Cited by 1,158Cancer-related Molecular PathwaysGenomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

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Sibling rivalry in the E2F family

Trimarchi, Jeffrey M., Lees, Jacqueline A.·2002·Nature Reviews Molecular Cell Biology

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Abstract

The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me-pull-you' regulation, and what are its biological consequences?

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Authors: Trimarchi, J. M., & Lees, J. A.
Affiliations: Massachusetts Institute of Technology (US)
Corresponding author: Lees, Jacqueline A.
ORCID: Trimarchi, Jeffrey M.
Lees, Jacqueline A.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2002-01
Volume: 3
Issue: 1
Pages: 11-20
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm714
OpenAlex: W2791873134
Cited by: 1,158
References: 133
Citations by year: 2026: 8 · 2025: 17 · 2024: 19 · 2023: 21 · 2022: 27 · 2021: 29 · 2020: 43 · 2019: 42 · 2018: 20 · 2017: 39 · 2016: 35 · 2015: 31 · 2014: 27 · 2013: 51 · 2012: 62
FWCI: 9.83
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: E2F transcription factors, cell cycle regulation, cell proliferation, cell cycle exit, terminal differentiation, cell division, transcriptional regulation
MeSH terms: Animals, Cell Cycle, Cell Differentiation, Cell Division, Chromatin, DNA-Binding Proteins, Gene Expression Regulation, Humans, Models, Genetic, Neoplasms, Transcription Factors, Retinoblastoma Protein, Apoptosis, Protein Structure, Tertiary, Cell Cycle Proteins, E2F Transcription Factors, E2F6 Transcription Factor, Mice

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