Erratum: Clearance systems in the brain—implications for Alzheimer diseaser
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CAA is caused by Aβ deposition in the vascular wall of small brain arteries and capillaries and develops as a result of an imbalance between Aβ production and clearance, particularly faulty transvascular and perivascular clearance of Aβ from the brain.
“CAA is caused by A 𝛃 deposition in the vascular wall of small brain arteries and capillaries and develops as a result of an imbalance between A 𝛃 production and clearance, particularly faulty transvascular and perivascular clearance of A 𝛃 from the brain (318, 420, 581, 640).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [581]
Solutes diffuse across brain extracellular spaces and are cleared along the basement membranes of arterial vessel walls by perivascular interstitial fluid flow, which travels in the reverse direction of blood flow.
“Besides the major role of transvascular transport in clearance of solutes across the BBB by CMT, RMT, major facilitators, and active efflux transporters (514, 682, 693), solutes diffuse across brain ECS and are cleared along the basement membranes of the arterial vessel walls by the perivascular ISF flow, which travels in the reverse direction of the blood flow (37, 514, 581) (FIGURE 4) .”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [581]
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Clearance systems in the brain—implications for Alzheimer disease
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- Authors
- Tarasoff-Conway, J. M., Carare, R. O., Osorio, R. S., Glodzik, L., Butler, T., Fieremans, E., Axel, L., Rusinek, H., Nicholson, C., Zlokovic, B. V., Frangione, B., Blennow, K., Ménard, J., Zetterberg, H., Wisniewski, T., & de Leon, M. J.
- ORCID
- Venue
- Nature Reviews Neurology
- Published
- 2016-03-29
- Volume
- 12
- Issue
- 4
- Pages
- 248-248
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W2776765027
- Cited by
- 61
- References
- 2
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 8 · 2020: 2 · 2019: 8 · 2018: 11 · 2017: 7 · 2016: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Neurology (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, glymphatic system, brain waste clearance, glial cells
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