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Antisense transcripts are targets for activating small RNAs
Open accessAbstract
Agents that activate expression of specific genes to probe cellular pathways or alleviate disease would go beyond existing approaches for controlling gene expression. Duplex RNAs complementary to promoter regions can repress or activate gene expression. The mechanism of these promoter-directed antigene RNAs (agRNAs) has been obscure. Other work has revealed noncoding transcripts that overlap mRNAs. The function of these noncoding transcripts is also not understood. Here we link these two sets of enigmatic results. We find that antisense transcripts are the target for agRNAs that activate or repress expression of progesterone receptor (PR). agRNAs recruit Argonaute proteins to PR antisense transcripts and shift localization of the heterogeneous nuclear ribonucleoprotein-k, RNA polymerase II and heterochromatin protein 1γ. Our data demonstrate that antisense transcripts have a central role in recognition of the PR promoter by both activating and inhibitory agRNAs.
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Metadata
- Authors
- Schwartz, J. C., Younger, S. T., Nguyen, N.-B., Hardy, D. B., Monia, B. P., Corey, D. R., & Janowski, B. A.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2008-07-06
- Volume
- 15
- Issue
- 8
- Pages
- 842-848
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2085516557
- Cited by
- 274
- References
- 1
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Schwartz, J. C., Younger, S. T., Nguyen, N.-B., Hardy, D. B., Monia, B. P., Corey, D. R., & Janowski, B. A. (2008). Antisense transcripts are targets for activating small RNAs. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.1444
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
