Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB

Llorian, Miriam, Schwartz, Schraga, Clark, Tyson A, Hollander, Dror, Tan, Lit-Yeen, Spellman, Rachel, Gordon, Adele, Schweitzer, Anthony C, de la Grange, Pierre, Ast, Gil, Smith, Christopher W J·2010·Nature Structural & Molecular Biology
DOI 10.1038/nsmb.1881

Cited by (261)

Items 201–261 of 261

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  10. Predicting cell-type-specific exon inclusion in the human brain reveals more complex splicing mechanisms in neurons than glia
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  11. The leader RNA of SARS-CoV-2 sequesters polypyrimidine tract binding protein (PTBP1) and influences pre-mRNA splicing in infected cells
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  12. The Role of mRNA Alternative Processing in Mammalian Neurodevelopment
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  13. Sweet taste perception in mice is blunted by PTBP1-regulated skipping of Tas1r2 exon 4
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  14. RBPMS and RBPMS2 Cooperate to Safeguard Cardiac Splicing
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  16. The role of alternative splicing in lung cancer
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  17. Alterations of the skeletal muscle nuclear proteome after acute exercise reveals a post-transcriptional influence.
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  18. Splicing-Sensitive DNA-Microarrays: Peculiarities and Applicationin Biomedical Research (Review)
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  19. My road to alternative splicing control: from simple paths to loops and interconnections
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  20. hnRNP and hnRNP-Like Proteins in Splicing Control: Molecular Mechanisms and Implication in Human Pathologies
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  21. KATMAP: Inferring splicing factor activity and regulatory targets from knockdown data
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  22. Reducing polypyrimidine tract‑binding protein 1 fails to promote neuronal transdifferentiation on HT22 and mouse astrocyte cells under physiological conditions
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  23. Looping in on splicing: CRIC-seq uncovers PTBP1’s long-range RNA regulatory rules
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  24. Characterization of the regulation of CD46 alternative splicing
    Sze Jing Tang · 2016 · DR-NTU (Nanyang Technological University)
  25. KIS counteracts PTBP2 and regulates alternative exon usage in neurons
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  26. PTBP1 depletion in mature astrocytes reveals distinct splicing alterations without neuronal features
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  27. Ancestral intronic splicing regulatory elements in the SCNα gene family
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  28. PTBP1: A master regulator of neural development and transdifferentiation—promise and pitfalls
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  29. PTBP1 (polypyrimidine tract binding protein 1)
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  30. Splice Factor Polypyrimidine tract-binding protein 1 (Ptbp1) is Required for Immune Priming of the Endothelium in Atherogenic Disturbed Flow Conditions
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  31. CRIC-seq reveals positional rule of PTBP1-mediated long-range RNA looping in splicing regulation
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  32. miRNA-mediated expression of RBFOX2 governs the splicing transition from progenitors to neurons in the developing brain
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  33. Identification of novel signaling pathways for cardiomyocyte differentiation and growth
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  34. A Genome-Scale Analysis of Alternative Splicing Regulation by Splicing Factors in C. elegans
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  35. High-throughput analysis of gene expression and alternative splicing in cardiac hypertrophy
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  36. Étude des protéines de liaison à l'ARN des familles PTB et ARE-BP au cours du développement chez le xénope
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  37. Grand Celebration: 10th Anniversary of the Human Genome Project
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  38. Ptbp1-Activateded Co-Transcriptional Splicing Controls Epigenetic Status of Pluripotent Stem Cells
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  39. Mechanisms of mRNA processing defects in inherited THOC6 intellectual disability syndrome
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  40. TGF-β-induced MIR99AHG synergizes with PTBP1 to trigger a splicing switch of SMARCA1 that promotes invadopodia formation for metastasis in colorectal cancer
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  41. Supplementary Data from The Splicing Factor PTBP1 Promotes Expression of Oncogenic Splice Variants and Predicts Poor Prognosis in Patients with Non–muscle-Invasive Bladder Cancer
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  42. Supplementary Data from The Splicing Factor PTBP1 Promotes Expression of Oncogenic Splice Variants and Predicts Poor Prognosis in Patients with Non–muscle-Invasive Bladder Cancer
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  43. RAVER1 interconnects lethal EMT and miR/RISC activity by the control of alternative splicing
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  44. Computational Modeling and Inference of Alternative Splicing Regulation.
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  45. Pol II degradation activates cell death independently from the loss of transcription
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  46. Lysine acetylation plays a role in RNA binding protein-regulated alternative pre-mRNA splicing
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  47. PTBP1 Depletion in Mature Astrocytes Reveals Distinct Splicing Alterations Without Neuronal Features
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  48. PTBP1 Depletion in Mature Astrocytes Reveals Distinct Splicing Alterations Without Neuronal Features
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  49. Additional file 1 of MTSplice predicts effects of genetic variants on tissue-specific splicing
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  50. Additional file 2 of MTSplice predicts effects of genetic variants on tissue-specific splicing
    Cheng, Jun, Çelik, Muhammed Hasan, Anshul Bharat Kundaje, Julien Gagneur · 2021 · Figshare
  51. RNAMaRs: an interpretable framework for inferring multivalent RNA Motifs and cognate Regulators of Splicing
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  52. Decoding exon inclusion in the human brain reveals more divergent splicing mechanisms in neurons than glia
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  53. Forces that shape the transcriptome: Linking cellular mechanosensing to mRNA splicing
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  54. Comprehensive immunological and molecular analysis revealed inflammation-related diagnostic signatures in chronic rhinosinusitis
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  55. Variabilité phénotypique et épissage : combinaison d'analyses in vitro et in silico du gène CFTR
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  56. Study of molecules with nonsense mutation correction capacity
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  57. Alteration of alternative splicing in the pathogenesis of liver disease
    Hualin Wang · 2017 · theses.fr (ABES)
  58. Biais de composition nucléotidique des gènes et épissage alternatif
    Sébastien Lemaire · 2019 · theses.fr (ABES)
  59. Novel CuCLIP-seq for in situ covalently captured protein-binding RNAs
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  60. A positional and combinatorial regulatory code for alternative splicing
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  61. Rewiring of Nestin+ Cells Through PTBP1/PKM2 Axis Restores Notch-Dependent Neural Circuit Regeneration After Spinal Cord Injury
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