T cells encountering myeloid cells programmed for amino acid-dependent immunosuppression use Rictor/mTORC2 protein for proliferative checkpoint decisions

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603 · see citing works

Protective and pathogenic functions of macrophage subsets

Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269 · see citing works

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works

Coordinated regulation of myeloid cells by tumours

Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544 · see citing works

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020 · see citing works

Regulation of immune responses by L-arginine metabolism

Bronte, V., & Zanovello, P. (2005) · Nature Reviews Immunology · doi:10.1038/nri1668 · Cited by 1,775 · see citing works

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Geiger, R., Rieckmann, J. C., Wolf, T., Basso, C., Feng, Y., Fuhrer, T., Kogadeeva, M., Picotti, P., Meissner, F., Mann, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.031 · Cited by 1,775 · see citing works

The role of interleukin-2 during homeostasis and activation of the immune system

Boyman, O., & Sprent, J. (2012) · Nature reviews. Immunology · doi:10.1038/nri3156 · Cited by 1,656 · see citing works

mTOR differentially regulates effector and regulatory T cell lineage commitment

Delgoffe, G. M., Kole, T., Zheng, Y., Zarek, P. E., Matthews, K., Xiao, B., Worley, P., Kozma, S., & Powell, J. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.014 · Cited by 1,293 · see citing works

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B., Worley, P. F., & Powell, J. D. (2011) · Nature Immunology · doi:10.1038/ni.2005 · Cited by 1,111 · see citing works

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

Munn, D. H., & Mellor, A. L. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.10.001 · Cited by 1,037 · see citing works

L-arginine availability regulates T-lymphocyte cell-cycle progression.

Rodriguez, P. C., Quiceno, D. G., & Ochoa, A. C. (2007) · Blood · doi:10.1182/blood-2006-06-031856 · Cited by 926 · see citing works

Amino acid signalling upstream of mTOR

Jewell, J. L., Russell, R. C., & Guan, K.-L. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3522 · Cited by 894 · see citing works

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

Chantranupong, L., Scaria, S. M., Saxton, R. A., Gygi, M. P., Shen, K., Wyant, G. A., Wang, T., Harper, J. W., Gygi, S. P., & Sabatini, D. M. (2016) · Cell · doi:10.1016/j.cell.2016.02.035 · Cited by 843 · see citing works

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M., Wilson, M. S., El Kasmi, K. C., Smith, A. M., Thompson, R. W., Cheever, A. W., Murray, P. J., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000371 · Cited by 816 · see citing works

The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1

Wang, S., Tsun, Z., Wolfson, R. L., Shen, K., Wyant, G., Plovanich, M. E., Yuan, E. D., Jones, T. D., Chantranupong, L., Comb, W. C., et al. (2015) · Science · doi:10.1126/science.1257132 · Cited by 772 · see citing works

LXR signaling couples sterol metabolism to proliferation in the acquired immune response

Bensinger, S. J., Bradley, M. N., Joseph, S. B., Zelcer, N., Janssen, E. M., Hausner, M. A., Shih, R., Parks, J. S., Edwards, P. A., Jamieson, B. D., et al. (2008) · Cell · doi:10.1016/j.cell.2008.04.052 · Cited by 711 · see citing works

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Rebsamen, M., Pochini, L., Stasyk, T., de Araújo, M. E. G., Galluccio, M., Kandasamy, R. K., Snijder, B., Fauster, A., Rudashevskaya, E. L., Bruckner, M., et al. (2015) · Nature · doi:10.1038/nature14107 · Cited by 673 · see citing works

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

El Kasmi, K. C., Qualls, J. E., Pesce, J. T., Smith, A. M., Thompson, R. W., Henao-Tamayo, M., Basaraba, R. J., König, T., Schleicher, U., Koo, M.-S., et al. (2008) · Nature Immunology · doi:10.1038/ni.1671 · Cited by 646 · see citing works

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

Huang, S., Rutkowsky, J. M., Snodgrass, R. G., Ono‐Moore, K. D., Schneider, D. A., Newman, J. W. I., Adams, S. H., & Hwang, D. H. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d029546 · Cited by 591 · see citing works

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

Levin, A. M., Bates, D. L., Ring, A. M., Krieg, C., Lin, J. T., Su, L., Moraga, I., Raeber, M. E., Bowman, G. R., Novick, P. A., et al. (2012) · Nature · doi:10.1038/nature10975 · Cited by 552 · see citing works

IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice

Bronte, V., Serafini, P., Santo, C. D., Marigo, I., Tosello, V., Mazzoni, A., Segal, D. M., Staib, C., Löwel, M., Sutter, G., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.270 · Cited by 513 · see citing works

l -Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes

Rodrı́guez, P. C., Zea, A. H., DeSalvo, J., Culotta, K. S., Zabaleta, J., Quiceno, D. G., Ochoa, J. B., & Ochoa, A. C. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.3.1232 · Cited by 494 · see citing works

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2

Demetriades, C., Doumpas, N., & Teleman, A. A. (2014) · Cell · doi:10.1016/j.cell.2014.01.024 · Cited by 412 · see citing works

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

Keller, T. L., Zocco, D., Sundrud, M. S., Hendrick, M., Edenius, M., Yum, J., Kim, Y. J., Lee, H., Cortese, J. F., Wirth, D. F., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.790 · Cited by 395 · see citing works

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

Yang, K., Shrestha, S., Zeng, H., Karmaus, P. W. F., Neale, G. A. M., Vogel, P., Guertin, D. A., Lamb, R. F., & Chi, H. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.015 · Cited by 389 · see citing works

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

Gundra, U. M., Girgis, N. M., Ruckerl, D., Jenkins, S., Ward, L. N., Kurtz, Z. D., Wiens, K. E., Tang, M. S., Basu-Roy, U., Mansukhani, A., et al. (2014) · Blood · doi:10.1182/blood-2013-08-520619 · Cited by 371 · see citing works

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

Cobbold, S. P., Adams, E., Farquhar, C. A., Nolan, K. F., Howie, D., Lui, K. O., Fairchild, P. J., Mellor, A. L., Ron, D., & Waldmann, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903919106 · Cited by 336 · see citing works

Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production

Rutschman, R. L., Lang, R., Hesse, M., Ihle, J. N., Wynn, T. A., & Murray, P. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2173 · Cited by 324 · see citing works

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

Saxton, R., Chantranupong, L., Knockenhauer, K., Schwartz, T., & Sabatini, D. (2016) · Nature · doi:10.1038/nature19079 · Cited by 301 · see citing works

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

Yang, K., Neale, G. A. M., Green, D. R., He, W., & Chi, H. (2011) · Nature Immunology · doi:10.1038/ni.2068 · Cited by 294 · see citing works

Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via l -Arginine Metabolism

Norian, L. A., Rodrı́guez, P. C., O’Mara, L. A., Zabaleta, J., Ochoa, A. C., Cella, M., & Allen, P. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2826 · Cited by 270 · see citing works

Amino acid auxotrophy as a system of immunological control nodes

Murray, P. J. (2016) · Nature Immunology · doi:10.1038/ni.3323 · Cited by 248 · see citing works

Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2

Huber, S., Hoffmann, R. F. G., Muskens, F., & Voehringer, D. (2010) · Blood · doi:10.1182/blood-2010-02-271981 · Cited by 207 · see citing works

T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells

Marigo, I., Zilio, S., Desantis, G., Mlecnik, B., Agnellini, A. H. R., Ugel, S., Sasso, M. S., Qualls, J. E., Kratochvill, F., Zanovello, P., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.08.004 · Cited by 204 · see citing works

Regulation of T cells by mTOR: the known knowns and the known unknowns

Pollizzi, K. N., & Powell, J. D. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.11.005 · Cited by 196 · see citing works

Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1

Qualls, J. E., Subramanian, C., Rafi, W., Smith, A. M., Balouzian, L., DeFreitas, A. A., Shirey, K. A., Reutterer, B., Kernbauer, E., Stockinger, S., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.07.012 · Cited by 184 · see citing works

Macrophage activation governs schistosomiasis‐induced inflammation and fibrosis

Barron, L., & Wynn, T. A. (2011) · European Journal of Immunology · doi:10.1002/eji.201141869 · Cited by 183 · see citing works

Translational Control of Inducible Nitric Oxide Synthase by IL-13 and Arginine Availability in Inflammatory Macrophages

El-Gayar, S., Thüring, H., Pfeilschifter, J. M., Röllinghoff, M., & Bogdan, C. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4561 · Cited by 180 · see citing works

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

Carroll, B., Maetzel, D., Maddocks, O., Otten, G., Ratcliff, M., Smith, G. R., Dunlop, E., Passos, J., Davies, O. R., Jaenisch, R., et al. (2016) · eLife · doi:10.7554/elife.11058 · Cited by 177 · see citing works

Coordination of Lipid Metabolism in Membrane Biogenesis

Nohturfft, A., & Zhang, S. C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175344 · Cited by 175 · see citing works

Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity

Offman, M. N., Król, M., Patel, N. R., Krishnan, S., Liu, J., Saha, V., & Bates, P. A. (2010) · Blood · doi:10.1182/blood-2010-07-298422 · Cited by 164 · see citing works

Distinct Dimer Interaction and Regulation in Nitric-oxide Synthase Types I, II, and III

Panda, K., Rosenfeld, R. J., Ghosh, S., Meade, A. L., Getzoff, E. D., & Stuehr, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203749200 · Cited by 126 · see citing works

Arginase I Suppresses IL-12/IL-23p40–Driven Intestinal Inflammation during Acute Schistosomiasis

Herbert, D. R., Orekov, T., Roloson, A., Ilies, M., Perkins, C. L., O’Brien, W. E., Cederbaum, S. D., Christianson, D. W., Zimmermann, N., Rothenberg, M. E., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902009 · Cited by 125 · see citing works

Incomplete Deletion of IL-4Rα by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

Vannella, K., Barron, L., Borthwick, L., Kindrachuk, K. N., Narasimhan, P., Hart, K. M., Thompson, R. W., White, S., Cheever, A., Ramalingam, T., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004372 · Cited by 108 · see citing works

Microenvironmental arginine depletion by macrophages in vivo

Currie, G. A., Gyure, L. A., & Cifuentes, L. (1979) · British Journal of Cancer · doi:10.1038/bjc.1979.112 · Cited by 95 · see citing works

Ly6Chi Monocyte Recruitment Is Responsible for Th2 Associated Host-Protective Macrophage Accumulation in Liver Inflammation due to Schistosomiasis

Nascimento, M., Huang, S. C., Smith, A. M., Everts, B., Lam, W. Y., Bassity, E., Gautier, E. L., Randolph, G. J., & Pearce, E. J. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004282 · Cited by 90 · see citing works

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8 + T Cells

Ross, S. H., Rollings, C., Anderson, K. E., Hawkins, P. T., Stephens, L. R., & Cantrell, D. A. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.022 · Cited by 89 · see citing works

Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation

Barron, L., Smith, A. M., Kasmi, K. C. E., Qualls, J. E., Huang, X., Cheever, A. W., Borthwick, L. A., Wilson, M. S., Murray, P. J., & Wynn, T. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061961 · Cited by 84 · see citing works

Induced arginine transport via cationic amino acid transporter‐1 is necessary for human T‐cell proliferation

Werner, A., Amann, E., Schnitzius, V., Habermeier, A., Luckner‐Minden, C., Leuchtner, N., Rupp, J., Closs, E. I., & Munder, M. (2015) · European Journal of Immunology · doi:10.1002/eji.201546047 · Cited by 82 · see citing works

Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing

de Velde, L.-A. V., Guo, X.-Z. J., Barbaric, L., Smith, A. M., Oguin, T. H., Thomas, P. G., & Murray, P. J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.079 · Cited by 82 · see citing works

Modulation of human lymphocyte proliferation by amino acids

Chuang, J.-L., YU, C. L., & WANG, S. R. (1990) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1990.tb05310.x · Cited by 55 · see citing works

CAT2 arginine transporter deficiency significantly reduces iNOS‐mediated NO production in astrocytes

Manner, C. K., Nicholson, B., & MacLeod, C. L. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01695.x · Cited by 53 · see citing works

Activation of muscarinic cholinergic receptors enhances the volume‐sensitive efflux of myo‐inositol from SH‐SY5Y neuroblastoma cells

Loveday, D., Heacock, A. M., & Fisher, S. K. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02021.x · Cited by 39 · see citing works

Proliferating Helper T Cells Require Rictor/mTORC2 Complex to Integrate Signals from Limiting Environmental Amino Acids

de Velde, L.-A. V., & Murray, P. J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.c116.763623 · Cited by 33 · see citing works

Restriction of Chlamydia pneumoniae replication in human dendritic cell by activation of indoleamine 2,3-dioxygenase

Njau, F., Geffers, R., Thalmann, J., Haller, H. G., & Wagner, A. D. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.07.006 · Cited by 32 · see citing works

Coupled IL-2–Dependent Extracellular Feedbacks Govern Two Distinct Consecutive Phases of CD4 T Cell Activation

Waysbort, N., Russ, D., Chain, B., & Friedman, N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301575 · Cited by 31 · see citing works

CD4+ TCR Repertoire Heterogeneity in Schistosoma mansoni-Induced Granulomas

Hogan, L. H., Wang, M., Suresh, M., Co, D. O., Weinstock, J. V., & Sándor, M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.11.6386 · Cited by 31 · see citing works

IL-2-dependent induction of G1 cyclins in primary T cells is not blocked by rapamycin or cyclosporin A

Turner, J. M. (1993) · International Immunology · doi:10.1093/intimm/5.10.1199 · Cited by 30 · see citing works

Pancreatic cancer: Advances and challenges

Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works

Extracellular vesicles in immunomodulation and tumor progression

Marar, C., Starich, B., & Wirtz, D. (2021) · Nature Immunology · doi:10.1038/s41590-021-00899-0 · Cited by 597 · see citing works

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

Steggerda, S. M., Bennett, M. K., Chen, J., Emberley, E. D., Huang, T. C., Janes, J. R., Li, W., MacKinnon, A. L., Makkouk, A., Marguier, G. M., et al. (2017) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-017-0308-4 · Cited by 488 · see citing works

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

Renner, K., Singer, K., Koehl, G. E., Geissler, E. K., Peter, K., Siska, P. J., & Kreutz, M. P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00248 · Cited by 378 · see citing works

Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

Yang, L., Chu, Z., Liu, M., Zou, Q., Li, J., Liu, Q., Wang, Y., Wang, T., Xiang, J., & Wang, B. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01453-1 · Cited by 363 · see citing works

Metabolic orchestration of the wound healing response

Eming, S. A., Murray, P. J., & Pearce, E. J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.017 · Cited by 319 · see citing works

Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma

Czystowska, M., Sosnowska, A., Nowis, D., Ramji, K., Szajnik, M. E., Chlebowska, J., Wolińska, E., Gaj, P., Grażul, M., Pilch, Z., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10979-3 · Cited by 315 · see citing works

Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment

Tharp, K. M., Kersten, K., Maller, O., Timblin, G. A., Stashko, C., Canale, F. P., Menjivar, R. E., Hayward, M.-K., Berestjuk, I., ten Hoeve, J., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00775-4 · Cited by 304 · see citing works

Arginine Metabolism in Myeloid Cells Shapes Innate and Adaptive Immunity

Rodrı́guez, P. C., Ochoa, A. C., & Al-Khami, A. A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00093 · Cited by 287 · see citing works

Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

Harris, N. L., & Loke, P. (2017) · Immunity · doi:10.1016/j.immuni.2017.11.015 · Cited by 211 · see citing works

mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions

Huang, H., Long, L., Zhou, P., Chapman, N. M., & Chi, H. (2020) · Immunological Reviews · doi:10.1111/imr.12845 · Cited by 193 · see citing works

Altered cancer metabolism in mechanisms of immunotherapy resistance

Ramapriyan, R., Caetano, M. S., Barsoumian, H. B., Mafra, A. C. P., Zambalde, É. P., Menon, H., Tsouko, E., Welsh, J. W., & Cortez, M. A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.11.004 · Cited by 171 · see citing works

B7-H3 Suppresses Antitumor Immunity via the CCL2–CCR2–M2 Macrophage Axis and Contributes to Ovarian Cancer Progression

Miyamoto, T., Murakami, R., Hamanishi, J., Tanigaki, K., Hosoe, Y., Mise, N., Takamatsu, S., Mise, Y., Ukita, M., Taki, M., et al. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0407 · Cited by 154 · see citing works

Wnt Signaling in Cancer Metabolism and Immunity

El‐Sahli, S., Xie, Y., Wang, L., & Liu, S. (2019) · Cancers · doi:10.3390/cancers11070904 · Cited by 123 · see citing works

Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats

Munshi, S., Loh, M. K., Ferrara, N., DeJoseph, M. R., Ritger, A., Padival, M., Record, M. J., Urban, J. H., & Rosenkranz, J. A. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.11.023 · Cited by 117 · see citing works

B7-H3 Suppresses Antitumor Immunity via the CCL2–CCR2–M2 Macrophage Axis and Contributes to Ovarian Cancer Progression

Miyamoto, T., Murakami, R., Hamanishi, J., Tanigaki, K., Hosoe, Y., Mise, N., Takamatsu, S., Mise, Y., Ukita, M., Taki, M., et al. (2022) · Institutional Repositories DataBase (IRDB) · doi:10.14989/doctor.k23801 · Cited by 112 · see citing works

IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer

Zeitler, L., & Murray, P. J. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104827 · Cited by 95 · see citing works

Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression

Werner, A., Koschke, M., Leuchtner, N., Luckner‐Minden, C., Habermeier, A., Rupp, J., Heinrich, C., Conradi, R., Closs, E. I., & Munder, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00864 · Cited by 98 · see citing works

Turning cold tumors into hot tumors to ignite immunotherapy

Liu, Y., Wang, Y., Wang, S., Li, J., He, W. A., Fan, X.-J., & Wan, X. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02477-6 · Cited by 107 · see citing works

Nutrients: Signal 4 in T cell immunity

Raynor, J. L., & Chi, H. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20221839 · Cited by 94 · see citing works

Metabolic features of macrophages in inflammatory diseases and cancer

Na, Y. R., Je, S., & Seok, S. H. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.10.044 · Cited by 94 · see citing works

De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function

Wu, R., Chen, X., Kang, S., Wang, T., Gnanaprakasam, J. R., Yao, Y., Liu, L., Zheng, S. G., Fan, G., Burns, M. R., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc4275 · Cited by 87 · see citing works

Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy

Lv, Y., Li, Z., Liu, S., Zhou, Z., Jinling, S., Ba, Y., Weng, S., Zuo, A., Xu, H. W., Luo, P., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02407-6 · Cited by 83 · see citing works

Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion

Chen, F., El-Naccache, D. W., Ponessa, J. J., Lemenze, A. D., Espinosa, V., Wu, W., Lothstein, K. E., Jin, L., Antao, O. Q., Weinstein, J. S., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110215 · Cited by 61 · see citing works

Immunometabolism of tumor-associated macrophages: A therapeutic perspective

Karimova, A. F., Khalitova, A. R., Suezov, R. V., Markov, N., Mukhamedshina, Y. O., Rizvanov, A. A., Huber, M., Simon, H., & Brichkina, A. I. (2025) · European Journal of Cancer · doi:10.1016/j.ejca.2025.115332 · Cited by 64 · see citing works

Novel high‐docosahexaenoic‐acid tuna oil supplementation modulates gut microbiota and alleviates obesity in high‐fat diet mice

Zhang, J., Yi, C., Han, J., Ming, T., Zhou, J., Lu, C., Li, Y., & Su, X. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1941 · Cited by 57 · see citing works

Spatially mapping the tumour immune microenvironments of non-small cell lung cancer

Desharnais, L., Sorin, M., Rezanejad, M., Liu, B., Karimi, E., Atallah, A., Swaby, A. M., Yu, M. W., Doré, S., Hartner, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56546-x · Cited by 58 · see citing works

Boronic acid-based arginase inhibitors in cancer immunotherapy

Borek, B., Gajda, T., Gołȩbiowski, A., & Błaszczyk, R. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115658 · Cited by 54 · see citing works

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

Biswas, A., Shouval, D. S., Griffith, A. E., Goettel, J. A., Field, M., Kang, Y. H., Konnikova, L., Janssen, E., Redhu, N. S., Thrasher, A. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03670-6 · Cited by 51 · see citing works

Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1–Dependent Myeloid Cells

de Velde, L.-A. V., Allen, E. K., Crawford, J. C., Wilson, T. L., Guy, C. S., Russier, M., Zeitler, L., Bahrami, A., Finkelstein, D., Pelletier, S. W., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0691 · Cited by 50 · see citing works

Interrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer

Sanctis, F. D., Lamolinara, A., Boschi, F., Musiu, C., Caligola, S., Trovato, R., Fiore, A., Frusteri, C., Anselmi, C., Poffe, O., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003549 · Cited by 46 · see citing works

Helminth Infections Induce Tissue Tolerance Mitigating Immunopathology but Enhancing Microbial Pathogen Susceptibility

Yap, G. S., & Gause, W. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02135 · Cited by 41 · see citing works

The Adaptive Complexity of Cancer

Derbal, Y. (2018) · BioMed Research International · doi:10.1155/2018/5837235 · Cited by 40 · see citing works

Integrating T cell metabolism in cancer immunotherapy

Dugnani, E., Pasquale, V., Bordignon, C., Canu, A., Piemonti, L., & Monti, P. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.09.039 · Cited by 38 · see citing works

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells

Kim, Y., Sundrud, M. S., Zhou, C., Edenius, M., Zocco, D., Powers, K., Zhang, M., Mazitschek, R., Rao, A., Yeo, C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913788117 · Cited by 40 · see citing works

Yogurt-sourced probiotic bacteria alleviate shrimp tropomyosin-induced allergic mucosal disorders, potentially through microbiota and metabolism modifications

Fu, L., Fu, S., Wang, C., Xie, M., & Wang, Y. (2019) · Allergology International · doi:10.1016/j.alit.2019.05.013 · Cited by 37 · see citing works

Dynamic polarization of tumor-associated macrophages and their interaction with intratumoral T cells in an inflamed tumor microenvironment: from mechanistic insights to therapeutic opportunities

Han, J., Dong, L., Wu, M., & Ma, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1160340 · Cited by 35 · see citing works

Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth

Badeaux, M. D., Rolig, A. S., Agnello, G., Enzler, D., Kasiewicz, M. J., Priddy, L., Wiggins, J. F., Muir, A., Sullivan, M. R., Cleef, J. V., et al. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0317 · Cited by 33 · see citing works

Preparation and purification of an immunoregulatory peptide from Stolephorus chinensis of the East Sea of China

Xu, B., Ye, L., Tang, Y., Zheng, J., Tian, X., Yang, Y., & Yang, Z. (2020) · Process Biochemistry · doi:10.1016/j.procbio.2020.08.011 · Cited by 30 · see citing works

Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1

Paduch, K., Debus, A., Rai, B., Schleicher, U., & Bogdan, C. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801249 · Cited by 29 · see citing works

Tumor Immune Microenvironment in Gynecologic Cancers

Margul, D. J., Yu, C., & AlHilli, M. M. (2023) · Cancers · doi:10.3390/cancers15153849 · Cited by 24 · see citing works

l-Citrulline Metabolism in Mice Augments CD4+ T Cell Proliferation and Cytokine Production In Vitro, and Accumulation in the Mycobacteria-Infected Lung

Lange, S., McKell, M. C., Schmidt, S., Hossfeld, A. P., Chaturvedi, V., Kinder, J. M., McAlees, J. W., Lewkowich, I. P., Way, S. S., Turner, J., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01561 · Cited by 25 · see citing works

Worms: Pernicious parasites or allies against allergies?

McSorley, H. J., Chayé, M. A. M., & Smits, H. H. (2018) · Parasite Immunology · doi:10.1111/pim.12574 · Cited by 25 · see citing works

Perioperative arginine prevents metastases by accelerating natural killer cell recovery after surgery

Angka, L., de Souza, C. T., Baxter, K. E., Khan, S., Market, M., Martel, A. B., Tai, L., Kennedy, M. A., Bell, J. C., & Auer, R. C. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.05.024 · Cited by 22 · see citing works

Precision Targeting Strategies in Pancreatic Cancer: The Role of Tumor Microenvironment

Vitorakis, N., Gargalionis, A. N., Papavassiliou, K. A., Adamopoulos, C., & Papavassiliou, A. G. (2024) · Cancers · doi:10.3390/cancers16162876 · Cited by 22 · see citing works

Metabolic manipulation of the tumour immune microenvironment

Wan, M., Ding, Y., Li, Z., Wang, X., & Xu, M. (2021) · Immunology · doi:10.1111/imm.13444 · Cited by 20 · see citing works

Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF

Dichtl, S., Sanin, D. E., Koss, C. K., Willenborg, S., Petzold, A., Tanzer, M. C., Dahl, A., Kabat, A. M., Lindenthal, L., Zeitler, L., et al. (2022) · Life Science Alliance · doi:10.26508/lsa.202101315 · Cited by 18 · see citing works

Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis

Lercher, A., Popa, A., Viczenczová, C., Kosack, L., Klavins, K., Agerer, B., Opitz, C. A., Lanz, T. V., Platten, M., & Bergthaler, A. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008973 · Cited by 18 · see citing works

Metabolic orchestration of T lineage differentiation and function

Yong, C. S. M., Moussa, D. A., Cretenet, G., Kinet, S., Dardalhon, V., & Taylor, N. N. (2017) · FEBS Letters · doi:10.1002/1873-3468.12849 · Cited by 16 · see citing works

Detection and functional evaluation of arginase-1 isolated from human PMNs and murine MDSC

Canè, S., & Bronte, V. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.07.022 · Cited by 16 · see citing works

Expanding TOR Complex 2 Signaling: Emerging Regulators and New Connections

An, P., Xu, W., Luo, J., & Luo, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.713806 · Cited by 15 · see citing works

Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners

Doshi, A. S., Cantin, S., Hernandez, M., Srinivasan, S. S., Tentarelli, S., Griffin, M., Wang, Y., Pop-Damkov, P., Prickett, L. B., Kankkonen, C., et al. (2023) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-22-0431 · Cited by 13 · see citing works

Metabolic landscape of the healthy pancreas and pancreatic tumor microenvironment

Bonilla, M. E., Radyk, M. D., Perricone, M. D., Elhossiny, A. M., Harold, A. C., Medina-Cabrera, P. I., Kadiyala, P., Shi, J., Frankel, T. L., Carpenter, E. S., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.180114 · Cited by 12 · see citing works

Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress

Scaglione, M., Knight, M., Trihemasava, K., Rome, K., Archambault, A., Oh, J., Tanaka, E., Hall, E., Le, T. N. V., Lines, C. L., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.04.004 · Cited by 10 · see citing works

Myeloid mechano-metabolic programming restricts anti-tumor immunityPreprint

Tharp, K. M., Kersten, K., Maller, O., Timblin, G. A., Stashko, C., Canale, F. P., Hayward, M.-K., Berestjuk, I., ten Hoeve-Scott, J., Samad, B., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.14.499764 · Cited by 8 · see citing works

Heyndrickxia coagulans as a next-generation probiotic: current evidence and future perspectives

Ke, S., Chen, Z., Qi, Y., Zhang, J., Chen, Q., Chen, J., & Bo, H. (2025) · Food & Function · doi:10.1039/d5fo03559g · Cited by 7 · see citing works

Systematic analysis of TREM2 and its carcinogenesis in pancreatic cancer

Zheng, W., Yu, W., Hua, R., He, J., Wu, N., Tian, S., Huang, W., & Qin, L. (2024) · Translational Cancer Research · doi:10.21037/tcr-24-201 · Cited by 6 · see citing works

Bcl-6 expression by CD4+ T cells determines concomitant immunity and host resistance across distinct parasitic infections

Meli, A. P., Russell, G. A., Swaminathan, S., Weichselbaum, L., MacMahon, C. A., Pernet, E., Karo‐Atar, D., Rogers, D., Rochette, A., Fontès, G., et al. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.08.004 · Cited by 5 · see citing works

Immunological roulette: Luck or something more? Considering the connections between host and environment in TB

Pearl, J. E., Das, M., & Cooper, A. M. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.145 · Cited by 4 · see citing works

The regulatory role and mechanism of energy metabolism and immune response in head and neck cancer

Li, H., Qiu, P., Oyang, L., Yang, W., Li, S., Han, Y., Peng, M., Tan, S., Xia, L., Lin, J., et al. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101607 · Cited by 3 · see citing works

Differential cell survival outcomes in response to diverse amino acid stress

Russier, M., Fiore, A., Bici, A., Groß, A., Tanzer, M., Yeroslaviz, A., Mann, M., & Murray, P. J. (2025) · Life Science Alliance · doi:10.26508/lsa.202503324 · Cited by 3 · see citing works

Tumor–immune metabolic tug-of-war: from immune escape to targeting metabolic rewiring in cancer therapy

Foglia, B., Nurcis, J., Signorini, M., & Cannito, S. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1823145 · Cited by 3 · see citing works

Biosynthetic plasticity enables CD8+ T cell functional resilience under nutrient stressPreprint

Scaglione, M., Knight, M., Trihemasava, K., Rome, K., Archambault, A., Oh, J., Tanaka, E., Hall, E., Le, T. N. V., Lines, C. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.22.632829 · Cited by 3 · see citing works

Mapping the immune landscape of PCa: From tumor microenvironment to therapeutics

Huang, S., Ou, Y., Zhuang, W., Huang, J., Wang, B., Li, Z., & Huang, H. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189586 · Cited by 2 · see citing works

Monocyte-Derived Alveolar Macrophages Mediate Resistance to Migrating Helminths Through Depletion of Arginine AvailabilityPreprint

Chen, F., El-Naccache, D. W., Ponessa, J. J., Lemenze, A. D., Espinosa, V., Wu, W., Lothstein, K. E., Jin, L., Rivera, A., Siracusa, M. C., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3725764 · Cited by 1 · see citing works

Lung macrophages mediate helminth resistance through differential activation of recruited monocyte-derived alveolar macrophages and arginine depletionPreprint

Chen, F., El-Naccache, D. W., Ponessa, J. J., Lemenze, A. D., Espinosa, V., Wu, W., Lothstein, K. E., Jin, L., Antao, O. Q., Weinstein, J. S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.02.322388 · Cited by 1 · see citing works

Rictor CRISPR Gene Editing by Lipid Nanoparticle Delivery Stimulates Anti-tumor Immunity in Breast Cancer Liver Metastasis ModelPreprint

Ali, Y., Galbraith, T., Abdelfattah, N., Žiemys, A., Wong, T. L., Hashimoto, C., Faisal, M., Xu, Q., Cook, H., Pandita, T. K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.26.661471 · Cited by 1 · see citing works

Proteomic changes in the extracellular environment of sea bass thymocytes exposed to 17α-ethinylestradiol in vitro.

Moreira, C., Hétru, J., Paiola, M., Duflot, A., Chan, P., Vaudry, D., Pinto, P., Monsinjon, T., & Knigge, T. (2021) · Comparative Biochemistry and Physiology - Part D:Genomics and Proteomics · doi:10.1016/j.cbd.2021.100911 · Cited by 1 · see citing works

[Commemorative stamps for the International Year of the Handicapped --classified according to rehabilitative aspects].

Bläsig, W. (1983) · PubMed

Data from Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth

Badeaux, M. D., Rolig, A. S., Agnello, G., Enzler, D., Kasiewicz, M. J., Priddy, L., Wiggins, J. F., Muir, A., Sullivan, M. R., Cleef, J. V., et al. (2023) · doi:10.1158/2326-6066.c.6550171

Data from Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth

Badeaux, M. D., Rolig, A. S., Agnello, G., Enzler, D., Kasiewicz, M. J., Priddy, L., Wiggins, J. F., Muir, A., Sullivan, M. R., Cleef, J. V., et al. (2023) · doi:10.1158/2326-6066.c.6550171.v1

Therapeutic Potential of Extracellular Vesicles from Different Cell Sources

Wang, X., & Li, Z. (2023) · doi:10.1002/9783527842155.ch3

Kynurenine Metabolism Mediates Tumor Progression in Renal Cell CarcinomaPreprint

Miller, K. M., Rounseville, S. P., Castro-Portuguez, R., Railey, R., Dang, H. T. L., Dundore, K., Espejo, L. S., Freitas, S., & Sutphin, G. L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.10.705186

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

张晓娟, Liu, Y., Hou, Y., & Niu, H. (2026) · MedComm · doi:10.1002/mco2.70884

Research progress on the interconnected network of mitophagy and energy metabolism in tumors

赵康杓, Du, Y., Fang, J., Cao, M., & Wang, X. (2026) · ONCOLOGIE · doi:10.1515/oncologie-2026-0244

BindingDB Entry 50012858: Boronic acid-based arginase inhibitors in cancer immunotherapy.

BindingDB (2022) · UC San Diego · doi:10.7270/q2ws8xzc

Arginine metabolism and sensing by mTOR in T cells

Senkevitch, E., Frauwirth, K. A., Tuchman, M., & Bequette, B. J. (2011) · The FASEB Journal · doi:10.1096/fasebj.25.1_supplement.918.3

Proliferating Helper T Cells Require Rictor/mTORC2 Complex to Integrate Signals from Limiting Environmental Amino Acids

de Velde, L.-A. V., & Murray, P. J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.c116.763623 · Cited by 33 · see citing works

Low Arginine Confers Immunosuppressive Properties Upon Activated CD4 T Cells via Metabolic and Transcriptional ReprogrammingPreprint

Zou, Z., Cheng, Q., Zhou, J., Guo, C., Hadjinicolaou, A. V., Salio, M., Liang, X., Du, Y., Yao, W., Wang, D., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4505991

ATF4-SLC7A11-GSH axis mediates the acquisition of immunosuppressive properties by activated CD4+ T cells in low arginine condition

Zou, Z., Cheng, Q., Zhou, J., Guo, C., Hadjinicolaou, A. V., Salio, M., Liang, X., Yang, C., Du, Y., Yao, W., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113995 · Cited by 69 · see citing works

L-arginine metabolism in myeloid cells controls T-lymphocyte functions

Bronte, V., Serafini, P., Mazzoni, A., Segal, D. M., & Zanovello, P. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00132-7 · Cited by 588 · see citing works