The DOI matches its Crossref record; 106 of the 107 references it cites were found in a registry or an index.
Epigenetic regulation in psychiatric disorders
Abstract
Many neurological and most psychiatric disorders are not due to mutations in a single gene; rather, they involve molecular disturbances entailing multiple genes and signals that control their expression. Recent research has demonstrated that complex 'epigenetic' mechanisms, which regulate gene activity without altering the DNA code, have long-lasting effects within mature neurons. This review summarizes recent evidence for the existence of sustained epigenetic mechanisms of gene regulation in neurons that have been implicated in the regulation of complex behaviour, including abnormalities in several psychiatric disorders such as depression, drug addiction and schizophrenia.
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In the citing paper
“Valproic acid, sodium butyrate, and Vorinostat (SAHA) are examples of HDAC inhibitors that are currently used to target depression, schizophrenia, BD, PTSD and are being preclinically explored for ASD (120).”
From The clinical use of epigenetics in psychiatry: a narrative review of epigenetic mechanisms, key candidate genes, and precision psychiatry (2025) · cites this paper as [120]
In the citing paper
“The regulation of gene expression is a critical molecular mechanism mediating stable adaptations and maladaptations in the brain.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [24]
In the citing paper
“The pathophysiology of MDD and response to antidepressants are suggested to be controlled by epigenetic modulation of transcription.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [24]
In the citing paper
“Indeed, disruptions in transcription occur in various brain areas in preclinical models of depression and in MDD patients.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [24]
Citations
Cites
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Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
Self-citationNEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
Self-citationControl of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R., Chevalier, B. S., Johnstone, S. E., Cole, M. F., Isono, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,296
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
Self-citationSustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780
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Cited by
Sorted by citations
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
Self-citationBelmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166
(2009) · Cited by 2,013
Synaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397
Metadata
- Authors
- Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Nestler, Eric J.
- Venue
- Nature reviews. Neuroscience
- Published
- 2007-05
- Volume
- 8
- Issue
- 5
- Pages
- 355-367
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2052714177
- Cited by
- 1,400
- References
- 107
- Citations by year
- 2026: 14 · 2025: 33 · 2024: 33 · 2023: 28 · 2022: 25 · 2021: 51 · 2020: 45 · 2019: 56 · 2018: 64 · 2017: 71 · 2016: 100 · 2015: 91 · 2014: 108 · 2013: 122 · 2012: 123
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-12-13)
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- epigenetic regulation, mental illness, gene expression, neurons, learning and memory, depression, drug addiction, schizophrenia, complex behavior, brain development
- MeSH terms
- Animals, Mental Disorders, Brain, Gene Expression Regulation, Humans, Models, Biological, Neurons, Epigenesis, Genetic
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