Cited by 681Memory and Neural MechanismsHistone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

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Histone acetylation: molecular mnemonics on the chromatin

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Gräff, Johannes, Tsai, Li-Huei·2013·Nature Reviews Neuroscience

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Abstract

Long-lasting memories require specific gene expression programmes that are, in part, orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in cognitive processes, histone acetylation has spurred considerable interest. Whereas increments in histone acetylation have consistently been shown to favour learning and memory, a lack thereof has been causally implicated in cognitive impairments in neurodevelopmental disorders, neurodegeneration and ageing. As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.

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Authors: Gräff, J., & Tsai, L.-H.
Affiliations: Broad Institute (US)
Corresponding author: Tsai, Li-Huei
ORCID: Gräff, Johannes
Tsai, Li-Huei
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2013-01-17
Volume: 14
Issue: 2
Pages: 97-111
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3427
OpenAlex: W2072106835
Cited by: 680
References: 183
Citations by year: 2026: 41 · 2025: 47 · 2024: 57 · 2023: 48 · 2022: 72 · 2021: 68 · 2020: 36 · 2019: 47 · 2018: 40 · 2017: 48 · 2016: 53 · 2015: 36 · 2014: 61 · 2013: 26
FWCI: 4.99
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: Howard Hughes Medical Institute
National Institute of Neurological Disorders and Stroke (NS078839, R01NS078839, NS51874, R01NS051874)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: histone acetylation, histone deacetylase inhibitors, memory, learning, epigenetic mechanisms, chromatin, cognitive frailty, neurodegeneration, aging, neurodevelopmental disorders, cognitive impairment, gene expression
MeSH terms: Acetylation, Aging, Animals, Chromatin, Cognition Disorders, Histone Deacetylases, Histones, Humans, Memory, Neuronal Plasticity, Epigenesis, Genetic, Histone Deacetylase 2, Histone Deacetylase Inhibitors

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Histone acetylation: molecular mnemonics on the chromatin

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