Cited by 681Memory and Neural MechanismsHistone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

The DOI matches its Crossref record; 183 of the 183 references it cites were found in a registry or an index.

Histone acetylation: molecular mnemonics on the chromatin

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Gräff, Johannes, Tsai, Li-Huei·2013·Nature Reviews Neuroscience

Abstract

Long-lasting memories require specific gene expression programmes that are, in part, orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in cognitive processes, histone acetylation has spurred considerable interest. Whereas increments in histone acetylation have consistently been shown to favour learning and memory, a lack thereof has been causally implicated in cognitive impairments in neurodevelopmental disorders, neurodegeneration and ageing. As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.

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Crossref · 10.1038/nrn3427

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Metadata

Authors
Gräff, J., & Tsai, L.-H.
Affiliations
Broad Institute (US)
Corresponding author
Tsai, Li-Huei
Venue
Nature Reviews Neuroscience
Published
2013-01-17
Volume
14
Issue
2
Pages
97-111
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2072106835
Cited by
680
References
183
Citations by year
2026: 41 · 2025: 47 · 2024: 57 · 2023: 48 · 2022: 72 · 2021: 68 · 2020: 36 · 2019: 47 · 2018: 40 · 2017: 48 · 2016: 53 · 2015: 36 · 2014: 61 · 2013: 26
FWCI
4.99
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Neurological Disorders and Stroke (NS078839, R01NS078839, NS51874, R01NS051874)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
histone acetylation, histone deacetylase inhibitors, memory, learning, epigenetic mechanisms, chromatin, cognitive frailty, neurodegeneration, aging, neurodevelopmental disorders, cognitive impairment, gene expression
MeSH terms
Acetylation, Aging, Animals, Chromatin, Cognition Disorders, Histone Deacetylases, Histones, Humans, Memory, Neuronal Plasticity, Epigenesis, Genetic, Histone Deacetylase 2, Histone Deacetylase Inhibitors

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