The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Cartilage biology in osteoarthritis—lessons from developmental biology
Open accessAbstract
Developmental processes are emerging as a key element in the etiology and pathogenesis of osteoarthritis. In this Review, the authors describe the latest supporting evidence that links skeletal development with osteoarthritis, including the roles of chondrogenesis, patterning and joint formation in cartilage development and predisposition to osteoarthritis, and chondrocyte hypertrophy in cartilage degeneration. The cellular and molecular mechanisms responsible for the initiation and progression of osteoarthritis (OA), and in particular cartilage degeneration in OA, are not completely understood. Increasing evidence implicates developmental processes in OA etiology and pathogenesis. Herein, we review this evidence. We first examine subtle changes in cartilage development and the specification and formation of joints, which predispose to OA development, and second, we review the switch from an articular to a hypertrophic chondrocyte phenotype that is thought to be part of the OA pathological process ultimately resulting in cartilage degeneration. The latest studies are summarized and we discuss the concepts emerging from these findings in cartilage biology, in the light of our understanding of the developmental processes involved.
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Stöckl, S., Göttl, C., Grifka, J., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,656
Developmental regulation of the growth plate
Kronenberg, H. M. (2003) · Nature · doi:10.1038/nature01657 · Cited by 2,849
Sox9 is required for cartilage formation
Bi, W., Deng, J. M., Zhang, Z., Behringer, R. R., & de Crombrugghe, B. (1999) · Nature Genetics · doi:10.1038/8792 · Cited by 1,758
The surface of articular cartilage contains a progenitor cell population
Dowthwaite, G. P., Bishop, J. C., Redman, S. N., Khan, I. M., Rooney, P., Evans, D. J. R., Haughton, L., Bayram, Z., Boyer, S., Thomson, B., et al. (2004) · Journal of Cell Science · doi:10.1242/jcs.00912 · Cited by 916
Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily
Storm, E. E., Huynh, T. V., Copeland, N. G., Jenkins, N. A., Kingsley, D. M., & Lee, S.-J. (1994) · Nature · doi:10.1038/368639a0 · Cited by 854
Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian Skeleton
Brunet, L. J., McMahon, J. A., McMahon, A. P., & Harland, R. M. (1998) · Science · doi:10.1126/science.280.5368.1455 · Cited by 825
MicroRNA-140 plays dual roles in both cartilage development and homeostasis
Miyaki, S., Sato, T., Inoue, A., Otsuki, S., Ito, Y., Yokoyama, S., Kato, Y., Takemoto, F., Nakasa, T., Yamashita, S., et al. (2010) · Genes & Development · doi:10.1101/gad.1915510 · Cited by 660
Little, C. B., Barai, A., Burkhardt, D., Smith, S. M., Fosang, A. J., Werb, Z., Shah, M., & Thompson, E. W. (2009) · Arthritis & Rheumatism · doi:10.1002/art.25002 · Cited by 642
Yang, X., Chen, L., Xu, X., Li, C., Huang, C., & Deng, C.-X. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.1.35 · Cited by 638
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
Akiyama‡, H., Kim‡, J.-E., Nakashima, K., Balmes, G., Iwai, N., Deng, J. M., Zhang, Z., Martin, J. F., Behringer, R. R., Nakamura, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504750102 · Cited by 605
Cited by
TGFβ signaling in cartilage development and maintenance
Wang, W., Rigueur, D., & Lyons, K. M. (2014) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.21058 · Cited by 298
Functional testing of thousands of osteoarthritis-associated variants for regulatory activity
Klein, J. C., Keith, A., Rice, S. J., Shepherd, C., Agarwal, V., Loughlin, J., & Shendure, J. (2019) · Nature Communications · doi:10.1038/s41467-019-10439-y · Cited by 92
Zhao, L., Lai, Y., Jiao, H., & Huang, J. (2024) · Nature Communications · doi:10.1038/s41467-024-47633-6 · Cited by 69
Metadata
- Authors
- Pitsillides, A. A., & Beier, F.
- Venue
- Nature Reviews Rheumatology
- Published
- 2011-09-27
- Volume
- 7
- Issue
- 11
- Pages
- 654-663
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- OpenAlex
- W2065587003
- Cited by
- 254
- References
- 105
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
