Major depressive disorder

Belmaker, R.H.; Agam, Galila

doi:10.1056/nejmra073096

Cited by 2,166Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

Major depressive disorder

Belmaker, R.H., Agam, Galila·2008·New England Journal of Medicine

DOI 10.1056/nejmra073096

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Abstract

This review of major depressive disorder is a comprehensive account of the genetic, biochemical, and neurophysiological changes that have been implicated in the disorder. No single mechanism can account for all the clinical variations in this condition. The monoamine oxidase theory can explain many of the actions of antidepressants, but genetic factors, stress, and psychosocial factors also play a part in depression.

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The serotonin system is the most widely used pharmacological target for treating depression and anxiety.
“It is the most widely used pharmacological target for treating depression and anxiety (Belmaker and Agam, 2008; Ravindran and Stein, 2010)”
From Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems (2018) · cites this paper as Belmaker and Agam, 2008

Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391 · see citing works
Translating the Histone Code
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733 · see citing works
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 4,981 · cited 1× · see citing works
“resulting in dendritic atrophy, reduction in spinogenesis, apoptosis of neurons, and possibly inhibition of adult neurogenesis [25].”
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621 · see citing works
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880 · see citing works
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,513 · see citing works
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431 · see citing works
Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203 · cited 1× · see citing works
“symptoms [135,136].”
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693 · see citing works
Allelic Variation of Human Serotonin Transporter Gene Expression
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221 · see citing works
The Corticosteroid Receptor Hypothesis of Depression
Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016 · see citing works
5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works
Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
Circadian rhythms from multiple oscillators: lessons from diverse organisms
Bell‐Pedersen, D., Cassone, V. M., Earnest, D. J., Golden, S. S., Hardin, P. E., Thomas, T. L., & Zoran, M. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1633 · Cited by 1,481 · see citing works
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477 · see citing works
Molecular analysis of mammalian circadian rhythms
Reppert, S. M., & Weaver, D. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.647 · Cited by 1,444 · see citing works
Epigenetic regulation in psychiatric disorders
Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400 · see citing works
Childhood Sexual Abuse and Adult Psychiatric and Substance Use Disorders in Women: An Epidemiological and Cotwin Control Analysis
Kendler, K. S., Bulik, C. M., Silberg, J., Hettema, J. M., Myers, J., & Prescott, C. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.953 · Cited by 1,259 · see citing works
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225 · see citing works
Adult hippocampal neurogenesis in depression
Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206 · see citing works
When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197 · see citing works
Depression and cortisol responses to psychological stress: A meta-analysis
Burke, H. M., Davis, M. C., Otte, C., & Mohr, D. C. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.02.010 · Cited by 1,194 · see citing works
The cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182 · see citing works
Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164 · see citing works
Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders
Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146 · see citing works
Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301408 · Cited by 1,027 · see citing works
Course of illness, hippocampal function, and hippocampal volume in major depression
MacQueen, G. M., Campbell, S., McEwen, B. S., Macdonald, K., Amano, S., Joffe, R. T., Nahmias, C., & Young, L. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337481100 · Cited by 980 · see citing works
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976 · see citing works
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
Lyons, W. E., Mamounas, L. A., Ricaurte, G. A., Coppola, V., Reid, S. W., Bora, S. H., Wihler, C., Koliatsos, V. E., & Tessarollo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15239 · Cited by 862 · see citing works
Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies
Ruhé, H. G., Mason, N. S., & Schene, A. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001949 · Cited by 861 · see citing works
Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy
Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846 · see citing works
Comparison of Treatment Effects between Animal Experiments and Clinical Trials: Systematic Review
Perel, P., Roberts, I., Sena, E., Wheble, P., Briscoe, C., Sandercock, P., Macleod, M., Mignini, L. E., Jayaram, P., & Khan, K. S. (2007) · BMJ · doi:10.1136/bmj.39048.407928.be · Cited by 827 · see citing works
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822 · see citing works
Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817 · see citing works
Mania-like behavior induced by disruption of CLOCK
Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609625104 · Cited by 803 · see citing works
Social supports and serotonin transporter gene moderate depression in maltreated children
Kaufman, J., Yang, B., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D. S., Krystal, J. H., & Gelernter, J. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404376101 · Cited by 801 · see citing works
Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects
Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800 · see citing works
Neurogenesis in the Adult Brain
Gage, F. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00612.2002 · Cited by 796 · see citing works
Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works
The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
Müller, N., Schwarz, M. J., Dehning, S., Douhe, A., Cerovecki, A., Goldstein-Müller, B., Spellmann, I., Hetzel, G., Maino, K., Kleindienst, N., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001805 · Cited by 794 · see citing works
A Swedish National Twin Study of Lifetime Major Depression
Kendler, K. S., Gatz, M., Gardner, C. O., & Pedersen, N. L. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.109 · Cited by 794 · see citing works
Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover proliferation, and survival in the adult dentate gyrus
Sairanen, M., Lucas, G., Ernfors, P., Castrén, M., & Castrén, E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3741-04.2005 · Cited by 763 · see citing works
Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762 · see citing works
Antidepressants increase neural progenitor cells in the human hippocampus
Boldrini, M., Underwood, M. D., Hen, R., Rosoklija, G. B., Dwork, A. J., John Mann, J., & Arango, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.75 · Cited by 686 · see citing works
Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
Heldt, S. A., Stanek, L., Chhatwal, J. P., & Ressler, K. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001957 · Cited by 684 · see citing works
Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis
Zhang, X., Beaulieu, J., Sotnikova, T. D., Gainetdinov, R. R., & Caron, M. G. (2004) · Science · doi:10.1126/science.1097540 · Cited by 683 · see citing works
PSYCHONEUROENDOCRINOLOGY OF DEPRESSION
Plotsky, P. M., Owens, M. J., & Nemeroff, C. B. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70006-x · Cited by 672 · see citing works
Hippocampal Neurogenesis: Regulation by Stress and Antidepressants
Dranovsky, A., & Hen, R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.082 · Cited by 663 · see citing works
Neuroimaging studies of mood disorder effects on the brain
Sheline, Y. I. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00347-0 · Cited by 660 · see citing works
Effects of Citalopram and Interpersonal Psychotherapy on Depression in Patients With Coronary Artery Disease: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) Trial
Lespérance, F., Frasure-Smith, N., Koszycki, D., Laliberté, M.-A., van Zyl, L. T., Baker, B., Swenson, J. R., Ghatavi, K., Abramson, B. L., Dorian, P., et al. (2007) · JAMA · doi:10.1001/jama.297.4.367 · Cited by 658 · see citing works
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
Choudary, P. V., Molnar, M., Evans, S. J., Tomita, H., Li, J., Vawter, M. P., Myers, R., Bunney, W. E., Akil, H., Watson, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507901102 · Cited by 653 · see citing works
Genes, Environment, and Personality
Bouchard, T. J. (1994) · Science · doi:10.1126/science.8209250 · Cited by 633 · see citing works
Organization of the human serotonin transporter gene
Lesch, K., Balling, U., Groß, J., Strauss, K. M., Wolozin, B. L., Murphy, D. L., & Riederer, P. F. (1994) · Journal of Neural Transmission · doi:10.1007/bf01276434 · Cited by 628 · see citing works
Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder
Nemets, B., Stahl, Z., & Belmaker, R. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.3.477 · Cited by 627 · see citing works
Self-citation
Major Depressive Disorder
D, M. F. M., & Kendler, K. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00112-4 · Cited by 619 · see citing works
Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
Karege, F., Vaudan, G., Schwald, M., Perroud, N., & La Harpe, R. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.020 · Cited by 600 · see citing works
The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study
Neves-Pereira, M., Mundo, E., Muglia, P., King, N. A., Macciardi, F. M., & Kennedy, J. L. (2002) · The American Journal of Human Genetics · doi:10.1086/342288 · Cited by 594 · see citing works
Low Brain-Derived Neurotrophic Factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity
Karege, F., Bondolfi, G., Gervasoni, N., Schwald, M., Aubry, J., & Bertschy, G. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.008 · Cited by 594 · see citing works
Elevated Monoamine Oxidase A Levels in the Brain: An Explanation for the Monoamine Imbalance of Major Depression
Meyer, J. H., Ginovart, N., Boovariwala, A., Sagrati, S., Hussey, D., Garcia, A., Young, T., Praschak-Rieder, N., Wilson, A. A., & Houle, S. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1209 · Cited by 585 · see citing works
Association of depression with medical illness: Does cortisol play a role?
Brown, E. S., Varghese, F. P., & McEwen, B. S. (2004) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00473-6 · Cited by 578 · see citing works
Alterations in 5-HT 1B Receptor Function by p11 in Depression-Like States
Svenningsson, P., Chergui, K., Rachleff, I., Flajolet, M., Zhang, X., Yacoubi, M. E., Vaugeois, J.-M., Nomikos, G. G., & Greengard, P. (2006) · Science · doi:10.1126/science.1117571 · Cited by 572 · see citing works
GABAergic dysfunction in mood disorders
Brambilla, P., Pérez, J., Barale, F., Schettini, G., & Soares, J. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001362 · Cited by 567 · see citing works
Is mood chemistry?
Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563 · see citing works
Histone Deacetylase Inhibitors Exhibit Anti-Inflammatory and Neuroprotective Effects in a Rat Permanent Ischemic Model of Stroke: Multiple Mechanisms of Action
Kim, H. J., Rowe, M. K., Ren, M., Hong, J., Chen, P.-S., & Chuang, D. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.120188 · Cited by 557 · see citing works
Nuclear Receptor Rev-erbα Is a Critical Lithium-Sensitive Component of the Circadian Clock
Yin, L., Wang, J., Klein, P. S., & Lazar, M. A. (2006) · Science · doi:10.1126/science.1121613 · Cited by 556 · see citing works
Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal
Surget, A., Saxe, M., Leman, S., Ibarguen-Vargas, Y., Chalon, S., Griebel, G., Hen, R., & Belzung, C. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.022 · Cited by 556 · see citing works
BDNF in schizophrenia, depression and corresponding animal models
Angelucci, F., Brené, S., & Mathé, A. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001637 · Cited by 548 · see citing works
Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse
Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541 · see citing works
Treatment of Depression in Patients With Alcohol or Other Drug Dependence
Nunes, E. V., & LEVIN, F. R. (2004) · JAMA · doi:10.1001/jama.291.15.1887 · Cited by 535 · see citing works
Polymorphism in serotonin transporter gene associated with susceptibility to major depression
Ogilvie, A. D., Battersby, S., Fink, G., Harmar, A. J., Goodwin, G. M., Bubb, V. J., & Smith, C. A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90079-3 · Cited by 530 · see citing works
The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways
Millan, M. J., Gobert, A., Lejeune, F., Dekeyne, A., Newman‐Tancredi, A., Pasteau, V., Rivet, J., & Cussac, D. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051797 · Cited by 516 · see citing works
Effects of Antidepressant Medication on Morbidity and Mortality in Depressed Patients After Myocardial Infarction
Taylor, C. B. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.7.792 · Cited by 512 · see citing works
Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors
Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502 · see citing works
Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes
Jope, R. S. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00206-2 · Cited by 501 · see citing works
Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography
Malison, R. T., Price, L. H., Berman, R., van Dyck, C. H., Pelton, G. H., Carpenter, L., Sanacora, G., Owens, M. J., Nemeroff, C. B., Rajeevan, N., et al. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00272-8 · Cited by 496 · see citing works
Regulation of dopaminergic transmission and cocaine reward by the Clock gene
McClung, C. A., Sidiropoulou, K., Vitaterna, M., Takahashi, J. S., White, F. J., Cooper, D. C., & Nestler, E. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503584102 · Cited by 493 · see citing works
Neurogenesis in adult primate neocortex: an evaluation of the evidence
RAKIC, P. T. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn700 · Cited by 491 · see citing works
Initiation and adaptation: a paradigm for understanding psychotropic drug action
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.2.151 · Cited by 490 · see citing works
The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS
Chen, G., Zeng, W., YUAN, P., Huang, L., Jiang, Y., Zhao, Z., & Manji, H. K. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.720879.x · Cited by 489 · see citing works
3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity
Sheline, Y. I. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00994-x · Cited by 485 · see citing works
Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression
Zhang, X., Gainetdinov, R. R., Beaulieu, J.-M., Sotnikova, T. D., Burch, L. H., Williams, R. B., Schwartz, D. A., Krishnan, K. R. R., & Caron, M. G. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.014 · Cited by 473 · see citing works
Bipolar Disorder
Belmaker, R. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmra035354 · Cited by 473 · see citing works
Self-citation
Antidepressant-Induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates
Perera, T. D., Coplan, J. D., Lisanby, S. H., Lipira, C. M., Arif, M., Carpio, C., Spitzer, G., Santarelli, L., Scharf, B., Hen, R., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0237-07.2007 · Cited by 461 · see citing works
An Opponent-Process Theory of Motivation
Solomon, R. L., & Corbit, J. D. (2008) · Cited by 461 · see citing works
Quantitative Cerebral Anatomy in Depression
Coffey, C. E. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820130009002 · Cited by 459 · see citing works
Neuroendocrine aspects of hypercortisolism in major depression
Parker, K. J., Schatzberg, A. F., & Lyons, D. M. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00016-8 · Cited by 455 · see citing works
The circadian basis of winter depression
Lewy, A. J., Lefler, B. J., Emens, J. S., & Bauer, V. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602425103 · Cited by 451 · see citing works
Neocortical neurogenesis in humans is restricted to development
Bhardwaj, R. D., Curtis, M. A., Spalding, K. L., Buchholz, B. A., Fink, D., Björk-Eriksson, T., Nordborg, C., Gage, F. H., Druid, H., Eriksson, P. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605177103 · Cited by 448 · see citing works
Histone Modifications at Gene Promoter Regions in Rat Hippocampus after Acute and Chronic Electroconvulsive Seizures
Tsankova, N. M., Kumar, A., & Nestler, E. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0589-04.2004 · Cited by 447 · see citing works
The Mood‐Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase‐3
Chen, G., Huang, L., Jiang, Y., & Manji, H. K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0721327.x · Cited by 439 · see citing works
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438 · see citing works
GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression
Rajkowska, G., O'Dwyer, G., Teleki, Z., Stockmeier, C. A., & Miguel-Hidalgo, J. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301234 · Cited by 430 · see citing works
Cortical 5-HT 2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice
Weisstaub, N., Zhou, M., Lira, A., Lambe, E. K., González‐Maeso, J., Hornung, J., Sibille, E. L., Underwood, M. D., Itohara, S., Dauer, W. T., et al. (2006) · Science · doi:10.1126/science.1123432 · Cited by 425 · see citing works
The Medical Management of Depression
Mann, J. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050730 · Cited by 423 · see citing works
Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood
Hampp, G., Ripperger, J. A., Houben, T., Schmutz, I., Blex, C., Perreau‐Lenz, S., Brunk, I., Spanagel, R., Ahnert‐Hilger, G., Meijer, J. H., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.012 · Cited by 419 · see citing works
Early Onset of Selective Serotonin Reuptake Inhibitor Antidepressant Action: Systematic Review and Meta-analysis
Taylor, M. J., Freemantle, N., Geddes, J. R., & Bhagwagar, Z. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1217 · Cited by 406 · see citing works
Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-Releasing Hormone Receptors and GABAAReceptor Subunits in Frontal Cortical Brain Region
Merali, Z., Du, L., Hrdina, P., Palkovits, M., Faludi, G., Poulter, M. O., & Anisman, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4734-03.2004 · Cited by 400 · see citing works
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
Airan, R. D., Meltzer, L. A., Roy, M., Gong, Y., Chen, H., & Deisseroth, K. (2007) · Science · doi:10.1126/science.1144400 · Cited by 396 · see citing works
Circadian rhythms in depression and recovery: evidence for blunted amplitude as the main chronobiological abnormality
Souêtre, E., Salvati, E., Belugou, J.-L., Pringuey, D., Candito, M., Krebs, B., Ardisson, J.-L., & Darcourt, G. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90207-2 · Cited by 396 · see citing works
Association of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism With Reduced Hippocampal Volumes in Major Depression
Frodl, T., Schüle, C., Schmitt, G., Born, C., Baghai, T., Zill, P., Bottlender, R., Rupprecht, R., Bondy, B., Reiser, M., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.4.410 · Cited by 394 · see citing works
Mood Disturbances and Regional Cerebral Metabolic Abnormalities inRecently Abstinent Methamphetamine Abusers
London, E. D., Simon, S. L., Berman, S. M., Mandelkern, M. A., Lichtman, A. M., Bramen, J. E., Shinn, A. K., Miotto, K. A., Learn, J. E., Dong, Y., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.73 · Cited by 385 · see citing works
Anterior Cingulate, Gyrus Rectus, and Orbitofrontal Abnormalities in Elderly Depressed Patients: An MRI-Based Parcellation of the Prefrontal Cortex
Ballmaier, M., Toga, A. W., Blanton, R. E., Sowell, E. R., Lavretsky, H., Peterson, J. R., Pham, D. L., & Kumar, A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.99 · Cited by 384 · see citing works
Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression
Hastings, R. S., Parsey, R. V., Oquendo, M. A., Arango, V., & Mann, J. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300371 · Cited by 378 · see citing works
Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior
Boyle, M. P., Brewer, J. A., Funatsu, M., Wozniak, D. F., Tsien, J. Z., Izumi, Y., & Muglia, L. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406458102 · Cited by 378 · see citing works
The Flinders Sensitive Line rat: A selectively bred putative animal model of depression
Overstreet, D. H., Friedman, E. M., Mathé, A. A., & Yadid, G. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.015 · Cited by 375 · see citing works
A Role for Glycogen Synthase Kinase-3β in the Mammalian Circadian Clock
Iitaka, C., Miyazaki, K., Akaike, T., & Ishida, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503526200 · Cited by 373 · see citing works
Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain
Bauer, M., Heinz, A., & Whybrow, P. C. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000963 · Cited by 370 · see citing works
The Role of CREB in Depression and Antidepressant Treatment
Blendy, J. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.003 · Cited by 365 · see citing works
The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons
Yasuda, S., Liang, M.-H., Marinova, Z., Yahyavi, A., & Chuang, D.-M. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002099 · Cited by 358 · see citing works
Effects of physical exercise on depression, neuroendocrine stress hormones and physiological fitness in adolescent females with depressive symptoms
Nabkasorn, C., Miyai, N., Sootmongkol, A., Junprasert, S., Yamamoto, H., Arita, M., & Miyashita, K. (2006) · European Journal of Public Health · doi:10.1093/eurpub/cki159 · Cited by 353 · see citing works
Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls
Deuschle, M., Schweiger, U., Weber, B., Gotthardt, U., Körner, A., Schmider, J., Standhardt, H., Lammers, C.-H., & Heuser, I. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.1.3689 · Cited by 344 · see citing works
Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference
Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppä, T., Lichtermann, D., Praschak-Rieder, N., Neumeister, A., Nilsson, L.-G., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300121 · Cited by 341 · see citing works
Dysregulation of Endogenous Opioid Emotion Regulation Circuitry in Major Depression in Women
Kennedy, S. E., Koeppe, R. A., Young, E. A., & Zubieta, J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1199 · Cited by 339 · see citing works
A BDNF Coding Variant is Associated with the NEO Personality Inventory Domain Neuroticism, a Risk Factor for Depression
Sen, S., Nesse, R. M., Stoltenberg, S. F., Li, S., Gleiberman, L., Chakravarti, A., Weder, A. B., & Burmeister, M. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300053 · Cited by 331 · see citing works
Functional but not structural subgenual prefrontal cortex abnormalities in melancholia
Pizzagalli, D. A., Oakes, T. R., Fox, A. S., Chung, M. K., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Benca, R. M., & Davidson, R. J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001501 · Cited by 331 · see citing works
cAMP Response Element-Binding Protein Is Essential for the Upregulation of Brain-Derived Neurotrophic Factor Transcription, But Not the Behavioral or Endocrine Responses to Antidepressant Drugs
Conti, A. C., Cryan, J. F., Dalvi, A., Lucki, I., & Blendy, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03262.2002 · Cited by 328 · see citing works
Mood Disorders and Substance Use Disorder: A Complex Comorbidity
Quello, S. B., Brady, K. T., & Sonne, S. C. (2005) · Science & Practice Perspectives · doi:10.1151/spp053113 · Cited by 326 · see citing works
Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis
Banasr, M., Soumier, A., Hery, M., Mocaër, E., & Daszuta, A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.025 · Cited by 318 · see citing works
Pathophysiology of hypercortisolism in depression
Carroll, B. J., Cassidy, F., Naftolowitz, D., Tatham, N. E., Wilson, W. H., Iranmanesh, A., Liu, P. Y., & Veldhuis, J. D. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00967.x · Cited by 317 · see citing works
Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor
Holick, K. A., Lee, D. C., Hen, R., & Dulawa, S. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301399 · Cited by 313 · see citing works
Reduction in Occipital Cortex γ-Aminobutyric Acid Concentrations in Medication-Free Recovered Unipolar Depressed and Bipolar Subjects
Bhagwagar, Z., Wylezinska, M., Jezzard, P., Evans, J., Ashworth, F., Sule, A., Matthews, P. M., & Cowen, P. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.048 · Cited by 304 · see citing works
Reduced Brain Norepinephrine and Dopamine Release in Treatment-Refractory Depressive Illness: Evidence in Support of the Catecholamine Hypothesis of Mood Disorders
Lambert, G., Johansson, M., Ågren, H., & Friberg, P. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.787 · Cited by 303 · see citing works
Molecular studies of major depressive disorder: the epigenetic perspective
Mill, J. S., & Petronis, A. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001992 · Cited by 302 · see citing works
The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression
Gillespie, N. A., Whitfield, J. B., WILLIAMS, B., Heath, A. C., & Martin, N. G. (2004) · Psychological Medicine · doi:10.1017/s0033291704002727 · Cited by 299 · see citing works
The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines
Spalletta, G., Bossù, P., Ciaramella, A., Bria, P., Caltagirone, C., & Robinson, R. G. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001879 · Cited by 293 · see citing works
Factor analysis of Forced Swimming test, Sucrose Preference test and Open Field test on enriched, social and isolated reared rats
Sáenz, J. C. B., Rodríguez‐Villagra, O. A., & Trías, J. F. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.12.001 · Cited by 291 · see citing works
5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern
Hedlund, P. B., Huitron-Resendiz, S., Henriksen, S. J., & Sutcliffe, J. G. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.012 · Cited by 281 · see citing works
Nicotinic acetylcholine receptors as targets for antidepressants
Shytle, R. D., Silver, A. A., Lukas, R. J., Newman, M. B., Sheehan, D. V., & Sanberg, P. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001035 · Cited by 279 · see citing works
Reliability and validity of the cocaine selective severity assessment
Kampman, K. M., Volpicelli, J. R., Mcginnis, D. E., Alterman, A. I., Weinrieb, R. M., D’Angelo, L., & Epperson, L. E. (1998) · Addictive Behaviors · doi:10.1016/s0306-4603(98)00011-2 · Cited by 272 · see citing works
Molecular Clock Genes in Man and Lower Animals Possible Implications for Circadian Abnormalities in Depression
Bunney, W. E. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00145-1 · Cited by 268 · see citing works
Antidepressant actions of the exercise-regulated gene VGF
Hunsberger, J. G., Newton, S. S., Bennett, A., Duman, C. H., Russell, D., Salton, S. R., & Duman, R. S. (2007) · Nature Medicine · doi:10.1038/nm1669 · Cited by 267 · see citing works
Endophenotypes in bipolar disorder
Lenox, R. H., Gould, T. D., & Manji, H. K. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10360 · Cited by 264 · see citing works
Extending the Bereavement Exclusion for Major Depression to Other Losses
Wakefield, J. C., Schmitz, M. F., First, M. B., & Horwitz, A. V. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.4.433 · Cited by 263 · see citing works
The Homocysteine Hypothesis of Depression
Folstein, M. F., Liu, T., Peter, I., Buel, J., Arsenault, L. N., Scott, T. M., & Qiu, W. W. Q. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.6.861 · Cited by 263 · see citing works
Imipramine Treatment and Resiliency Exhibit Similar Chromatin Regulation in the Mouse Nucleus Accumbens in Depression Models
Wilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., & Nestler, E. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0932-09.2009 · Cited by 262 · see citing works
Meta-analysis of serotonin transporter polymorphisms and affective disorders
Lotrich, F. E., & Pollock, B. G. (2004) · Psychiatric Genetics · doi:10.1097/00041444-200409000-00001 · Cited by 261 · see citing works
Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression
Schmidt, P. J., Daly, R. C., Bloch, M., SMITH, M. J., Danaceau, M. A., Clair, L. S. S., Murphy, J. H., Haq, N., & Rubinow, D. R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.154 · Cited by 252 · see citing works
Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders
Morilak, D. A., & Frazer, A. (2004) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145704004080 · Cited by 252 · see citing works
Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade
Millan, M. J., Brocco, M., Gobert, A., & Dekeyne, A. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1962-z · Cited by 248 · see citing works
Influence of sleep-wake and circadian rhythm disturbances in psychiatric disorders.
Boivin, D. B. (2000) · PubMed Central · Cited by 247 · see citing works
Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3
Kim, A. J., Shi, Y., Austin, R. C., & Werstuck, G. H. (2004) · Journal of Cell Science · doi:10.1242/jcs.01562 · Cited by 233 · see citing works
Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain
Desouza, L. A., Ladiwala, U., Daniel, S. M., Agashe, S., Vaidya, R. A., & Vaidya, V. A. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.010 · Cited by 231 · see citing works
Reduced cell proliferation in the dentate gyrusis not correlated with the development of learned helplessness
Vollmayr, B., Simonis, C., Weber, S., Gass, P., & Henn, F. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00527-4 · Cited by 229 · see citing works
Probing Brain Reward System Function in Major Depressive Disorder: Altered Response to Dextroamphetamine
Tremblay, L. K., Naranjo, C. A., Cardenas, L., Herrmann, N., & Busto, U. E. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.5.409 · Cited by 229 · see citing works
Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptine
Reagan, L. P., Rosell, D. R., Wood, G. E., Spedding, M., Muñoz, C., Rothstein, J. D., & McEwen, B. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307294101 · Cited by 221 · see citing works
Stress increases vulnerability to inflammation in the rat prefrontal cortex
de Pablos, R. M., Villarán, R. F., Argüelles, S., Herrera, A. J., Venero, J. L., Ayala, A., Cano, J., & Machado, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0802-06.2006 · Cited by 215 · see citing works
In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors.
Kable, J. W., Murrin, L. C., & Bylund, D. B. (2000) · PubMed · Cited by 207 · see citing works
Clinical and Biological Effects of Mifepristone Treatment for Psychotic Depression
Flores, B. H., Kenna, H., Keller, J., Solvason, H. B., & Schatzberg, A. F. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300884 · Cited by 203 · see citing works
Dehydroepiandrosterone Augmentation in the Management of Negative, Depressive, and Anxiety Symptoms in Schizophrenia
Strous, R. D., Maayan, R., Lapidus, R., Stryjer, R., Lustig, M., Kotler, M., & Weizman, A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.2.133 · Cited by 201 · see citing works
Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics
Seeman, P., Ko, F., & Tallerico, T. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001682 · Cited by 200 · see citing works
The α2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety
Schramm‐Sapyta, N. L., McDonald, M. P., & Limbird, L. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04875.2001 · Cited by 194 · see citing works
Neurogenesis and depression: etiology or epiphenomenon?
Henn, F. A., & Vollmayr, B. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.011 · Cited by 192 · see citing works
Neuroanatomic Correlates of Psychopathologic Components of Major Depressive Disorder
Milak, M. S., Parsey, R. V., Keilp, J. G., Oquendo, M. A., Malone, K. M., & Mann, J. J. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.397 · Cited by 177 · see citing works
Cytokines and depression: fortuitous or causative association?
Dantzer, R., Wollman, E., Vitkovic, L., & Yirmiya, R. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000572 · Cited by 174 · see citing works
Decreased Prefrontal Myo-Inositol in Major Depressive Disorder
Coupland, N. J., Ogilvie, C. J., Hegadoren, K., Seres, P., Hanstock, C. C., & Allen, P. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.027 · Cited by 174 · see citing works
Striatal dopamine transporter density in major depression
Laasonen-Balk, T., Kuikka, J. T., Viinam�ki, H., Husso, M., Lehtonen, J., & Tiihonen, J. (1999) · Psychopharmacology · doi:10.1007/s002130051005 · Cited by 172 · see citing works
Lithium lengthens the circadian period of individual suprachiasmatic nucleus neurons
Abe, M., Herzog, E. D., & Block, G. D. (2000) · Neuroreport · doi:10.1097/00001756-200009280-00042 · Cited by 169 · see citing works
Posttranscriptional and Posttranslational Regulation of Clock Genes
Harms, E., Kivimäe, S., Young, M. W., & Sáez, L. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730404268111 · Cited by 166 · see citing works
Long-term down-regulation of BDNF mRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response
Kozlovsky, N., Matar, M. A., Kaplan, Z., Kotler, M., Zohar, J., & Cohen, H. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007560 · Cited by 165 · see citing works
Diurnal differences in dopamine transporter and tyrosine hydroxylase levels in rat brain: dependence on the suprachiasmatic nucleus
Sleipness, E. P., Sorg, B. A., & Jansen, H. T. (2007) · Brain Research · doi:10.1016/j.brainres.2006.10.063 · Cited by 160 · see citing works
Dopamine D2-Like Receptors and the Antidepressant Response
Gershon, A. A., Vishne, T. H., & Grunhaus, L. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.031 · Cited by 159 · see citing works
Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder
Shimon, H., Agam, G., Belmaker, R. H., Hyde, T. M., & Kleinman, J. E. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.8.1148 · Cited by 157 · see citing works
Self-citation
A ‘crash’ course on psychostimulant withdrawal as a model of depression
Barr, A. M., Markou, A., & Phillips, A. G. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02086-2 · Cited by 156 · see citing works
Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than “depressive”
Zörner, B., Wolfer, D. P., Brandis, D., Kretz, O., Zacher, C., Madani, R., Kadow, I. C. G., Lipp, H., Klein, R., Henn, F. A., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00418-9 · Cited by 145 · see citing works
Clinical Characteristics of Major Depression That Predict Risk of Depression in Relatives
Kendler, K. S., Gardner, C. O., & Prescott, C. A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.322 · Cited by 144 · see citing works
Par-4 Links Dopamine Signaling and Depression
Park, S. K., Nguyen, M. D., Fischer, A., Luke, M. P.-S., Affar, E. B., Dieffenbach, P. B., Tseng, H.-C., Shi, Y., & Tsai, L. (2005) · Cell · doi:10.1016/j.cell.2005.05.031 · Cited by 144 · see citing works
Dopamine receptor-mediated regulation of neuronal “clock” gene expression
Imbesi, M., Yildiz, S., Arslan, A. D., Sharma, R., Manev, H., & Uz, T. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.044 · Cited by 141 · see citing works
Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus
Lee, K. J., Kim, S.-J., Kim, S.-W., Choi, S.-H., Shin, Y.-C., Park, S.-H., Moon, B., Cho, E., Lee, M.-S., Choi, S.-H., et al. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.6 · Cited by 138 · see citing works
Elevated agonist binding to α2-adrenoceptors in the locus coeruleus in major depression
Ordway, G. A., Schenck, J. E., Stockmeier, C. A., May, W., & Klimek, V. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01728-6 · Cited by 134 · see citing works
Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice
Tanda, K., Nishi, A., Matsuo, N., Nakanishi, K., Yamasaki, N., Sugimoto, T., Toyama, K., Takao, K., & Miyakawa, T. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-19 · Cited by 134 · see citing works
Animal models of craving for ethanol
Koob, G. F. (2000) · Addiction · doi:10.1080/09652140050111663 · Cited by 127 · see citing works
Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone
Scaccianoce, S., Bianco, P. D., Paolone, G., Caprioli, D., Modafferi, A. M. E., Nencini, P., & Badiani, A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.04.024 · Cited by 122 · see citing works
Normal Prefrontal Gamma-Aminobutyric Acid Levels in Remitted Depressed Subjects Determined by Proton Magnetic Resonance Spectroscopy
Hasler, G., Neumeister, A., van der Veen, J. W. C., Tumonis, T., Bain, E., Shen, J., Drevets, W. C., & Charney, D. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.017 · Cited by 122 · see citing works
Early Life Stress Alters Adult Serotonin 2C Receptor Pre-mRNA Editing and Expression of the α Subunit of the Heterotrimeric G-Protein Gq
Bhansali, P., Dunning, J., Singer, S. E., David, L., & Schmauss, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4632-06.2007 · Cited by 113 · see citing works
Reductions in cholesterol and synaptic markers in association cortex in mood disorders
Beasley, C. L., Honer, W. G., von Bergmann, K., Falkai, P., Lütjohann, D., & Bayer, T. A. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00239.x · Cited by 112 · see citing works
A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression
West, D. V., Del‐Favero, J., Aulchenko, Y. S., Oswald, P., Souery, D., Forsgren, T., Sluijs, S., Belkacem, S., Adolfsson, R., Mendlewicz, J., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001420 · Cited by 110 · see citing works
Elevated Central Serotonin Transporter Binding Availability in Acutely Abstinent Cocaine-Dependent Patients
Jacobsen, L. K., Staley, J. K., Malison, R. T., Zoghbi, S. S., Seibyl, J. P., Kosten, T. R., & Innis, R. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1134 · Cited by 110 · see citing works
Sand rats see the light: Short photoperiod induces a depression-like response in a diurnal rodent
Einat, H., Kronfeld‐Schor, N., & Eilam, D. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.006 · Cited by 108 · see citing works
Combined Treatment With Sertraline and Liothyronine in Major Depression
Cooper‐Kazaz, R., Apter, J. T., Cohen, R., Karagichev, L., Muhammed-Moussa, S., Grupper, D., Drori, T., Newman, M. E., Sackeïm, H. A., Gläser, B., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.6.679 · Cited by 106 · see citing works
Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression
Chen, F., Madsen, T. M., Wegener, G., & Nyengaard, J. R. (2009) · Hippocampus · doi:10.1002/hipo.20718 · Cited by 103 · see citing works
Basic concepts in the study of diseases with complex genetics
Burmeister, M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00316-3 · Cited by 102 · see citing works
Is dopamine implicated in the antidepressant-like effects of selective serotonin reuptake inhibitors in the mouse forced swimming test?
Renard, C. E., Fiocco, A. J., Clénet, F., Hascoët, M., & Bourin, M. (2001) · Psychopharmacology · doi:10.1007/s002130100836 · Cited by 100 · see citing works
Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats
Torregrossa, M. M., Jutkiewicz, E. M., Mosberg, H. I., Balboni, G., Watson, S. J., & Woods, J. H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.11.005 · Cited by 98 · see citing works
In Vivo Gene Modification Elucidates Subtype-Specific Functions of α2-Adrenergic Receptors
Kable, J. W., Murrin, L. C., & Bylund, D. B. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39196-7 · Cited by 98 · see citing works
Serotonin transporter gene polymorphism and affective disorder.
Kunugi, H., Tatsumi, M., Sakai, T., Hattori, M., & Nanko, S. (1996) · PubMed · Cited by 96 · see citing works
Transcranial Magnetic Stimulation in Clinical Psychiatry
Belmaker, R. H. (2006) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615377510 · Cited by 95 · see citing works
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The Bidirectional Relationship of Depression and Inflammation: Double Trouble
Beurel, E., Toups, M., & Nemeroff, C. B. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.002 · Cited by 2,136 · see citing works
A Handbook for the Study of Mental Health Second Edition
Scheid, T. L., & Brown, T. N. (2009) · Cited by 1,320 · see citing works
Oxidative Stress and the Central Nervous System
Salim, S. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237503 · Cited by 1,268 · see citing works
Circadian rhythm disruption and mental health
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030 · see citing works
Assessing salivary cortisol in large-scale, epidemiological research
Adam, E. K., & Kumari, M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.011 · Cited by 936 · see citing works
A Heuristic for Developing Transdiagnostic Models of Psychopathology: Explaining Multifinality and Divergent Trajectories
Nolen-Hoeksema, S., & Watkins, E. R. (2011) · Perspectives on Psychological Science · doi:10.1177/1745691611419672 · Cited by 863 · see citing works
Association of Serum Interleukin 6 and C-Reactive Protein in Childhood With Depression and Psychosis in Young Adult Life: A Population-Based Longitudinal Study
Khandaker, G. M., Pearson, R. M., Zammit, S., Lewis, G., & Jones, P. B. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1332 · Cited by 846 · see citing works
Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile
Penninx, B. W., Milaneschi, Y., Lamers, F., & Vogelzangs, N. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-129 · Cited by 839 · see citing works
Major depressive disorder
Marx, W., Penninx, B. W. J. H., Solmi, M., Furukawa, T. A., Firth, J., Carvalho, A. F., & Berk, M. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00454-1 · Cited by 850 · see citing works
What are 'good' depression symptoms? Comparing the centrality of DSM and non-DSM symptoms of depression in a network analysis
Fried, E. I., Epskamp, S., Nesse, R. M., Tuerlinckx, F., & Borsboom, D. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.005 · Cited by 751 · see citing works
Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694 · see citing works
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
Casarotto, P. C., Girych, M., Fred, S. M., Kovaleva, V., Moliner, R., Enkavi, G., Biojone, C., Cannarozzo, C., Sahu, M. P., Kaurinkoski, K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.034 · Cited by 663 · see citing works
Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis
Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663 · see citing works
Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress
Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y., & Jin, F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.033 · Cited by 651 · see citing works
Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease
Mattson, M. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1418.005 · Cited by 640 · see citing works
Monoamine neurocircuitry in depression and strategies for new treatments
Hamon, M., & Blier, P. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.04.009 · Cited by 643 · see citing works
Pathophysiology of depression: do we have any solid evidence of interest to clinicians?
HASLER, G. (2010) · World Psychiatry · doi:10.1002/j.2051-5545.2010.tb00298.x · Cited by 604 · see citing works
Depression in Parkinson disease—epidemiology, mechanisms and management
Aarsland, D., Påhlhagen, S., Ballard, C. G., Ehrt, U., & Svenningsson, P. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.189 · Cited by 597 · see citing works
Association of the Mediterranean Dietary Pattern With the Incidence of Depression
Sánchez‐Villegas, A., Delgado‐Rodríguez, M., Alonso, Á., Schlatter, J., Lahortiga‐Ramos, F., Serra‐Majem, L., & Martínez‐González, M. Á. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.129 · Cited by 581 · see citing works
Oxidative Stress and Psychological Disorders
Salim, S. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120230309 · Cited by 557 · see citing works
Gender and Mental Health
Rosenfield, S., & Mouzon, D. M. (2012) · Handbooks of sociology and social research · doi:10.1007/978-94-007-4276-5_14 · Cited by 553 · see citing works
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
Dang, R., Wang, M., Li, X., Wang, H., Liu, L., Wu, Q., Zhao, J., Ji, P., Zhong, L., Licinio, J., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02400-6 · Cited by 538 · see citing works
Current Developments of Coumarin Compounds in Medicinal Chemistry
Peng, X.-M., Damu, G. L. V., & Zhou, C. H. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319210013 · Cited by 506 · see citing works
Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems
Ren, J., Friedmann, D., Xiong, J., Liu, C. D., Ferguson, B. R., Weerakkody, T., DeLoach, K. E., Ran, C., Pun, A., Sun, Y., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.043 · Cited by 498 · see citing works
Comorbidity of insomnia and depression
Staner, L. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.09.003 · Cited by 481 · see citing works
Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence
Sarris, J. J., Panossian, A. G., Schweitzer, I., Stough, C. K. K., & Scholey, A. B. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.04.002 · Cited by 479 · see citing works
Bidirectional Microglia–Neuron Communication in Health and Disease
Szepesi, Z., Manouchehrian, O., Bachiller, S., & Deierborg, T. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00323 · Cited by 459 · see citing works
Children’s Depression Rating Scale – Revised (CDRS-R)
Keller, F., Grieb, J., Ernst, M., Spröber, N., Fegert, J. M., & Kölch, M. G. (2011) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000090 · Cited by 453 · see citing works
Prospective biomarkers of major depressive disorder: A systematic review and meta-analysis
Kennis, M., Gerritsen, L., van Dalen, M., Williams, A., Cuijpers, P., & Bockting, C. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0585-z · Cited by 435 · see citing works
Mitochondrial Dysfunction and Psychiatric Disorders
Rezin, G. T., Amboni, G., Zugno, A. I., Quevedo, J., & STRECK, E. L. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9865-8 · Cited by 443 · see citing works
Bidirectional Association Between Depression and Type 2 Diabetes Mellitus in Women
Pan, A., Lucas, M., Sun, Q., van Dam, R. M., Franco, O. H., Manson, J. E., Willett, W. C., Ascherio, A., & Hu, F. B. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.356 · Cited by 447 · see citing works
Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses
Sarris, J., Murphy, J., Mischoulon, D., Papakostas, G. I., Fava, M., Berk, M., & Ng, C. H. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15091228 · Cited by 436 · see citing works
Psychopathology and the Human Connectome: Toward a Transdiagnostic Model of Risk For Mental Illness
Buckholtz, J. W., & Meyer‐Lindenberg, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.002 · Cited by 433 · see citing works
Mood and gut feelings
Forsythe, P., Sudo, N., Dinan, T., Taylor, V. H., & Bienenstock, J. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.058 · Cited by 429 · see citing works
Fear erasure in mice requires synergy between antidepressant drugs and extinction training
Karpova, N. N., Pickenhagen, A., Lindholm, J., Tiraboschi, E., Kulesskaya, N., Ágústsdóttir, A., Antila, H., Popova, D., Akamine, Y., Sullivan, R., et al. (2011) · Science · doi:10.1126/science.1214592 · Cited by 382 · see citing works
Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs
Gulbins, E., Palmada, M., Reichel, M., Lüth, A., Böhmer, C., Amato, D., Müller, C. P., Tischbirek, C. H., Groemer, T. W., Tabatabai, G., et al. (2013) · Nature Medicine · doi:10.1038/nm.3214 · Cited by 384 · see citing works
Brain‐derived neurotrophic factor as a biomarker for mood disorders: An historical overview and future directions
Hashimoto, K. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02113.x · Cited by 388 · see citing works
Neurobiology of depression: an integrated view of key findings
Maletic, V., Robinson, M., Oakes, T. M. M., Iyengar, S., Ball, S. G., & Russell, J. D. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01602.x · Cited by 387 · see citing works
Regional brain volume in depression and anxiety disorders
van Tol, M.-J., van der Wee, N. J. A., van den Heuvel, O. A., Nielen, M. M. A., Demenescu, L. R., Aleman, A., Renken, R., van Buchem, M. A., Zitman, F. G., & Veltman, D. J. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.121 · Cited by 370 · see citing works
Emerging role of glutamate in the pathophysiology of major depressive disorder
Hashimoto, K. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.005 · Cited by 381 · see citing works
Recognizing Depression from the Microbiota–Gut–Brain Axis
Liang, S., Wu, X., Hu, X., Wang, T., & Jin, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061592 · Cited by 387 · see citing works
The importance of norepinephrine in depression
Briley, M., & Chantal, M. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s19619 · Cited by 373 · see citing works
Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression
Bernard, R., Kerman, I. A., Thompson, R. C., Jones, E. G., Bunney, W. E., Barchas, J. D., Schatzberg, A. F., Myers, R. M., Akil, H., & Watson, S. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.44 · Cited by 372 · see citing works
Inflammasomes in neuroinflammation and changes in brain function: a focused review
Singhal, G., Jaehne, E. J., Corrigan, F., Toben, C. G., & Baune, B. T. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00315 · Cited by 365 · see citing works
The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential
Lambert, D. G. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2572 · Cited by 361 · see citing works
The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies
Zhang, W.-N., Chang, S.-H., Guo, L.-Y., Zhang, K.-L., & Wang, J. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.039 · Cited by 355 · see citing works
Immobility in the forced swim test is adaptive and does not reflect depression
Molendijk, M. L., & de Kloet, E. R. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.028 · Cited by 354 · see citing works
Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder
Soria, V., Martínez‐Amorós, È., Escaramís, G., Valero, J., Pérez‐Egea, R., García, C. B., Gutiérrez‐Zotes, A., Puigdemont, D., Bayés, M., Crespo, J. M., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.230 · Cited by 352 · see citing works
The Role of BDNF in Depression on the Basis of Its Location in the Neural Circuitry
Yu, H., & Chen, Z.-Y. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.184 · Cited by 343 · see citing works
Data-driven subtypes of major depressive disorder: a systematic review
van Loo, H. M., de Jonge, P., Romeijn, J., Kessler, R. C., & Schoevers, R. A. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-156 · Cited by 322 · see citing works
Brain membrane lipids in major depression and anxiety disorders
Müller, C. P., Reichel, M., Mühle, C., Rhein, C., Gulbins, E., & Kornhuber, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.014 · Cited by 308 · see citing works
Gut microbiota in neurodegenerative disorders
Sarkar, S. R., & Banerjee, S. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.01.004 · Cited by 319 · see citing works
Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei
Ren, J., Isakova, A., Friedmann, D., Zeng, J., Grutzner, S. M., Pun, A., Zhao, G. Q., Kolluru, S. S., Wang, R., Lin, R., et al. (2019) · eLife · doi:10.7554/elife.49424 · Cited by 304 · see citing works
Interoceptive dysfunction: Toward an integrated framework for understanding somatic and affective disturbance in depression
Harshaw, C. (2015) · Psychological Bulletin · doi:10.1037/a0038101 · Cited by 302 · see citing works
Labeling and Stigma
Link, B. G., & Phelan, J. C. (2012) · Handbooks of sociology and social research · doi:10.1007/978-94-007-4276-5_25 · Cited by 304 · see citing works
Rapid recovery from major depression using magnesium treatment
Eby, G. A., & Eby, K. L. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.01.047 · Cited by 291 · see citing works
Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders
Gaiteri, C., Ding, Y., French, B., Tseng, G. C., & Sibille, E. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12106 · Cited by 289 · see citing works
An excitatory synapse hypothesis of depression
Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works
Neurobiological effects of exercise on major depressive disorder: A systematic review
Schuch, F. B., Deslandes, A. C., Stubbs, B., Gosmann, N. P., Silva, C. T. B. D., & Fleck, M. P. D. A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.012 · Cited by 279 · see citing works
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies
Shyn, S. I., Shi, J., Kraft, J. B., Potash, J. B., Knowles, J. A., Weissman, M. M., Garriock, H. A., Yokoyama, J. S., McGrath, P. J., Peters, E. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.125 · Cited by 270 · see citing works
Visually Interpretable Representation Learning for Depression Recognition from Facial Images
Zhou, X., Jin, K., Shang, Y., & Guo, G. (2018) · IEEE Transactions on Affective Computing · doi:10.1109/taffc.2018.2828819 · Cited by 273 · see citing works
Sex differences in gut microbiota in patients with major depressive disorder
Chen, J.-J., Zheng, P., Liu, Y.-Y., Zhong, X.-G., Wang, H.-Y., Guo, Y.-J., & Xie, P. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s159322 · Cited by 272 · see citing works
The neurobiology of depression in later-life: Clinical, neuropsychological, neuroimaging and pathophysiological features
Naismith, S. L., Norrie, L. M., Mowszowski, L., & Hickie, I. B. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.009 · Cited by 269 · see citing works
Depression in neurodegenerative diseases: Common mechanisms and current treatment options
Galts, C., Bettio, L. E. B., Jewett, D. C., Yang, C. C., Brocardo, P. S., Rodrigues, A. L. S., Thacker, J. S., & Gil‐Mohapel, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.002 · Cited by 268 · see citing works
Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts
Muglia, P., Tozzi, F., Galwey, N. W., Francks, C., Upmanyu, R., Kong, X., Antoniades, A., Domenici, E., Perry, J., Rothen, S., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.131 · Cited by 265 · see citing works
Agomelatine in the Treatment of Major Depressive Disorder
Stahl, S. M., D, M. F. M., Trivedi, M. H., Caputo, A., Shah, A., & Post, A. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05471blu · Cited by 262 · see citing works
Automated Depression Diagnosis Based on Deep Networks to Encode Facial Appearance and Dynamics
Zhu, Y. M., Shang, Y., Shao, Z., & Guo, G. (2017) · IEEE Transactions on Affective Computing · doi:10.1109/taffc.2017.2650899 · Cited by 260 · see citing works
Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression
Mößner, R., Mikova, O., Koutsilieri, E., Saoud, M., Ehlis, A., Müller, N., Fallgatter, A. J., & Riederer, P. F. (2007) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701263303 · Cited by 248 · see citing works
Microglia: An Interface between the Loss of Neuroplasticity and Depression
Singhal, G., & Baune, B. T. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00270 · Cited by 252 · see citing works
Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis
Tian, P., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.01.007 · Cited by 257 · see citing works
Technostress at work and mental health: concepts and research results
Dragano, N., & Lunau, T. (2020) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000613 · Cited by 274 · see citing works
Identification of psychiatric disorder subtypes from functional connectivity patterns in resting-state electroencephalography
Zhang, Y., Wu, W., Toll, R. T., Naparstek, S., Maron-Katz, A., Watts, M., Gordon, J., Jeong, J., Astolfi, L., Shpigel, E., et al. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-020-00614-8 · Cited by 241 · see citing works
Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress
Milior, G., Lecours, C., Samson, L., Bisht, K., Poggini, S., Pagani, F., Deflorio, C., Lauro, C., Alboni, S., Limatola, C., et al. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.024 · Cited by 247 · see citing works
Selecting an Appropriate Animal Model of Depression
Hao, Y., Ge, H., Sun, M., & Gao, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194827 · Cited by 247 · see citing works
Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence
Najjar, S., Pearlman, D. M., Devinsky, O., Najjar, A., & Zagzag, D. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-142 · Cited by 248 · see citing works
Burnout and depression in nurses: a systematic review and meta-analysis
Chen, C., & Meier, S. T. (2021) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2021.104099 · Cited by 246 · see citing works
Dietary Fat Intake and the Risk of Depression: The SUN Project
Sánchez‐Villegas, A., Verberne, L. D. M., de Irala, J., Ruiz‐Canela, M., Toledo, E., Serra‐Majem, L., & Martínez‐González, M. Á. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016268 · Cited by 246 · see citing works
The 5-HT7 receptor and disorders of the nervous system: an overview
Hedlund, P. B. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1626-0 · Cited by 239 · see citing works
An affective disorder in zebrafish with mutation of the glucocorticoid receptor
Ziv, L., Muto, A., Schoonheim, P. J., Meijsing, S. H., Strasser, D., Ingraham, H. A., Schaaf, M. J. M., Yamamoto, K. R., & Baier, H. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.64 · Cited by 241 · see citing works
Helplessness: a systematic translational review of theory and evidence for its relevance to understanding and treating depression.
Pryce, C., Azzinnari, D., Spinelli, S., Seifritz, E., Tegethoff, M., & Meinlschmidt, G. (2011) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2011.06.006 · Cited by 227 · see citing works
Vitamin D and the occurrence of depression: causal association or circumstantial evidence?
Bertone-Johnson, E. R. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00220.x · Cited by 240 · see citing works
Herbal Medicine for Anxiety, Depression and Insomnia
Liu, L., Liu, C., Wang, Y., Wang, P., Li, Y., & Li, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x1304150831122734 · Cited by 243 · see citing works
Gene expression in major depressive disorder
Jansen, R., Penninx, B. W. J. H., Madar, V, Xia, K., Milaneschi, Y., Hottenga, J. J., Hammerschlag, A. R., Beekman, A., van der Wee, N., Smit, J. H., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.57 · Cited by 224 · see citing works
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial
Nagele, P., Duma, A., Kopec, M., Gebara, M. A., Parsoei, A., Walker, M., Janski, A., Panagopoulos, V. N., Cristancho, P., Miller, J. P., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.016 · Cited by 230 · see citing works
Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
Gulbins, A., Schumacher, F., Becker, K. A., Wilker, B., Soddemann, M., Boldrin, F., Müller, C. P., Edwards, M. J., Goodman, M. D., Caldwell, C. C., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0090-9 · Cited by 230 · see citing works
Longitudinal Study of Depressive Symptoms in Patients With Metastatic Gastrointestinal and Lung Cancer
Lo, C., Zimmermann, C., Rydall, A., Walsh, A., Jones, J. M., Moore, M. J., Shepherd, F. A., Gagliese, L., & Rodin, G. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.9712 · Cited by 228 · see citing works
Increased Risk for Abnormal Depression Scores in Women With Polycystic Ovary Syndrome
Dokras, A., Clifton, S. C., Futterweit, W., & Wild, R. A. (2010) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e318202b0a4 · Cited by 229 · see citing works
The Kappa Opioid Receptor: From Addiction to Depression, and Back
Lalanne, L., Ayrancı, G., Kieffer, B. L., & Lutz, P.-É. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00170 · Cited by 227 · see citing works
Mediterranean dietary pattern and prevalence and incidence of depressive symptoms in mid-aged women: results from a large community-based prospective study
Rienks, J., Dobson, A. J., & Mishra, G. D. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.193 · Cited by 224 · see citing works
Child sexual abuse in the etiology of depression: a systematic review of reviews
Maniglio, R. (2010) · Depression and Anxiety · doi:10.1002/da.20687 · Cited by 219 · see citing works
The neurobiology of depression—revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms
Albert, P. R., Benkelfat, C., & Descarries, L. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0190 · Cited by 221 · see citing works
Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats
Hao, Z., Wang, W., Guo, R., & Liu, H. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.02.025 · Cited by 242 · see citing works
Inflammatory dietary pattern and risk of depression among women
Lucas, M., Chocano-Bedoya, P. O., Shulze, M. B., Mirzaei, F., O’Reilly, É. J., Okereke, O. I., Hu, F. B., Willett, W. C., & Ascherio, A. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.09.014 · Cited by 217 · see citing works
Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer’s Disease
Ehrenberg, A. J., Suemoto, C. K., Resende, E. D. P. F., Petersen, C., Leite, R. E. P., Rodriguez, R. D., Ferretti‐Rebustini, R. E. D. L., You, M. Y., Oh, J. Y., Nitríni, R., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180688 · Cited by 218 · see citing works
Relevance of Stress and Female Sex Hormones for Emotion and Cognition
ter Horst, J. P., de Kloet, E. R., Schächinger, H., & Oitzl, M. S. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9774-2 · Cited by 212 · see citing works
Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis
Chudzik, A., Orzyłowska, A., Rola, R., & Stanisz, G. J. (2021) · Biomolecules · doi:10.3390/biom11071000 · Cited by 212 · see citing works
Diabetes and Mental Health
Robinson, D. J., Coons, M., Haensel, H., Vallis, M., & Yale, J.-F. (2018) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.10.031 · Cited by 209 · see citing works
Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder
Wittenborn, A. K., Rahmandad, H., Rick, J., & Hosseinichimeh, N. (2016) · Psychological Medicine · doi:10.1017/s0033291715002044 · Cited by 207 · see citing works
Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression
Liu, C.-H., Yang, M.-H., Zhang, G.-Z., Wang, X.-X., Li, B., Li, M., Woelfer, M., Walter, M., & Wang, L. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01732-5 · Cited by 210 · see citing works
A Molecular Signature of Depression in the Amygdala
Sibille, E. L., Wang, Y., Joeyen-Waldorf, J., Gaiteri, C., Surget, A., Oh, S., Belzung, C., Tseng, G. C., & Lewis, D. A. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08121760 · Cited by 208 · see citing works

Guest Editorial / Misafir EditoryalDüşünen Adam The Journal of Psychiatry and Neurological Sciences 2014;27:181-185 DOI: 10.5350/DAJPN20142703001
Gonul, A. S., & Aksoy, B. (2015)
The Biology of Affective Disorders
Sachar, E. J., & Baron, M. (1979) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.02.030179.002445 · Cited by 66 · see citing works
Neurodevelopmental and Neurobiological Aspects of Major Depressive Disorder
Rawdin, B., Lindqvist, D., Bush, N. R., Hamilton, S. P., Boparai, R., Mackin, R. S., Reus, V. I., Mellon, S. H., & Wolkowitz, O. M. (2014) · Oxford University Press eBooks · doi:10.1093/med/9780199937806.003.0004 · Cited by 1 · see citing works
Major depressive disorder: a genetic view
Arango, M. R., Díaz, E. S., Peláez, M. C. V., Marín-Cárdenas, J. S., Sánchez, L. M. M., & González, D. G. (2017) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.15332/s1794-9998.2017.0002.11 · Cited by 2 · see citing works
New insights into the neurobiological mechanisms of major depressive disorders
Fakhoury, M. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.01.005 · Cited by 41 · see citing works

Authors: Belmaker, R. H., & Agam, G.
Affiliations: Ben-Gurion University of the Negev (IL)
ORCID: Belmaker, R.H.
Agam, Galila
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2008-01-03
Volume: 358
Issue: 1
Pages: 55-68
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra073096
OpenAlex: W2129579709
Cited by: 2,166
References: 245
Citations by year: 2026: 74 · 2025: 83 · 2024: 115 · 2023: 91 · 2022: 105 · 2021: 158 · 2020: 128 · 2019: 130 · 2018: 132 · 2017: 129 · 2016: 130 · 2015: 147 · 2014: 123 · 2013: 126 · 2012: 116
FWCI: 12.69
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: major depressive disorder, depression, genetic factors, biochemical mechanisms, neurophysiology, monoamine oxidase, antidepressants, stress, psychosocial factors
MeSH terms: Animals, Antidepressive Agents, Corticotropin-Releasing Hormone, Depressive Disorder, Major, Major Depressive Disorder, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Norepinephrine, Pituitary-Adrenal System, Serotonin, Stress, Psychological, Biogenic Monoamines

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