The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Cellular and molecular mechanisms of renal fibrosis
Open accessAbstract
Renal fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost all progressive chronic kidney diseases. Renal fibrosis is also a reliable predictor of prognosis and a major determinant of renal insufficiency. Irrespective of the initial causes, renal fibrogenesis is a dynamic and converging process that consists of four overlapping phases: priming, activation, execution and progression. Nonresolving inflammation after a sustained injury sets up the fibrogenic stage (priming) and triggers the activation and expansion of matrix-producing cells from multiple sources through diverse mechanisms, including activation of interstitial fibroblasts and pericytes, phenotypic conversion of tubular epithelial and endothelial cells and recruitment of circulating fibrocytes. Upon activation, matrix-producing cells assemble a multicomponent, integrin-associated protein complex that integrates input from various fibrogenic signals and orchestrates the production of matrix components and their extracellular assembly. Multiple cellular and molecular events, such as tubular atrophy, microvascular rarefaction and tissue hypoxia, promote scar formation and ensure a vicious progression to end-stage kidney failure. This Review outlines our current understanding of the cellular and molecular mechanisms of renal fibrosis, which could offer novel insights into the development of new therapeutic strategies.
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Cites
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Cellular and molecular mechanisms of fibrosis
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Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
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Integrin–TGF‐β crosstalk in fibrosis, cancer and wound healing
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“Integrins are a family of heterodimeric transmembrane receptors that consist of α and β subunits and bind to the ECM and to the cytoskeleton, thereby integrating the 'outside-in' and 'inside-out' signals between cells and their extracellular environment”
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Cited by
Fibrosis–a common pathway to organ injury and failure
Rockey, D. C., Bell, P. D., & Hill, J. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1300575 · Cited by 1,428
Recent Developments in Myofibroblast Biology
Hinz, B., Phan, S. H., Thannickal, V. J., Prunotto, M., Desmoulière, A., Varga, J., De Wever, O., Mareel, M., & Gabbiani, G. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.02.004 · Cited by 1,193
Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment
Samsu, N. (2021) · BioMed Research International · doi:10.1155/2021/1497449 · Cited by 1,001
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MicroRNAs in kidney physiology and disease
Trionfini, P., Benigni, A., & Remuzzi, G. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.202 · Cited by 353
Metadata
- Authors
- Liu, Y.
- Venue
- Nature Reviews Nephrology
- Published
- 2011-10-18
- Volume
- 7
- Issue
- 12
- Pages
- 684-696
- ISSN
- 1745-8323 (ISSN-L)
- 1759-5061
- 1759-507X
- OpenAlex
- W2033457930
- Cited by
- 1,446
- References
- 8
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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