The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Synthetic biology in mammalian cells: next generation research tools and therapeutics
Open accessAbstract
Recent progress in DNA manipulation and gene circuit engineering has greatly improved our ability to programme and probe mammalian cell behaviour. These advances have led to a new generation of synthetic biology research tools and potential therapeutic applications. Programmable DNA-binding domains and RNA regulators are leading to unprecedented control of gene expression and elucidation of gene function. Rebuilding complex biological circuits such as T cell receptor signalling in isolation from their natural context has deepened our understanding of network motifs and signalling pathways. Synthetic biology is also leading to innovative therapeutic interventions based on cell-based therapies, protein drugs, vaccines and gene therapies.
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Cites
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Cited by
Chen, T.-T., Yi, J.-T., Zhao, Y.-Y., & Chu, X. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b04457 · Cited by 462
Control theory meets synthetic biology
Del Vecchio, D., Dy, A. J., & Qian, Y. (2016) · Journal of The Royal Society Interface · doi:10.1098/rsif.2016.0380 · Cited by 283
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
Hess, G. T., Tycko, J., Yao, D., & Bassik, M. C. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.029 · Cited by 234
Systems and synthetic biology approaches to alter plant cell walls and reduce biomass recalcitrance
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Multidisciplinary approach to genomics research in Africa: the AfriCRAN model
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Metadata
- Authors
- Lienert, F., Lohmueller, J. J., Garg, A., & Silver, P. A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2014-01-17
- Volume
- 15
- Issue
- 2
- Pages
- 95-107
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1993018547
- Cited by
- 280
- References
- 142
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Lienert, F., Lohmueller, J. J., Garg, A., & Silver, P. A. (2014). Synthetic biology in mammalian cells: next generation research tools and therapeutics. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm3738
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
