The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Designing customized cell signalling circuits
Open accessAbstract
Living cells have evolved a broad array of complex signalling responses, which enables them to survive diverse environmental challenges and execute specific physiological functions. Our increasingly sophisticated understanding of the molecular mechanisms of cell signalling networks in eukaryotes has revealed a remarkably modular organization and synthetic biologists are exploring how this can be exploited to engineer cells with novel signalling behaviours. This approach is beginning to reveal the logic of how cells might evolve innovative new functions and moves us towards the exciting possibility of engineering custom cells with precise sensing–response functions that could be useful in medicine and biotechnology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene
Choi, K.-W., & Benzer, S. (1994) · Cell · doi:10.1016/0092-8674(94)90579-7 · Cited by 339
Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1
Yu, B., Martins, I. R. S., Li, P., Amarasinghe, G. K., Umetani, J., Fernandez-Zapico, M. E., Billadeau, D. D., Machius, M., Tomchick, D. R., & Rosen, M. K. (2010) · Cell · doi:10.1016/j.cell.2009.12.033 · Cited by 156
Cited by
Genetic circuit design automation
Nielsen, A. A. K., Der, B. S., Shin, J., Vaidyanathan, P., Paralanov, V., Strychalski, E. A., Ross, D., Densmore, D., & Voigt, C. A. (2016) · Science · doi:10.1126/science.aac7341 · Cited by 1,020
Principles of genetic circuit design
Brophy, J. A. N., & Voigt, C. A. (2014) · Nature Methods · doi:10.1038/nmeth.2926 · Cited by 931
Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors
Roybal, K. T., Williams, J. Z., Morsut, L., Rupp, L. J., Kolinko, I., Choe, J. H., Walker, W. J., McNally, K. A., & Lim, W. A. (2016) · Cell · doi:10.1016/j.cell.2016.09.011 · Cited by 721
Self-citationEngineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology
Wang, B., Kitney, R. I., Joly, N., & Buck, M. (2011) · Nature Communications · doi:10.1038/ncomms1516 · Cited by 425
Synthetic biology in mammalian cells: next generation research tools and therapeutics
Lienert, F., Lohmueller, J. J., Garg, A., & Silver, P. A. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3738 · Cited by 280
Metadata
- Authors
- Lim, W. A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2010-05-19
- Volume
- 11
- Issue
- 6
- Pages
- 393-403
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2092059846
- Cited by
- 257
- References
- 2
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Designing customized cell signalling circuits. https://app.cochat.ai/papers/10.1038/nrm2904
- The paper
- Lim, W. A. (2010). Designing customized cell signalling circuits. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm2904
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
