Appreciating force and shape—the rise of mechanotransduction in cell biology

Iskratsch, Thomas; Wolfenson, Haguy; Sheetz, Michael P.

doi:10.1038/nrm3903

Cited by 798Cellular Mechanics and InteractionsHippo pathway signaling and YAP/TAZForce Microscopy Techniques and Applications

Appreciating force and shape—the rise of mechanotransduction in cell biology

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Iskratsch, Thomas, Wolfenson, Haguy, Sheetz, Michael P.·2014·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm3903PMC PMC9339222

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Abstract

Although the shapes of organisms are encoded in their genome, the developmental processes that lead to the final form of vertebrates involve a constant feedback between dynamic mechanical forces, and cell growth and motility. Mechanobiology has emerged as a discipline dedicated to the study of the effects of mechanical forces and geometry on cell growth and motility—for example, during cell-matrix adhesion development—through the signalling process of mechanotransduction.

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Cells such as macrophages actively interact with their mechanical environment and modulate their inflammatory activity in response.
“Cells such as macrophages are known to actively interact with their mechanical environment and modulate their inflammatory activity in response (Iskratsch et al., 2014).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Iskratsch et al., 2014
The Abstract describes cells dynamically interacting with mechanical aspects of their microenvironment, and Future perspective and conclusions says cells actively test that environment and respond to it. Neither passage establishes the claim specifically for macrophages or says that mechanical cues modulate their inflammatory activity. (LLM, conf=0.85)
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Authors: Iskratsch, T., Wolfenson, H., & Sheetz, M. P.
Affiliations: Columbia University (US)
National University of Singapore (SG)
Corresponding author: Sheetz, Michael P.
ORCID: Iskratsch, Thomas
Wolfenson, Haguy
Sheetz, Michael P.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2014-10-30
Volume: 15
Issue: 12
Pages: 825-833
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm3903
PMC: PMC9339222
OpenAlex: W1970570245
Cited by: 798
References: 125
Citations by year: 2026: 46 · 2025: 61 · 2024: 76 · 2023: 73 · 2022: 90 · 2021: 80 · 2020: 77 · 2019: 71 · 2018: 73 · 2017: 62 · 2016: 48 · 2015: 39 · 2014: 2
FWCI: 5.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: National Institute of Biomedical Imaging and Bioengineering (R01EB001480)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Force Microscopy Techniques and Applications
Keywords: mechanotransduction, mechanobiology, mechanical forces, cell shape, cell growth, cell motility, cell-matrix adhesion, developmental forms, geometry
MeSH terms: Animals, Biomechanical Phenomena, Cell Biology, Extracellular Matrix, Mechanotransduction, Cellular, History, 20th Century, History, 21st Century

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Appreciating force and shape—the rise of mechanotransduction in cell biology

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