The role of metabolism in the pathogenesis of osteoarthritis
Open accessAbstract
Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a resting regulatory state to a highly metabolically activate state to maintain energy homeostasis. This phenomenon also leads to an increase in metabolic intermediates for the biosynthesis of inflammatory and degradative proteins, which in turn activate key transcription factors and inflammatory signalling pathways involved in catabolic processes, and the persistent perpetuation of drivers of pathogenesis. In the past few years, several studies have demonstrated that metabolism has a key role in inflammatory joint diseases. In particular, metabolism is drastically altered in osteoarthritis (OA) and aberrant immunometabolism may be a key feature of many phenotypes of OA. This Review focuses on aberrant metabolism in the pathogenesis of OA, summarizing the current state of knowledge on the role of impaired metabolism in the cells of the osteoarthritic joint. We also highlight areas for future research, such as the potential to target metabolic pathways and mediators therapeutically.
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A systems medicine approach to degenerative joint disease diagnosis combines many data streams to provide a thorough evaluation of joint health across many biological levels.
“From molecular pathways to tissue-level alterations, a systems medicine approach to degenerative joint disease diagnosis combines many data streams to provide a thorough evaluation of joint health across many biological levels [8].”
From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [8]
The Conclusions (page unavailable) propose combining metabolomics, proteomics, lipidomics and bioinformatics to investigate osteoarthritis pathways, and describe changes in cartilage, bone and synovium. They do not describe a systems-medicine diagnostic approach that integrates molecular and tissue-level data to provide a comprehensive evaluation of joint health. (LLM, conf=0.84)
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Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease
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“From molecular pathways to tissue-level alterations, a systems medicine approach to degenerative joint disease diagnosis combines many data streams to provide a thorough evaluation of joint health across many biological levels [8].”
- Authors
- Mobasheri, A., Rayman, M. P., Gualillo, O., Sellam, J., van der Kraan, P., & Fearon, U.
- Affiliations
- University of Surrey (GB)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Inserm (FR)
- Trinity College Dublin (IE)
- Corresponding author
- Mobasheri, Ali
- Venue
- Nature Reviews Rheumatology
- Published
- 2017-04-06
- Volume
- 13
- Issue
- 5
- Pages
- 302-311
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- OpenAlex
- W2604174049
- Cited by
- 742
- References
- 6
- Citations by year
- 2026: 84 · 2025: 98 · 2024: 106 · 2023: 80 · 2022: 103 · 2021: 81 · 2020: 71 · 2019: 53 · 2018: 41 · 2017: 20 · 2012: 1
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- HAL (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Funders
- European Commission (625746, 305815, FP7-PEOPLE-2013-IEF, FP7-PEOPLE-2013, 115770, 734899)
- Instituto de Salud Carlos III (734899, PI14/00016, PI14/, RD16/0012/0014, RD16/0012, RIER RD16/0012/0014, 00016)
- European Regional Development Fund (734899)
- FP7 People: Marie-Curie Actions (FP7-PEOPLE-2013-IEF, 625746, FP7-PEOPLE-2013)
- FP7 Health (305815)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- osteoarthritis, immunometabolism, cellular metabolism, metabolic reprogramming, cartilage, synovium, joint inflammation, energy homeostasis, catabolism, inflammatory signaling, metabolic intermediates, metabolic pathway targeting
- MeSH terms
- Animals, Energy Metabolism, Humans, Osteoarthritis, Signal Transduction, Metabolic Networks and Pathways
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