AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network
Open accessAbstract
Efficient control of energy metabolic homeostasis, enhanced stress resistance, and qualified cellular housekeeping are the hallmarks of improved healthspan and extended lifespan. AMPK signaling is involved in the regulation of all these characteristics via an integrated signaling network. Many studies with lower organisms have revealed that increased AMPK activity can extend the lifespan. Experiments in mammals have demonstrated that AMPK controls autophagy through mTOR and ULK1 signaling which augment the quality of cellular housekeeping. Moreover, AMPK-induced stimulation of FoxO/DAF-16, Nrf2/SKN-1, and SIRT1 signaling pathways improves cellular stress resistance. Furthermore, inhibition of NF-κB signaling by AMPK suppresses inflammatory responses. Emerging studies indicate that the responsiveness of AMPK signaling clearly declines with aging. The loss of sensitivity of AMPK activation to cellular stress impairs metabolic regulation, increases oxidative stress and reduces autophagic clearance. These age-related changes activate innate immunity defence, triggering a low-grade inflammation and metabolic disorders. We will review in detail the signaling pathways of this integrated network through which AMPK controls energy metabolism, autophagic degradation and stress resistance and ultimately the aging process.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sensitivity to AMPK declines with age, thus promoting the argument that activators of AMPK, such as metformin, could delay aging.
“Worthy of note is that the sensitivity to AMPK declines with age thus promoting the argument that activators of AMPK, such as metformin, could delay aging (61).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [61]
Reduced sensitivity to AMPK activation with age or disease could result in reduced healthspan and lifespan.
“Furthermore, reduced sensitivity to AMPK activation with age or disease could result in reduced healthspan and lifespan (61).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Xie, Z., Zhang, J., Wu, J., Viollet, B., & Zou, M. (2008) · Diabetes · doi:10.2337/db08-0610 · Cited by 163 · see citing works
RetractedAging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506 · see citing works
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023 · see citing works
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Mihaylova, M. M., & Shaw, R. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2329 · Cited by 2,923 · see citing works
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750 · see citing works
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600 · see citing works
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280 · see citing works
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · see citing works
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works
Jung, C. H., Ro, S.-H., Cao, J., Otto, N. M., & Kim, D.-H. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.017 · Cited by 2,090 · see citing works
Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085 · see citing works
Mammalian autophagy: core molecular machinery and signaling regulation
Yang, Z., & Klionsky, D. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.014 · Cited by 1,956 · see citing works
FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953 · see citing works
NF-κB, Inflammation, and Metabolic Disease
Baker, R. G., Hayden, M. S., & Ghosh, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.008 · Cited by 1,952 · see citing works
Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935 · see citing works
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935 · see citing works
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works
Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Mäkelä, T. P., Alessi, D. R., & Hardie, D. G. (2003) · Journal of Biology · doi:10.1186/1475-4924-2-28 · Cited by 1,666 · see citing works
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638 · see citing works
Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,633 · see citing works
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., & Thompson, C. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.027 · Cited by 1,619 · see citing works
Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,496 · see citing works
Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489 · see citing works
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,473 · see citing works
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361 · see citing works
Genetic pathways that regulate ageing in model organisms
Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337 · see citing works
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · see citing works
Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
Haigis, M. C., & Guarente, L. P. (2006) · Genes & Development · doi:10.1101/gad.1467506 · Cited by 1,295 · see citing works
Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i>
Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270 · see citing works
Circadian Control of the NAD <sup>+</sup> Salvage Pathway by CLOCK-SIRT1
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P. (2009) · Science · doi:10.1126/science.1170803 · Cited by 1,198 · see citing works
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works
The antioxidant function of the p53 tumor suppressor
Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,110 · see citing works
Kawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.052 · Cited by 1,090 · see citing works
The role of the Atg1/ULK1 complex in autophagy regulation
Mizushima, N. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.004 · Cited by 1,062 · see citing works
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053 · see citing works
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
Altarejos, J. Y., & Montminy, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3072 · Cited by 1,035 · see citing works
Calorie restriction, SIRT1 and metabolism: understanding longevity
Bordone, L., & Guarente, L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1616 · Cited by 1,021 · see citing works
The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases
Hurley, R. L., Anderson, K. A., Franzone, J. M., Kemp, B. E., Means, A. R., & Witters, L. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503824200 · Cited by 1,021 · see citing works
Vousden, K. H., & Ryan, K. M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2715 · Cited by 959 · see citing works
Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals
Hulbert, A. J., Pamplona, R., Buffenstein, R., & Buttemer, W. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00047.2006 · Cited by 926 · see citing works
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
Tullet, J. M. A., Hertweck, M., An, J. H., Baker, J., Hwang, J. Y., Liu, S., Oliveira, R. P., Baumeister, R., & Blackwell, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.01.030 · Cited by 923 · see citing works
AMPK and SIRT1: a long-standing partnership?
Ruderman, N. B., Julia Xu, X., Nelson, L., Cacicedo, J. M., Saha, A. K., Lan, F., & Ido, Y. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00745.2009 · Cited by 903 · see citing works
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
Kalender, A., Selvaraj, A., Kim, S. Y., Gulati, P., Brûlé, S., Viollet, B., Kemp, B. E., Bardeesy, N., Dennis, P., Schlager, J. J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.014 · Cited by 889 · see citing works
Autophagy gone awry in neurodegenerative diseases
Wong, E. S. P., & Cuervo, A. M. (2010) · Nature Neuroscience · doi:10.1038/nn.2575 · Cited by 883 · see citing works
IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a
Hu, M. C.-T., Lee, D.-F., Xia, W., Golfman, L. S., Ou-Yang, F., Yang, J.-Y., Zou, Y., Bao, S., Hanada, N., Saso, H., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00302-2 · Cited by 868 · see citing works
Salminen, A., Hyttinen, J. M. T., & Kaarniranta, K. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0748-0 · Cited by 866 · see citing works
Self-citationDNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein
Tran, H. G., Brunet, A., Grenier, J. M., Datta, S. R., Fornace, A. J., DiStefano, P. S., Chiang, L. W., & Greenberg, M. E. (2002) · Science · doi:10.1126/science.1068712 · Cited by 860 · see citing works
SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1
Lan, F., Cacicedo, J. M., Ruderman, N., & Ido, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805711200 · Cited by 825 · see citing works
Greer, E. L., Oskoui, P. R., Banko, M. R., Maniar, J. M., Gygi, M. P., Gygi, S. P., & Brunet, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705325200 · Cited by 820 · see citing works
Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.047 · Cited by 801 · see citing works
Stress-activated cap’n’collar transcription factors in aging and human disease
Sykiotis, G. P., & Bohmann, D. (2010) · Science Signaling · doi:10.1126/scisignal.3112re3 · Cited by 776 · see citing works
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
Hansen, M., Chandra, A., Mitic, L. L., Onken, B., Driscoll, M., & Kenyon, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040024 · Cited by 766 · see citing works
Stressing the role of FoxO proteins in lifespan and disease
van der Horst, A., & Burgering, B. M. T. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2190 · Cited by 759 · see citing works
The mitochondrial‐lysosomal axis theory of aging
Brunk, U. T., & Terman, A. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02869.x · Cited by 727 · see citing works
Hariharan, N., Maejima, Y., Nakae, J., Paik, J., DePinho, R. A., & Sadoshima, J. (2010) · Circulation Research · doi:10.1161/circresaha.110.227371 · Cited by 688 · see citing works
A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders
Kim, J., Cha, Y., & Surh, Y. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.09.007 · Cited by 686 · see citing works
Onken, B., & Driscoll, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008758 · Cited by 671 · see citing works
Age-related decline in chaperone-mediated autophagy
Cuervo, A. M., & Dice, J. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002102200 · Cited by 665 · see citing works
FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging
Demontis, F., & Perrimon, N. (2010) · Cell · doi:10.1016/j.cell.2010.10.007 · Cited by 656 · see citing works
The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector
Screaton, R. A., Conkright, M. D., Katoh, Y., Best, J. L., Canettieri, G., Jeffries, S., Guzmán, E., Niessen, S., Yates, J. R., Takemori, H., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.015 · Cited by 649 · see citing works
Apfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S., & Curtis, R. (2004) · Genes & Development · doi:10.1101/gad.1255404 · Cited by 643 · see citing works
Kume, S., Uzu, T., Horiike, K., Chin-Kanasaki, M., Isshiki, K., Araki, S.-I., Sugimoto, T., Haneda, M., Kashiwagi, A., & Koya, D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41376 · Cited by 640 · see citing works
Sirtuins in aging and age-related disease
Longo, V. D., & Kennedy, B. K. (2006) · Cell · doi:10.1016/j.cell.2006.07.002 · Cited by 628 · see citing works
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., et al. (2011) · Nature · doi:10.1038/nature10296 · Cited by 624 · see citing works
Vaseva, A. V., & Moll, U. M. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.10.005 · Cited by 618 · see citing works
Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors
Brigelius-Flohé, R., & Flohé, L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3534 · Cited by 577 · see citing works
Greer, E. L., & Brunet, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00459.x · Cited by 574 · see citing works
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., et al. (2010) · Science · doi:10.1126/science.1182228 · Cited by 570 · see citing works
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
Reznick, R. M., Zong, H., Li, J., Morino, K., Moore, I. K., Yu, H. J., Liu, Z.-X., Dong, J., Mustard, K. J., Hawley, S. A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.008 · Cited by 555 · see citing works
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
Chau, M. D. L., Gao, J., Yang, Q., Wu, Z., & Gromada, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006962107 · Cited by 548 · see citing works
Autophagy and aging: keeping that old broom working
Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527 · see citing works
Zhang, C., & Cuervo, A. M. (2008) · Nature Medicine · doi:10.1038/nm.1851 · Cited by 520 · see citing works
AMPK: a metabolic gauge regulating whole-body energy homeostasis
Lage, R., Diéguez, C., Vidal‐Puig, A., & López, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.09.007 · Cited by 503 · see citing works
Metformin Inhibits Proinflammatory Responses and Nuclear Factor-κB in Human Vascular Wall Cells
Isoda, K., Young, J. L., Zirlik, A., MacFarlane, L. A., Tsuboi, N., Gerdes, N., Schönbeck, U., & Libby, P. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000201938.78044.75 · Cited by 499 · see citing works
Hattori, Y., Suzuki, K., Hattori, S., & Kasai, K. (2006) · Hypertension · doi:10.1161/01.hyp.0000221429.94591.72 · Cited by 487 · see citing works
The Association of AMPK with ULK1 Regulates Autophagy
Lee, J. W., Park, S., Takahashi, Y., & Wang, H.-G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015394 · Cited by 482 · see citing works
AMPK and the biochemistry of exercise: implications for human health and disease
Richter, E. A., & Ruderman, N. B. (2009) · Biochemical Journal · doi:10.1042/bj20082055 · Cited by 481 · see citing works
Momcilovic, M., Hong, S. P., & Carlson, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604399200 · Cited by 475 · see citing works
Delayed ageing through damage protection by the Arf/p53 pathway
Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature · doi:10.1038/nature05949 · Cited by 466 · see citing works
Motif module map reveals enforcement of aging by continual NF-κB activity
Adler, A. S., Sinha, S., Kawahara, T. L. A., Zhang, J. Y., Segal, E., & Chang, H. Y. (2007) · Genes & Development · doi:10.1101/gad.1588507 · Cited by 466 · see citing works
Tremblay, F., Brûlé, S., Hee Um, S., Li, Y., Masuda, K., Roden, M., Sun, X. J., Krebs, M., Polakiewicz, R. D., Thomas, G., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706517104 · Cited by 465 · see citing works
Can autophagy promote longevity?
Madeo, F., Tavernarakis, N., & Kroemer, G. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-842 · Cited by 433 · see citing works
FoxO Transcription Factors Promote Autophagy in Cardiomyocytes
Sengupta, A., Molkentin, J. D., & Yutzey, K. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.024406 · Cited by 428 · see citing works
Genetic links between diet and lifespan: shared mechanisms from yeast to humans
Bishop, N. A., & Guarente, L. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2188 · Cited by 421 · see citing works
AMP-activated protein kinase and its downstream transcriptional pathways
Cantó, C., & Auwerx, J. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0454-z · Cited by 421 · see citing works
Regulation of NF-κB, Th Activation, and Autoinflammation by the Forkhead Transcription Factor Foxo3a
Lin, L., Hron, J. D., & Peng, S. L. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.016 · Cited by 420 · see citing works
Yang, Z., Kahn, B. B., Shi, H., & Xue, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123620 · Cited by 411 · see citing works
Akt Activity Negatively Regulates Phosphorylation of AMP-activated Protein Kinase in the Heart
Kovacic, S., Soltys, C.-L. M., Barr, A., Shiojima, I., Walsh, K., & Dyck, J. R. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305371200 · Cited by 407 · see citing works
Caloric restriction, SIRT1 and longevity
Cantó, C., & Auwerx, J. (2009) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.03.008 · Cited by 395 · see citing works
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
Mair, W., Morantte, I., Rodrigues, A. P. C., Manning, G., Montminy, M., Shaw, R. J., & Dillin, A. (2011) · Nature · doi:10.1038/nature09706 · Cited by 393 · see citing works
AMPK alterations in cardiac physiology and pathology: enemy or ally?
Dyck, J. R. B., & Lopaschuk, G. D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109389 · Cited by 386 · see citing works
The two-stage mechanism controlling cellular senescence and immortalization
Wright, W. E., & Shay, J. W. (1992) · Experimental Gerontology · doi:10.1016/0531-5565(92)90069-c · Cited by 383 · see citing works
AMPK inhibition in health and disease
Viollet, B., Horman, S., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andreelli, F. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2010.488215 · Cited by 383 · see citing works
FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor
Chen, C.-C., Jeon, S., Bhaskar, P. T., Nogueira, V., Sundararajan, D., Tonic, I., Park, Y., & Hay, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.008 · Cited by 369 · see citing works
Maddocks, O. D. K., & Vousden, K. H. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0735-5 · Cited by 359 · see citing works
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
Feng, Z., & Levine, A. J. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.03.004 · Cited by 359 · see citing works
Life Extension in the Dwarf Mouse
Bartke, A., & Brown‐Borg, H. M. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)63006-7 · Cited by 354 · see citing works
The interaction between FOXO and SIRT1: tipping the balance towards survival
Giannakou, M. E., & Partridge, L. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.07.006 · Cited by 354 · see citing works
Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
Fogarty, S., & Hardie, D. G. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.09.012 · Cited by 351 · see citing works
Horman, S., Vertommen, D., Heath, R. B., Neumann, D., Mouton, V., Woods, A., Schlattner, U., Wallimann, T., Carling, D., Hue, L., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506850200 · Cited by 345 · see citing works
Autophagy is Required for Dietary Restriction-Mediated Life Span Extension in<i>C. elegans</i>
Jia, K., & Levine, B. (2007) · Autophagy · doi:10.4161/auto.4989 · Cited by 341 · see citing works
SIRT1 and p53, effect on cancer, senescence and beyond
Yi, J., & Luo, J. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.05.002 · Cited by 340 · see citing works
Kuro‐o, M. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.02.005 · Cited by 336 · see citing works
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke
McCullough, L. D., Zeng, Z., Li, H., Landree, L. E., McFadden, J., & Ronnett, G. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409985200 · Cited by 333 · see citing works
Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway
Yu, M., Li, H., Liu, Q., Liu, F., Tang, L., Li, C., Yuan, Y., Zhan, Y., Xu, W., Li, W., et al. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.01.014 · Cited by 319 · see citing works
Nutrition and Longevity in the Rat
Berg, B. N., & Simms, H. S. (1960) · Journal of Nutrition · doi:10.1093/jn/71.3.255 · Cited by 316 · see citing works
p53, Oxidative Stress, and Aging
Liu, D., & Xu, Y. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3644 · Cited by 315 · see citing works
The role of CREB signaling in Alzheimer’s disease and other cognitive disorders
Saura, C. A., & Valero, J. (2011) · revneuro · doi:10.1515/rns.2011.018 · Cited by 312 · see citing works
Sapkota, G. P., Kieloch, A., Lizcano, J., Laín, S., Arthur, J. S., Williams, M. R., Morrice, N., Deák, M., & Alessi, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009953200 · Cited by 308 · see citing works
Metabolic reprogramming, caloric restriction and aging
Anderson, R. M., & Weindruch, R. H. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.11.005 · Cited by 300 · see citing works
AMPK as a mediator of hormonal signalling
Lim, C. T., Kola, B., & Korbonits, M. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0063 · Cited by 298 · see citing works
Zhang, J., Gao, Z., Yin, J., Quon, M. J., & Ye, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806480200 · Cited by 297 · see citing works
Anisimov, V. N., Berstein, L. M., Popovich, I. G., Zabezhinski, M. A., Egormin, P. A., Piskunova, T. S., Semenchenko, A. V., Tyndyk, M. L., Yurova, M. N., Kovalenko, I. G., et al. (2011) · Aging · doi:10.18632/aging.100273 · Cited by 285 · see citing works
Okoshi, R., Ozaki, T., Yamamoto, H., Ando, K., Koida, N., Ono, S., Koda, T., Kamijo, T., Nakagawara, A., & Kizaki, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705232200 · Cited by 277 · see citing works
Ungvari, Z. I., Bailey‐Downs, L. C., Sosnowska, D., Gautam, T., Koncz, P., Losonczy, G., Ballabh, P., de Cabo, R., Sonntag, W. E., & Csiszár, A. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01134.2010 · Cited by 274 · see citing works
Regulation of the aging process by autophagy.
Salminen, A., & Kaarniranta, K. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.03.004 · Cited by 270 · see citing works
Self-citationFeng, Z., Hu, W., Teresky, A. K., Hernando, E., Cordon-Cardo, C., & Levine, A. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708043104 · Cited by 264 · see citing works
How to Live Long and Prosper: Autophagy, Mitochondria, and Aging
Yen, W.-L., & Klionsky, D. J. (2008) · Physiology · doi:10.1152/physiol.00013.2008 · Cited by 264 · see citing works
Dong, Y., Zhang, M., Liang, B., Xie, Z., Zhao, Z., Asfa, S., Choi, H. C., & Zou, M. (2010) · Circulation · doi:10.1161/circulationaha.109.900928 · Cited by 263 · see citing works
Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice
Anisimov, V. N., Zabezhinski, M. A., Popovich, I. G., Piskunova, T. S., Semenchenko, A. V., Тындык, М. Л., Yurova, M. N., Antoch, M. P., & Blagosklonny, M. V. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091050 · Cited by 257 · see citing works
Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts
Kang, H. T., Lee, K. B., Kim, S. Y., Choi, H. R., & Park, S. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023367 · Cited by 254 · see citing works
Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity
Lewis, K. N., Mele, J., Hayes, J. D., & Buffenstein, R. (2010) · Integrative and Comparative Biology · doi:10.1093/icb/icq034 · Cited by 247 · see citing works
Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN‐1
Park, S., Tedesco, P. M., & Johnson, T. E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00473.x · Cited by 242 · see citing works
The Extending Network of FOXO Transcriptional Target Genes
van der Vos, K. E., & Coffer, P. J. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3419 · Cited by 242 · see citing works
Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models
Viollet, B., Andreelli, F., Jørgensen, S. B., Perrin, C., Flamez, D., Mu, J., Wojtaszewski, J. F. P., Schuit, F. C., Birnbaum, M., Richter, E., et al. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310216 · Cited by 241 · see citing works
Friedman, D. B., & Johnson, T. E. (1988) · Journal of Gerontology · doi:10.1093/geronj/43.4.b102 · Cited by 240 · see citing works
Autophagy Regulates Ageing in<i>C. elegans</i>
Hars, E. S., Qi, H., Jin, S. V., Cai, L., Hu, C., & Liu, L. F. (2007) · Autophagy · doi:10.4161/auto.3636 · Cited by 238 · see citing works
Length of Life and Nutrition in the Rat
Ross, M. H. (1961) · Journal of Nutrition · doi:10.1093/jn/75.2.197 · Cited by 237 · see citing works
Li, X., Song, J., Zhang, L., LeMaire, S. A., Hou, X., Zhang, C., Coselli, J. S., Chen, L., Wang, X. L., Zhang, Y., et al. (2009) · Diabetes · doi:10.2337/db08-1512 · Cited by 237 · see citing works
Helenius, M., Hänninen, M., Lehtinen, S. K., & Salminen, A. (1996) · Biochemical Journal · doi:10.1042/bj3180603 · Cited by 232 · see citing works
Self-citationNorris, C. M., Kadish, I., Blalock, E. M., Chen, K.-C., Thibault, V., Porter, N. M., Landfield, P. W., & Kraner, S. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0365-05.2005 · Cited by 229 · see citing works
Hwang, J., Kwon, D. Y., & Yoon, S. H. (2009) · New Biotechnology · doi:10.1016/j.nbt.2009.03.005 · Cited by 221 · see citing works
p53, ROS and senescence in the control of aging
Vigneron, A., & Vousden, K. H. (2010) · Aging · doi:10.18632/aging.100189 · Cited by 221 · see citing works
Fibroblast growth factor 21: from pharmacology to physiology
Kliewer, S. A., & Mangelsdorf, D. J. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28449b · Cited by 219 · see citing works
Helenius, M. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0045 · Cited by 217 · see citing works
Curtis, R., O'Connor, G., & DiStefano, P. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00205.x · Cited by 215 · see citing works
Calcineurin Links Ca2+Dysregulation with Brain Aging
Foster, T. C., Sharrow, K., Masse, J. R., Norris, C. M., & Kumar, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-04066.2001 · Cited by 214 · see citing works
Budanov, A. V. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3530 · Cited by 203 · see citing works
Autophagy: Regulation and role in disease
Meijer, A. J., & Codogno, P. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360903044068 · Cited by 199 · see citing works
The Klotho gene family as a regulator of endocrine fibroblast growth factors.
Kurosu, H., & Kuro-o, M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.052 · Cited by 196 · see citing works
Loss of p53 enhances catalytic activity of IKKβ through O-linked β-N-acetyl glucosamine modification
Kawauchi, K., Araki, K., Tobiume, K., & Tanaka, N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813210106 · Cited by 193 · see citing works
Mihaylova, V. T., Borland, C. Z., Manjarrez, L., Stern, M., & Sun, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7427 · Cited by 192 · see citing works
Álvarez-Guardia, D., Palomer, X., Coll, T., Davidson, M. M., Chan, T. O., Feldman, A. M., Laguna, J. C., & Vázquez‐Carrera, M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq080 · Cited by 187 · see citing works
Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle
Saleem, A., Adhihetty, P. J., & Hood, D. A. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.90346.2008 · Cited by 182 · see citing works
FOXO transcription factors in ageing and cancer
Greer, E. L., & Brunet, A. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01780.x · Cited by 179 · see citing works
Insulin/IGF-1 paradox of aging: Regulation via AKT/IKK/NF-κB signaling
Salminen, A., & Kaarniranta, K. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2009.10.006 · Cited by 177 · see citing works
Self-citationThe FoxO transcription factors and metabolic regulation
Nakae, J., Oki, M., & Cao, Y. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.025 · Cited by 176 · see citing works
Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival
Liu, X., Peyton, K. J., Shebib, A. R., Wang, H., Korthuis, R. J., & Durante, W. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00749.2010 · Cited by 171 · see citing works
Salminen, A., Kauppinen, A., Suuronen, T., & Kaarniranta, K. (2008) · BioEssays · doi:10.1002/bies.20799 · Cited by 167 · see citing works
Self-citationKo, H. J., Zhang, Z., Jung, D. Y., Jun, J. Y., Ma, Z., Jones, K. E., Chan, S. Y., & Kim, J. K. (2009) · Diabetes · doi:10.2337/db08-1361 · Cited by 159 · see citing works
Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF-κB
Yang, X., Tajkhorshid, E., & Chen, L. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01343-09 · Cited by 143 · see citing works
Bergamini, E., Cavallini, G., Donati, A., & Gori, Z. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.05.007 · Cited by 142 · see citing works
AMPK exerts dual regulatory effects on the PI3K pathway
Tao, R., Gong, J., Luo, X., Zang, M., Guo, W., Wen, R., & Luo, Z. (2010) · Journal of Molecular Signaling · doi:10.1186/1750-2187-5-1 · Cited by 142 · see citing works
AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction
Turdi, S., Fan, X., Li, J., Zhao, J., Huff, A. F., Du, M., & Ren, J. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00586.x · Cited by 141 · see citing works
Metformin for aging and cancer prevention
Anisimov, V. N. (2010) · Aging · doi:10.18632/aging.100230 · Cited by 140 · see citing works
Nrf2 Signaling, a Mechanism for Cellular Stress Resistance in Long-Lived Mice
Leiser, S. F., & Miller, R. A. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01145-09 · Cited by 137 · see citing works
Kim, H., Park, K., Yoo, E.-K., Kim, Y.-H., Kim, Y.-N., Kim, H., Kim, H. T., Park, J., Lee, K.-U., Jang, W. G., et al. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1456 · Cited by 136 · see citing works
Bourg, É. L. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.01.004 · Cited by 136 · see citing works
FoxO4 Inhibits NF-κB and Protects Mice Against Colonic Injury and Inflammation
Zhou, W. H., Cao, Q., Peng, Y. S., Zhang, Q.-J., Castrillón, D. H., DePinho, R. A., & Liu, Z. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.049 · Cited by 134 · see citing works
The effects of p53 on whole organism longevity are mediated by autophagy
Tavernarakis, N., Pasparaki, A., Tasdemir, E., Maiuri, M. C., & Kroemer, G. (2008) · Autophagy · doi:10.4161/auto.6730 · Cited by 132 · see citing works
MacLaine, N. J., & Hupp, T. R. (2009) · Aging · doi:10.18632/aging.100047 · Cited by 129 · see citing works
Chiacchiera, F., Matrone, A., Ferrari, E., Ingravallo, G., Sasso, G. L., Murzilli, S., Petruzzelli, M., Salvatore, L., Moschetta, A., & Simone, C. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.36 · Cited by 120 · see citing works
ER stress and hormetic regulation of the aging process
Salminen, A., & Kaarniranta, K. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.003 · Cited by 115 · see citing works
Self-citationPhysiological Functions of Pten in Mouse Tissues.
Kishimoto, H., Hamada, K., Saunders, M. E., Backman, S. A., Sasaki, T., Nakano, T., Mak, T. W., & Suzuki, A. (2003) · Cell Structure and Function · doi:10.1247/csf.28.11 · Cited by 114 · see citing works
Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKα
Wan, Q., Weiqiang, K., Zhu, Q., Pengju, Z., & Liu, Y. (2007) · Experimental & Molecular Medicine · doi:10.1038/emm.2007.59 · Cited by 113 · see citing works
Ning, J., Xi, G., & Clemmons, D. R. (2011) · Endocrinology · doi:10.1210/en.2011-0155 · Cited by 112 · see citing works
Control of p53 and NF-κB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging
Salminen, A., & Kaarniranta, K. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.012 · Cited by 111 · see citing works
Self-citationLength of life and caloric intake
Ross, M. H. (1972) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/25.8.834 · Cited by 110 · see citing works
Przybysz, A. J., Choe, K. P., Roberts, L. J., & Strange, K. B. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.02.004 · Cited by 108 · see citing works
p53 and ARF: unexpected players in autophagy
Balaburski, G. M., Hontz, R. D., & Murphy, M. E. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.02.007 · Cited by 107 · see citing works
Ppm1E is an in cellulo AMP-activated protein kinase phosphatase
Voß, M., Paterson, J., Kelsall, I. R., Martín‐Granados, C., Hastie, C. J., Peggie, M. W., & Cohen, P. T. W. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.08.010 · Cited by 106 · see citing works
Kitamura, N., Nakamura, Y., Miyamoto, Y., Miyamoto, T., Kabu, K., Yoshida, M., Futamura, M., Ichinose, S., & Arakawa, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016060 · Cited by 105 · see citing works
Peng, S. L. (2008) · Oncogene · doi:10.1038/onc.2008.26 · Cited by 101 · see citing works
Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks
Kawahara, T. L. A., Rapicavoli, N. A., Wu, A. R., Qu, K., Quake, S. R., & Chang, H. Y. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002153 · Cited by 101 · see citing works
Central effects of the somatotropic system
Schneider, H., Pagotto, U., & Stalla, G. K. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490377 · Cited by 100 · see citing works
Helenius, M., Kyrylenko, S., Vehviläinen, P., & Salminen, A. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601750100669 · Cited by 97 · see citing works
Self-citationDisruption of Protein Kinase A in Mice Enhances Healthy Aging
Enns, L. C., Morton, J., Treuting, P. R., Emond, M. J., Wolf, N. S., McKnight, G. S., Rabinovitch, P. S., & Ladiges, W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005963 · Cited by 96 · see citing works
TOR-Driven Aging: Speeding Car Without Brakes
Blagosklonny, M. V. (2009) · Cell Cycle · doi:10.4161/cc.8.24.10310 · Cited by 95 · see citing works
Ning, J., & Clemmons, D. R. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0474 · Cited by 89 · see citing works
Crosstalk between p53 and FOXO Transcription Factors
You, H., & Mak, T. W. (2004) · Cell Cycle · doi:10.4161/cc.4.1.1401 · Cited by 88 · see citing works
The Endoplasmic Reticulum Stress Response and Aging
Naidoo, N. N. (2009) · Reviews in the Neurosciences · doi:10.1515/revneuro.2009.20.1.23 · Cited by 87 · see citing works
Ljubicic, V., & Hood, D. A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00483.x · Cited by 87 · see citing works
The Regulation of Aging and Longevity: A New and Complex Role of p53
Feng, Z., Lin, M., & Wu, R. (2011) · Genes & Cancer · doi:10.1177/1947601911410223 · Cited by 87 · see citing works
Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2Cα
Marley, A. E., SULLIVAN, J. E., Carling, D., Abbott, W. M., Smith, G., TAYLOR, I. W. F., Carey, F., & Beri, R. K. (1996) · Biochemical Journal · doi:10.1042/bj3200801 · Cited by 86 · see citing works
Autophagy Dysfunction in Alzheimer’s Disease
Li, L., Zhang, X., & Le, W. (2010) · Neurodegenerative Diseases · doi:10.1159/000276710 · Cited by 81 · see citing works
TP53 and MTOR crosstalk to regulate cellular senescence
Galluzzi, L., Kepp, O., & Kroemer, G. (2010) · Aging · doi:10.18632/aging.100202 · Cited by 81 · see citing works
Age-related changes in AMP-activated protein kinase after stroke
Liu, F., Benashski, S. E., Persky, R., Xu, Y., Li, J., & McCullough, L. D. (2011) · AGE · doi:10.1007/s11357-011-9214-8 · Cited by 76 · see citing works
TORC‐SIK cascade regulates CREB activity through the basic leucine zipper domain
Takemori, H., Kajimura, J., & Okamoto, M. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05889.x · Cited by 67 · see citing works
Sestrins at the crossroad between stress and aging
Lee, J. H., Bodmer, R., Bier, E., & Karin, M. (2010) · Aging · doi:10.18632/aging.100157 · Cited by 64 · see citing works
A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila
Funakoshi, M., Tsuda, M., Muramatsu, K., Hatsuda, H., Morishita, S., & Aigaki, T. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.01.090 · Cited by 63 · see citing works
AMPK activators – potential therapeutics for metabolic and other diseases
Zhou, G., Sebhat, I. K., & Zhang, B. B. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01967.x · Cited by 63 · see citing works
Lee, S. K., Lee, J. O., Kim, J. H., Kim, S. J., You, G. Y., Moon, J. W., Jung, J. H., Park, S. H., Uhm, K., Park, J., et al. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23000 · Cited by 59 · see citing works
Using Mice to Examine p53 Functions in Cancer, Aging, and LongevityPreprint
Donehower, L. A. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001081 · Cited by 56 · see citing works
Autophagy genes mediate the effect of calcineurin on life span in C. elegans
Dwivedi, M., Song, H.-O., & Ahnn, J. (2009) · Autophagy · doi:10.4161/auto.5.5.8157 · Cited by 55 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Reactive oxygen species: from health to disease
Brieger, K., Schiavone, S., Miller Jr., F. J., & Krause, K.-H. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13659 · Cited by 1,133 · see citing works
Regulation and function of AMPK in physiology and diseases
Jeon, S. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.81 · Cited by 1,122 · see citing works
Mitochondrial dysfunction in cell senescence and aging
Miwa, S., Kashyap, S., Chini, E., & von Zglinicki, T. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158447 · Cited by 1,061 · see citing works
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules
Markmiller, S., Soltanieh, S., Server, K. L., Mak, R., Jin, W., Fang, M. Y., Luo, E., Krach, F., Yang, D., Sen, A., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.032 · Cited by 895 · see citing works
AMPK, insulin resistance, and the metabolic syndrome
Ruderman, N. B., Carling, D., Prentki, M., & Cacicedo, J. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67227 · Cited by 877 · see citing works
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances
Xu, X., Pang, Y., & Fan, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02253-4 · Cited by 939 · see citing works
Benefits of Metformin in Attenuating the Hallmarks of Aging
Kulkarni, A. S., Gubbi, S., & Barzilai, N. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.001 · Cited by 766 · see citing works
The role of metabolism in the pathogenesis of osteoarthritis
Mobasheri, A., Rayman, M. P., Gualillo, O., Sellam, J., van der Kraan, P., & Fearon, U. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.50 · Cited by 742 · see citing works
Emerging regulators of the inflammatory process in osteoarthritis
Liu‐Bryan, R., & Terkeltaub, R. A. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.162 · Cited by 656 · see citing works
Metformin reverses established lung fibrosis in a bleomycin model
Rangarajan, S., Bone, N. B., Zmijewska, A. A., Jiang, S., Park, D. W., Bernard, K. F., Locy, M. L., Ravi, S., Deshane, J. S., Mannon, R. B., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0087-6 · Cited by 565 · see citing works
Mitochondria as playmakers of apoptosis, autophagy and senescence
Abate, M., Festa, A., Falco, M., Lombardi, A., Luce, A., Grimaldi, A., Zappavigna, S., Sperlongano, P., Irace, C., Caraglia, M., et al. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.022 · Cited by 543 · see citing works
Inflammaging: disturbed interplay between autophagy and inflammasomes
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2012) · Aging · doi:10.18632/aging.100444 · Cited by 511 · see citing works
Self-citationChronic inflammation and the hallmarks of aging
Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471 · see citing works
Sirtuins, a promising target in slowing down the ageing process
Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017) · Biogerontology · doi:10.1007/s10522-017-9685-9 · Cited by 470 · see citing works
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, S. T. S., Šmejkal, K., Malaník, M., et al. (2019) · Theranostics · doi:10.7150/thno.30787 · Cited by 465 · see citing works
Ageing, metabolism and cardiovascular disease
Costantino, S., Paneni, F., & Cosentino, F. (2015) · The Journal of Physiology · doi:10.1113/jp270538 · Cited by 465 · see citing works
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14023834 · Cited by 457 · see citing works
Self-citationRedox regulation by NRF2 in aging and disease
Schmidlin, C. J., Dodson, M. B., Madhavan, L., & Zhang, D. D. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.016 · Cited by 441 · see citing works
Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer
Liu, G., Pei, F., Yang, F., Li, L., Amin, A. D., Liu, S., Buchan, J. R., & Cho, W. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020367 · Cited by 424 · see citing works
Xian, H., Liu, Y., Nilsson, A. R., Gatchalian, R., Crother, T. R., Tourtellotte, W. G., Zhang, Y., Alemán-Muench, G. R., Lewis, G. M., Chen, W., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.004 · Cited by 407 · see citing works
Bardaweel, S. K., Gül, M., Alzweiri, M., Ishaqat, A., ALSalamat, H., & Bashatwah, R. M. (2018) · Eurasian Journal of Medicine · doi:10.5152/eurasianjmed.2018.17397 · Cited by 376 · see citing works
Cortese-Krott, M. M., Koning, A. M., Kuhnle, G., Nagy, P., Bianco, C. L., Pasch, A., Wink, D. A., Fukuto, J. M., Jackson, A. A., van Goor, H., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7083 · Cited by 363 · see citing works
Song, Y. M., Lee, Y.-H., Kim, J.-W., Ham, D.-S., Kang, E.-S., Cha, B. S., Lee, H. C., & Lee, B.-W. (2015) · Autophagy · doi:10.4161/15548627.2014.984271 · Cited by 332 · see citing works
Insulin resistance and Parkinson’s disease: A new target for disease modification?
Athauda, D. S., & Foltynie, T. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.10.001 · Cited by 333 · see citing works
The role of autophagy in bone metabolism and clinical significance
Wang, J., Zhang, Y., Cao, J., Wang, Y., Anwar, N., Zhang, Z., Zhang, D., Ma, Y., Xiao, Y., Xiao, L., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2186112 · Cited by 327 · see citing works
Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity
Seals, D. R., Justice, J. N., & LaRocca, T. J. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.282665 · Cited by 314 · see citing works
Sacitharan, P. (2019) · Sub-cellular biochemistry · doi:10.1007/978-981-13-3681-2_6 · Cited by 113 · see citing works
Collins, K. H., Herzog, W., MacDonald, G. Z., Reimer, R. A., Rios, J. L., Smith, I. C. P., Zernicke, R. F., & Hart, D. A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00112 · Cited by 311 · see citing works
Wang, Y., Zhao, X., Lotz, M., Terkeltaub, R. A., & Liu‐Bryan, R. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39182 · Cited by 303 · see citing works
Han, X., Tai, H., Wang, X., Wang, Z., Zhou, J., Wei, X., Ding, Y., Gong, H., Mo, C., Zhang, J., et al. (2016) · Aging Cell · doi:10.1111/acel.12446 · Cited by 302 · see citing works
Inflammatory risk factors, biomarkers and associated therapy in ischaemic stroke
Esenwa, C. C., & Elkind, M. S. V. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.125 · Cited by 282 · see citing works
Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278 · see citing works
Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders
Jęśko, H. M., Wencel, P. L., Strosznajder, R. P., & Strosznajder, J. B. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2110-y · Cited by 262 · see citing works
Ashabi, G., Khalaj, L., Khodagholi, F., Goudarzvand, M., & Sarkaki, A. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9632-2 · Cited by 256 · see citing works
AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging
Bujak, A. L., Crane, J. D., Lally, J., Ford, R. J., Kang, S. J., Rebalka, I. A., Green, A. E., Kemp, B. E., Hawke, T. J., Schertzer, J. D., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.016 · Cited by 252 · see citing works
Mitochondrial sirtuins, metabolism, and aging
Ji, Z., Liu, G., & Qu, J. T. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.11.005 · Cited by 245 · see citing works
Review: Metabolic Regulation of Inflammation in Osteoarthritis
Berenbaum, F., Griffin, T. M., & Liu‐Bryan, R. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39842 · Cited by 244 · see citing works
Nutrition for the ageing brain: Towards evidence for an optimal diet
Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.010 · Cited by 241 · see citing works
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
Widjaja, A. A., Lim, W.-W., Viswanathan, S., Chothani, S., Corden, B., Dasan, C. M., Goh, J. W. T., Lim, R., Singh, B. K., Tan, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07701-9 · Cited by 238 · see citing works
Dewanjee, S., Chakraborty, P., Bhattacharya, H., Chacko, L., Singh, B., Chaudhary, A., Javvaji, K., Pradhan, S. R., Vallamkondu, J., Dey, A., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.09.032 · Cited by 235 · see citing works
Metabolic features of the cell danger response
Naviaux, R. K. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.08.006 · Cited by 235 · see citing works
Obesity and aging: Molecular mechanisms and therapeutic approaches
Santos, A. L., & Sinha, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101268 · Cited by 240 · see citing works
Autophagy and aging: Maintaining the proteome through exercise and caloric restriction
Escobar, K. A., Cole, N. H., Mermier, C. M., & VanDusseldorp, T. A. (2018) · Aging Cell · doi:10.1111/acel.12876 · Cited by 226 · see citing works
Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans
Edwards, C., Canfield, J., Copes, N., Brito, A. G., Rehan, M. A. Y., Lipps, D., Brunquell, J., Westerheide, S. D., & Bradshaw, P. C. (2015) · BMC Genetics · doi:10.1186/s12863-015-0167-2 · Cited by 218 · see citing works
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.003 · Cited by 206 · see citing works
Self-citationZhao, H., Chen, S., Gao, K., Zhou, Z., Wang, C., Shen, Z., Guo, Y., Li, Z., Wan, Z., Liu, C., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.027 · Cited by 202 · see citing works
Marzetti, E., Csiszár, A., Dutta, D., Balagopal, G., Calvani, R., & Leeuwenburgh, C. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00936.2012 · Cited by 197 · see citing works
Liu, Y., Tang, G., Li, Y., Wang, Y., Chen, X., Gu, X., Zhang, Z., Wang, Y., & Yang, G. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0177-4 · Cited by 186 · see citing works
Advances in Understanding of the Role of Lipid Metabolism in Aging
Chung, K. W. (2021) · Cells · doi:10.3390/cells10040880 · Cited by 185 · see citing works
Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis
Tumurkhuu, G., Shimada, K., Dagvadorj, J., Crother, T., Zhang, W., Luthringer, D., Gottlieb, R., Chen, S., & Arditi, M. (2016) · Circulation Research · doi:10.1161/circresaha.116.308362 · Cited by 164 · see citing works
Yeo, E.-J. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0233-3 · Cited by 175 · see citing works
Autophagy and apoptosis cascade: which is more prominent in neuronal death?
Gupta, R. V., Ambasta, R. K., & Kumar, P. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04004-4 · Cited by 171 · see citing works
Regulation of reproduction and longevity by nutrient-sensing pathways
Templeman, N. M., & Murphy, C. T. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201707168 · Cited by 166 · see citing works
Emerging targets in osteoarthritis therapy
Goldring, M. B., & Berenbaum, F. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.03.004 · Cited by 164 · see citing works
Karnewar, S., Neeli, P. K., Panuganti, D., Kotagiri, S., Mallappa, S., Jain, N., Jerald, M. K., & Kotamraju, S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.01.018 · Cited by 161 · see citing works
Targeting AMPK signaling as a neuroprotective strategy in Parkinson’s disease
Curry, D. W., Stutz, B., Andrews, Z., & Elsworth, J. (2018) · Journal of Parkinson's Disease · doi:10.3233/jpd-171296 · Cited by 149 · see citing works
Wu, S., Wu, Y., Wu, T.-P., & Wei, Y. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.10.034 · Cited by 159 · see citing works
Viiri, J., Amadio, M., Marchesi, N., Hyttinen, J. M. T., Kivinen, N., Sironen, R. K., Rilla, K. J., Akhtar, S., Provenzani, A., D’Agostino, V., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069563 · Cited by 158 · see citing works
Self-citationAMPK and NRF2: Interactive players in the same team for cellular homeostasis?
Petsouki, E., Cabrera, S. N. S., & Heiß, E. H. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.07.014 · Cited by 157 · see citing works
Mechanisms of and Potential Medications for Oxidative Stress in Ovarian Granulosa Cells: A Review
Liu, S., Jia, Y., Meng, S., Luo, Y., Yang, Q., & Pan, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119205 · Cited by 165 · see citing works
Burtscher, J., Millet, G. P., Place, N., Kayser, B., & Zanou, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126479 · Cited by 158 · see citing works
The Signaling Pathways Regulating NLRP3 Inflammasome Activation
Chen, M.-Y., Ye, X.-J., He, X.-H., & Ouyang, D.-Y. (2021) · Inflammation · doi:10.1007/s10753-021-01439-6 · Cited by 154 · see citing works
Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil
Menéndez, J. A., Joven, J., Aragonès, G., Barrajón‐Catalán, E., Beltrán‐Debón, R., Borrás‐Linares, I., Camps, J., Corominas-Faja, B., Cufí, S., Fernández‐Arroyo, S., et al. (2013) · Cell Cycle · doi:10.4161/cc.23756 · Cited by 150 · see citing works
Obas, V., & Vasan, R. S. (2018) · Clinical Science · doi:10.1042/cs20171156 · Cited by 148 · see citing works
Cellular Senescence as the Causal Nexus of Aging
Bhatia‐Dey, N., Kanherkar, R. R., Stair, S. E., Makarev, E., & Csoka, A. B. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00013 · Cited by 147 · see citing works
Anti-aging pharmacology: Promises and pitfalls
Vaiserman, A. M., Lushchak, O. V., & Koliada, A. K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.004 · Cited by 144 · see citing works
Kciuk, M., Alam, M., Ali, N., Rashid, S., Głowacka, P., Rajamanikandan, S., Çeli̇k, İ., Yahya, E. B., Dubey, A., Zerroug, E., et al. (2023) · Molecules · doi:10.3390/molecules28135246 · Cited by 148 · see citing works
Yang, J. H., Shin, B. Y., Han, J. Y., Kim, M. G., Wi, J. E., Kim, Y. W., Cho, I. J., Kim, S. C., Shin, S. M., & Ki, S. H. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.10.026 · Cited by 137 · see citing works
Liu, D., Cai, Z., Yang, Y.-T., Lu, W.-H., Pan, L.-Y., Xiao, W.-F., & Li, Y. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.10.009 · Cited by 137 · see citing works
AMPK orchestrates an elaborate cascade protecting tissue from fibrosis and aging
Jiang, S., Li, T. X., Yang, Z. P., Yi, W., Di, S., Sun, Y., Wang, D., & Yang, Y. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.07.001 · Cited by 136 · see citing works
Nutritional influences on age-related skeletal muscle loss
Welch, A. A. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003698 · Cited by 136 · see citing works
Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling
Cheng, D., Xu, Q., Wang, Y., Li, G., Sun, W., Ma, D., Zhou, S., Liu, Y., Han, L., & Ni, C. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03036-5 · Cited by 133 · see citing works
How functional foods play critical roles in human health
Pang, G., Xie, J., Chen, Q., & Zhi-he, H. (2012) · Food Science and Human Wellness · doi:10.1016/j.fshw.2012.10.001 · Cited by 129 · see citing works
Ji, R., Jia, F., Chen, X., Wang, Z.-H., Jin, W., & Yang, J. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.109094 · Cited by 132 · see citing works
Zhang, L., Zhang, Z., Wang, J., Lv, D., Zhu, T., Wang, F., Tian, X., Yao, Y., Ji, P., & Liu, G. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12550 · Cited by 129 · see citing works
Mitochondrial complex I as a therapeutic target for Alzheimer's disease
Trushina, E. V., Trushin, S., & Hasan, M. F. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.11.003 · Cited by 130 · see citing works
Huang, Q., Wang, T., Yang, L., & Wang, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18051063 · Cited by 128 · see citing works
Singh, S., Singh, A. K., Garg, G., & Rizvi, S. I. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.11.004 · Cited by 127 · see citing works
RetractedKlotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease
Donate‐Correa, J., Martín-Carro, B., Cannata-Andía, J. B., Fernández, C. M., & Navarro‐González, J. F. (2023) · Antioxidants · doi:10.3390/antiox12020239 · Cited by 130 · see citing works
Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence
Park, J. T., Lee, Y.-S., Cho, K. A., & Park, S. C. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.08.003 · Cited by 123 · see citing works
wang, L., Quan, N., Sun, W., Chen, X., Cates, C. A., Rousselle, T. V., Zhou, X., Zhao, X., & Li, J. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy033 · Cited by 122 · see citing works
Regulation of longevity by FGF21: interaction between energy metabolism and stress responses
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.004 · Cited by 121 · see citing works
Self-citationSalminen, A., Kauppinen, A., & Kaarniranta, K. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01795-9 · Cited by 122 · see citing works
Self-citationThe Effects of Calorie Restriction on Autophagy: Role on Aging Intervention
Chung, K. W., & Chung, H. Y. (2019) · Nutrients · doi:10.3390/nu11122923 · Cited by 121 · see citing works
Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J.-P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., et al. (2017) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv309 · Cited by 119 · see citing works
(2024) · doi:10.1016/j.cmet.2024.01.015 · Cited by 119 · see citing works
Pu, Y., Zhang, H., Wang, P., Zhao, Y. C., Li, Q., Wei, X., Cui, Y., Sun, J., Shang, Q., Liu, D., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000354516 · Cited by 118 · see citing works
Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P. S., Pinto, M., Jin, L., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.03.009 · Cited by 110 · see citing works
Giampieri, F., Álvarez-Suárez, J. M., Cordero, M. D., Gasparrini, M., Forbes-Hernández, T. Y., Afrin, S., Santos‐Buelga, C., Paramás, A. M. G., Astolfi, P., Rubini, C., et al. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.05.017 · Cited by 115 · see citing works
Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging
Yu, M., Zhang, H., Wang, B. Z., Zhang, Y., Zheng, X., Shao, B., Zhuge, Q., & Jin, K. (2021) · Cells · doi:10.3390/cells10030660 · Cited by 114 · see citing works
Zhao, X., Petursson, F., Viollet, B., Lotz, M., Terkeltaub, R. A., & Liu‐Bryan, R. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38791 · Cited by 114 · see citing works
Inflammation and intracellular metabolism: new targets in OA
Liu‐Bryan, R. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.12.016 · Cited by 113 · see citing works
AMP-activated protein kinase: A target for old drugs against diabetes and cancer
Russo, G. L., Russo, M., & Ungaro, P. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.023 · Cited by 113 · see citing works
Lewińska, A., Adamczyk‐Grochala, J., Błoniarz, D., Olszowka, J., Kulpa-Greszta, M., Litwinienko, G., Tomaszewska, A., Wnuk, M., & Pązik, R. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101337 · Cited by 113 · see citing works
Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent
Bayliak, M. M., & Lushchak, V. I. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101237 · Cited by 115 · see citing works
Stress proteins in aging and life span
Murshid, A., Eguchi, T., & Calderwood, S. K. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.798873 · Cited by 111 · see citing works
Metformin as a geroprotector: experimental and clinical evidence
Piskovatska, V., Stefanyshyn, N., Storey, K. B., Vaiserman, A. M., & Lushchak, O. V. (2018) · Biogerontology · doi:10.1007/s10522-018-9773-5 · Cited by 110 · see citing works
Effects of exercise on cellular and tissue aging
Carapeto, P. V., & Aguayo-Mazzucato, C. (2021) · Aging · doi:10.18632/aging.203051 · Cited by 107 · see citing works
Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia
Lee, Y. Y., Lee, E.-J., Park, J., Jang, S., Kim, D., & Kim, H.-S. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9657-x · Cited by 107 · see citing works
The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells
White, J. P., Billin, A. N., Campbell, M. E., Russell, A. J., Huffman, K. M., & Kraus, W. E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.014 · Cited by 104 · see citing works
- Authors
- Salminen, A., & Kaarniranta, K.
- Affiliations
- University of Eastern Finland (FI)
- Corresponding author
- Salminen, Antero
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 11
- Issue
- 2
- Pages
- 230-241
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2111322904
- Cited by
- 860
- References
- 211
- Citations by year
- 2026: 71 · 2025: 74 · 2024: 86 · 2023: 88 · 2022: 72 · 2021: 92 · 2020: 64 · 2019: 49 · 2018: 64 · 2017: 41 · 2016: 42 · 2015: 49 · 2014: 27 · 2013: 33 · 2012: 8
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Ageing Research Reviews (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Academy of Finland
- University of Eastern Finland, Kuopio, Finland
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- AMPK, aging, healthspan, lifespan extension, energy metabolism, autophagy, mTOR signaling, SIRT1, NF-κB signaling, stress tolerance, oxidative stress, low-grade inflammation, innate immunity, metabolic disorders
- MeSH terms
- Aging, Animals, Autophagy, Energy Metabolism, Enzyme Activation, Humans, Stress, Physiological, Signal Transduction, Cellular Senescence, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
