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HIF1 and oxygen sensing in the brain

Sharp, Frank R., Bernaudin, Myriam·2004·Nature Reviews Neuroscience

DOI 10.1038/nrn1408

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
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Background
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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
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“, abrogates the interaction between HIF1 and the transcriptional co-activator p300/CB”
Background
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
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“Indeed, heregulin and IGF1 induce phosphorylation of the translational regulatory proteins 4EBP, p70 S6 kinase and EIF4E, which are substrates for the PI3K–AKT–FRAP/mTOR pathwa”
Background
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
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A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
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Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
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Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction
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Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
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Regulation and Destabilization of HIF-1α by ARD1-Mediated Acetylation
Jeong, J.-W., Bae, M.-K., Ahn, M.-Y., Kim, S.-H., Sohn, T.-K., Bae, M.-H., Yoo, M.-A., Song, E. J., Lee, K.-J., & Kim, K.-W. (2002) · Cell · doi:10.1016/s0092-8674(02)01085-1 · Cited by 716
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
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Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science · doi:10.1126/science.1088805 · Cited by 704
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway
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Cobalt Inhibits the Interaction between Hypoxia-inducible Factor-α and von Hippel-Lindau Protein by Direct Binding to Hypoxia-inducible Factor-α
Yuan, Y., Hilliard, G., Ferguson, T., & Millhorn, D. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300463200 · Cited by 638
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice.
Scortegagna, M., Ding, K., Oktay, Y., Gaur, A., Thurmond, F., Yan, L.-J., Marck, B. T., Matsumoto, A. M., Shelton, J. M., Richardson, J. A., et al. (2003) · Nature Genetics · doi:10.1038/ng1266 · Cited by 496
A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets
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The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling
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Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases
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Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
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Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
Sun, X., He, G., Qing, H., Zhou, W., Dobie, F., Cai, F., Staufenbiel, M., Huang, L. E., & Song, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606298103 · Cited by 605
Regulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593
The Alzheimer's disease Beta-secretase enzyme, BACE1
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Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities
Adibhatla, R. M., & Hatcher, J. F. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2668 · Cited by 480
Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?
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See all 568

Authors: Sharp, F. R., & Bernaudin, M.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-06
Volume: 5
Issue: 6
Pages: 437-448
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1408
OpenAlex: W2016934775
Cited by: 568
References: 36
FWCI: 1.02
Type: journal article
Language: en
Open access: closed

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HIF1 and oxygen sensing in the brain

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