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Design principles of biochemical oscillators
Open accessAbstract
Cellular rhythms are generated by complex interactions among genes, proteins and metabolites. They are used to control every aspect of cell physiology, from signalling, motility and development to growth, division and death. We consider specific examples of oscillatory processes and discuss four general requirements for biochemical oscillations: negative feedback, time delay, sufficient 'nonlinearity' of the reaction kinetics and proper balancing of the timescales of opposing chemical reactions. Positive feedback is one mechanism to delay the negative-feedback signal. Biological oscillators can be classified according to the topology of the positive- and negative-feedback loops in the underlying regulatory mechanism.
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“Regardless of the type of representation chosen, the importance of taking into account the system dynamics has to be acknowledged [25,26].”
From Reverse engineering and identification in systems biology: strategies, perspectives and challenges (2014) · cites this paper as [26]
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Metadata
- Authors
- Novák, B., & Tyson, J. J.
- Affiliations
- University of Oxford (GB)
- Virginia Tech (US)
- Corresponding author
- Novák, Béla
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2008-10-30
- Volume
- 9
- Issue
- 12
- Pages
- 981-991
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC2796343
- OpenAlex
- W2030945597
- Cited by
- 1,137
- References
- 72
- Citations by year
- 2026: 56 · 2025: 56 · 2024: 71 · 2023: 52 · 2022: 77 · 2021: 80 · 2020: 79 · 2019: 67 · 2018: 81 · 2017: 69 · 2016: 60 · 2015: 57 · 2014: 65 · 2013: 62 · 2012: 72
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01gm078989-13)
- Biotechnology and Biological Sciences Research Council
- National Institute of General Medical Sciences (R01-GM078989, R01GM079207)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
- Keywords
- biochemical oscillators, cellular rhythms, negative feedback, time delay, positive feedback, gene regulatory networks, oscillations
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Kinetics, Models, Biological, Signal Transduction, Feedback, Physiological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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