The second wave of synthetic biology: from modules to systems

Stochastic Gene Expression in a Single Cell

Elowitz, M. B., Levine, A. J., Siggia, E. D., & Swain, P. S. (2002) · Science · doi:10.1126/science.1070919 · Cited by 5,441

Stability and Complexity in Model Ecosystems

May, R. M. (2001) · Princeton University Press eBooks · doi:10.1515/9780691206912 · Cited by 5,229

A synthetic oscillatory network of transcriptional regulators

Elowitz, M., & Leibler, S. (2000) · Nature · doi:10.1038/35002125 · Cited by 4,812

Construction of a genetic toggle switch in Escherichia coli

Gardner, T. S., Cantor, C. R., & Collins, J. J. (2000) · Nature · doi:10.1038/35002131 · Cited by 4,310

STABILITY AND COMPLEXITY IN MODEL ECOSYSTEMS

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Production of the antimalarial drug precursor artemisinic acid in engineered yeast

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Stability and Complexity in Model Ecosystems.

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Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

Martin, V. J. J., Pitera, D. J., Withers, S. T., Newman, J. D., & Keasling, J. D. (2003) · Nature Biotechnology · doi:10.1038/nbt833 · Cited by 1,720

PEST sequences and regulation by proteolysis

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Noise in eukaryotic gene expression

Blake, W. J., Kærn, M., Cantor, C. R., & Collins, J. J. (2003) · Nature · doi:10.1038/nature01546 · Cited by 1,636

Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome

Gibson, D. G., Benders, G. A., Andrews-Pfannkoch, C., Denisova, E. A., Baden-Tillson, H., Zaveri, J., Stockwell, T. B., Brownley, A., Thomas, D. W., Algire, M. A., et al. (2008) · Science · doi:10.1126/science.1151721 · Cited by 1,243

Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression

Nelson, D. E., Ihekwaba, A. E. C., Elliott, M., Johnson, J. R., Gibney, C. A., Foreman, B. E., Nelson, G., See, V., Horton, C. A., Spiller, D. G., et al. (2004) · Science · doi:10.1126/science.1099962 · Cited by 1,186

A synthetic multicellular system for programmed pattern formation

Basu, S., Gerchman, Y., Collins, C. H., Arnold, F. H., & Weiss, R. (2005) · Nature · doi:10.1038/nature03461 · Cited by 1,158

A vesicle bioreactor as a step toward an artificial cell assembly

Noireaux, V., & Libchaber, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408236101 · Cited by 1,152

Gene Regulation at the Single-Cell Level

Rosenfeld, N., Young, J. W., Alon, U., Swain, P. S., & Elowitz, M. B. (2005) · Science · doi:10.1126/science.1106914 · Cited by 1,104

A fast, robust and tunable synthetic gene oscillator

Stricker, J., Cookson, S., Bennett, M. R., Mather, W., Tsimring, L. S., & Hasty, J. (2008) · Nature · doi:10.1038/nature07389 · Cited by 1,102

Multistability in the lactose utilization network of Escherichia coli

Ozbudak, E. M., Thattai, M., Lim, H. N., Shraiman, B. I., & van Oudenaarden, A. (2004) · Nature · doi:10.1038/nature02298 · Cited by 1,030

Essential genes of a minimal bacterium

Glass, J. I., Assad-Garcia, N., Alperovich, N., Yooseph, S., Lewis, M. R., Maruf, M., Hutchison, C. A., Smith, H. O., & Venter, J. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510013103 · Cited by 912

Noise Propagation in Gene Networks

Pedraza, J. M., & van Oudenaarden, A. (2005) · Science · doi:10.1126/science.1109090 · Cited by 796

Modelling Biological Populations in Space and Time

Renshaw, E. (1991) · Cambridge University Press eBooks · doi:10.1017/cbo9780511624094 · Cited by 790

Engineering BioBrick vectors from BioBrick parts

Shetty, R. P., Endy, D., & Knight, T. F. (2008) · Journal of Biological Engineering · doi:10.1186/1754-1611-2-5 · Cited by 755

Refinement and standardization of synthetic biological parts and devices

Canton, B., Labno, A., & Endy, D. (2008) · Nature Biotechnology · doi:10.1038/nbt1413 · Cited by 749

Modelling Biological Populations in Space and Time

Appleton, D. (1993) · Journal of the Royal Statistical Society Series C (Applied Statistics) · doi:10.2307/2986249 · Cited by 722

Development of Genetic Circuitry Exhibiting Toggle Switch or Oscillatory Behavior in Escherichia coli

Atkinson, M. R., Savageau, M. A., Myers, J. T., & Ninfa, A. J. (2003) · Cell · doi:10.1016/s0092-8674(03)00346-5 · Cited by 710

Programmed population control by cell–cell communication and regulated killing

You, L., Cox, R. S., Weiss, R., & Arnold, F. H. (2004) · Nature · doi:10.1038/nature02491 · Cited by 708

Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion

Becskei, A., Séraphin, B., & Serrano, L. G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.10.2528 · Cited by 687

Template-directed synthesis of a genetic polymer in a model protocell

Mansy, S. S., Schrum, J. P., Krishnamurthy, M., Tobé, S., Treco, D. A., & Szostak, J. W. (2008) · Nature · doi:10.1038/nature07018 · Cited by 684

Oscillations and variability in the p53 system

Geva‐Zatorsky, N., Rosenfeld, N., Itzkovitz, S., Milo, R., Sigal, A., Dekel, E., Yarnitzky, T., Liron, Y., Polak, P. P., Lahav, G., et al. (2006) · Molecular Systems Biology · doi:10.1038/msb4100068 · Cited by 658

Stochastic Gene Expression in a Lentiviral Positive-Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity

Weinberger, L. S., Burnett, J., Toettcher, J. E., Arkin, A. P., & Schaffer, D. V. (2005) · Cell · doi:10.1016/j.cell.2005.06.006 · Cited by 633

Mechanisms of noise-resistance in genetic oscillators.

Vilar, J. M. G., Kueh, H. Y., Barkai, N., & Leibler, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092133899 · Cited by 595

A tunable synthetic mammalian oscillator

Tigges, M., Marquez‐Lago, T. T., Stelling, J., & Fussenegger, M. (2009) · Nature · doi:10.1038/nature07616 · Cited by 573

Environmentally Controlled Invasion of Cancer Cells by Engineered Bacteria

Anderson, J. C., Clarke, E. J., Arkin, A. P., & Voigt, C. A. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.10.076 · Cited by 572

Higher-Order Cellular Information Processing with Synthetic RNA Devices

Win, M. N., & Smolke, C. D. (2008) · Science · doi:10.1126/science.1160311 · Cited by 548

Engineered riboregulators enable post-transcriptional control of gene expression

Isaacs, F. J., Dwyer, D. J., Ding, C., Pervouchine, D. D., Cantor, C. R., & Collins, J. J. (2004) · Nature Biotechnology · doi:10.1038/nbt986 · Cited by 547

Amorphous computing

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ROSETTALIGAND: Protein–small molecule docking with full side‐chain flexibility

Meiler, J., & Baker, D. A. (2006) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.21086 · Cited by 520

Ultrasensitivity and noise propagation in a synthetic transcriptional cascade

Hooshangi, S., Thiberge, S. Y., & Weiss, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408507102 · Cited by 489

A universal RNAi-based logic evaluator that operates in mammalian cells

Rinaudo, K., Bleris, L. G., Maddamsetti, R., Subramanian, S., Weiss, R., & Benenson, Y. (2007) · Nature Biotechnology · doi:10.1038/nbt1307 · Cited by 483

A synthetic Escherichia coli predator–prey ecosystem

Balagadde, F., Song, H., Ozaki, J., Collins, C. H., Barnet, M., Arnold, F. H., Quake, S. R., & You, L. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.24 · Cited by 475

Riboswitches as antibacterial drug targets

Blount, K., & Breaker, R. R. (2006) · Nature Biotechnology · doi:10.1038/nbt1268 · Cited by 472

Spatiotemporal control of gene expression with pulse-generating networks

Basu, S., Mehreja, R., Thiberge, S. Y., Chen, M., & Weiss, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307571101 · Cited by 466

Directed evolution of a genetic circuit

Yokobayashi, Y., Weiss, R., & Arnold, F. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252535999 · Cited by 457

Synthetic cooperation in engineered yeast populations

Shou, W., Ram, S., & Vilar, J. M. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610575104 · Cited by 454

Terpenoids: Opportunities for Biosynthesis of Natural Product Drugs Using Engineered Microorganisms

Ajikumar, P. K., Tyo, K. E. J., Carlsen, S., Mucha, O., Too, H., & Stephanopoulos, G. N. (2008) · Molecular Pharmaceutics · doi:10.1021/mp700151b · Cited by 451

Towards synthesis of a minimal cell

Forster, A. C., & Church, G. M. (2006) · Molecular Systems Biology · doi:10.1038/msb4100090 · Cited by 437

A modular and extensible RNA-based gene-regulatory platform for engineering cellular function

Win, M. N., & Smolke, C. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703961104 · Cited by 396

Transitions from Nonliving to Living Matter

Rasmussen, S., Chen, L., Deamer, D. W., Krakauer, D. C., Packard, N. H., Stadler, P. F., & Bedau, M. A. (2004) · Science · doi:10.1126/science.1093669 · Cited by 384

Programmable ligand-controlled riboregulators of eukaryotic gene expression

Bayer, T. S., & Smolke, C. D. (2005) · Nature Biotechnology · doi:10.1038/nbt1069 · Cited by 382

Environmental signal integration by a modular AND gate

Anderson, J. C., Voigt, C. A., & Arkin, A. P. (2007) · Molecular Systems Biology · doi:10.1038/msb4100173 · Cited by 378

Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics

Bashor, C. J., Helman, N. C., Yan, S., & Lim, W. A. (2008) · Science · doi:10.1126/science.1151153 · Cited by 347

An engineered epigenetic transgene switch in mammalian cells

Kramer, B. P., Viretta, A. U., Baba, M. D., Aubel, D., Weber, W., & Fussenegger, M. (2004) · Nature Biotechnology · doi:10.1038/nbt980 · Cited by 336

Non-coding RNAs, epigenetics and complexity

Costa, F. F. (2007) · Gene · doi:10.1016/j.gene.2007.12.008 · Cited by 334

Multipass membrane protein structure prediction using Rosetta

Yarov-Yarovoy, V. M., Schonbrun, J., & Baker, D. A. (2005) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.20817 · Cited by 323

Design of genetic networks with specified functions by evolution in silico

François, P., & Hakim, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304532101 · Cited by 281

A Tunable Genetic Switch Based on RNAi and Repressor Proteins for Regulating Gene Expression in Mammalian Cells

Deans, T. L., Cantor, C. R., & Collins, J. J. (2007) · Cell · doi:10.1016/j.cell.2007.05.045 · Cited by 279

The Kinetics of Ligand Binding by an Adenine-Sensing Riboswitch

Wickiser, J. K., Cheah, M. T., Breaker, R. R., & Crothers, D. M. (2005) · Biochemistry · doi:10.1021/bi051008u · Cited by 276

Noise in transcription negative feedback loops: simulation and experimental analysis

Dublanche, Y., Michalodimitrakis, K., Kuemmerer, N., Foglierini, M., & Serrano, L. (2006) · Molecular Systems Biology · doi:10.1038/msb4100081 · Cited by 265

Epigenetic reprogramming and imprinting in origins of disease

Tang, W., & Ho, S. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-007-9042-4 · Cited by 261

Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium

Brenner, K., Karig, D., Weiss, R., & Arnold, F. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704256104 · Cited by 244

Genetically modified organisms for the environment: stories of success and failure and what we have learned from them.

Cases, I., & de Lorenzo, V. (2005) · PubMed · Cited by 238

Artificial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thaliana

Chen, M., & Weiss, R. (2005) · Nature Biotechnology · doi:10.1038/nbt1162 · Cited by 215

Combinatorial promoter design for engineering noisy gene expression

Murphy, K. F., Balázsi, G., & Collins, J. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608451104 · Cited by 211

Synthetic ecosystems based on airborne inter- and intrakingdom communication

Weber, W., Baba, M. D., & Fussenegger, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701382104 · Cited by 200

Prediction of the structure of symmetrical protein assemblies

André, I., Bradley, P. H., Wang, C., & Baker, D. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702626104 · Cited by 178

Toward an artificial cell based on gene expression in vesicles

Noireaux, V., Bar‐Ziv, R., Godefroy, J., Salman, H., & Libchaber, A. J. (2005) · Physical Biology · doi:10.1088/1478-3975/2/3/p01 · Cited by 169

The future of human gene therapy

Rubanyi, G. M. (2001) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(01)00004-8 · Cited by 167

Design of artificial cell–cell communication using gene and metabolic networks

Bülter, T., Lee, S., Wong, W. W., Fung, E., Connor, M. R., & Liao, J. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306484101 · Cited by 166

Selection of fluorescent aptamer beacons that light up in the presence of zinc

Rajendran, M., & Ellington, A. D. (2007) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-007-1735-8 · Cited by 159

Protein synthesis in liposomes with a minimal set of enzymes

Murtas, G., Kuruma, Y., Bianchini, P., Diaspro, A., & Luisi, P. L. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.201 · Cited by 145

Computational Design of a New Hydrogen Bond Network and at Least a 300-fold Specificity Switch at a Protein−Protein Interface

Joachimiak, Ł. A., Kortemme, T., Stoddard, B. L., & Baker, D. A. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.05.022 · Cited by 142

Design and Construction of a Double Inversion Recombination Switch for Heritable Sequential Genetic Memory

Ham, T. S., Lee, S. K., Keasling, J. D., & Arkin, A. P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002815 · Cited by 141

A Global View of Transcriptional Regulation by Nuclear Receptors: Gene Expression, Factor Localization, and DNA Sequence Analysis

Kininis, M., & Kraus, W. L. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06005 · Cited by 141

Towards programming languages for genetic engineering of living cells

Pedersen, M., & Phillips, A. (2009) · Journal of The Royal Society Interface · doi:10.1098/rsif.2008.0516.focus · Cited by 141

A synthetic time-delay circuit in mammalian cells and mice

Weber, W., Stelling, J., Rimann, M., Keller, B., Baba, M. D., Weber, C. C., Aubel, D., & Fussenegger, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606398104 · Cited by 138

Optimizing Genetic Circuits by Global Sensitivity Analysis

Feng, X., Hooshangi, S., Chen, D. D., Li, G., Weiss, R., & RABITZ, H. A. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.044131 · Cited by 135

Robustness analysis and tuning of synthetic gene networks

Batt, G., Yordanov, B., Weiss, R., & Belta, C. A. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm362 · Cited by 132

Microbially Derived Artemisinin: A Biotechnology Solution to the Global Problem of Access to Affordable Antimalarial Drugs

Hale, V., Keasling, J. D., Renninger, N. S., & Diagana, T. T. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.198 · Cited by 131

Intron length increases oscillatory periods of gene expression in animal cellsPreprint

Swinburne, I. A., Míguez, D. G., Landgraf, D., & Silver, P. A. (2008) · Genes & Development · doi:10.1101/gad.1696108 · Cited by 130

Synthetic Gene Circuits: Design with Directed Evolution

Haseltine, E. L., & Arnold, F. H. (2007) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.36.040306.132600 · Cited by 129

Chemical regulation of epigenetic modifications: Opportunities for new cancer therapy

Zheng, Y. G., Wu, J., Chen, Z., & Goodman, M. (2008) · Medicinal Research Reviews · doi:10.1002/med.20120 · Cited by 126

Reengineering a Natural Riboswitch by Dual Genetic Selection

Nomura, Y., & Yokobayashi, Y. (2007) · Journal of the American Chemical Society · doi:10.1021/ja076298b · Cited by 113

An Artificial Aptazyme‐Based Riboswitch and its Cascading System in E. coli

Ogawa, A., & Maeda, M. (2007) · ChemBioChem · doi:10.1002/cbic.200700478 · Cited by 106

Codeine-binding RNA aptamers and rapid determination of their binding constants using a direct coupling surface plasmon resonance assay

Win, M. N., Klein, J. S., & Smolke, C. D. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl718 · Cited by 102

Defossiling Fuel: How Synthetic Biology Can Transform Biofuel Production

Savage, D. F., Way, J. C., & Silver, P. A. (2008) · ACS Chemical Biology · doi:10.1021/cb700259j · Cited by 100

Chemical Aspects of Synthetic Biology

Luisi, P. L. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790053 · Cited by 95

OptCircuit: An optimization based method for computational design of genetic circuits

Dasika, M. S., & Maranas, C. D. (2008) · BMC Systems Biology · doi:10.1186/1752-0509-2-24 · Cited by 90

Cellular Logic with Orthogonal Ribosomes

Rackham, O., & Chin, J. W. (2005) · Journal of the American Chemical Society · doi:10.1021/ja055338d · Cited by 88

Photonic boolean logic gates based on DNA aptamers

Yoshida, W., & Yokobayashi, Y. (2006) · Chemical Communications · doi:10.1039/b613201d · Cited by 83

A tightly regulated inducible expression system utilizing the fim inversion recombination switch

Ham, T. S., Lee, S. K., Keasling, J. D., & Arkin, A. P. (2006) · Biotechnology and Bioengineering · doi:10.1002/bit.20916 · Cited by 81

Prediction of structures of multidomain proteins from structures of the individual domains

Wollacott, A. M., Zanghellini, A., Murphy, P. M., & Baker, D. A. (2006) · Protein Science · doi:10.1110/ps.062270707 · Cited by 61

Modulation of gene expression from the arabinose-inducible araBAD promoter

Khlebnikov, A., Skaug, T., & Keasling, J. D. (2002) · Journal of Industrial Microbiology & Biotechnology · doi:10.1038/sj.jim.7000259 · Cited by 60

Recapitulation and Design of Protein Binding Peptide Structures and Sequences

Sood, V. D., & Baker, D. A. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.01.045 · Cited by 58

Engineering bacteria to solve the Burnt Pancake Problem

Haynes, K. A., Broderick, M. L., Brown, A., Butner, T. L., Dickson, J. O., Harden, W. L., Heard, L. H., Jessen, E. L., Malloy, K. J., Ogden, B. J., et al. (2008) · Journal of Biological Engineering · doi:10.1186/1754-1611-2-8 · Cited by 57

A synthetic de‐greening gene circuit provides a reporting system that is remotely detectable and has a re‐set capacity

Antunes, M. S., Ha, S., Tewari‐Singh, N., Morey, K. J., Trofka, A. M., Kugrens, P., Deyholos, M. K., & Medford, J. I. (2006) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2006.00205.x · Cited by 54

Development of a novel biosensor for the detection of arsenic in drinking water

Aleksic, J., de Mora, K., Millar, A. J., Davidson, B., Kozma‐Bognár, L., Ma, H., French, C. E., Bizzari, F., Elfick, A. P. D., Wilson, J., et al. (2007) · IET Synthetic Biology · doi:10.1049/iet-stb:20060002 · Cited by 52

Model-Driven Designs of an Oscillating Gene Network

Tuttle, L. M., Salis, H. M., Tomshine, J. R., & Kaznessis, Y. N. (2005) · Biophysical Journal · doi:10.1529/biophysj.105.064204 · Cited by 52

Dual selection of a genetic switch by a single selection marker

Nomura, Y., & Yokobayashi, Y. (2006) · Biosystems · doi:10.1016/j.biosystems.2006.07.006 · Cited by 49

Optimization of a Stochastically Simulated Gene Network Model via Simulated Annealing

Tomshine, J. R., & Kaznessis, Y. N. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.083485 · Cited by 48

Synthetic tetracycline-inducible regulatory networks: computer-aided design of dynamic phenotypes

Sotiropoulos, V., & Kaznessis, Y. N. (2007) · BMC Systems Biology · doi:10.1186/1752-0509-1-7 · Cited by 40

Lecithin‐Based Water‐In‐Oil Compartments as Dividing Bioreactors

Fiordemondo, D., & Stano, P. (2007) · ChemBioChem · doi:10.1002/cbic.200700112 · Cited by 40

Construction of an artificial intercellular communication network using the nitric oxide signaling elements in mammalian cells

Wang, W., Chen, Z., Kang, B.-G., & Li, R. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.11.023 · Cited by 39

A genetic time‐delay circuitry in mammalian cells

Weber, W., Kramer, B. P., & Fussenegger, M. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21463 · Cited by 37

ChemInform Abstract: Chemical Regulations of Epigenetic Modifications: Opportunities for New Cancer Therapy

Zheng, Y. G., Wu, J., Chen, Z., & Goodman, M. (2008) · ChemInform · doi:10.1002/chin.200847259 · Cited by 37

Oscillations in transcription factor dynamics: a new way to control gene expression

Nelson, D. E., Sée, V., Nelson, G., & White, M. (2004) · Biochemical Society Transactions · doi:10.1042/bst0321090 · Cited by 35

Mis-translation of a Computationally Designed Protein Yields an Exceptionally Stable Homodimer: Implications for Protein Engineering and Evolution

Dantas, G. A., Watters, A. L., Lunde, B. M., Eletr, Z. M., Isern, N., Roseman, T., Lipfert, J., Doniach, S., Tompa, M., Kuhlman, B. A., et al. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.07.092 · Cited by 33

Modelling Biological Populations in Space and Time.

Speirs, D. C., & Renshaw, E. (1994) · Journal of Applied Ecology · doi:10.2307/2404457 · Cited by 32

Transcription factor logic using chemical complementation

Bronson, J. E., Mazur, W. W., & Cornish, V. W. (2007) · Molecular BioSystems · doi:10.1039/b713852k · Cited by 31

Building a Parallel Metabolism within the Cell

Filipovska, A., & Rackham, O. (2008) · ACS Chemical Biology · doi:10.1021/cb700185e · Cited by 28

RNA and RNP as new molecular parts in synthetic biology

Saito, H., & Inoue, T. (2007) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2007.07.952 · Cited by 28

RNA as a Versatile and Powerful Platform for Engineering Genetic Regulatory Tools

Win, M. N., & Smolke, C. D. (2007) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2007.10648106 · Cited by 27

Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter

Yang, W., & Paschen, W. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.011 · Cited by 25

Cultivating plant synthetic biology from systems biology

Bowen, T. A., Zdunek, J. K., & Medford, J. I. (2008) · New Phytologist · doi:10.1111/j.1469-8137.2008.02433.x · Cited by 24

Sustained Oscillations in Extended Genetic Oscillatory Systems

Goh, K.-I., Kahng, B., & Cho, K. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.128017 · Cited by 23

Plasmid-borne prokaryotic gene expression: Sources of variability and quantitative system characterization

Bagh, S., Mazumder, M., Velauthapillai, T., Sardana, V., Dong, G. Q., Movva, A. B., Lim, L. H., & McMillen, D. R. (2008) · Physical Review E · doi:10.1103/physreve.77.021919 · Cited by 20

Prediction of translation initiation sites in human mRNA sequences with AUG start codon in weak Kozak context: A neural network approach

Tikole, S., & Sankararamakrishnan, R. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.008 · Cited by 18

Computer-aided design of modular protein devices: Boolean AND gene activation

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