Cited by 1,158Cancer-related Molecular PathwaysGenomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 132 of the 133 references it cites were found in a registry or an index.

Sibling rivalry in the E2F family

Trimarchi, Jeffrey M., Lees, Jacqueline A.·2002·Nature Reviews Molecular Cell Biology

Open this paper in CoChat — free account

Abstract

The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me-pull-you' regulation, and what are its biological consequences?

Integrity signals

Registry

Crossref · 10.1038/nrm714

Cites

132 of 132 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Translating the Histone Code
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
Cancer Cell Cycles
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Bannister, A. J., Zegerman, P., Partridge, J. F., Miska, E. A., Thomas, J. O., Allshire, R. C., & Kouzarides, T. (2001) · Nature · doi:10.1038/35065138 · Cited by 2,903
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868
The regulation of E2F by pRB-family proteins.
Dyson, N. (1998) · Genes & Development · doi:10.1101/gad.12.15.2245 · Cited by 2,317
Effects of an Rb mutation in the mouse
Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., & Weinberg, R. A. (1992) · Nature · doi:10.1038/359295a0 · Cited by 1,755
E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins
Nevins, J. R. (1992) · Science · doi:10.1126/science.1411535 · Cited by 1,506
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
Lee, E. Y.-H. P., Chang, C.-Y., Hu, N., Wang, Y.-C. J., Lai, C., Herrup, K., Lee, W., & Bradley, A. (1992) · Nature · doi:10.1038/359288a0 · Cited by 1,264
Retinoblastoma protein recruits histone deacetylase to repress transcription
Brehm, A., Miska, E. A., McCance, D. J., Reid, J. L., Bannister, A. J., & Kouzarides, T. (1998) · Nature · doi:10.1038/35404 · Cited by 1,231
The Rb/E2F pathway: expanding roles and emerging paradigms
Harbour, J. W., & Dean, D. C. (2000) · Genes & Development · doi:10.1101/gad.813200 · Cited by 1,153
Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARFPreprint
Jacobs, J. J. L., Scheijen, B., Voncken, J. W., Kieboom, K., Berns, A. J. M., & van Lohuizen, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2678 · Cited by 1,069
Requirement for a functional Rb-1 gene in murine development
Clarke, A. R., Maandag, E. R., van ROON, M. A., van der Lugt, N. M. T., van der Valk, M., Hooper, M., Berns, A. J. M., & Rielef, H. T. (1992) · Nature · doi:10.1038/359328a0 · Cited by 1,006
Rb Interacts with Histone Deacetylase to Repress Transcription
Luo, R. X., Postigo, A. A., & Dean, D. C. (1998) · Cell · doi:10.1016/s0092-8674(00)80940-x · Cited by 957
Expression of transcription factor E2F1 induces quiescent cells to enter S phase
Johnson, D. G., Schwarz, J. K., Cress, W. D., & Nevins, J. R. (1993) · Nature · doi:10.1038/365349a0 · Cited by 943
Rb targets histone H3 methylation and HP1 to promoters
Nielsen, S. J., Schneider, R., Bauer, U., Bannister, A. J., Morrison, A. J., O’Carroll, D., Firestein, R., Cleary, M. L., Jenuwein, T., Herrera, R. E., et al. (2001) · Nature · doi:10.1038/35087620 · Cited by 940
p14ARF links the tumour suppressors RB and p53
Bates, S., Phillips, A. C., Clark, P. A., Stott, F., Peters, G., Ludwig, R. L., & Vousden, K. H. (1998) · Nature · doi:10.1038/25867 · Cited by 918
p53 and E2F-1 cooperate to mediate apoptosis.
Wu, X., & Levine, A. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3602 · Cited by 840
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
Kaelin, W. G., Krek, W., Sellers, W. R., DeCaprio, J. A., Ajchenbaum, F., Fuchs, C. S., Chittenden, T. D., Li, Y., Farnham, P., Blanar, M. A., et al. (1992) · Cell · doi:10.1016/0092-8674(92)90108-o · Cited by 819
Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging
van Lohuizen, M., Verbeek, S. J., Scheljen, B., Wientjens, E., van der Guidon, H., & Berns, A. J. M. (1991) · Cell · doi:10.1016/0092-8674(91)90382-9 · Cited by 763
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
Field, S. J., Tsai, F., Kuo, F. C., Zubiaga, A. M., Kaelin, W. G., Livingston, D. M., Orkin, S. H., & Greenberg, M. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81255-6 · Cited by 754
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
Qin, X. Q., Livingston, D. M., Kaelin, W. G., & Adams, P. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10918 · Cited by 753
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosisPreprint
Müller, H., Bracken, A. P., Vernell, R., Moroni, M. C., Christians, F. C., Grassilli, E., Prosperini, E., Vigo, E., Oliner, J. D., & Helin, K. (2001) · Genes & Development · doi:10.1101/gad.864201 · Cited by 752
Role for the p53 homologue p73 in E2F-1-induced apoptosis
Irwin, M. S., Marín, M. C., Phillips, A. C., Seelan, R. S., Smith, D. I., Liu, W., Flores, E. R., Tsai, K. Y., Jacks, T., Vousden, K. H., et al. (2000) · Nature · doi:10.1038/35036614 · Cited by 710
Distinct roles for E2F proteins in cell growth control and apoptosis
DeGregori, J. V., Leone, G. W., Miron, A., Jakoi, L., & Nevins, J. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7245 · Cited by 704
Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1
Yamasaki, L., Jacks, T., Bronson, R. T., Goillot, E., Harlow, E., & Dyson, N. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81254-4 · Cited by 699
Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and RB-hSWI/SNF.
Zhang, H. S., Gavin, M., Dahiya, A., Postigo, A. A., Ma, D., Luo, R. X., Harbour, J. W., & Dean, D. C. (2000) · Cell · doi:10.1016/s0092-8674(00)80625-x · Cited by 658
Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression
Takahashi, Y., Rayman, J. B., & Dynlacht, B. D. (2000) · Genes & Development · doi:10.1101/gad.14.7.804 · Cited by 621
The E2F1–3 transcription factors are essential for cellular proliferation
Wu, L., Timmers, C. D., Maiti, B., Saavedra, H. I., Sang, L., Chong, G. T., Nuckolls, F., Giangrande, P. H., Wright, F. A., Field, S. J., et al. (2001) · Nature · doi:10.1038/35106593 · Cited by 620
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
Helin, K., Lees, J. A., Vidal, M., Dyson, N. J., Harlow, E., & Fattaey, A. (1992) · Cell · doi:10.1016/0092-8674(92)90107-n · Cited by 613
Self-citation
Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis
Ishida, S., Huang, E. S., Zuzan, H., Spang, R., Leone, G. W., West, M., & Nevins, J. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.14.4684-4699.2001 · Cited by 596
Deregulated Expression of E2F-1 Induces S-Phase Entry and Leads to Apoptosis
Shan, B., & Lee, W. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8166 · Cited by 536
Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice
Haupt, Y., Alexander, W. S., Barri, G., Klinken, S. P., & Adams, J. M. (1991) · Cell · doi:10.1016/0092-8674(91)90383-a · Cited by 513
Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.Preprint
Helin, K., Wu, C. L., Fattaey, A., Lees, J. A., Dynlacht, B. D., Ngwu, C., & Harlow, E. E. (1993) · Genes & Development · doi:10.1101/gad.7.10.1850 · Cited by 496
Self-citation
Regulation of cell proliferation by the E2F transcription factors
Helin, K. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80058-0 · Cited by 491
Inhibition of E2F-1 Transactivation by Direct Binding of the Retinoblastoma Protein
Helin, K., Harlow, E. E., & Fattaey, A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6501 · Cited by 472
Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs.Preprint
Chen, P., Riley, D. J., Chen, Y., & Lee, W. (1996) · Genes & Development · doi:10.1101/gad.10.21.2794 · Cited by 449
The Retinoblastoma Protein Binds to a Family of E2F Transcription Factors
Lees, J. A., Saito, M., Vidal, M., Valentine, M. B., Look, T., Harlow, E. E., Dyson, N. J., & Helin, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7813 · Cited by 441
Self-citation
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.
Lin, W.-C., Lin, F., & Nevins, J. R. (2001) · PubMed Central · Cited by 440
Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor
Bandara, L. R., & Thangue, N. B. L. (1991) · Nature · doi:10.1038/351494a0 · Cited by 433
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes
Hurford, R. K., Cobrinik, D., Lee, M. H., & Dyson, N. (1997) · Genes & Development · doi:10.1101/gad.11.11.1447 · Cited by 431
Shared role of the pRB-related p130 and p107 proteins in limb development.Preprint
Cobrinik, D. E., Lee, M. H., Hannon, G. J., Mulligan, G., Bronson, R. T., Dyson, N. J., Harlow, E. E., Beach, D., Weinberg, R. A., & Jacks, T. (1996) · Genes & Development · doi:10.1101/gad.10.13.1633 · Cited by 429
E2F3 activity is regulated during the cell cycle and is required for the induction of S phasePreprint
Leone, G. W., DeGregori, J. V., Yan, Z., Jakoi, L., Ishida, S., Williams, R. S., & Nevins, J. R. (1998) · Genes & Development · doi:10.1101/gad.12.14.2120 · Cited by 400
The retinoblastoma protein pathway and the restriction point
Bartek, J., Bártková, J., & Lukas, J. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80081-0 · Cited by 390
Cell cycle regulation of the human cdc2 gene.
Dalton, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05231.x · Cited by 382
PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2APreprint
Altiok, S., Xu, M. J., & Spiegelman, B. M. (1997) · Genes & Development · doi:10.1101/gad.11.15.1987 · Cited by 378
Mutation of E2f-1 Suppresses Apoptosis and Inappropriate S Phase Entry and Extends Survival of Rb-Deficient Mouse Embryos
Tsai, K. Y., Hu, Y., Macleod, K. F., Crowley, D., Yamasaki, L., & Jacks, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80274-9 · Cited by 372
The Retinoblastoma Protein Acts as a Transcriptional Coactivator Required for Osteogenic Differentiation
Thomas, D. M., Carty, S. A., Piscopo, D. M., Lee, J.-S., Wang, W.-F., Forrester, W. C., & Hinds, P. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00327-6 · Cited by 361
Mechanisms of transcriptional memory
Francis, N. J., & Kingston, R. E. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073039 · Cited by 354
Role of the p53-homologue p73 in E2F1-induced apoptosis
Stiewe, T., & Pützer, B. M. (2000) · Nature Genetics · doi:10.1038/82617 · Cited by 351
E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.
Flemington, E. K., Speck, S. H., & Kaelin, W. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.6914 · Cited by 346
An E2F‐binding site mediates cell‐cycle regulated repression of mouse B‐myb transcription.
Lam, E. W. ‐., & Watson, R. J. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05932.x · Cited by 343
E2f3 is critical for normal cellular proliferationPreprint
Humbert, P. O., Verona, R. I., Trimarchi, J. M., Rogers, C., Dandapani, S. V., & Lees, J. A. (2000) · Genes & Development · doi:10.1101/gad.14.6.690 · Cited by 336
Self-citation
Targeted disruption of p107: functional overlap between p107 and Rb.Preprint
Lee, M. H., Williams, B. O., Mulligan, G., Mukai, S., Bronson, R. T., Dyson, N. J., Harlow, E., & Jacks, T. (1996) · Genes & Development · doi:10.1101/gad.10.13.1621 · Cited by 335
The retinoblastoma gene family: cousins with overlapping interests
Mulligan, G. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01470-x · Cited by 334
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
Lissy, N. A., Davis, P. K., Irwin, M. S., Kaelin, W. G., & Dowdy, S. F. (2000) · Nature · doi:10.1038/35036608 · Cited by 330
Molecular Cloning of Cellular Genes Encoding Retinoblastoma-Associated Proteins: Identification of a Gene with Properties of the Transcription Factor E2F
Shan, B., Zhu, X., Chen, P., Durfee, T. J., Yang, Y., Sharp, D., & Lee, W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5620 · Cited by 330
E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry
Moberg, K. H., Starz‐Gaiano, M., & Lees, J. A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1436 · Cited by 328
Self-citation
CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase
Vigo, E., Müller, H., Prosperini, E., Hateboer, G., Cartwright, P., Moroni, M. C., & Helin, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6379 · Cited by 326
E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.Preprint
Beijersbergen, R. L., Kerkhoven, R. M., Zhu, L., Carlée, L., Voorhoeve, P. M., & Bernards, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2680 · Cited by 321
E2F Repression by C/EBPα Is Required for Adipogenesis and Granulopoiesis In Vivo
Porse, B. T., Pedersen, T. Å., Xu, X., Lindberg, B. G., Wewer, U. M., Friis-Hansen, L. J., & Nerlov, C. (2001) · Cell · doi:10.1016/s0092-8674(01)00516-5 · Cited by 318
Deregulated Expression of E2F Family Members Induces S-Phase Entry and Overcomes p16 INK4A -Mediated Growth Suppression
Lukas, J., Petersen, B. O., Holm, K., Bartek, J., & Helin, K. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1047 · Cited by 305
E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control
Gaubatz, S., Lindeman, G. J., Ishida, S., Jakoi, L., Nevins, J. R., Livingston, D. M., & Rempel, R. E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00071-x · Cited by 302
Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.Preprint
Vairo, G., Livingston, D. M., & Ginsberg, D. (1995) · Genes & Development · doi:10.1101/gad.9.7.869 · Cited by 293
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice
Yamasaki, L., Bronson, R. T., Williams, B. O., Dyson, N. J., Harlow, E., & Jacks, T. (1998) · Nature Genetics · doi:10.1038/ng0498-360 · Cited by 283
E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.Preprint
Hsieh, J.-K., Fredersdorf, S., Kouzarides, T., Martin, K., & Lü, X. (1997) · Genes & Development · doi:10.1101/gad.11.14.1840 · Cited by 278
A new component of the transcription factor DRTF1/E2F
Girling, R., Partridge, J. F., Bandara, L. R., Burden, N., Totty, N. F., Hsuan, J. J., & Thangue, N. B. L. (1993) · Nature · doi:10.1038/362083a0 · Cited by 276
The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex
Trimarchi, J. M., Fairchild, B., Wen, J. H., & Lees, J. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1519 · Cited by 270
Self-citation
Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members
Krek, W., Livingston, D. M., & Shirodkar, S. (1993) · Science · doi:10.1126/science.8248803 · Cited by 267
Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance.
Hu, N., Gutsmann, A., Herbert, D. C., Bradley, A., Lee, W., & Lee, E. Y. (1994) · PubMed · Cited by 266
Myc Requires Distinct E2F Activities to Induce S Phase and Apoptosis
Leone, G. W., Sears, R. C., Huang, E. S., Rempel, R. E., Nuckolls, F., Park, C., Giangrande, P. H., Wu, L., Saavedra, H. I., Field, S. J., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00275-1 · Cited by 265
Induction of DNA synthesis and apoptosis are separable functions of E2F-1.Preprint
Phillips, A. C., Bates, S., Ryan, K. M., Helin, K., & Vousden, K. H. (1997) · Genes & Development · doi:10.1101/gad.11.14.1853 · Cited by 259
BRG-1 is required for RB-mediated cell cycle arrest
Strobeck, M. W., Knudsen, K. E., Fribourg, A. F., DeCristofaro, M. F., Weissman, B. E., Imbalzano, A. N., & Knudsen, E. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.7748 · Cited by 258
Functional synergy between DP‐1 and E2F‐1 in the cell cycle‐regulating transcription factor DRTF1/E2F.
Bandara, L. R., Buck, V., Zamanian, M., Johnston, L. H., & Thangue, N. B. L. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06116.x · Cited by 257
Oncogenic capacity of the E2F1 gene.
Johnson, D. G., Cress, W. D., Jakoi, L., & Nevins, J. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12823 · Cited by 249
In Vivo Association of E2F and DP Family Proteins
Wu, C., Zukerberg, L. R., Ngwu, C., Harlow, E., & Lees, J. A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2536 · Cited by 249
Self-citation
A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.
Ikeda, M., Jakoi, L., & Nevins, J. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3215 · Cited by 246
Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter.Preprint
Hsiao, K., McMahon, S., & Farnham, P. (1994) · Genes & Development · doi:10.1101/gad.8.13.1526 · Cited by 240
E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways
Phillips, A. C., Ernst, M. K., Bates, S., Rice, N. R., & Vousden, K. H. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80387-1 · Cited by 239
Target gene specificity of E2F and pocket protein family members in living cells
Wells, J., Boyd, K. E., Fry, C. J., Bartley, S. M., & Farnham, P. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5797-5807.2000 · Cited by 229
Transcriptional Repression by the Retinoblastoma Protein through the Recruitment of a Histone Methyltransferase
Vandel, L., Nicolas, E., Vaute, O., Ferreira, R., Ait‐Si‐Ali, S., & Trouche, D. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6484-6494.2001 · Cited by 229
E2F-5, a New E2F Family Member That Interacts with p130 In Vivo
Hijmans, E. M., Voorhoeve, P. M., Beijersbergen, R. L., Veer, L. V. ‘., & Bernards, R. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3082 · Cited by 229
E2F Activity Is Regulated by Cell Cycle-Dependent Changes in Subcellular Localization
Verona, R. I., Moberg, K. H., Estes, S. D., Starz‐Gaiano, M., Vernon, J. P., & Lees, J. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.12.7268 · Cited by 228
Self-citation
E2F-6, a member of the E2F family that can behave as a transcriptional repressor
Trimarchi, J. M., Fairchild, B., Verona, R. I., Moberg, K. H., Andon, N. L., & Lees, J. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2850 · Cited by 223
Self-citation
Mre11 Complex and DNA Replication: Linkage to E2F and Sites of DNA Synthesis
Maser, R. S., Mirzoeva, O. K., Wells, J. M., Olivares, H. A., Williams, B. R., Zinkel, R. A., Farnham, P., & Petrini, J. H. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.6006-6016.2001 · Cited by 215
E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.Preprint
DeGregori, J. V., Leone, G. W., Ohtani, K., Miron, A., & Nevins, J. R. (1995) · Genes & Development · doi:10.1101/gad.9.23.2873 · Cited by 209
Overexpression of E2F‐1 in rat embryo fibroblasts leads to neoplastic transformation.
Singh, P., Wong, S. H., & Hong, W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06635.x · Cited by 208
Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6.
Chen, P., Riley, D. J., Chen‐Kiang, S., & Lee, W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.465 · Cited by 208
E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
Ziebold, U., Reza, T., Caron, A., & Lees, J. A. (2001) · Genes & Development · doi:10.1101/gad.858801 · Cited by 200
Self-citation
Linking the Rb and Polycomb Pathways
Dahiya, A., Wong, S., Gonzalo, S., Gavin, M., & Dean, D. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00346-x · Cited by 198
What does ‘chromatin remodeling’ mean?
Aalfs, J. D., & Kingston, R. E. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01689-3 · Cited by 198
Key Roles for E2F1 in Signaling p53-Dependent Apoptosis and in Cell Division within Developing Tumors
Pan, H., Yin, C., Dyson, N. J., Harlow, E., Yamasaki, L., & Dyke, T. V. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80273-7 · Cited by 197
Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear Localization
Müller, H., Moroni, M. C., Vigo, E., Petersen, B. O., Bártek, J., & Helin, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5508 · Cited by 195
Cloning and characterization of E2F-2, a Novel Protein with the Biochemical Properties of Transcription Factor E2F
Ivey-Hoyle, M., Conroy, R. R., Huber, H. E., Goodhart, P. J., Oliff, A. I., & Heimbrook, D. C. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7802 · Cited by 194
Multiple members of the E2F transcription factor family are the products of oncogenes.
Xu, G., Livingston, D. M., & Krek, W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1357 · Cited by 194
E2F4 Is Essential for Normal Erythrocyte Maturation and Neonatal Viability
Humbert, P. O., Rogers, C., Ganiatsas, S., Landsberg, R. L., Trimarchi, J. M., Dandapani, S. V., Brugnara, C., Erdman, S. E., Schrenzel, M. D., Bronson, R. T., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00029-0 · Cited by 193
Self-citation
E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.
Kowalik, T. F., DeGregori, J. V., Leone, G. W., Jakoi, L., & Nevins, J. R. (1998) · PubMed · Cited by 190
E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription
Cartwright, P., Müller, H., Wagener, C., Holm, K., & Helin, K. (1998) · Oncogene · doi:10.1038/sj.onc.1201975 · Cited by 189
Identification of a Novel E2F3 Product Suggests a Mechanism for Determining Specificity of Repression by Rb Proteins
Leone, G. W., Nuckolls, F., Ishida, S., Adams, M., Sears, R. C., Jakoi, L., Miron, A., & Nevins, J. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3626-3632.2000 · Cited by 187
Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6
Gaubatz, S., Wood, J. G., & Livingston, D. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9190 · Cited by 180
A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targetingPreprint
Lindeman, G. J., Dagnino, L., Gaubatz, S., Xu, Y., Bronson, R. T., Warren, H. B., & Livingston, D. M. (1998) · Genes & Development · doi:10.1101/gad.12.8.1092 · Cited by 178
Loss of E2F4 Activity Leads to Abnormal Development of Multiple Cellular Lineages
Rempel, R. E., Sáenz-Robles, M. T., Storms, R. W., Morham, S. G., Ishida, S., Engel, A., Jakoi, L., Melhem, M. F., Pipas, J. M., Smith, C. A., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00030-7 · Cited by 172
Role of the LXCXE Binding Site in Rb Function
Dahiya, A., Gavin, M., Luo, R. X., & Dean, D. C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6799-6805.2000 · Cited by 169
C/EBPα Inhibits Cell Growth via Direct Repression of E2F-DP-Mediated Transcription
Slomiany, B. A., D'Arigo, K. L., Kelly, M. M., & Kurtz, D. T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5986-5997.2000 · Cited by 166
Functional antagonism between E2F family membersPreprint
Frolov, M. V., Huen, D. S., Nolan-Stevaux, O., Dimova, D. K., Balczarek-Strang, K., Elsdon, M. J., & Dyson, N. J. (2001) · Genes & Development · doi:10.1101/gad.903901 · Cited by 165
Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.
Schwarz, J., Bassing, C. H., Kovesdi, I., Datto, M., Blazing, M. A., George, S., Wang, X. F., & Nevins, J. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.2.483 · Cited by 164
In Vivo Structure of the Human cdc2 Promoter: Release of a p130–E2F-4 Complex from Sequences Immediately Upstream of the Transcription Initiation Site Coincides with Induction of cdc2 Expression
Tommasi, S., & Pfeifer, G. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6901 · Cited by 163
E2F-1:DP-1 Induces p53 and Overrides Survival Factors To Trigger Apoptosis
Hiebert, S. W., Packham, G., Strom, D. K., Haffner, R., Oren, M., Zambetti, G. P., & Cleveland, J. L. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6864 · Cited by 163
DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.
Dynlacht, B. D., Brook, A., Dembski, M., Yenush, L., & Dyson, N. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6359 · Cited by 157
Cell Cycle Regulation of E2F Site Occupation in Vivo
Zwicker, J., Liu, N., Engeland, K., Lucibello, F. C., & Müller, R. (1996) · Science · doi:10.1126/science.271.5255.1595 · Cited by 152
Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members
Magae, J., Wu, C., Illenye, S. A., Harlow, E., & Heintz, N. H. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.7.1717 · Cited by 151
Adenovirus E1A targets key regulators of cell proliferation.
Dyson, N. J., & Harlow, E. (1992) · PubMed · Cited by 147
Requirements for Cell Cycle Arrest by p16INK4a
Bruce, J. L., Hurford, R. K., Classon, M., Koh, J., & Dyson, N. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00072-1 · Cited by 146
An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells
Thangue, N. B. L., & Rigby, P. W. J. (1987) · Cell · doi:10.1016/0092-8674(87)90453-3 · Cited by 141
E2F and Histone Deacetylase Mediate Transforming Growth Factor β Repression of cdc25A during Keratinocyte Cell Cycle Arrest
Iavarone, A., & Massagué, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.916 · Cited by 132
An E2F-like repressor of transcription
Morkel, M., Wenkel, J., Bannister, A. J., Kouzarides, T., & Hagemeier, C. (1997) · Nature · doi:10.1038/37507 · Cited by 120
E2F1 and E2F2 Determine Thresholds for Antigen-Induced T-Cell Proliferation and Suppress Tumorigenesis
Zhu, J. W., Field, S. J., Gore, L., Thompson, M. A., Yang, H., Fujiwara, Y., Cardiff, R. D., Greenberg, M. E., Orkin, S. H., & DeGregori, J. V. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.24.8547-8564.2001 · Cited by 120
Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1
Dyson, N. J., Dembski, M., Fattaey, A., Ngwu, C., Ewen, M. E., & Helin, K. (1993) · Journal of Virology · doi:10.1128/jvi.67.12.7641-7647.1993 · Cited by 109
Cyclin A Expression Is under Negative Transcriptional Control during the Cell Cycle
Huet, X., Rech, J., Plet, A., Vié, A., & Blanchard, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3789 · Cited by 109
E2F4 Is Exported from the Nucleus in a CRM1-Dependent Manner
Gaubatz, S., Lees, J. A., Lindeman, G. J., & Livingston, D. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1384-1392.2001 · Cited by 107
Self-citation
Rb-mediated chromatin structure regulation and transcriptional repression
Zhang, H. S., & Dean, D. C. (2001) · Oncogene · doi:10.1038/sj.onc.1204338 · Cited by 107
A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.
Zhu, J. W., DeRyckere, D., Li, F. X., Wan, Y. Y., & DeGregori, J. V. (1999) · PubMed · Cited by 89
p19ARF Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo
Tolbert, D., Lu, X., Yin, C., Tantama, M., & Dyke, T. V. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.1.370-377.2002 · Cited by 85
Functional analysis of mouse Polycomb group genes.
van Lohuizen, M. (1998) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050126 · Cited by 79
Cellular memory of transcriptional states by Polycomb-group proteins
Jacobs, J. J. L., & van Lohuizen, M. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1999.0304 · Cited by 76
E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest
Mann, D. J., & Jones, N. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00515-8 · Cited by 76
Establishment of Irreversible Growth Arrest in Myogenic Differentiation Requires the RB LXCXE-Binding Function
Chen, T.-T., & Wang, J. Y. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5571-5580.2000 · Cited by 71
p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin.
Meng, R., Phillips∥, P. C., & El‐Deiry, W. S. (1999) · International Journal of Oncology · doi:10.3892/ijo.14.1.5 · Cited by 69
E2F4 Actively Promotes the Initiation and Maintenance of Nerve Growth Factor-Induced Cell Differentiation
Persengiev, S. P., Kondova, I. I., & Kilpatrick, D. L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6048 · Cited by 67
ARF Is Not Required for Apoptosis in Rb Mutant Mouse Embryos
Tsai, K. Y., MacPherson, D. P., Rubinson, D. A., Crowley, D. G., & Jacks, T. (2002) · Current Biology · doi:10.1016/s0960-9822(01)00659-5 · Cited by 63
A role for E2F1 in the induction of apoptosis during thymic negative selection.
García, I., Murga, M., Vicario, A., Field, S. J., & Zubiaga, A. M. (2000) · PubMed · Cited by 49
Tumorigenic and Developmental Effects of Combined Germ-line Mutations in Rb and p53Preprint
Williams, B. O., Morgenbesser, S. D., DePinho, R. A., & Jacks, T. (1994) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1994.059.01.050 · Cited by 11

Research works printed but not linked: 1

Weinberg, R. A. The retinoblastoma gene and gene product. Cancer Surv. 12, 43–57 (1992).

Sorted by citations

Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.017 · Cited by 2,888
The role of MicroRNAs in human cancer
Peng, Y., & Croce, C. M. (2016) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2015.4 · Cited by 2,566
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278

See all 1,158

Authors: Trimarchi, J. M., & Lees, J. A.
Affiliations: Massachusetts Institute of Technology (US)
Corresponding author: Lees, Jacqueline A.
ORCID: Trimarchi, Jeffrey M.
Lees, Jacqueline A.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2002-01
Volume: 3
Issue: 1
Pages: 11-20
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm714
OpenAlex: W2791873134
Cited by: 1,158
References: 133
Citations by year: 2026: 8 · 2025: 17 · 2024: 19 · 2023: 21 · 2022: 27 · 2021: 29 · 2020: 43 · 2019: 42 · 2018: 20 · 2017: 39 · 2016: 35 · 2015: 31 · 2014: 27 · 2013: 51 · 2012: 62
FWCI: 9.83
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: E2F transcription factors, cell cycle regulation, cell proliferation, cell cycle exit, terminal differentiation, cell division, transcriptional regulation
MeSH terms: Animals, Cell Cycle, Cell Differentiation, Cell Division, Chromatin, DNA-Binding Proteins, Gene Expression Regulation, Humans, Models, Genetic, Neoplasms, Transcription Factors, Retinoblastoma Protein, Apoptosis, Protein Structure, Tertiary, Cell Cycle Proteins, E2F Transcription Factors, E2F6 Transcription Factor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sibling rivalry in the E2F family

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks