Amino acid signalling upstream of mTOR

Jewell, Jenna L., Russell, Ryan C., Guan, Kun-Liang·2013·Nature Reviews Molecular Cell Biology

Cited by (905)

Items 201–300 of 905

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  2. DAP-kinase and autophagy
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  3. The mTORC1/4E-BP pathway coordinates hemoglobin production with L -leucine availability
    Jacky Chung, Daniel E. Bauer, Alireza Ghamari, Christopher P. Nizzi, Kathryn M. Deck, Paul D. Kingsley, Yvette Y. Yien, Nicholas C. Huston, Caiyong Chen, Iman J. Schultz et al. · 2015 · Science Signaling
  4. Balancing act: matching growth with environment by the TOR signalling pathway
    Rossana Henriques, László Bögre, Beatrix M. Horváth, Zoltán Magyar · 2014 · Journal of Experimental Botany
  5. T cells encountering myeloid cells programmed for amino acid-dependent immunosuppression use Rictor/mTORC2 protein for proliferative checkpoint decisions
    Van de Velde, Lee-Ann, Subramanian, Chitra, Smith, Amber M., Barron, Luke, Qualls, Joseph E., Neale, Geoffrey, Alfonso-Pecchio, Adolfo, Jackowski, Suzanne, Rock, Charles O., Wynn, Thomas A. et al. · 2017 · Journal of Biological Chemistry
  6. Autophagy—from molecular mechanisms to clinical relevance
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  7. Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation
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  8. Recent progress in the study of the Rheb family GTPases
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  9. Curcumin confers hepatoprotection against AFB1-induced toxicity via activating autophagy and ameliorating inflammation involving Nrf2/HO-1 signaling pathway
    Muhammad Ishfaq, Xinghe Wang, Sihong Li, Rui Li, Xiuying Zhang · 2018 · Molecular Biology Reports
  10. A single-molecule electrical approach for amino acid detection and chirality recognition
    Zihao Liu, Xingxing Li, Hiroshi Masai, Xinyi Huang, Susumu Tsuda, Jun Terao, Jinlong Yang, Xuefeng Guo · 2021 · Science Advances
  11. Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice
    Arnaud Francois, Faraj Terro, Nathalie Quellard, Béatrice Fernandez, Damien Chassaing, Thierry Janet, Agnès Rioux Bilan, Marc Paccalin, Guylène Page · 2014 · Molecular Brain
  12. GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling
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  13. Redox regulation of autophagy in healthy brain and neurodegeneration
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  14. Autophagy, Oxidative Stress and Cancer Development
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  15. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
    Tianlong Zhang, Rong Wang, Zhijing Wang, Xiangxiang Wang, Fang Wang, Jianping Ding · 2017 · Nature Communications
  16. The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
    Po‐Yuan Ke · 2018 · International Journal of Molecular Sciences
  17. The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids
    van Sadelhoff, Joris H. J., Perez Pardo, Paula, Wu, Jiangbo, Garssen, Johan, van Bergenhenegouwen, Jeroen, Hogenkamp, Astrid, Hartog, Anita, Kraneveld, Aletta D. · 2019 · Frontiers in Endocrinology
  18. Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation
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  19. This Is the End: Regulation of Rab7 Nucleotide Binding in Endolysosomal Trafficking and Autophagy
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  20. The mTOR Signaling Pathway in Myocardial Dysfunction in Type 2 Diabetes Mellitus
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  21. mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation
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  22. Associations Between Dietary Protein Sources, Plasma BCAA and Short-Chain Acylcarnitine Levels in Adults
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  24. Interleukin-18 up-regulates amino acid transporters and facilitates amino acid–induced mTORC1 activation in natural killer cells
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  25. Phosphorus Availability Regulates TORC1 Signaling via LST8 in Chlamydomonas
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  26. Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
    Zhang, Ya-Kun, Qu, Yuan-Yuan, Lin, Yan, Wu, Xiao-Hui, Chen, Hou-Zao, Wang, Xu, Zhou, Kai-Qiang, Wei, Yun, Guo, Fushen, Yao, Cui-Fang et al. · 2017 · Nature Communications
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  28. Spatial and functional separation of mTORC1 signalling in response to different amino acid sources
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  29. CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model
    Rui-Song Ye, Min Pi, John V. Cox, Satoru Ken Nishimoto, L. Darryl Quarles · 2017 · Journal of Experimental & Clinical Cancer Research
  30. HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner
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  31. V-ATPase/mTOR Signaling Regulates Megalin-Mediated Apical Endocytosis
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  32. Amino Acid Sensing via General Control Nonderepressible-2 Kinase and Immunological Programming
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  33. Dietary sodium acetate improves high-fat diet utilization through promoting differential nutrients metabolism between liver and muscle in Nile tilapia (Oreochromis niloticus)
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  34. Autophagy and cell reprogramming
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  35. A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals
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  36. Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting.
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  38. Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane
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  42. Cardiomyocyte health: adapting to metabolic changes through autophagy
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  43. l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism
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  45. Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state
    Hsiang‐Ting Lei, Jinming Ma, Silvia Sanchez Martinez, Tamir Gonen · 2018 · Nature Structural & Molecular Biology
  46. Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances
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  49. Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane
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  50. Effect of Nutrition on Statural Growth
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  51. mTOR controls kidney epithelia in health and disease
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  52. General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae
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  53. Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition
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  57. Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional Signals
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  58. Role of mTORC1 Controlling Proteostasis after Brain Ischemia
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  59. mTOR and metabolic regulation of conventional and regulatory T cells
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  60. System-L amino acid transporters play a key role in pancreatic β-cell signalling and function
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  61. Rapamycin‐sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary
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  62. Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging
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  63. The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis
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  64. Pharmacological regulators of autophagy and their link with modulators of lupus disease
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  65. Recurrent mutations in the MTOR regulator RRAGC in follicular lymphoma
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  72. Dramatic antitumor effects of the dual mTORC1 and mTORC2 inhibitor AZD2014 in hepatocellular carcinoma.
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  94. Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models
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