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The prion hypothesis: from biological anomaly to basic regulatory mechanism
Open accessAbstract
Prions are unusual proteinaceous infectious agents that are typically associated with a class of fatal degenerative diseases of the mammalian brain. However, the discovery of fungal prions, which are not associated with disease, suggests that we must now consider the effect of these factors on basic cellular physiology in a different light. Fungal prions are epigenetic determinants that can alter a range of cellular processes, including metabolism and gene expression pathways, and these changes can lead to a range of prion-associated phenotypes. The mechanistic similarities between prion propagation in mammals and fungi suggest that prions are not a biological anomaly but instead could be a newly appreciated and perhaps ubiquitous regulatory mechanism.
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Metadata
- Authors
- Tuite, M. F., & Serio, T. R.
- Affiliations
- University of Kent (GB)
- Brown University (US)
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2010-11-17
- Volume
- 11
- Issue
- 12
- Pages
- 823-833
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC3003427
- OpenAlex
- W1982935057
- Cited by
- 146
- References
- 154
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 13 · 2019: 2 · 2018: 8 · 2017: 10 · 2016: 7 · 2015: 10 · 2014: 14 · 2013: 11 · 2012: 21
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Kent Academic Repository (University of Kent) (submittedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health
- Biotechnology and Biological Sciences Research Council (BB/H012982/1)
- National Institute of General Medical Sciences (R01GM069802)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- prions, fungal prions, epigenetic regulation, prion propagation, neurodegenerative diseases, gene expression regulation
- MeSH terms
- Animals, Cell Physiological Phenomena, Fungi, Gene Expression Regulation, Humans, Models, Biological, Phenotype, Prions, Signal Transduction, Prion Diseases, Epigenesis, Genetic
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