Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

Sen, Zümrüt Duygu; Danyeli, Lena Vera; Woelfer, Marie; Lamers, Femke; Wagner, Gerd; Sobanski, Thomas; Walter, Martin

doi:10.1016/j.bbi.2020.12.020

Cited by 70Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

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Sen, Zümrüt Duygu, Danyeli, Lena Vera, Woelfer, Marie, Lamers, Femke, Wagner, Gerd, Sobanski, Thomas, Walter, Martin·2021·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2020.12.020

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Abstract

Insulin resistance (IR) and related disorders, such as T2DM, increase the risk of major depressive disorder (MDD) and vice versa. Current evidence indicates that psychological stress and overeating can induce chronic low-grade inflammation that can interfere with glutamate metabolism in MDD as well as insulin signaling, particularly in the atypical subtype. Here we first review the interactive role of inflammatory processes in the development of MDD, IR and related metabolic disorders. Next, we describe the role of the anterior cingulate cortex in the pathophysiology of MDD and IR-related disorders. Furthermore, we outline how specific clinical features of atypical depression, such as hyperphagia, are more associated with inflammation and IR-related disorders. Finally, we examine the regional specificity of the effects of inflammation on the brain that show an overlap with the functional and morphometric brain patterns activated in MDD and IR-related disorders.

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Symptoms of increased appetite, energy balance disturbances and hypersomnia are shared between atypical MDD and metabolic diseases including obesity, the metabolic syndrome and diabetes mellitus.
“symptoms of increased appetite, energy balance disturbances and hypersomnia, which are shared between atypical MDD and metabolic diseases including obesity, the metabolic syndrome and diabetes mellitus15,257.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [257]
The discussion on p. 3 identifies increased appetite and hypersomnia as features of atypical MDD, and the discussion on p. 7 links increased appetite and lethargy to insulin-resistance-related disorders. The paper does not establish that increased appetite, energy-balance disturbances and hypersomnia are each shared symptoms of obesity, metabolic syndrome and diabetes. (LLM, conf=0.84)
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Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management
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Additional file 5 of Mechanism exploration of Gouqi-wentang formula against type 2 diabetes mellitus by phytochemistry and network pharmacology-based analysis and biological validation
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Authors: Sen, Z. D., Danyeli, L. V., Woelfer, M., Lamers, F., Wagner, G., Sobanski, T., & Walter, M.
Affiliations: Jena University Hospital (DE)
Leibniz Institute for Neurobiology (DE)
Amsterdam University Medical Centers (NL)
Corresponding author: Walter, Martin
ORCID: Danyeli, Lena Vera
Woelfer, Marie
Lamers, Femke
Wagner, Gerd
Sobanski, Thomas
Walter, Martin
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2021-03
Volume: 93
Pages: 335-352
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2020.12.020
OpenAlex: W3114780798
Cited by: 65
References: 305
Citations by year: 2026: 12 · 2025: 22 · 2024: 9 · 2023: 11 · 2022: 4 · 2021: 6 · 2020: 1
FWCI: 0.43
Type: journal article
Language: en
Open access: green
research.vumc.nl
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
Pure Amsterdam UMC (submittedVersion, cc-by)
Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by-nc-nd)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: Horizon 2020
Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: atypical depression, insulin resistance, low-grade inflammation, major depressive disorder, type 2 diabetes, hyperphagia, anterior cingulate cortex, glutamate metabolism, insulin signaling, psychological stress, neuroinflammation, brain morphometry
MeSH terms: Depression, Major Depressive Disorder, Humans, Inflammation, Insulin, Insulin Resistance

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Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

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