The DOI matches its Crossref record; 184 of the 185 references it cites were found in a registry or an index, and 1 are not checked yet.
Neuroplasticity in the context of motor rehabilitation after stroke
Open accessAbstract
Approximately one-third of patients with stroke exhibit persistent disability after the initial cerebrovascular episode, with motor impairments accounting for most poststroke disability. Exercise and training have long been used to restore motor function after stroke. Better training strategies and therapies to enhance the effects of these rehabilitative protocols are currently being developed for poststroke disability. The advancement of our understanding of the neuroplastic changes associated with poststroke motor impairment and the innate mechanisms of repair is crucial to this endeavor. Pharmaceutical, biological and electrophysiological treatments that augment neuroplasticity are being explored to further extend the boundaries of poststroke rehabilitation. Potential motor rehabilitation therapies, such as stem cell therapy, exogenous tissue engineering and brain-computer interface technologies, could be integral in helping patients with stroke regain motor control. As the methods for providing motor rehabilitation change, the primary goals of poststroke rehabilitation will be driven by the activity and quality of life needs of individual patients. This Review aims to provide a focused overview of neuroplasticity associated with poststroke motor impairment, and the latest experimental interventions being developed to manipulate neuroplasticity to enhance motor rehabilitation.
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“After stroke, many patients, even elderly patients, show substantial neurological improvement.6”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [6]
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Metadata
- Authors
- Dimyan, M. A., & Cohen, L. G.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Cohen, Leonardo G.
- Venue
- Nature Reviews Neurology
- Published
- 2011-01-18
- Volume
- 7
- Issue
- 2
- Pages
- 76-85
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- PMC
- PMC4886719
- OpenAlex
- W2053281035
- Cited by
- 732
- References
- 183
- Citations by year
- 2026: 56 · 2025: 77 · 2024: 60 · 2023: 64 · 2022: 63 · 2021: 60 · 2020: 56 · 2019: 49 · 2018: 36 · 2017: 33 · 2016: 30 · 2015: 40 · 2014: 40 · 2013: 37 · 2012: 22
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (ZIANS002978)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- neuroplasticity, stroke, motor rehabilitation, motor recovery, exercise therapy, stem cell therapy, brain-computer interface, motor control
- MeSH terms
- Stroke Rehabilitation, Exercise Therapy, Persons with Disabilities, Humans, Motor Activity, Neuronal Plasticity, Recovery of Function, Stroke
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