Xu, Y., Xu, R., Han, M., Huang, B., Chen, A., Qiu, C., Sun, T., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.07.136 · Cited by 29

Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

Leland, B. A., Chen, A. C., Zhao, A., Wharton, R. C., & King, M. C. (2018) · eLife · doi:10.7554/elife.33402 · Cited by 30

Abrogation of the G2/M checkpoint as a chemosensitization approach for alkylating agents

Lang, F., Cornwell, J. A., Kaur, K., Elmogazy, O., Zhang, W., Zhang, M., Song, H., Sun, Z., Wu, X., Aladjem, M. I., et al. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad252 · Cited by 28

NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage

Guan, J., Yu, S., & Zheng, X. (2017) · Protein & Cell · doi:10.1007/s13238-017-0455-x · Cited by 29

JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming process

Wang, L., Jiang, Z., Huang, D., Duan, J. E., Huang, C., Sullivan, S., Vali, K., Yin, Y., Zhang, M., Wegrzyn, J., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-4507-2 · Cited by 28

Assessment of Cannabidiol and Δ9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma

Andradas, C., Byrne, J., Kuchibhotla, M., Ancliffe, M., Jones, A. C., Carline, B., Hii, H. L., Truong, A., Storer, L. C. D., Ritzmann, T. A., et al. (2021) · Cancers · doi:10.3390/cancers13020330 · Cited by 29

The Trp53-Trp53inp1-Tnfrsf10b Pathway Regulates the Radiation Response of Mouse Spermatogonial Stem Cells

Ishii, K., Ishiai, M., Morimoto, H., Kanatsu‐Shinohara, M., Niwa, O., Takata, M., & Shinohara, T. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.08.006 · Cited by 28

Crystal structure and functional insights into uracil-DNA glycosylase inhibition by phage ϕ29 DNA mimic protein p56

Baños-Sanz, J. I., Mojardín, L., Sanz‐Aparicio, J., Lázaro, J. M., Villar, L., Serrano‐Heras, G., González, B., & Salas, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt395 · Cited by 28

Module 9: Cell Cycle and Proliferation

Berridge, M. J. (2012) · Cell Signalling Biology · doi:10.1042/csb0001009 · Cited by 33

Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells

Berton, S., Cusan, M., Segatto, I., Citron, F., D’Andrea, S., Benevol, S., Avanzo, M., Dall’Acqua, A., Schiappacassi, M., Bristow, R. G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00734-3 · Cited by 28

E4F1 Is a Master Regulator of CHK1-Mediated Functions

Grote, D., Moison, C., Duhamel, S., Chagraoui, J., Girard, S., Yang, J., Mayotte, N., Coulombe, Y., Masson, J., Brown, G. W., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.019 · Cited by 30

Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53

Duong, F. H. T., Dill, M. T., Matter, M. S., Makowska, Z., Calabrese, D., Dietsche, T., Ketterer, S., Terracciano, L., & Heim, M. H. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt258 · Cited by 28

Cell-Cycle Control and DNA-Damage Signaling in Mammals

Gómez, V., & Hergovich, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803309-8.00014-8 · Cited by 12

DNA damage and cell cycle checkpoint regulation

Garner, K. M. (2010) · doi:10.1349/ddlp.390

DNA damage checkpoint dynamics drive cell cycle phase transitionsPreprint

Chao, H. X., Poovey, C. E., Privette, A. A., Grant, G. D., Chao, H. Y., Cook, J. G., & Purvis, J. E. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/137307 · Cited by 4

Checkpoint and Coordinated Cellular Responses to DNA Damage

Yang, X. H., & Zou, L. (2006) · Springer eBooks · doi:10.1007/b136684 · Cited by 20

Interplay Between the Cell Cycle and Double-Strand Break Response in Mammalian Cells

Beishline, K., & Azizkhan‐Clifford, J. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0888-2_3 · Cited by 31