The histone variant macroH2A is an epigenetic regulator of key developmental genes

Buschbeck, Marcus, Uribesalgo, Iris, Wibowo, Indra, Rué, Pau, Martin, David, Gutierrez, Arantxa, Morey, Lluís, Guigó, Roderic +2 more·2009·Nature Structural & Molecular Biology

DOI 10.1038/nsmb.1665

Cited by (192)

Items 101–192 of 192

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Distinct Distribution of Ectopically Expressed Histone Variants H2A.Bbd and MacroH2A in Open and Closed Chromatin Domains
Elena S. Ioudinkova, Ana Barat, Andrey Pichugin, Elena N. Markova, I. V. Sklyar, Iryna Pirozhkova, Chloé Robin, Marc Lipinski, Vasily V. Ogryzko, Yegor S Vassetzky et al. · 2012 · PLoS ONE
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David S. Moura, Isabel F. Fernández, Gema Marín‐Royo, Inmaculada López-Sánchez, Elena Martín‐Doncel, Francisco M. De La Vega, Pedro A. Lazo · 2016 · Scientific Reports
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Mcad-mediated intercellular interactions activate satellite cell division
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The Histone Variant MacroH2A1 Regulates Target Gene Expression in Part by Recruiting the Transcriptional Coregulator PELP1
Kristine M. Hussey, Hongshan Chen, Christine Yang, Eugene Park, Nasun Hah, Hediye Erdjument‐Bromage, Paul Tempst, Matthew J. Gamble, W. Lee Kraus · 2014 · Molecular and Cellular Biology
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Evelyne Saade, Iryna Pirozhkova, Rakhan Aimbetov, Marc Lipinski, Vasily V. Ogryzko · 2015 · Aging Cell
Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype
Soraia Silva, Sara Monteiro‐Reis, Daniela Barros‐Silva, João Ramalho-Carvalho, Inês C. R. Graça, Isa C. Carneiro, Ana Teresa Martins, Jorge Oliveira, Luís Antunes, Sarah Hurtado-Bagès et al. · 2019 · Cancer Cell International
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D. Williamson Wes · 2011 · Frontiers in bioscience
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Simran Khurana, Tovah E. Markowitz, Juraj Kabat, Alison A. McBride · 2021 · mBio
Histone variants expression in peripheral blood mononuclear cells of patients with rheumatoid arthritis
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Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice
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Winfried H. Krueger, Lindsey C. Swanson, Borko Tanasijevic, Theodore P. Rasmussen · 2010 · The International Journal of Developmental Biology
Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm
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MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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Vincenzo Calvanese, Mario F. Fraga · 2012 · Advances in experimental medicine and biology
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Yan Li, Tan Tan, Le Zong, Dacheng He, Wei Tao, Qianjin Liang · 2012 · Chromosome Research
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The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A
Imke K. Mandemaker, Evelyn Fessler, David Corujo, Christiane Kotthoff, Andreas Wegerer, Clément Rouillon, Marcus Buschbeck, Lucas T. Jae, Francesca Mattiroli, Andreas G. Ladurner · 2023 · Cell Reports
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The Histone Variant MacroH2A1 Regulates Key Genes for Myogenic Cell Fusion in a Splice-Isoform Dependent Manner
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Joana Esteves de Lima, Frédéric Relaix · 2021 · International Journal of Molecular Sciences
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Cindy Law, Peter Cheung · 2012 · Sub-cellular biochemistry/Subcellular biochemistry
FACT mediates the depletion of macroH2A1.2 to expedite gene transcription
Dengyu Ji, Xue Xiao, Anfeng Luo, Xiongxiong Fan, Jingzhe Ma, Dayi Wang, Miaoran Xia, Lu Ma, Peng‐Ye Wang, Wei Li et al. · 2024 · Molecular Cell
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Cindy Law, Peter Cheung, Keyur K. Adhvaryu · 2015 · Current Molecular Biology Reports
The histone variant macroH2A confers functional robustness to the intestinal stem cell compartment
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Histone H2A variant H2A.B is enriched in transcriptionally active and replicating HSV-1 lytic chromatin
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Catpagavalli Asokanathan, Sharon Tierney, Christina R. Ball, George Buckle, Ami Day, S.W.M. Tanley, Adrian Bristow, Kevin Markey, Dorothy K.L. Xing, Chun‐Ting Yuen · 2017 · Analytical Biochemistry
Zebrafish macroH2A variants have distinct embryo localization and function
Elena González-Muñoz, Yohanna Arboleda-Estudillo, Sree Krishna Chanumolu, Hasan H. Otu, Jose Bernardo Cibelli · 2019 · Scientific Reports
The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation
Xiaoyuan Song, Josephine K. Bowen, Wei Miao, Yifan Liu, Martin A. Gorovsky · 2012 · Genes & Development
Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome
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Raisa A. Reyes-Castro, Shin-Yu Chen, Jacob Seemann, Samrat T. Kundu, Don Lynn Gibbons, Swathi Arur · 2023 · Science Advances
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Kathrin S. Heinz, Alexander W. Rapp, Corella S. Casas-Delucchi, Anne Lehmkuhl, Ismael Romero-Fernández, Antonio Sánchez, Oliver Holger Krämer, Juan Alberto Marchal, M. Cristina Cardoso · 2019 · Epigenetics & Chromatin
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Divya Nagarajan, Rebeca T Parracho, David Corujo, Minglu Xie, Ginte Kutkaite, Thale Kristin Olsen, Marta Rúbies Bedós, Maede Salehi, Ninib Baryawno, Michael P. Menden et al. · 2024 · Journal of Clinical Investigation
Histone Modifications and Histone Variants in Pluripotency and Differentiation
Andrew J. Bannister, Ana Mendanha Falcão, Gonçalo Castelo‐Branco · 2016 · Elsevier eBooks
Core histone families of mollusca: systematic identification, evolutionary insights, and functional analysis
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Annika Schmidt, Hui Zhang, Stéphanie Schmitt, Cathia Rausch, Oliver Popp, Jia‐Xuan Chen, Dušan Cmarko, Falk Butter, Gunnar A. G. Dittmar, Frederik Lermyte et al. · 2024 · Cells
The Histone H2A Variant MacroH2A1 Does Not Localize to the Centrosome
Nathalie Friedman, Michal Barzily-Rokni, Sara Isaac, Amir Eden · 2011 · PLoS ONE
A dynamic histone-based chromatin regulatory toolkit underpins genome and developmental evolution in an invertebrate clade
Francisco M. Martín-Zamora, Joby Cole, Rory D. Donnellan, Kero Guynes, Allan M. Carrillo-Baltodano, M. Dickman, Paul J. Hurd, J. Martín-Durán · 2025 · Genome Biology
Loss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization
René Winkler, Gemma Comas-Armangué, David Corujo, Adrián Sanz‐Moreno, Julia Calzada‐Wack, Shubhra Ashish Bhattacharya, Birgit Rathkolb, Nathalia Romanelli Vicente Dragano, Colina X. Qiao, Valentina Chiodi et al. · 2025 · Science Advances
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Miguel Vizoso, Manel Esteller · 2013 · Epigenetics
Histone variants: expanding the epigenetic potential of neurons one amino acid at a time
Bradley J. Lukasak, Erica Korb · 2025 · Trends in Biochemical Sciences
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Xiaolei Li, Zhiqiang Wu, Weidong Han · 2013 · Chinese Science Bulletin
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Gudrun Kausel, T. Vera, Guillermo Valenzuela, M. Lopez, Alex Romero, Marc Müller, Jaime E. Figueroa · 2010 · General and Comparative Endocrinology
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Antonia L. Pritchard · 2019 · Springer eBooks
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Nicolás G. Simonet, Joshua K. Thackray, Berta N. Vázquez, Alessandro Ianni, Maria Espinosa‐Alcantud, Julia Morales‐Sanfrutos, Sarah Hurtado-Bagès, Eduard Sabidó, Marcus Buschbeck, Jay A. Tischfield et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Histone Variants and Reprogramming in Early Development
Ana Bošković, Maria‐Elena Torres‐Padilla · 2014 · Epigenetics and human health
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Junjie Xiao, Guoping Li · 2016 · Elsevier eBooks
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Mohandass Kaviya, Thangavelu Sangeetha, Bharathi Kathirvel, Manoharan Rajesh, Kannan Vijayarani, Utthapon Issara, Balamuralikrishnan Balasubramanian, Vijaya Anand Arumugam · 2022 · Springer eBooks
Chromatin Dynamics and Higher-Order Chromatin Organization
Anette Zeilner, Paolo Piatti, Alexandra Lusser · 2012 · Encyclopedia of Molecular Cell Biology and Molecular Medicine
The evolution and developmental dynamics of histone-based chromatin regulation in Annelida
Francisco M. Martín-Zamora, Joby Cole, Rory D. Donnellan, Kero Guynes, Allan M. Carrillo‐Baltodano, Mark J. Dickman, Paul J. Hurd, José M. Martín-Durán · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
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Francisco M. Martín-Zamora, Joby Cole, Rory D. Donnellan, Kero Guynes, Allan M. Carrillo‐Baltodano, Mark J. Dickman, Paul J. Hurd, José María Martín-Durán · 2024 · Research Square
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Histone variant macroH2A confers resistance to nuclear reprogramming This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resultingworkunderthesameorsimilarlicensetothisone.Theworkmustbeattributedbacktotheoriginalauthorand commercial use is not permitted without specific permission.
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