Glutamate transporters: confining runaway excitation by shaping synaptic transmission

Long-Term Potentiation--A Decade of Progress?

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The metabotropic glutamate receptor (mGluRlα) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction

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Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse

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Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

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Inflammation, glutamate, and glia: a trio of trouble in mood disorders

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Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

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Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs

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Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes

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Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

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Glutamate Transporters and the Excitotoxic Path to Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis

Foran, E., & Trotti, D. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2444 · Cited by 268

Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission

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Thinking Outside the Cleft to Understand Synaptic Activity: Contribution of the Cystine-Glutamate Antiporter (System xc−) to Normal and Pathological Glutamatergic Signaling

Bridges, R., Lutgen, V., Lobner, D., & Baker, D. A. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.003889 · Cited by 205

Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications

Nimgampalle, M., Chakravarthy, H., Sharma, S., Shree, S., Bhat, A. R., Pradeepkiran, J. A., & Devanathan, V. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101994 · Cited by 207

Glutamate neurotransmission in rodent models of traumatic brain injury

Dorsett, C. R., McGuire, J. L., DePasquale, E. A. K., Gardner, A. E., Floyd, C. L., & McCullumsmith, R. E. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2015.4373 · Cited by 163

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

Xia, D., Lianoglou, S., Sandmann, T., Calvert, M., Suh, J. H., Thomsen, E., Dugas, J., Pizzo, M. E., DeVos, S. L., Earr, T. K., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00547-7 · Cited by 124

Age and Alzheimer’s disease gene expression profiles reversed by the glutamate modulator riluzole

Pereira, A. C., Gray, J. D., Kogan, J. F., Davidson, R. L., Rubin, T. G., Okamoto, M., Morrison, J. H., & McEwen, B. S. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.33 · Cited by 116

Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse.

Higashimori, H., Morel, L., Huth, J., Lindemann, L., Dulla, C., Taylor, A., Freeman, M., & Yang, Y. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt055 · Cited by 85

Localization of excitatory amino acid transporters EAAT1 and EAAT2 in human postmortem cortex: A light and electron microscopic study

Roberts, R. C., Roche, J. K., & McCullumsmith, R. E. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.019 · Cited by 76

Impaired glutamate recycling and GluN2B‐mediated neuronal calcium overload in mice lacking TGF‐β1 in the CNS

Koeglsperger, T., Li, S., Brenneis, C., Saulnier, J. L., Mayo, L., Carrier, Y., Selkoe, D. J., & Weiner, H. L. (2013) · Glia · doi:10.1002/glia.22490 · Cited by 73

An Expanded Narrative Review of Neurotransmitters on Alzheimer’s Disease: The Role of Therapeutic Interventions on Neurotransmission

Akyuz, E., Arulsamy, A., Aslan, F. S., Sarisözen, B., Guney, B., Hekimoglu, A., Yilmaz, B. N., Retinasamy, T., & Shaikh, M. F. (2025) · Molecular Neurobiology · doi:10.1007/s12035-024-04333-y · Cited by 69

Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

Sen, Z. D., Danyeli, L. V., Woelfer, M., Lamers, F., Wagner, G., Sobanski, T., & Walter, M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.12.020 · Cited by 65

Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP

Pita-Almenar, J. D., Zou, S., Colbert, C. M., & Eskin, A. (2012) · Learning & Memory · doi:10.1101/lm.023259.111 · Cited by 52

Sex and Adolescent Ethanol Exposure Influence Pavlovian Conditioned Approach

Madayag, A. C., Stringfield, S. J., Reissner, K. J., Boettiger, C. A., & Robinson, D. L. (2017) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13354 · Cited by 50

Proteome Analysis and Conditional Deletion of the EAAT2 Glutamate Transporter Provide Evidence against a Role of EAAT2 in Pancreatic Insulin Secretion in Mice

Zhou, Y., Waanders, L. F., Holmseth, S., Guo, C., Berger, U. V., Li, Y., Lehre, A.-C., Lehre, K. P., & Danbolt, N. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.529065 · Cited by 49

Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder

Porton, B., Greenberg, B. D., Askland, K., Serra, L. M., Gesmonde, J., Rudnick, G., Rasmussen, S. A., & Kao, H.-T. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.35 · Cited by 36

The “molecular soldiers” of the CNS: astrocytes, a comprehensive review on their roles and molecular signatures

Rupareliya, V. P., Singh, A. A., Butt, A. M., A, H., & Kumar, H. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176048 · Cited by 29

Astroglial FMRP deficiency cell-autonomously up-regulates miR-128 and disrupts developmental astroglial mGluR5 signaling.

Men, Y., Ye, L., Risgaard, R. D., Promes, V., Zhao, X., Paukert, M., & Yang, Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2014080117 · Cited by 26

Xenon attenuates hippocampal long-term potentiation by diminishing synaptic and extrasynaptic N-methyl-D-aspartate receptor currents

Kratzer, S., Mattusch, C., Kochs, E., Eder, M., Haseneder, R., & Rammes, G. (2012) · Anesthesiology · doi:10.1097/aln.0b013e3182475d66 · Cited by 21

Common and divergent pathways in early stages of glutamate and tau-mediated toxicities in neurodegeneration

Chongtham, A., Sharma, A., Nath, B., Murtha, K., Gorbachev, K., Ramakrishnan, A., Schmidt, E. F., Shen, L., & Pereira, A. C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114967 · Cited by 10