Prions of fungi: inherited structures and biological roles
Open accessAbstract
The term 'prion' means an infectious protein that does not need an accompanying nucleic acid. There are six fungal prions, including four self-propagating amyloids and two enzymes that are necessary to activate their inactive precursors. Here we explore the scope of the prion phenomenon, the biological and evolutionary roles of prions, the structural basis of the amyloid prions and the prominent role of chaperones (proteins that affect the folding of other proteins) and other cellular components in prion generation and propagation.
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Templated modification of protein structure subserves the transfer and storage of useful biological information in systems ranging from microbes to mammals.
“Moreover, the templated modification of protein structure also subserves the transfer and storage of useful biological information in systems ranging from microbes to mammals107-110.”
From Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders (2011) · cites this paper as [108]
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Yeast Prions Compared to Functional Prions and Amyloids
Wickner, R. B., Edskes, H. K., Son, M., Bezsonov, E. E., DeWilde, M., & Ducatez, M. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.04.022 · Cited by 42 · see citing works
Self-citationPrion dynamics and the quest for the genetic determinant in protein-only inheritance
Sindi, S., & Serio, T. R. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.09.003 · Cited by 42 · see citing works
Rebels with a cause: molecular features and physiological consequences of yeast prions
Garcia, D. M., & Jarosz, D. F. (2013) · FEMS Yeast Research · doi:10.1111/1567-1364.12116 · Cited by 40 · see citing works
Characterization of the amyloid bacterial inclusion bodies of the HET-s fungal prion
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[PSI+] prion propagation is controlled by inositol polyphosphates
Wickner, R. B., Kelly, A. C., Bezsonov, E. E., & Edskes, H. K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714361114 · Cited by 39 · see citing works
Self-citationFishing for Prion Protein Function
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RNA modulates aggregation of the recombinant mammalian prion protein by direct interaction
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Curing of Yeast [URE3] Prion by the Hsp40 Cochaperone Ydj1p Is Mediated by Hsp70
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Fish models in prion biology: Underwater issues
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Nonsense-mediated mRNA decay factors cure most [PSI+] prion variants
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Self-citationDistinct Type of Transmission Barrier Revealed by Study of Multiple Prion Determinants of Rnq1
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Prion Protein Biology Through the Lens of Liquid-Liquid Phase Separation
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Chemical and biophysical insights into the propagation of prion strains
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The [ RNQ +] prion: A model of both functional and pathological amyloid
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- Authors
- Wickner, R. B., Edskes, H. K., Shewmaker, F., & Nakayashiki, T.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Wickner, Reed B.
- Venue
- Nature Reviews Microbiology
- Published
- 2007-08
- Volume
- 5
- Issue
- 8
- Pages
- 611-618
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- PMC
- PMC2376760
- OpenAlex
- W2095076518
- Cited by
- 231
- References
- 124
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 9 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 11 · 2014: 6 · 2013: 17 · 2012: 24
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (Z01DK024943)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- fungal prions, prion protein, amyloid fibrils, cell fusion, prion propagation, molecular chaperones, protein folding, fungal genetics
- MeSH terms
- Amyloid, Fungal Proteins, Prions, Saccharomyces cerevisiae, Structure-Activity Relationship, Saccharomyces cerevisiae Proteins, Podospora
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