The DOI matches its Crossref record; 70 of the 72 references it cites were found in a registry or an index.
Design principles of biochemical oscillators
Open accessAbstract
Cellular rhythms are generated by complex interactions among genes, proteins and metabolites. They are used to control every aspect of cell physiology, from signalling, motility and development to growth, division and death. We consider specific examples of oscillatory processes and discuss four general requirements for biochemical oscillations: negative feedback, time delay, sufficient 'nonlinearity' of the reaction kinetics and proper balancing of the timescales of opposing chemical reactions. Positive feedback is one mechanism to delay the negative-feedback signal. Biological oscillators can be classified according to the topology of the positive- and negative-feedback loops in the underlying regulatory mechanism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Regardless of the type of representation chosen, the importance of taking into account the system dynamics has to be acknowledged [25,26].”
From Reverse engineering and identification in systems biology: strategies, perspectives and challenges (2014) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.
Monod, J., Wyman, J., & Changeux, J. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80285-6 · Cited by 7,681
A synthetic oscillatory network of transcriptional regulators
Elowitz, M., & Leibler, S. (2000) · Nature · doi:10.1038/35002125 · Cited by 4,812
Oscillation and Chaos in Physiological Control Systems
Mackey, M. C., & Glass, L. (1977) · Science · doi:10.1126/science.267326 · Cited by 4,184
A theory of biological pattern formation
Gierer, A., & Meinhardt, H. (1972) · Kybernetik · doi:10.1007/bf00289234 · Cited by 3,158
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
Hoffmann, A., Levchenko, A., Scott, M. L., & Baltimore, D. (2002) · Science · doi:10.1126/science.1071914 · Cited by 1,890
Evans, T., Rosenthal, E. T., Youngblom, J., Distel, D. L., & Hunt, T. (1983) · Cell · doi:10.1016/0092-8674(83)90420-8 · Cited by 1,516
Cell-signalling dynamics in time and space
Kholodenko, B. N. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1838 · Cited by 1,347
An amplified sensitivity arising from covalent modification in biological systems.
Goldbeter, A., & Koshland, D. E. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.6840 · Cited by 1,209
Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
Nelson, D. E., Ihekwaba, A. E. C., Elliott, M., Johnson, J. R., Gibney, C. A., Foreman, B. E., Nelson, G., See, V., Horton, C. A., Spiller, D. G., et al. (2004) · Science · doi:10.1126/science.1099962 · Cited by 1,186
Flagged first, then by citations
2 of the 72 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Thomas, R. & D'Ari, R. Biological Feedback (CRC Press, Boca Raton, 1990).
- Segel, L. A. Biological Kinetics (Cambridge University Press, Cambridge, 1991).
Cited by
Sorted by citations
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,786
A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence
Balasubramanian, D., Schneper, L. M., Kumari, H., & Mathee, K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1039 · Cited by 604
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence
Krause, M., & Gautreau, A. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3861 · Cited by 609
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 547
Greenwald, E. C., Mehta, S., & Zhang, J. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00333 · Cited by 502
Metadata
- Authors
- Novák, B., & Tyson, J. J.
- Affiliations
- University of Oxford (GB)
- Virginia Tech (US)
- Corresponding author
- Novák, Béla
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2008-10-30
- Volume
- 9
- Issue
- 12
- Pages
- 981-991
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC2796343
- OpenAlex
- W2030945597
- Cited by
- 1,137
- References
- 72
- Citations by year
- 2026: 56 · 2025: 56 · 2024: 71 · 2023: 52 · 2022: 77 · 2021: 80 · 2020: 79 · 2019: 67 · 2018: 81 · 2017: 69 · 2016: 60 · 2015: 57 · 2014: 65 · 2013: 62 · 2012: 72
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01gm078989-13)
- Biotechnology and Biological Sciences Research Council
- National Institute of General Medical Sciences (R01-GM078989, R01GM079207)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
- Keywords
- biochemical oscillators, cellular rhythms, negative feedback, time delay, positive feedback, gene regulatory networks, oscillations
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Kinetics, Models, Biological, Signal Transduction, Feedback, Physiological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
