Cited by 231Prion Diseases and Protein MisfoldingFungal and yeast genetics researchAlzheimer's disease research and treatments

Prions of fungi: inherited structures and biological roles

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Wickner, Reed B., Edskes, Herman K., Shewmaker, Frank, Nakayashiki, Toru·2007·Nature Reviews Microbiology

Abstract

The term 'prion' means an infectious protein that does not need an accompanying nucleic acid. There are six fungal prions, including four self-propagating amyloids and two enzymes that are necessary to activate their inactive precursors. Here we explore the scope of the prion phenomenon, the biological and evolutionary roles of prions, the structural basis of the amyloid prions and the prominent role of chaperones (proteins that affect the folding of other proteins) and other cellular components in prion generation and propagation.

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  • Templated modification of protein structure subserves the transfer and storage of useful biological information in systems ranging from microbes to mammals.

    “Moreover, the templated modification of protein structure also subserves the transfer and storage of useful biological information in systems ranging from microbes to mammals107-110.”

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Research works printed but not linked: 3

  1. [1]M'Gowan JP. Investigation into the disease of sheep called "scrapie". Edinburgh: Blackwood; 1914. [Google Scholar]
  2. [6]Wickner RB. In: Fields Virology. Fifth Edition. Knipe DM, Howley PM, editors. Lippincott: Williams & Wilkins; 2006. [Google Scholar]
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Authors
Wickner, R. B., Edskes, H. K., Shewmaker, F., & Nakayashiki, T.
Affiliations
National Institutes of Health (US)
Corresponding author
Wickner, Reed B.
Venue
Nature Reviews Microbiology
Published
2007-08
Volume
5
Issue
8
Pages
611-618
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W2095076518
Cited by
231
References
124
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 9 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 11 · 2014: 6 · 2013: 17 · 2012: 24
FWCI
2.19
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (Z01DK024943)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
fungal prions, prion protein, amyloid fibrils, cell fusion, prion propagation, molecular chaperones, protein folding, fungal genetics
MeSH terms
Amyloid, Fungal Proteins, Prions, Saccharomyces cerevisiae, Structure-Activity Relationship, Saccharomyces cerevisiae Proteins, Podospora

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