Cited by 370Cell Adhesion Molecules ResearchCellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Mechanisms that regulate adaptor binding to β-integrin cytoplasmic tails

Legate, Kyle R., Fässler, Reinhard·2009·Journal of Cell Science

Abstract

Cells recognize and respond to their extracellular environment through transmembrane receptors such as integrins, which physically connect the extracellular matrix to the cytoskeleton. Integrins provide the basis for the assembly of intracellular signaling platforms that link to the cytoskeleton and influence nearly every aspect of cell physiology; however, integrins possess no enzymatic or actin-binding activity of their own and thus rely on adaptor molecules, which bind to the short cytoplasmic tails of integrins, to mediate and regulate these functions. Many adaptors compete for relatively few binding sites on integrin tails, so regulatory mechanisms have evolved to reversibly control the spatial and temporal binding of specific adaptors. This Commentary discusses the adaptor proteins that bind directly to the tails of β integrins and, using talin, tensin, filamin, 14-3-3 and integrin-linked kinase (ILK) as examples, describes the ways in which their binding is regulated.

Integrity signals

Registry

Crossref · 10.1242/jcs.041624

Cites

174 of 174 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 175 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Legate, K. R., & Fässler, R.
Affiliations
  • Max Planck Institute of Biochemistry (DE)
  • Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
Venue
Journal of Cell Science
Published
2009-01-15
Volume
122
Issue
2
Pages
187-198
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
OpenAlex
W2092447350
Cited by
370
References
175
Citations by year
2026: 5 · 2025: 4 · 2024: 6 · 2023: 11 · 2022: 18 · 2021: 18 · 2020: 18 · 2019: 17 · 2018: 17 · 2017: 19 · 2016: 28 · 2015: 24 · 2014: 28 · 2013: 23 · 2012: 47
FWCI
2.90
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cell Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
beta-integrin, integrin cytoplasmic tail, adaptor proteins, talin, tensin, filamin, 14-3-3 proteins, integrin-linked kinase, integrin signaling, binding regulation, cell adhesion
MeSH terms
Amino Acid Sequence, Animals, Binding Sites, Cytoplasm, Cytoskeletal Proteins, Humans, Microfilament Proteins, Molecular Sequence Data, Sequence Alignment, Integrin beta Chains

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review