Cited by 201Metalloenzymes and iron-sulfur proteinsMitochondrial Function and PathologyEnzyme Structure and Function

Mammalian iron-sulphur proteins: novel insights into biogenesis and function

Rouault, Tracey A.·2015·Nature Reviews Molecular Cell Biology

Abstract

Iron-sulphur (Fe-S) clusters are inorganic cofactors that are found in nearly all species and are composed of various combinations of iron and sulphur atoms. Fe-S clusters can accept or donate single electrons to carry out oxidation and reduction reactions and to facilitate electron transport. Many details of how these complex modular structures are assembled and ligated to cellular proteins in the mitochondrial, nuclear and cytosolic compartments of mammalian cells remain unclear. Recent evidence indicates that a Leu-Tyr-Arg (LYR) tripeptide motif found in some Fe-S recipient proteins may facilitate the direct and shielded transfer of Fe-S clusters from a scaffold to client proteins. Fe-S clusters are probably an unrecognized and elusive cofactor of many known proteins.

Integrity signals

Registry

Crossref · 10.1038/nrm3909

Cites

112 of 112 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Rouault, T. A.
Affiliations
National Institutes of Health (US)
Corresponding author
Rouault, Tracey A.
Venue
Nature Reviews Molecular Cell Biology
Published
2014-11-26
Volume
16
Issue
1
Pages
45-55
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W1964601437
Cited by
201
References
112
Citations by year
2026: 10 · 2025: 16 · 2024: 17 · 2023: 8 · 2022: 12 · 2021: 17 · 2020: 17 · 2019: 20 · 2018: 23 · 2017: 27 · 2016: 19 · 2015: 15
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Metalloenzymes and iron-sulfur proteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
Keywords
iron-sulfur clusters, iron-sulfur proteins, iron-sulfur cluster assembly, electron transfer, mammalian cells, mitochondrial proteins, cytosolic proteins, nuclear proteins
MeSH terms
Animals, Electron Transport, Humans, Iron-Sulfur Proteins, Oxidation-Reduction, Amino Acid Motifs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review