Repurposing dopaminergic drugs for MS — the evidence mounts

The physiology, signaling, and pharmacology of dopamine receptors

Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763 · see citing works

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

Tzartos, J. S., Friese, M. A., Craner, M. J., Palace, J. A., Newcombe, J., Esiri, M. M., & Fugger, L. H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070690 · Cited by 1,180 · see citing works

The immunoregulatory role of dopamine: An update

Sarkar, C., Basu, B., Chakroborty, D., Dasgupta, P., & Basu, S. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.015 · Cited by 323 · see citing works

Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop

Cosentino, M., Fietta, A. M., Ferrari, M., Rasini, E., Bombelli, R., Carcano, E., Saporiti, F., Meloni, F., Marino, F., & Lecchini, S. (2006) · Blood · doi:10.1182/blood-2006-01-028423 · Cited by 318 · see citing works

Immunopathogenesis and immunotherapy of multiple sclerosis

Hemmer, B., Nessler, S., Zhou, D., Kieseier, B. C., & Hartung, H. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0154 · Cited by 253 · see citing works

The Dopaminergic System in Autoimmune Diseases

Pacheco, R., Contreras, F., & Zouali, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00117 · Cited by 161 · see citing works

Disturbed regulatory T cell homeostasis in multiple sclerosis

Venken, K., Hellings, N., Liblau, R., & Stinissen, P. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.12.003 · Cited by 149 · see citing works

Adrenergic and Dopaminergic Modulation of Immunity in Multiple Sclerosis: Teaching Old Drugs New Tricks?

Cosentino, M., & Marino, F. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9410-z · Cited by 92 · see citing works

The role of dopamine in modulation of Th-17 immune response in multiple sclerosis

Melnikov, M., Belousova, O., Владимирович, М. В., Pashenkov, M. V., & Boyко, A. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.01.020 · Cited by 55 · see citing works

Nerve-Driven Immunity

Levite, M. (2012) · Springer eBooks · doi:10.1007/978-3-7091-0888-8 · Cited by 30 · see citing works

A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles

Sey, N. Y. A., Hu, B., Mah, W., Fauni, H., McAfee, J. C., Rajarajan, P., Brennand, K. J., Akbarian, S., & Won, H. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0603-0 · Cited by 297 · see citing works

Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease

Matt, S. M., & Gaskill, P. J. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09851-4 · Cited by 286 · see citing works

Immunomodulatory Effects Mediated by Dopamine

Arreola, R., Álvarez-Herrera, S., Pérez‐Sánchez, G., Becerril‐Villanueva, E., Cruz-Fuentes, C. S., Flores-Gutiérrez, E. O., Garcés-Alvarez, M. E., de la Cruz-Aguilera, D. L., Medina‐Rivero, E., Hurtado‐Alvarado, G., et al. (2016) · Journal of Immunology Research · doi:10.1155/2016/3160486 · Cited by 137 · see citing works

Dopaminergic Regulation of Innate Immunity: a Review

Pinoli, M., Marino, F., & Cosentino, M. (2017) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-017-9749-2 · Cited by 130 · see citing works

Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis

Xue, R., Zhang, H., Pan, J., Du, Z., Zhou, W., Zhang, Z., Tian, Z., Zhou, R., & Bai, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02398 · Cited by 82 · see citing works

Dopamine, T cells and multiple sclerosis (MS)

Levite, M., Marino, F., & Cosentino, M. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-016-1640-4 · Cited by 56 · see citing works

Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis

Prado, C. E., Gaiazzi, M., González, H., Ugalde, V., Figueroa, A., Osorio‐Barrios, F., López, E., Lladser, Á., Rasini, E., Marino, F., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00571 · Cited by 46 · see citing works

Dopaminergic Therapeutics in Multiple Sclerosis: Focus on Th17-Cell Functions

Melnikov, M., Rogovskii, V., Boyко, A., & Pashenkov, M. V. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09852-3 · Cited by 41 · see citing works

Pien Tze Huang Alleviates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mice by Regulating Th1 and Th17 Cells

Qiu, X., Guo, Q., Liu, X., Luo, H., Fan, D., Deng, Y., Cui, H. L., Lu, C. C., Zhang, G., He, X., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01237 · Cited by 33 · see citing works

Dopaminergic Pathways in Obesity-Associated Inflammation

Leite, F., & Ribeiro, L. V. P. T. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09863-0 · Cited by 31 · see citing works

Decreased serum levels of sCD40L and IL-31 correlate in treated patients with Relapsing-Remitting Multiple Sclerosis

Guerrero-García, J. D. J., Rojas-Mayorquín, A. E., Valle, Y., Padilla‐Gutiérrez, J. R., Castañeda-Moreno, V. A., Mireles-Ramírez, M. A., Muñóz-Valle, J. F., & Ortuño‐Sahagún, D. (2017) · Immunobiology · doi:10.1016/j.imbio.2017.10.001 · Cited by 27 · see citing works

Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?

Melnikov, M., Pashenkov, M. V., & Boyко, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105313 · Cited by 24 · see citing works

The influence of biogenic amines on Th17-mediated immune response in multiple sclerosis

Melnikov, M., Rogovskii, V., Boyко, A., & Pashenkov, M. V. (2018) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2018.02.012 · Cited by 20 · see citing works

Th17-cells in depression: Implication in multiple sclerosis

Melnikov, M., & Lopatina, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1010304 · Cited by 19 · see citing works

The role of 5-HT2B-receptors in fluoxetine-mediated modulation of Th17- and Th1-cells in multiple sclerosis

Sviridova, A., Rogovskii, V., Кудрин, В. С., Pashenkov, M. V., Boyко, A., & Melnikov, M. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577608 · Cited by 21 · see citing works

Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs

Chen, X., Guo, M., Duan, Y.-Y., Jiang, F., Wu, H., Dong, S., Zhou, X., Thynn, H. N., Liu, C., Zhang, L., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.136477 · Cited by 19 · see citing works

Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis

Cosentino, M., Zaffaroni, M., Legnaro, M., Bombelli, R., Schembri, L., Baroncini, D., Bianchi, A., Clerici, R., Guidotti, M., Banfi, P., et al. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.07.008 · Cited by 19 · see citing works

Dopaminergic inhibition of human neutrophils is exerted through D1‐like receptors and affected by bacterial infection

Marino, F., Pinoli, M., Rasini, E., Martini, S. D., Luini, A., Pulze, L., Gasperina, D. D., Grossi, P., Legnaro, M., Ferrari, M., et al. (2022) · Immunology · doi:10.1111/imm.13550 · Cited by 17 · see citing works

Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunity

Prado, C. E., Osorio‐Barrios, F., Falcón, P., Espinoza, A., Sáez, J. J., Yuseff, M.-I., & Pacheco, R. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02338-1 · Cited by 17 · see citing works

MRP8/14 Is a Molecular Signature Triggered by Dopamine in HIV Latent Myeloid Targets That Increases HIV Transcription and Distinguishes HIV+ Methamphetamine Users with Detectable CSF Viral Load and Brain Pathology

Basova, L. V., Lindsey, A., McGovern, A., Gaskill, P. J., Rosander, A. M., Delorme-Walker, V., ElShamy, W. M., Pendyala, V. V., Ellis, R. J., Cherner, M., et al. (2023) · Viruses · doi:10.3390/v15061363 · Cited by 8 · see citing works

Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Ashraf-Uz-Zaman, M., Ji, G., Tidwell, D., Yin, L., Thakolwiboon, S., Pan, J., Junell, R., Griffin, Z., Shahi, S., Barthels, D., et al. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00647 · Cited by 7 · see citing works

In silico repurposing of CNS drugs for multiple sclerosis

Sardari, E., Ebadi, A., & Razzaghi‐Asl, N. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.104622 · Cited by 5 · see citing works

Neural Regulation of Inflammation: Pharmacological Mechanisms and Therapeutic Perspectives

Cosentino, M., & Marino, F. (2018) · Springer eBooks · doi:10.1007/978-3-319-77658-3_5 · Cited by 5 · see citing works

Progressive dopaminergic defect in a patient with primary progressive multiple sclerosis

Kaasinen, V., Joutsa, J., Rissanen, E., Airas, L. M., Soilu‐Hänninen, M., & Noponen, T. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.101385 · Cited by 3 · see citing works

The role of 5-HT2B-serotonin receptor in the modulatory effect of fluoxetine on interaction of macrophages with CD4+ T-cells in multiple sclerosis.

Lopatina, A., Евгеньевна, М. Н., Владимирович, М. В., Pashenkov, M. V., & Melnikov, M. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115519 · Cited by 2 · see citing works

Modulation of monocyte responses by progressive multiple sclerosis therapy.

Beyers, C. Z. (2020) · doi:10.26686/wgtn.17148233.v1 · Cited by 2 · see citing works

Blockade of D1-like dopaminergic receptors suppresses Th17-cell function in multiple sclerosis

Melnikov, M., Sviridova, A. A., Solodova, T., Lopatina, A., Pashenkov, M. V., & Boyko, A. N. (2021) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202112107282 · Cited by 1 · see citing works

D1 Receptor Blockade Suppresses the Function of Th-17 Cells in Multiple Sclerosis

Melnikov, M., Sviridova, A. A., Solodova, T., Lopatina, A., Pashenkov, M. V., & Boyko, A. N. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01267-7 · Cited by 1 · see citing works

Depression and Cancer: The Inflammatory Bridge

Leite, F., & Leite, Â. M. T. (2023) · Interdisciplinary cancer research · doi:10.1007/16833_2022_106 · Cited by 1 · see citing works

Norepinephrine and intestinal microbiome in the early stages of demyelination: clinical-immunological parallels

Sviridova, A. A., Кабаева, А. Р., Rogovskii, V., Kozhieva, M. K., Melnikov, M., & Boyko, A. N. (2019) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20191191028 · Cited by 1 · see citing works

Construction of miRNA-regulated drug-pathway network to screen drug repurposing candidates for multiple sclerosis

Kong, X., Wang, J., Cao, Y., Lu, X., Zhang, H., Zhang, X., Bo, C., Bai, M., Li, S., Jiao, Y., et al. (2022) · Medicine · doi:10.1097/md.0000000000029107 · Cited by 1 · see citing works

Dissecting molecular regulatory mechanisms underlying noncoding susceptibility SNPs associated with 19 autoimmune diseases using multi-omics integrative analysisPreprint

Chen, X., Guo, M.-R., Duan, Y.-Y., Jiang, F., Wu, H., Dong, S., Thynn, H. N., Liu, C., Zhang, L., Guo, Y., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/871384

The prospect of dopaminergic therapy in multiple sclerosis

Melnikov, M., Pashenkov, M. V., & Boyko, A. N. (2021) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202112102167

Perspectives for Dopaminergic Therapy in Multiple Sclerosis

Melnikov, M., Pashenkov, M. V., & Boyko, A. N. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01220-8

Faculty Opinions recommendation of A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.

Tiwari, V. K., & Singh, A. P. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737515832.793574153

Norepinephrine and intestinal microbiome in the early stages of demyelination: clinical-immunological parallels

Sviridova, A. A., Кабаева, А. Р., Rogovskii, V., Kozhieva, M. K., Melnikov, M., & Boyko, A. N. (2019) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201911910228

The role of dopamine receptors in the modulation of mononuclear phagocytes in multiple sclerosis

Lopatina, A., Sviridova, A. A., Belousova, O., Kuzmina, U. S., & Melnikov, M. (2024) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202412407279

The Role of Dopamine Receptors in the Modulation of Mononuclear Phagocytes in Multiple Sclerosis

Lopatina, A., Sviridova, A. A., Belousova, O., Kuzmina, U. S., & Melnikov, M. (2025) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-025-01763-6

The Role of D2-like Dopaminergic Receptor in Dopamine-mediated Modulation of Th17-cells in Multiple Sclerosis

Melnikov, M., Sviridova, A., Rogovskii, V., Кудрин, В. С., Владимирович, М. В., Boyко, A., & Pashenkov, M. V. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210823103859 · Cited by 9 · see citing works

The role of dopamine in regulating interactions of the immune and nervous system in multiple sclerosis

Melnikov, M., Hasaeva, M. A., Belousova, O., Владимирович, М. В., Pashenkov, M. V., & Boyко, A. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.08.1058 · Cited by 1 · see citing works

Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?

Melnikov, M., Pashenkov, M. V., & Boyко, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105313 · Cited by 24 · see citing works

The role of dopamine receptors in the modulation of mononuclear phagocytes in multiple sclerosis

Lopatina, A., Sviridova, A. A., Belousova, O., Kuzmina, U. S., & Melnikov, M. (2024) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202412407279

Dopaminergic Therapeutics in Multiple Sclerosis: Focus on Th17-Cell Functions

Melnikov, M., Rogovskii, V., Boyко, A., & Pashenkov, M. V. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09852-3 · Cited by 41 · see citing works